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Volumn 357, Issue 1-2, 1996, Pages 143-165

A role for apoptosis in the toxicity and mutagenicity of bleomycin in AHH-1 tk(+/-) human lymphoblastoid cells

Author keywords

Apoptosis; Bleomycin; Cytotoxicity; hprt mutation; Human lymphoblastoid cell; tk mutation

Indexed keywords

BLEOMYCIN;

EID: 0030601761     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(96)00095-4     Document Type: Article
Times cited : (17)

References (76)
  • 1
    • 0028925819 scopus 로고
    • Sequence-specific double-strand cleavage of DNA by Fe-bleomycin, 1. The detection of sequence-specific double-strand breaks using hairpin oligonucleotides
    • Absalon, M.J., J.W. Kozarich and J. Stubbe (1995) Sequence-specific double-strand cleavage of DNA by Fe-bleomycin, 1. The detection of sequence-specific double-strand breaks using hairpin oligonucleotides, Biochemistry, 34, 2065-2075.
    • (1995) Biochemistry , vol.34 , pp. 2065-2075
    • Absalon, M.J.1    Kozarich, J.W.2    Stubbe, J.3
  • 2
    • 0027438223 scopus 로고
    • Polymerase chain reaction-based deletion screening of bleomycin induced 6-thioguanine-resistant mutants in Chinese hamster ovary cells: The effects of an inhibitor and a mimic of superoxide dismutase
    • An, J. and A.W. Hsie (1993) Polymerase chain reaction-based deletion screening of bleomycin induced 6-thioguanine-resistant mutants in Chinese hamster ovary cells: The effects of an inhibitor and a mimic of superoxide dismutase, Mutation Res., 289, 215-222.
    • (1993) Mutation Res. , vol.289 , pp. 215-222
    • An, J.1    Hsie, A.W.2
  • 3
    • 0028354792 scopus 로고
    • Polymerase chain reaction-directed DNA sequencing of bleomycin-induced 'nondeletion'-type, 6-thioguanine-resistant mutants in Chinese hamster ovary cell derivative AS52: Effects of an inhibitor and a mimic of superoxide dismutase
    • An, J. and A.W. Hsie (1994) Polymerase chain reaction-directed DNA sequencing of bleomycin-induced 'nondeletion'-type, 6-thioguanine-resistant mutants in Chinese hamster ovary cell derivative AS52: Effects of an inhibitor and a mimic of superoxide dismutase, Environ. Mol. Mutagen., 23, 101-109.
    • (1994) Environ. Mol. Mutagen. , vol.23 , pp. 101-109
    • An, J.1    Hsie, A.W.2
  • 4
    • 0028987566 scopus 로고
    • Induction of bax-α precedes apoptosis in a human B lymphoma cell line: Potential role of the bcl-2 gene family in surface IgM-mediated apoptosis
    • Bargou, R.C., K. Bommert, P. Weinmann, P.T. Daniel, C. Wagener, M. Mapara and B. Dorken (1995) Induction of bax-α precedes apoptosis in a human B lymphoma cell line: potential role of the bcl-2 gene family in surface IgM-mediated apoptosis, Eur. J. Immunol., 25, 770-775.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 770-775
    • Bargou, R.C.1    Bommert, K.2    Weinmann, P.3    Daniel, P.T.4    Wagener, C.5    Mapara, M.6    Dorken, B.7
  • 5
    • 0025047803 scopus 로고
    • Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia
    • Barry, M.A., C.A. Behnke and A. Eastman (1990) Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia, Biochem. Pharmacol., 40, 2353-2362.
    • (1990) Biochem. Pharmacol. , vol.40 , pp. 2353-2362
    • Barry, M.A.1    Behnke, C.A.2    Eastman, A.3
  • 7
    • 0028096138 scopus 로고
    • DNA double-strand breakage by bleomycin in Ehrlich Ascites tumor cells as measured by nondenaturing filter elution
    • Byrnes, R.W. and D.H. Petering (1994) DNA double-strand breakage by bleomycin in Ehrlich Ascites tumor cells as measured by nondenaturing filter elution, Radiat. Res., 137, 162-170.
    • (1994) Radiat. Res. , vol.137 , pp. 162-170
    • Byrnes, R.W.1    Petering, D.H.2
  • 8
    • 0025035888 scopus 로고
    • Intracellular DNA strand scission and growth inhibition of Ehrlich Ascites tumor cells by bleomycin
    • Byrnes, R.W., J. Templin, D. Sem, S. Lyman and D.H. Petering (1990) Intracellular DNA strand scission and growth inhibition of Ehrlich Ascites tumor cells by bleomycin, Cancer Res., 50, 5275-5286.
    • (1990) Cancer Res. , vol.50 , pp. 5275-5286
    • Byrnes, R.W.1    Templin, J.2    Sem, D.3    Lyman, S.4    Petering, D.H.5
  • 9
    • 0028537065 scopus 로고
    • Kinetics of apoptosis and secondry necrosis in cultured rat thymocytes and S.49 mouse lymphoma and CEM human leukemia cells
    • Cejna, M., G. Fritsch, D. Printz, R. Schulte-Hermann and W. Bursch (1994) Kinetics of apoptosis and secondry necrosis in cultured rat thymocytes and S.49 mouse lymphoma and CEM human leukemia cells, Biochem. Cell Biol., 72, 677-685.
    • (1994) Biochem. Cell Biol. , vol.72 , pp. 677-685
    • Cejna, M.1    Fritsch, G.2    Printz, D.3    Schulte-Hermann, R.4    Bursch, W.5
  • 13
    • 0021187090 scopus 로고
    • Assay for gene mutation in a human lymphoblast line, AHH-1, competent for xenobiotic metabolism
    • Crespi, C.L. and W.G. Thilly (1984) Assay for gene mutation in a human lymphoblast line, AHH-1, competent for xenobiotic metabolism, Mutation Res., 128, 221-230.
    • (1984) Mutation Res. , vol.128 , pp. 221-230
    • Crespi, C.L.1    Thilly, W.G.2
  • 14
    • 0001308334 scopus 로고
    • Tests for mutagenic activity using mutation assays at two loci in human lymphoblast cell lines, TK6 and AHH-1
    • Crespi, C.L., C.G. Ryan, G.M. Seixas, T.R. Turner and B.W. Penman (1985) Tests for mutagenic activity using mutation assays at two loci in human lymphoblast cell lines, TK6 and AHH-1, Prog. Mutation Res., 5, 497-516.
    • (1985) Prog. Mutation Res. , vol.5 , pp. 497-516
    • Crespi, C.L.1    Ryan, C.G.2    Seixas, G.M.3    Turner, T.R.4    Penman, B.W.5
  • 15
    • 0026543962 scopus 로고
    • Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multi-parameter flow cytometry
    • Dive, C., C.D. Gregory, D.J. Phipps, D.L. Evans, A.E. Milner and A.H. Wylie (1992) Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multi-parameter flow cytometry, Biochim. Biophys. Acta, 1133, 275-285.
    • (1992) Biochim. Biophys. Acta , vol.1133 , pp. 275-285
    • Dive, C.1    Gregory, C.D.2    Phipps, D.J.3    Evans, D.L.4    Milner, A.E.5    Wylie, A.H.6
  • 16
    • 0024574046 scopus 로고
    • Micronucleus, chromosome aberration, and small-colony TK mutant analysis to quantitate chromosomal damage in L5178Y mouse lymphoma cells
    • Doerr, C.L., K. Harrington-Brock and M.M. Moore (1989) Micronucleus, chromosome aberration, and small-colony TK mutant analysis to quantitate chromosomal damage in L5178Y mouse lymphoma cells, Mutation Res., 222, 191-203.
    • (1989) Mutation Res. , vol.222 , pp. 191-203
    • Doerr, C.L.1    Harrington-Brock, K.2    Moore, M.M.3
  • 20
    • 0027279128 scopus 로고
    • Bcl-2 modulation of apoptosis induced by anticancer drugs: Resistance to thymidylate stress is independent of classical resistance pathways
    • Fisher, T.C., A.E. Milner, C.D. Gregory, A.L. Jackman, G.W. Aherne, J. Hartley, C. Dive and J.A. Hickman (1993) Bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways, Cancer Res., 53, 3321-3326.
    • (1993) Cancer Res. , vol.53 , pp. 3321-3326
    • Fisher, T.C.1    Milner, A.E.2    Gregory, C.D.3    Jackman, A.L.4    Aherne, G.W.5    Hartley, J.6    Dive, C.7    Hickman, J.A.8
  • 21
    • 0019404906 scopus 로고
    • Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates
    • Furth, E., W.G. Thilly, B.W. Penman, H.L. Liber and W.M. Rand (1981) Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates, Anal. Biochem., 110, 1-8.
    • (1981) Anal. Biochem. , vol.110 , pp. 1-8
    • Furth, E.1    Thilly, W.G.2    Penman, B.W.3    Liber, H.L.4    Rand, W.M.5
  • 22
    • 0025736675 scopus 로고
    • Biochemical evidence for two different mechanisms for bleomycin-induced cell killing
    • Giacci, A.J., J. Shieh, A. Cholon and J. M. Brown (1991) Biochemical evidence for two different mechanisms for bleomycin-induced cell killing, Mutation Res., 263, 69-75.
    • (1991) Mutation Res. , vol.263 , pp. 69-75
    • Giacci, A.J.1    Shieh, J.2    Cholon, A.3    Brown, J.M.4
  • 23
  • 24
    • 0025772343 scopus 로고
    • Induction of Bcl-2 expression by Epstein Barr virus latent membrane protein 1 protects infected B cells from programmed cell death
    • Henderson, A., M. Rowe, C. Gregory, D. Croom-Carter, F. Wang, R. Longnecker, E. Kieff and A. Rickinson (1991) Induction of Bcl-2 expression by Epstein Barr virus latent membrane protein 1 protects infected B cells from programmed cell death, Cell, 65, 1107-1115.
    • (1991) Cell , vol.65 , pp. 1107-1115
    • Henderson, A.1    Rowe, M.2    Gregory, C.3    Croom-Carter, D.4    Wang, F.5    Longnecker, R.6    Kieff, E.7    Rickinson, A.8
  • 25
    • 0017098632 scopus 로고
    • Single-strand scission and repair of DNA in mammalian cells by bleomycin
    • Iqbal, Z.M., K.W. Kohn, R.A.G. Ewig and A.J. Fornace (1976) Single-strand scission and repair of DNA in mammalian cells by bleomycin, Cancer Res., 36, 3834-3838.
    • (1976) Cancer Res. , vol.36 , pp. 3834-3838
    • Iqbal, Z.M.1    Kohn, K.W.2    Ewig, R.A.G.3    Fornace, A.J.4
  • 26
    • 0027892521 scopus 로고
    • Bcl-2 protein inhibits etopside-induced apoptosis through its effects on events subsequent to topoisomerase-II-induced DNA strand breaks and their repair
    • Kamesaki, S., H. Kamesaki, T.J. Jorgenson, A. Tanizawa, Y. Pommier and J. Cossman (1993) Bcl-2 protein inhibits etopside-induced apoptosis through its effects on events subsequent to topoisomerase-II-induced DNA strand breaks and their repair, Cancer Res., 53, 4251-4256.
    • (1993) Cancer Res. , vol.53 , pp. 4251-4256
    • Kamesaki, S.1    Kamesaki, H.2    Jorgenson, T.J.3    Tanizawa, A.4    Pommier, Y.5    Cossman, J.6
  • 27
    • 0028329172 scopus 로고
    • Apoptosis. Its significance in cancer and cancer therapy
    • Kerr, J.F.R., C.M. Winterford and B.V. Harmon (1994) Apoptosis. Its significance in cancer and cancer therapy, Cancer, 73, 2013-2026.
    • (1994) Cancer , vol.73 , pp. 2013-2026
    • Kerr, J.F.R.1    Winterford, C.M.2    Harmon, B.V.3
  • 29
    • 0025898973 scopus 로고
    • Molecular characterization of mutations at the hprt locus in V79 Chinese hamster cells induced by bleomycin in the presence of inhibitors of DNA repair
    • Koberle, B. and G. Speit (1991) Molecular characterization of mutations at the hprt locus in V79 Chinese hamster cells induced by bleomycin in the presence of inhibitors of DNA repair, Mutation Res., 249, 161-167.
    • (1991) Mutation Res. , vol.249 , pp. 161-167
    • Koberle, B.1    Speit, G.2
  • 30
    • 0028956550 scopus 로고
    • Regulators of cell death
    • Korsemeyer, S.J. (1995) Regulators of cell death, Trends Genet., 11, 101-105.
    • (1995) Trends Genet. , vol.11 , pp. 101-105
    • Korsemeyer, S.J.1
  • 33
    • 0028990145 scopus 로고
    • Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status
    • Little, J.B., H. Nagasawa, P.C. Keng, Y. Yu and C.Y. Li (1995) Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status, J. Biol. Chem., 270, 11033-11036.
    • (1995) J. Biol. Chem. , vol.270 , pp. 11033-11036
    • Little, J.B.1    Nagasawa, H.2    Keng, P.C.3    Yu, Y.4    Li, C.Y.5
  • 34
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe, S.W., E.M. Schmitt, A.W. Smith, B.A. Osborne and T. Jacks (I993a) p53 is required for radiation-induced apoptosis in mouse thymocytes, Nature, 362, 847-848.
    • (1993) Nature , vol.362 , pp. 847-848
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, A.W.3    Osborne, B.A.4    Jacks, T.5
  • 35
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe, S.W., H.E. Ruley, T. Jacks and D.E. Housman (1993b) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents, Cell, 74, 957-967.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 38
    • 0026781986 scopus 로고
    • Bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs
    • Miyashita, T. and J.C. Reed (1992) Bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs, Cancer Res., 52, 5407-5411.
    • (1992) Cancer Res. , vol.52 , pp. 5407-5411
    • Miyashita, T.1    Reed, J.C.2
  • 40
    • 0028216951 scopus 로고
    • The role of programmed cell death in the toxicity of the mutagens, ethyl methanesulfonate and N-ethyl-N′-nitrosourea, in AHH-1 lymphoblastoid cells
    • Morris, S.M., L.J. McGarrity, O.E. Domon, J.J. Chen, W.G. Hinson, T.J. Bucci, A.R. Warbritton and D.A. Casciano (1994a) The role of programmed cell death in the toxicity of the mutagens, ethyl methanesulfonate and N-ethyl-N′-nitrosourea, in AHH-1 lymphoblastoid cells, Mutation Res., 306, 19-34.
    • (1994) Mutation Res. , vol.306 , pp. 19-34
    • Morris, S.M.1    McGarrity, L.J.2    Domon, O.E.3    Chen, J.J.4    Hinson, W.G.5    Bucci, T.J.6    Warbritton, A.R.7    Casciano, D.A.8
  • 41
    • 0027931259 scopus 로고
    • Induction of mutations at the hypoxanthine phosphoribosyl transferase (HPRT) locus in AHH-1 human lymphoblastoid cells
    • Morris, S.M., O.E. Domon, K.B. Delclos, J.J. Chen and D.A. Casciano (1994b) Induction of mutations at the hypoxanthine phosphoribosyl transferase (HPRT) locus in AHH-1 human lymphoblastoid cells, Mutation Res., 310, 45-54.
    • (1994) Mutation Res. , vol.310 , pp. 45-54
    • Morris, S.M.1    Domon, O.E.2    Delclos, K.B.3    Chen, J.J.4    Casciano, D.A.5
  • 42
    • 0029001131 scopus 로고
    • Programmed cell death and mutation induction in AHH-1 human lymphoblastoid cells exposed to m-amsa
    • Morris, S.M., O.E. Domon, L.J. McGarrity, J.J. Chen and D.A. Casciano (1995) Programmed cell death and mutation induction in AHH-1 human lymphoblastoid cells exposed to m-amsa, Mutation Res., 329, 79-96.
    • (1995) Mutation Res. , vol.329 , pp. 79-96
    • Morris, S.M.1    Domon, O.E.2    McGarrity, L.J.3    Chen, J.J.4    Casciano, D.A.5
  • 44
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death
    • Oltvai, Z.N., C.L. Milliman and S.J. Korsemeyer (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death, Cell, 74, 609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsemeyer, S.J.3
  • 45
    • 0026707867 scopus 로고
    • The involvement of oncogenes and tumor suppressor genes in the control of apoptosis
    • Oren, M. (1992) The involvement of oncogenes and tumor suppressor genes in the control of apoptosis, Cancer Metast. Rev., 11, 141-148.
    • (1992) Cancer Metast. Rev. , vol.11 , pp. 141-148
    • Oren, M.1
  • 46
    • 0023640885 scopus 로고
    • Bleomycin, in contrast to gamma irradiation, induces extreme variation of DNA strand breakage from cell to cell
    • Ostling, O. and K.J. Johanson (1987) Bleomycin, in contrast to gamma irradiation, induces extreme variation of DNA strand breakage from cell to cell, Int. J. Radiat. Biol., 52, 683-691.
    • (1987) Int. J. Radiat. Biol. , vol.52 , pp. 683-691
    • Ostling, O.1    Johanson, K.J.2
  • 48
    • 0022221178 scopus 로고
    • Esterase activity, exclusion of propidium iodide, and proliferation in tumor cells exposed to anti-cancer agents: Phenomenon relevant to chemosensitivity determinations
    • Pavlik, E.J., R.C. Flanigan, J.R. Van Nagel, M.B. Hansen, E.S. Donaldson, K. Keaton, B. Doss, J. Bartman and D.E. Kenady (1985) Esterase activity, exclusion of propidium iodide, and proliferation in tumor cells exposed to anti-cancer agents: Phenomenon relevant to chemosensitivity determinations, Cancer Invest., 3, 413-426.
    • (1985) Cancer Invest. , vol.3 , pp. 413-426
    • Pavlik, E.J.1    Flanigan, R.C.2    Van Nagel, J.R.3    Hansen, M.B.4    Donaldson, E.S.5    Keaton, K.6    Doss, B.7    Bartman, J.8    Kenady, D.E.9
  • 49
    • 0000576972 scopus 로고
    • Genotoxicity of bleomycin
    • Povrik, L.F. and M.J.F. Austin (1991) Genotoxicity of bleomycin, Mutation Res., 257, 127-143.
    • (1991) Mutation Res. , vol.257 , pp. 127-143
    • Povrik, L.F.1    Austin, M.J.F.2
  • 50
    • 0024396338 scopus 로고
    • Structure of bleomycin-induced DNA double-strand breaks: Predominance of blunt ends and single-base 5′ extensions
    • Povrik, L.F., Y.H. Han and R.J. Steighner (1989) Structure of bleomycin-induced DNA double-strand breaks: Predominance of blunt ends and single-base 5′ extensions, Biochemistry, 28, 5808-5814.
    • (1989) Biochemistry , vol.28 , pp. 5808-5814
    • Povrik, L.F.1    Han, Y.H.2    Steighner, R.J.3
  • 51
    • 0028088766 scopus 로고
    • Single base-pair deletions induced by bleomycin at potential double-strand cleavage sites in the aprt gene of stationary phase Chinese hamster ovary D422 cells
    • Povrik, L.F., R.A.O. Bennett, P. Wang, P.S. Swerdlow and M.J. Finley Austin (1994) Single base-pair deletions induced by bleomycin at potential double-strand cleavage sites in the aprt gene of stationary phase Chinese hamster ovary D422 cells, J. Mol. Biol., 243, 216-226.
    • (1994) J. Mol. Biol. , vol.243 , pp. 216-226
    • Povrik, L.F.1    Bennett, R.A.O.2    Wang, P.3    Swerdlow, P.S.4    Austin, M.J.F.5
  • 52
    • 0027948119 scopus 로고
    • p53 status, DNA double-strand break repair proficiency, and radiation response of mouse lymphoid and myeloid cell lines
    • Radford, I.R. (1994a) p53 status, DNA double-strand break repair proficiency, and radiation response of mouse lymphoid and myeloid cell lines, Int. J. Radiat. Biol., 66, 557-560.
    • (1994) Int. J. Radiat. Biol. , vol.66 , pp. 557-560
    • Radford, I.R.1
  • 53
    • 0028224017 scopus 로고
    • Radiation response of mouse lymphoid and myeloid cell lines. Part I. Sensitivity to killing by ionizing radiation, rate of loss of viability and cell type of origin
    • Radford, L.R. (1994b) Radiation response of mouse lymphoid and myeloid cell lines. Part I. Sensitivity to killing by ionizing radiation, rate of loss of viability and cell type of origin, Int. J. Radiat. Biol., 65, 203-215.
    • (1994) Int. J. Radiat. Biol. , vol.65 , pp. 203-215
    • Radford, L.R.1
  • 54
    • 0028181452 scopus 로고
    • Radiation response of mouse lymphoid and myeloid cell lines. Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage
    • Radford, I.R. and T.K. Murphy (1994) Radiation response of mouse lymphoid and myeloid cell lines. Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage, Int. J. Radiat. Biol., 65, 229-239.
    • (1994) Int. J. Radiat. Biol. , vol.65 , pp. 229-239
    • Radford, I.R.1    Murphy, T.K.2
  • 55
    • 0028220486 scopus 로고
    • Radiation response of mouse lymphoid and myeloid cell lines. Part II. Apoptotic death is shown by all lines examined
    • Radford, I.R., T.K. Murphy, J.M. Radley and S.L. Ellis (1994) Radiation response of mouse lymphoid and myeloid cell lines. Part II. Apoptotic death is shown by all lines examined, Int. J. Radiat. Biol., 65, 217-227.
    • (1994) Int. J. Radiat. Biol. , vol.65 , pp. 217-227
    • Radford, I.R.1    Murphy, T.K.2    Radley, J.M.3    Ellis, S.L.4
  • 56
    • 0024308082 scopus 로고
    • Estimation of cell survival by flow cytometric quantification of fluorescein diacetate/propidium iodide viable cell number
    • Ross, D.D., C.C. Joneckis, J.V. Ordonez, A.M. Sisk, R.K. Wu, A.W. Hamburger and R.E. Nora (1989) Estimation of cell survival by flow cytometric quantification of fluorescein diacetate/propidium iodide viable cell number, Cancer Res., 49, 3776-3782.
    • (1989) Cancer Res. , vol.49 , pp. 3776-3782
    • Ross, D.D.1    Joneckis, C.C.2    Ordonez, J.V.3    Sisk, A.M.4    Wu, R.K.5    Hamburger, A.W.6    Nora, R.E.7
  • 58
    • 0027488644 scopus 로고
    • Sensitivity of insulin-secreting RIN m5F cells to undergoing apoptosis by the protein kinase C inhibitor staurosporine
    • Sanchez-Margalet, V., M. Lucas, F. Solano and R. Goberna (1993) Sensitivity of insulin-secreting RIN m5F cells to undergoing apoptosis by the protein kinase C inhibitor staurosporine, Exp. Cell Res., 209, 160-163.
    • (1993) Exp. Cell Res. , vol.209 , pp. 160-163
    • Sanchez-Margalet, V.1    Lucas, M.2    Solano, F.3    Goberna, R.4
  • 59
    • 0028980555 scopus 로고
    • Different sensitivity to cell killing and chromosome mutation induction by gamma rays in two human lymphoblastoid cell lines derived from a single donor: Possible role of apoptosis
    • Schwartz, J.L., R. Jordan, B.A. Sedita, M.J. Swenningson, J.P. Banath and P.L. Olive (1995) Different sensitivity to cell killing and chromosome mutation induction by gamma rays in two human lymphoblastoid cell lines derived from a single donor: possible role of apoptosis, Mutagenesis, 10, 227-233.
    • (1995) Mutagenesis , vol.10 , pp. 227-233
    • Schwartz, J.L.1    Jordan, R.2    Sedita, B.A.3    Swenningson, M.J.4    Banath, J.P.5    Olive, P.L.6
  • 60
    • 0028238213 scopus 로고
    • Immediate early up-regulation of bax expression by p53 but not by TGFβ1: A paradigm for distinct apoptotic pathways
    • Selvakumaran, M., H.K. Lin, T. Miyashita, H.G. Wang, S. Krajewski, J.C. Reed, B. Hoffman and D. Liebermann (1994) Immediate early up-regulation of bax expression by p53 but not by TGFβ1: a paradigm for distinct apoptotic pathways, Oncogene, 9, 1791-1798.
    • (1994) Oncogene , vol.9 , pp. 1791-1798
    • Selvakumaran, M.1    Lin, H.K.2    Miyashita, T.3    Wang, H.G.4    Krajewski, S.5    Reed, J.C.6    Hoffman, B.7    Liebermann, D.8
  • 61
    • 0027944860 scopus 로고
    • DNA damage induced by bleomycin, neocarzinostatin and melphalan in a precisely positioned nucleosome
    • Smith, B.L., G.B. Bauer and L.F. Povrik (1994) DNA damage induced by bleomycin, neocarzinostatin and melphalan in a precisely positioned nucleosome, J. Biol. Chem., 48, 30587-30594.
    • (1994) J. Biol. Chem. , vol.48 , pp. 30587-30594
    • Smith, B.L.1    Bauer, G.B.2    Povrik, L.F.3
  • 62
    • 0025044454 scopus 로고
    • Effect of in vitro cleavage of apurininc/apyrimidinic sites on bleomycin-induced mutagenesis of repackaged lambda phage
    • Steighner, R.J. and L.F. Povrik (1990) Effect of in vitro cleavage of apurininc/apyrimidinic sites on bleomycin-induced mutagenesis of repackaged lambda phage, Mutation Res., 240, 93-100.
    • (1990) Mutation Res. , vol.240 , pp. 93-100
    • Steighner, R.J.1    Povrik, L.F.2
  • 64
    • 0028238034 scopus 로고
    • Analysis of mitotic cell death caused by radiation in mouse leukemia L5178Y cells: Apoptosis is the ultimate form of cell death following mitotic failure
    • Tauchi, H. and S. Sawada (1994) Analysis of mitotic cell death caused by radiation in mouse leukemia L5178Y cells: apoptosis is the ultimate form of cell death following mitotic failure, Int. J. Radiat. Biol., 65, 449-455.
    • (1994) Int. J. Radiat. Biol. , vol.65 , pp. 449-455
    • Tauchi, H.1    Sawada, S.2
  • 65
    • 0027339397 scopus 로고
    • Apoptosis in C3H/10T1/2 embryonic mouse cells: Evidence for internucleosomal DNA modification in the absence of double-strand cleavage
    • Tomei, L.D., J.P. Shapiro and P.O. Cope (1993) Apoptosis in C3H/10T1/2 embryonic mouse cells: Evidence for internucleosomal DNA modification in the absence of double-strand cleavage. Proc. Natl. Acad. Sci. USA, 90, 853-857.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 853-857
    • Tomei, L.D.1    Shapiro, J.P.2    Cope, P.O.3
  • 66
    • 0027385319 scopus 로고
    • Bleomycin, an apoptosis-mimetic drug that induces two types of cell death depending upon the number of molecules internalized
    • Tounekti, O., G. Pron, J. Belehradek and L.M. Mir (1993) Bleomycin, an apoptosis-mimetic drug that induces two types of cell death depending upon the number of molecules internalized. Cancer Res., 53, 5462-5469.
    • (1993) Cancer Res. , vol.53 , pp. 5462-5469
    • Tounekti, O.1    Pron, G.2    Belehradek, J.3    Mir, L.M.4
  • 67
    • 0028916569 scopus 로고
    • Relationships between DNA fragmentation, chromatin condensation, and changes in flow cytometry profiles detected during apoptosis
    • Tounekti, O., J. Belehradek and L.M. Mir (1995) Relationships between DNA fragmentation, chromatin condensation, and changes in flow cytometry profiles detected during apoptosis. Exp. Cell Res., 217, 506-516.
    • (1995) Exp. Cell Res. , vol.217 , pp. 506-516
    • Tounekti, O.1    Belehradek, J.2    Mir, L.M.3
  • 68
    • 0028540186 scopus 로고
    • Endonuclease activities, chromatin structure, and DNA degradation in apoptosis
    • Walker, P.R. and M. Sikorska (1994) Endonuclease activities, chromatin structure, and DNA degradation in apoptosis, Biochem. Cell Biol., 72, 615-623.
    • (1994) Biochem. Cell Biol. , vol.72 , pp. 615-623
    • Walker, P.R.1    Sikorska, M.2
  • 69
    • 0029328641 scopus 로고
    • Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway
    • Woods, C.M., J. Zhu, P.A. McQueney, D. Bollag and E. Lazarides (1995) Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway, Mol. Med., 1, 506-526.
    • (1995) Mol. Med. , vol.1 , pp. 506-526
    • Woods, C.M.1    Zhu, J.2    McQueney, P.A.3    Bollag, D.4    Lazarides, E.5
  • 70
    • 0026670335 scopus 로고
    • Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: An overview
    • Wyllie, A.H. (1992) Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview, Cancer Metast. Rev., 11, 95-103.
    • (1992) Cancer Metast. Rev. , vol.11 , pp. 95-103
    • Wyllie, A.H.1
  • 71
    • 0028944890 scopus 로고
    • Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines
    • Xia, F., X. Wang, Y. H Wang, N.M. Tsang, D.W. Yandell, K.T. Kelsey and H.L. Liber (1995) Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines, Cancer Res., 55, 12-15.
    • (1995) Cancer Res. , vol.55 , pp. 12-15
    • Xia, F.1    Wang, X.2    Wang, Y.H.3    Tsang, N.M.4    Yandell, D.W.5    Kelsey, K.T.6    Liber, H.L.7
  • 72
    • 0029009258 scopus 로고
    • Radiation-induced apoptotic cell death in human gastric epithelial tumour cells: Correlation between mitotic death and apoptosis
    • Yanagihara, K., M. Nii, M. Numoto, K. Kamiya, H. Tauchi, S. Sawada and T. Seito (1995) Radiation-induced apoptotic cell death in human gastric epithelial tumour cells: correlation between mitotic death and apoptosis, Int. J. Radiat. Biol., 67, 677-685.
    • (1995) Int. J. Radiat. Biol. , vol.67 , pp. 677-685
    • Yanagihara, K.1    Nii, M.2    Numoto, M.3    Kamiya, K.4    Tauchi, H.5    Sawada, S.6    Seito, T.7
  • 74
    • 0025784539 scopus 로고
    • Wild-type p53 induces apoptosis of myeloid leukemia cells that is inhibited by interleukin-6
    • Yonish-Rouach, E., D. Resnitzky, J. Lotem, L. Sachs, A. Kimchi and M. Oren (1991) Wild-type p53 induces apoptosis of myeloid leukemia cells that is inhibited by interleukin-6, Nature, 352, 345-347.
    • (1991) Nature , vol.352 , pp. 345-347
    • Yonish-Rouach, E.1    Resnitzky, D.2    Lotem, J.3    Sachs, L.4    Kimchi, A.5    Oren, M.6
  • 75
    • 0027944228 scopus 로고
    • Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis
    • Zhan, Q. S. Fan, I. Bae, C. Guillouf, D.A. Liebermann, P.M. O'Connor, A.J. Fornace (1994) Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis, Oncogene, 9, 3743-3751.
    • (1994) Oncogene , vol.9 , pp. 3743-3751
    • Zhan, Q.1    Fan, S.2    Bae, I.3    Guillouf, C.4    Liebermann, D.A.5    O'Connor, P.M.6    Fornace, A.J.7
  • 76
    • 0028986587 scopus 로고
    • The relative radiosensitivity of TK6 and WI-L2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status
    • Zhen, W., C.M. Denault, K. Loviscek, S. Walter, L. Geng and A.T.M. Vaughn (1995) The relative radiosensitivity of TK6 and WI-L2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status, Mutation Res., 346, 85-92.
    • (1995) Mutation Res. , vol.346 , pp. 85-92
    • Zhen, W.1    Denault, C.M.2    Loviscek, K.3    Walter, S.4    Geng, L.5    Vaughn, A.T.M.6


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