-
1
-
-
0026782875
-
Generation and analysis of random point mutations in an antibody CDR2 sequence: Many mutated antibodies lose their ability to bind antigen
-
Chen, C., V. A. Roberts, and M. B. Rittenberg. 1992. Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen. J. Exp. Med. 176:855.
-
(1992)
J. Exp. Med.
, vol.176
, pp. 855
-
-
Chen, C.1
Roberts, V.A.2
Rittenberg, M.B.3
-
2
-
-
0004032583
-
-
U.S. Department of Health and Human Services, Bethesda
-
Kabat, E. A., T. T. Wu, H. M. Perry, K. S. Gottesman, and C. Foeller. 1991. Sequences of Proteins of Immunological Interest, 5th Ed. U.S. Department of Health and Human Services, Bethesda.
-
(1991)
Sequences of Proteins of Immunological Interest, 5th Ed.
-
-
Kabat, E.A.1
Wu, T.T.2
Perry, H.M.3
Gottesman, K.S.4
Foeller, C.5
-
3
-
-
0024159308
-
Genetics of the phosphocholine-specific antibody response to Streptococcus pneumoniae: Germline but not mutated T15 antibodies are dominantly selected
-
Claflin, J. L., and J. Berry. 1988. Genetics of the phosphocholine-specific antibody response to Streptococcus pneumoniae: germline but not mutated T15 antibodies are dominantly selected. J. Immunol. 141:4012.
-
(1988)
J. Immunol.
, vol.141
, pp. 4012
-
-
Claflin, J.L.1
Berry, J.2
-
4
-
-
0023161407
-
Somatic mutation in anti-phosphorylcholine antibodies
-
Malipiero, U. V., N. S. Levy, and P. J. Gearhart. 1987. Somatic mutation in anti-phosphorylcholine antibodies. Immunol. Rev. 96:59.
-
(1987)
Immunol. Rev.
, vol.96
, pp. 59
-
-
Malipiero, U.V.1
Levy, N.S.2
Gearhart, P.J.3
-
5
-
-
0019972628
-
Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae
-
Briles, D. E., C. Forman, S. Hudak, and J. L. Claflin. 1982. Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae. J. Exp. Med. 156:1177.
-
(1982)
J. Exp. Med.
, vol.156
, pp. 1177
-
-
Briles, D.E.1
Forman, C.2
Hudak, S.3
Claflin, J.L.4
-
6
-
-
0023053742
-
Phosphocholine binding immunoglobulin Fab McPC603: An x-ray diffraction study at 2.7A
-
Satow, Y., G. H. Cohen, E. A. Padlan, and D. R. Davies. 1986. Phosphocholine binding immunoglobulin Fab McPC603: an x-ray diffraction study at 2.7A. J. Mol. Biol. 190:593.
-
(1986)
J. Mol. Biol.
, vol.190
, pp. 593
-
-
Satow, Y.1
Cohen, G.H.2
Padlan, E.A.3
Davies, D.R.4
-
7
-
-
0013484210
-
The three dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site
-
Segal, D. M., E. A. Padlan, G. H. Cohen, S. Rudikoff, M. Potter, and D. R. Davies. 1974. The three dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site. Proc. Natl. Acad. Sci. USA 71:4298.
-
(1974)
Proc. Natl. Acad. Sci. USA
, vol.71
, pp. 4298
-
-
Segal, D.M.1
Padlan, E.A.2
Cohen, G.H.3
Rudikoff, S.4
Potter, M.5
Davies, D.R.6
-
8
-
-
0017104125
-
Structural basis for the specificity of phosphorylcholine-binding immunoglobulins
-
Padlan, E. A., D. R. Davies, S. Rudikoff, and M. Potter. 1976. Structural basis for the specificity of phosphorylcholine-binding immunoglobulins. Immunochemistry 13:945.
-
(1976)
Immunochemistry
, vol.13
, pp. 945
-
-
Padlan, E.A.1
Davies, D.R.2
Rudikoff, S.3
Potter, M.4
-
9
-
-
0024368992
-
Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: Proposal of a structural mechanism
-
Chien, N. C., V. A. Roberts, A. M. Giusti, M. D. Scharff, and E. D. Getzoff. 1989. Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism. Proc. Natl. Acad. Sci. USA 86:5532.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 5532
-
-
Chien, N.C.1
Roberts, V.A.2
Giusti, A.M.3
Scharff, M.D.4
Getzoff, E.D.5
-
10
-
-
0342740028
-
Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity
-
Diamond, B., and M. D. Scharff. 1984. Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc. Natl. Acad. Sci. USA 81:5841.
-
(1984)
Proc. Natl. Acad. Sci. USA
, vol.81
, pp. 5841
-
-
Diamond, B.1
Scharff, M.D.2
-
11
-
-
0025804934
-
Mapping and modification of an antibody hapten binding site: A site-directed mutagenesis study of McPC603
-
Glockshuber, R., J. Stadlmuller, and A. Pluckthun. 1991. Mapping and modification of an antibody hapten binding site: a site-directed mutagenesis study of McPC603. Biochemistry 30:3049.
-
(1991)
Biochemistry
, vol.30
, pp. 3049
-
-
Glockshuber, R.1
Stadlmuller, J.2
Pluckthun, A.3
-
12
-
-
0025729732
-
A V region mutation in a phosphocholine-binding monoclonal antibody results in loss of antigen binding
-
Kobrin, B. J., S. Buhl, M. J. Shulman, and M. D. Scharff. 1991. A V region mutation in a phosphocholine-binding monoclonal antibody results in loss of antigen binding. J. Immunol. 146:2017.
-
(1991)
J. Immunol.
, vol.146
, pp. 2017
-
-
Kobrin, B.J.1
Buhl, S.2
Shulman, M.J.3
Scharff, M.D.4
-
13
-
-
0019976115
-
Single amino acid substitution altering antigen binding specificity
-
Rudikoff, S., A. Giusti, W. D. Cook, and M. D. Scharff. 1982. Single amino acid substitution altering antigen binding specificity. Proc. Natl. Acad. Sci. USA 79: 1979.
-
(1982)
Proc. Natl. Acad. Sci. USA
, vol.79
, pp. 1979
-
-
Rudikoff, S.1
Giusti, A.2
Cook, W.D.3
Scharff, M.D.4
-
14
-
-
0028013654
-
Catalytic antibody model and mutagenesis implicate arginine in transition-state stabilization
-
Roberts, V. A., J. Stewart, S. J. Benkovic, and E. D. Getzoff. 1994. Catalytic antibody model and mutagenesis implicate arginine in transition-state stabilization. J. Mol. Biol. 235:1098.
-
(1994)
J. Mol. Biol.
, vol.235
, pp. 1098
-
-
Roberts, V.A.1
Stewart, J.2
Benkovic, S.J.3
Getzoff, E.D.4
-
15
-
-
0023278330
-
Canonical structures for the hypervariable regions of immunoglobulins
-
Chothia, C., and A. M. Lesk. 1987. Canonical structures for the hypervariable regions of immunoglobulins. J. Mol. Biol. 196:901.
-
(1987)
J. Mol. Biol.
, vol.196
, pp. 901
-
-
Chothia, C.1
Lesk, A.M.2
-
16
-
-
0017411710
-
The Protein Data Bank: A computer-based archival file for macromolecular structures
-
Bernstein, F. C., T. F. Koetzle, G. J. B. Williams, J. E. Meyer, M. D. Brice, J. R. Rodgers, O. Kennard, T. Shimanouchi, and M. Tasumi. 1977. The Protein Data Bank: a computer-based archival file for macromolecular structures. J. Mol. Biol. 112:535.
-
(1977)
J. Mol. Biol.
, vol.112
, pp. 535
-
-
Bernstein, F.C.1
Koetzle, T.F.2
Williams, G.J.B.3
Meyer, J.E.4
Brice, M.D.5
Rodgers, J.R.6
Kennard, O.7
Shimanouchi, T.8
Tasumi, M.9
-
19
-
-
0022032207
-
On the specificity of antibody/antigen interactions: Phosphocholine binding to McPC603 and the correlation of three dimensional structure and sequence data
-
Padlan, E. A., G. H. Cohen, and D. R. Davies. 1985. On the specificity of antibody/antigen interactions: phosphocholine binding to McPC603 and the correlation of three dimensional structure and sequence data. Ann. Inst. Pasteur Immunol. 136C:271.
-
(1985)
Ann. Inst. Pasteur Immunol.
, vol.136 C
, pp. 271
-
-
Padlan, E.A.1
Cohen, G.H.2
Davies, D.R.3
-
20
-
-
0015970666
-
Immunoglobulin structure: Amino terminal sequences of mouse myeloma proteins that bind phosphorylcholine
-
Barstad, P., S. Rudikoff, M. Potter, M. Cohn, W. Konigsberg, and L. Hood. 1974. Immunoglobulin structure: amino terminal sequences of mouse myeloma proteins that bind phosphorylcholine. Science 183:962.
-
(1974)
Science
, vol.183
, pp. 962
-
-
Barstad, P.1
Rudikoff, S.2
Potter, M.3
Cohn, M.4
Konigsberg, W.5
Hood, L.6
-
21
-
-
0017725138
-
Structure-function relationships in phosphorylcholine-binding mouse myeloma proteins
-
Goetze, A. M., and I. H. Richards. 1977. Structure-function relationships in phosphorylcholine-binding mouse myeloma proteins. Proc. Natl. Acad. Sci. USA 74: 2109.
-
(1977)
Proc. Natl. Acad. Sci. USA
, vol.74
, pp. 2109
-
-
Goetze, A.M.1
Richards, I.H.2
-
22
-
-
0016331193
-
The presence of arginyl residues and carboxylate groups in the phosphorylcholine-binding site of mouse myeloma protein, HOPC8
-
Grossberg, A. L., L. M. Krausz, L. Rendina, and D. Pressman. 1974. The presence of arginyl residues and carboxylate groups in the phosphorylcholine-binding site of mouse myeloma protein, HOPC8. J. Immunol. 113:1807.
-
(1974)
J. Immunol.
, vol.113
, pp. 1807
-
-
Grossberg, A.L.1
Krausz, L.M.2
Rendina, L.3
Pressman, D.4
-
23
-
-
0029148418
-
Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen
-
Casson, L. P., and T. Manser. 1995. Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen. J. Exp. Med. 182:743.
-
(1995)
J. Exp. Med.
, vol.182
, pp. 743
-
-
Casson, L.P.1
Manser, T.2
-
24
-
-
0017747498
-
Unusual distribution of amino acids in complementarity-determining (hypervariable) segments of heavy and light chains of immunoglobulins and their possible roles in specificity of antibody combining sites
-
Kabat, E. A., T. T. Wu, and H. Bilofsky. 1977. Unusual distribution of amino acids in complementarity-determining (hypervariable) segments of heavy and light chains of immunoglobulins and their possible roles in specificity of antibody combining sites. J. Biol. Chem. 252:6609.
-
(1977)
J. Biol. Chem.
, vol.252
, pp. 6609
-
-
Kabat, E.A.1
Wu, T.T.2
Bilofsky, H.3
-
25
-
-
0024362070
-
On the attribution of binding energy in antigen-antibody complexes McPC603, D1.3, and HyHEL-5
-
Novotny, J., R. E. Bruccoleri, and F. A. Saul. 1989. On the attribution of binding energy in antigen-antibody complexes McPC603, D1.3, and HyHEL-5. Biochemistry 28:4735.
-
(1989)
Biochemistry
, vol.28
, pp. 4735
-
-
Novotny, J.1
Bruccoleri, R.E.2
Saul, F.A.3
-
26
-
-
0025063143
-
Framework residue 71 is a major determinant of the position and conformation of the second hypervariable region in the VH domains of immunoglobulins
-
Tramontano, A., C. Chothia, and A. M. Lesk. 1990. Framework residue 71 is a major determinant of the position and conformation of the second hypervariable region in the VH domains of immunoglobulins. J. Mol. Biol. 215:175.
-
(1990)
J. Mol. Biol.
, vol.215
, pp. 175
-
-
Tramontano, A.1
Chothia, C.2
Lesk, A.M.3
-
27
-
-
0024844388
-
Conformations of immunoglobulin hypervariable regions
-
Chothia, C., A. M. Lesk, A. Tramontano, M. Levitt, S. J. Smith-Gill, G. Air, S. Sheriff, E. A. Padlan, D. Davies, W. R. Tulip, P. M. Colman, S. Spinelli, P. M. Alzari, and R. J. Poljak. 1989. Conformations of immunoglobulin hypervariable regions. Nature 342:877.
-
(1989)
Nature
, vol.342
, pp. 877
-
-
Chothia, C.1
Lesk, A.M.2
Tramontano, A.3
Levitt, M.4
Smith-Gill, S.J.5
Air, G.6
Sheriff, S.7
Padlan, E.A.8
Davies, D.9
Tulip, W.R.10
Colman, P.M.11
Spinelli, S.12
Alzari, P.M.13
Poljak, R.J.14
-
28
-
-
0345001068
-
The murine antibody response to phosphocholine
-
M. I. Greene and A. Nisonoff, eds. Plenum Press, New York
-
Claflin, J. L., J. Wolfe, A. Maddalena, and S. Hudak. 1984. The murine antibody response to phosphocholine. In The Biology of Idiotypes. M. I. Greene and A. Nisonoff, eds. Plenum Press, New York, p. 171.
-
(1984)
The Biology of Idiotypes
, pp. 171
-
-
Claflin, J.L.1
Wolfe, J.2
Maddalena, A.3
Hudak, S.4
-
29
-
-
0024456149
-
Patterns of mutations and selection in antibodies to the phosphocholine-specific determinant in Proteus morganii
-
Claflin, J. L., J. George, C. Dell, and J. Berry. 1989. Patterns of mutations and selection in antibodies to the phosphocholine-specific determinant in Proteus morganii. J. Immunol. 143:3054.
-
(1989)
J. Immunol.
, vol.143
, pp. 3054
-
-
Claflin, J.L.1
George, J.2
Dell, C.3
Berry, J.4
-
30
-
-
0029047689
-
Enhancement and destruction of antibody function by somatic mutation: Unequal occurrence is controlled by V gene combinatorial associations
-
Chen, C., V. A. Roberts, S. Stevens, M. Brown, M. P. Stenzel-Poore, and M. B. Rittenberg. 1995. Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations. EMBO J. 14:2784.
-
(1995)
EMBO J.
, vol.14
, pp. 2784
-
-
Chen, C.1
Roberts, V.A.2
Stevens, S.3
Brown, M.4
Stenzel-Poore, M.P.5
Rittenberg, M.B.6
-
31
-
-
0027955736
-
X-ray structures of fragments from binding and nonbinding versions of a humanized anti-CD18 antibody: Structural indications of the key role of VH residues 59 to 65
-
Eigenbrot, C., T. Gonzalez, J. Mayeda, P. Carter, W. Werther, T. Hotaling, J. Fox, and J. Kessler. 1994. X-ray structures of fragments from binding and nonbinding versions of a humanized anti-CD18 antibody: structural indications of the key role of VH residues 59 to 65. Proteins Struct. Fund. Genet. 18:49.
-
(1994)
Proteins Struct. Fund. Genet.
, vol.18
, pp. 49
-
-
Eigenbrot, C.1
Gonzalez, T.2
Mayeda, J.3
Carter, P.4
Werther, W.5
Hotaling, T.6
Fox, J.7
Kessler, J.8
-
32
-
-
0025082684
-
Additivity of mutational effects in proteins
-
Wells, J. A. 1990. Additivity of mutational effects in proteins. Biochemistry 29: 8509.
-
(1990)
Biochemistry
, vol.29
, pp. 8509
-
-
Wells, J.A.1
-
33
-
-
0020687181
-
Restriction in IgM expression. IV. Affinity analysis of monoclonal anti-phosphocholine antibodies
-
Rodwell, J. D., P. J. Gearhart, and F. Karush. 1983. Restriction in IgM expression. IV. Affinity analysis of monoclonal anti-phosphocholine antibodies. J. Immunol. 130:313.
-
(1983)
J. Immunol.
, vol.130
, pp. 313
-
-
Rodwell, J.D.1
Gearhart, P.J.2
Karush, F.3
-
34
-
-
0027305024
-
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells
-
Jacob, J., J. Przylepa, C. Miller, and G. Kelsoe. 1993. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J. Exp. Med. 178: 1293.
-
(1993)
J. Exp. Med.
, vol.178
, pp. 1293
-
-
Jacob, J.1
Przylepa, J.2
Miller, C.3
Kelsoe, G.4
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