Trichothecinols A, B and C, potent anti-tumor, promoting sesquiterpenoids from the fungus Trichothecium roseum

Tetrahedron Letters

Volumn 37, Issue 51, 1996, Pages 9219-9220

  Iida, Akira ^a   Konishi, Kazuhide ^a   Kubo, Hiroki ^a   Tomioka, Kiyoshi ^a   Tokuda, Harukuni ^b   Nishino, Hoyoku ^b  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; SESQUITERPENOID;

ARTICLE; DRUG IDENTIFICATION; DRUG ISOLATION; EPSTEIN BARR VIRUS; FUNGUS; INFRARED SPECTROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE;

FUNGI; HUMAN HERPESVIRUS 4; TRICHOTHECIUM ROSEUM;

EID: 0030590990     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(96)02187-9     Document Type: Article

References (15)

1. 1. Freeman, G. G.; Gill, J. J.; Waring, W. S. J. Chem. Soc. 1959, 1105-1132; Godteredsen, W. O.; Vangedal, S. Acta. Chem. Scand. 1965, 19, 1088-1102.
2. 1. Freeman, G. G.; Gill, J. J.; Waring, W. S. J. Chem. Soc. 1959, 1105-1132; Godteredsen, W. O.; Vangedal, S. Acta. Chem. Scand. 1965, 19, 1088-1102.
3. 2. Ito, Y.; Yanase, S.; Fujita, J.; Harayama, T.; Takashima, M.; Imanaka, H. Cancer Lett. 1981, 13, 29-37; Tokuda, H.; Ohigashi, H.; Koshimizu, K.; Ito, Y. ibid, 1986, 33, 279-286.
4. 2. Ito, Y.; Yanase, S.; Fujita, J.; Harayama, T.; Takashima, M.; Imanaka, H. Cancer Lett. 1981, 13, 29-37; Tokuda, H.; Ohigashi, H.; Koshimizu, K.; Ito, Y. ibid, 1986, 33, 279-286.
5. 3), δ 79.30 (d, C-2), 78.77 (d, C-3), 83.17 (d, C-4), 48.87 (s, C-5), 44.39 (s, C-6), 42.03 (t, C-7), 198.46 (s, C-8), 137.77 (s, C-9), 137.24 (d, C-10), 70.97 (d, C-11), 64.50 (s, C-12), 46.63 (t, C-13), 5.90 (q, C-14), 18.40 (q, C-15), 15.33 (q, C-16), 167.81 (s, C-1′), 119.89 (d, C-2′), 147.05 (d, C-3′), 15.57 (q, C-4′) .
6. 4. Gyimesi, J.; Melera, A. Tetrahedron Lett. 1967, 1665-1673; Hanson, J. R.; Marten, T.; Siverns, M. J. Chem. Soc. Perkin I 1974, 1033-1036.
7. 4. Gyimesi, J.; Melera, A. Tetrahedron Lett. 1967, 1665-1673; Hanson, J. R.; Marten, T.; Siverns, M. J. Chem. Soc. Perkin I 1974, 1033-1036.
8. 5. Ohtani, I.; Kusumi, T.; Kashman, Y.; Kakisawa, H. J. Am. Chem. Soc. 1991, 113, 4092-4096.
9. 3), δ 36.91 (t, C-3), 67.83 (d, C-8).
10. 3), δ 78.81 (d, C-3), 67.73 (d, C-8).
11. 8. For a review, see: Murakami, A.; Ohigasi, H.; Koshimizu, K. Biosci. Biotech. Biochem. 1996, 60, 1-8.
12. 9. Berenblum, I. Cancer Res. 1941, 1, 44-48; Pilot, H. C.; Dragan, Y. P. FASEB J. 1991, 5, 2280-2286.
13. 9. Berenblum, I. Cancer Res. 1941, 1, 44-48; Pilot, H. C.; Dragan, Y. P. FASEB J. 1991, 5, 2280-2286.
14. 10. Sporn, M. B. Cancer Res. 1976, 36, 821-830.
15. 11. This study was financially supported in part by Grants-in-Aid from the Ministry of Education, Science, Sports, and Culture, and from the Ministry of Health and Welfare for the Second Term Comprehensive 10-Year Strategy for Cancer Control, Japan.