Biological formation of the 1,3-butadiene DNA adducts 7-N-(2-hydroxy-3-buten-1-yl)guanine, 7-N-(1-hydroxy-3-buten-2-yl)guanine and 7-N-(2,3,4-trihydroxy-butyl)guanine

Toxicology

Volumn 113, Issue 1-3, 1996, Pages 328-330

  Bolt, Hermann M ^a   Jelitto, Brigitte ^a  

^a LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

1,3 butadiene; DNA adducts; genotoxicity

Indexed keywords

1,3 BUTADIENE; GUANINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; COW; DNA ADDUCT; DNA ALKYLATION; GENOTOXICITY; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; THYMUS;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0030605158     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(96)03467-1     Document Type: Conference Paper

References (8)

1. Beland, F.A., Dooley, K.L. and Casciano, D.A. (1979) Rapid isolation of carcinogen-bound DNA and RNA by hydroxyapatite chromatography. J. Chromatogr. 174, 177-186.
2. Bolt, H.M. and Leutbecher, M. (1993). Dose-DNA adduct relationship for ethylene oxide. Arch. Toxicol. 67, 712-713.
3. Bolt, H.M. and Jelitto, B. (1996) Synthesis and characterization of 1,3-butadiene-DNA-adducts. Fresenius Environ. Bull. (in press).
4. 14C]vinyl chloride in the rat. Arch. Toxicol. 35, 153-162.
5. Citti, L., Gervasi, P.G., Turchi, G., Belluci, G. and Bianchini, R. (1984) The reaction of 3,4-epoxy-1-butene with deoxyguanosine and DNA in vitro: synthesis and characterization of the main adducts. Carcinogenesis 5, 47-52.
6. Gwinner, L.M., Laib, R.J., Filser, J.G. and Bolt, H.M. (1983) Evidence of chloroethylene oxide being the reactive metabolite of vinyl chloride towards DNA: comparative studies with 2,2′-dichlorodiethylether. Carcinogenesis 4, 1483-1486.
7. Jelitto, B., Vangala, R.R. and Laib, R.J. (1989) Species differences in DNA damage by butadiene: role of diepoxybutane. Arch. Toxicol. 13, 246-249.
8. 14C]2-methylpropene (isobutene). Arch. Toxicol. 68, 71-72.