Aggregated-disaggregated, refractory platelets retain sensitivity to ristocetin

Thrombosis Research

Volumn 84, Issue 4, 1996, Pages 253-266

  White, James G ^a   Rao, Gundu H R ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

glycoprotein Ib IX; immunogold cytochemistry; receptor density; refractory platelets; ristocetin agglutination

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADRENALIN; PROSTAGLANDIN E1; RISTOCETIN; THROMBIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOGOLD STAINING; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION;

ADULT; ALPROSTADIL; BLOOD PLATELETS; DOWN-REGULATION; DRUG SYNERGISM; EPINEPHRINE; HUMANS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; RISTOCETIN; THROMBIN;

EID: 0030588625     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(96)00185-5     Document Type: Article

References (26)

1. SIXMA, J.J. Interaction of blood platelets with the vessel wall. In: Haemostasis and Thrombosis, Vol. 1, 3rd Ed., Bloom AL, Forbes CD, Thomas DP and Tuddenham EGD, eds, London, Churchill-Livingstone, 1994, pp 259-285.
2. GEORGE J.N., NURDEN A.T., PHILLIPS D.R. Molecular defects in interactions of platelets with the vessel wall. N Engl J Med. 311:1984;1084-1098.
3. DE GROOT P.G., SIXMA J.J. Platelet adhesion. Br J Haematol. 75:1990;308-312.
4. GEORGE J.N., TORRES M.M. Thrombin decreases von Willebrand factor binding to platelet glycoprotein Ib. Blood. 71:1988;1253-1259.
5. MICHELSON A.D., BARNARD M.R. Thrombin-induced changes in platelet membrane glycoproteins Ib, IX and IIb-IIIa complex. Blood. 70:1987;1673-1678.
6. MICHELSON A.D., ELLIS P.A., BARNARD M.R., MATIC G.B., VILES A.F., KESTIN A.S. Down-regulation of the platelet surface glycoprotein Ib-IX complex in whole blood stimulated by thrombin, adenosine diphosphate or an in vivo wound. Blood. 77:1991;770-779.
7. HOURDILLE P., HEILMANN E., COMBRIE R., WINCKLER J., CLEMETSON K.J., NURDEN A.T. Thrombin induces a rapid redistribution of glycoprotein Ib-IX complexes within the membrane systems of activated human platelets. Blood. 76:1990;1503-1513.
8. HOURDILLE P., GRALNICK H.R., HEILMANN E., DERLON A., FERRER A.-M., VERZON G., NURDEN A.T. von Willebrand factor bound to glycoprotein Ib is cleared from the platelet surface after platelet activation with thrombin. Blood. 79:1992;2011-2021.
9. NURDEN A., CAZES E., BAHOUR C., HUMBERT M., COMBRIE R., PAPONNEAU A., WINCKLER J., NURDEN P. Confirmation that GPIb/IX complexes have a reduced surface distribution on platelets activated by thrombin and TRAP-14-mer peptide. Br J Haematol. 90:1995;645-654.
10. ESCOLAR G., CLEMETSON K., WHITE J.G. Persistence of mobile receptors on surface and suspension-activated platelets. J Lab Clin Med. 123:1994;536-546.
11. ESCOLAR G., WHITE J.G. Organization of von Willebrand factor (vWF) on surface-activated platelets. Arterioscl Thromb. 13:1993;1852-1858.
12. WHITE J.G., KRUMWIEDE M.D., COCKING-JOHNSON D.J., ESCOLAR G. Influence of combined thrombin stimulation, surface activation and receptor occupancy on organization of GPIb/IX receptors on human platelets. Br J Haematol. 88:1994;137-148.
13. WHITE J.G., KRUMWIEDE M.D., COCKING-JOHNSON D.K., ESCOLAR G. Redistribution of GPIb/IX and GPIIb/IIIa during spreading of discoid platelets. Br J Haematol. 90:1995;633-644.
14. WHITE J.G., KRUMWIEDE M., COCKING-JOHNSON D., RAO G.H.R., ESCOLAR G. Retention of GPIb/IX receptors on external surfaces of thrombin-activated platelets in suspension. Blood. 86:1995;3468-3478.
15. RAO G.H.R., WHITE J.G. Disaggregation and reaggregation of "irreversibly" aggregated platelets: a method for more complete evaluation of anti-platelet drugs. Agents Actions. 16:1985;425-434.
16. 2) induced dissociation of ADP aggregated platelets. Prostagland Med. 4:1980;385-397.
17. WHITE J.G. Interaction of membrane systems in blood platelets. Am J Path. 66:1972;295-312.
18. GERRARD J.M., PHILLIPS D.R., RAO G.H.R., PLOW E.F., WALZ D.A., ROSS R., HARKER L.A., WHITE J.G. Biochemical studies of two patients with the gray platelet syndrome: selective deficiency of platelet alpha granules. J Clin Invest. 66:1980;102-109.
19. MICHELSON A.D. Platelet activation by thrombin can be directly measured in whole blood through use of the peptide GPRP and flow cytometry: methods and clinical applications. Blood Coag Fibrinol. 5:1994;121-131.
20. WHITE, J.G., LEE, J.Y., RAO, G.H.R. Thrombin-induced inhibition of platelet agglutination by von Willebrand factor (vWF): Reversal by ionized calcium (submitted for publication).
21. GRANT R.A., ZUCKER M.B., MC PHERSON J. ADP-induced inhibition of von Willebrand factor-mediated platelet agglutination. Am J Physiol. 230:1976;1406-1410.
22. HAGEN I., SOLUM N.O., OLSEN T. Membrane alterations in connection with the release reaction in human platelets as studied by the lactoperoxidase-iodination technique and by agglutination with bovine factor VIII-related protein. Biochim Biophys Acta. 468:1977;1-10.
23. MILLS D.C.B., HUNCHAK K., KARL D.W., KIRBY E.P. Effect of platelet activation on the agglutination of platelets by von Willebrand factor. Molec Pharm. 37:1990;271-277.
24. MICHELSON A.D., BENOIT S.E., KROLL M.H., MING-LI J., ROHRER M.J., KESTIN A.S., BARNARD M.R. The activation-induced decrease in the platelet-surface expression of the glycoprotein Ib/IX complex is reversible. Blood. 83:1994;3562-3573.
25. RAO G.H.R., PELLER J., WHITE J.G. Influence of ionized calcium on thrombin-mediated down-regulation of platelet glycoprotein Ib/IX receptors (submitted for publication).
26. MICHELSON A.D., BENOIT S.E., FURMAN M.R., NURDEN P., NURDEN A.T. The platelet surface expression of glycoproteins V, Ia regulated by two independent mechanisms: proteolysis and a reversible cytoskeletal mediated redistribution to the surface-connected canalicular system. Blood. 87:1996;1396-1408.