Tolerance to single, but not multiple, amino acid replacements in antibody VH CDR2: A means of minimizing B cell wastage from somatic hypermutation?

Journal of Immunology

Volumn 156, Issue 9, 1996, Pages 3285-3291

  Brown, McKay ^a   Rittenberg, Marvin B ^a   Chen, Ching ^a,c   Roberts, Victoria A ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ANTIBODY; ARGININE; IMMUNOGLOBULIN HEAVY CHAIN; PHOSPHORYLCHOLINE; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; COMPUTER MODEL; CONTROLLED STUDY; IMMUNOGLOBULIN VARIABLE REGION; MOUSE; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; SOMATIC MUTATION;

AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; BINDING SITES, ANTIBODY; IMMUNE TOLERANCE; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MODELS, IMMUNOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MYELOMA PROTEINS; POINT MUTATION;

EID: 0030009781     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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