The platelet surface expression of glycoprotein V is regulated by two independent mechanisms: Proteolysis and a reversible cytoskeletal-mediated redistribution to the surface-connected canalicular system

Blood

Volumn 87, Issue 4, 1996, Pages 1396-1408

  Michelson, Alan D ^a   Benoit, Stephen E ^b   Furman, Mark I ^b   Barnard, Marc R ^b   Nurden, Paquita ^b   Nurden, Alan T ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; ADENOSINE DIPHOSPHATE; ADRENALIN; CATHEPSIN G; CYTOCHALASIN B; GLYCOPROTEIN; GLYCOPROTEIN IB; LEUKOCYTE ELASTASE; THROMBIN; THROMBIN RECEPTOR; THROMBIN RECEPTOR ACTIVATING PEPTIDE;

ACTIN POLYMERIZATION; ADULT; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOSKELETON; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; MALE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; THROMBOCYTE ACTIVATION; THROMBOCYTE MEMBRANE;

ACTINS; ADENOSINE DIPHOSPHATE; ADULT; AMINO ACID SEQUENCE; BLOOD PLATELETS; CALCIUM; CATHEPSINS; CELL COMPARTMENTATION; CELL DEGRANULATION; CYTOSKELETON; EPINEPHRINE; HUMANS; IMMUNOHISTOCHEMISTRY; LEUKOCYTE ELASTASE; MOLECULAR SEQUENCE DATA; PANCREATIC ELASTASE; PEPTIDE FRAGMENTS; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; SERINE ENDOPEPTIDASES; THROMBIN;

EID: 0030049005     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.4.1396.bloodjournal8741396     Document Type: Article

References (56)

1. Modderman PW, Admiraal LG, Sonnenberg A, von dem Borne AE: Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane. J Biol Chem 267:364, 1992
2. Ruggeri ZM: The platelet glycoprotein Ib-IX complex. Prog Hemost Thromb 10:35, 1991
3. Roth GJ: Developing relationships: arterial platelet adhesion, glycoprotein Ib, and leucine-rich glycoproteins. Blood 77:5, 1991
4. Lopez JA: The platelet glycoprotein Ib-IX complex. Blood Coagul Fibrinolysis 5:97, 1994
5. Wenger RH, Wicki AN, Kieffer N, Adolph S, Hameister H, Clemetson KJ: The 5′ flanking region and chromosomal localization of the gene encoding human platelet membrane glycoprotein Ib alpha. Gene 85:517, 1989
6. Hickey MJ, Deaven LL, Roth GJ: Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3. FEBS Lett 274:189, 1990
7. Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA, Tedder TF, Todd RF: CD antigens 1993. Blood 83:879, 1994
8. Michelson AD: CD42 cluster workshop report, in Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA, Tedder TF, Todd RF (eds): Leucocyte Typing V. Oxford, UK, Oxford, 1995, p 1309
9. Nurden AT: Congenital abnormalities of platelet membrane glycoproteins, in Kunicki TJ, George JN (eds): Platelet Immunobiology. Philadelphia, PA, Lippincott, 1989, p 63
10. Coller BS, Peerschke EI, Scudder LE, Sullivan CA: Studies with a murine monoclonal antibody that abolishes ristocetin-induced binding of von Willebrand factor to platelets: Additional evidence in support of GPIb as a platelet receptor for von Willebrand factor. Blood 61:99, 1983
11. Du X, Beutler L, Ruan C, Castaldi PA, Berndt MC: Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane. Blood 69:1524, 1987
12. Harmon JT, Jamieson GA: The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor sites for thrombin. J Biol Chem 261:13224, 1986
13. Yamamoto N, Greco NJ, Barnard MR, Tanoue K, Yamazaki H, Jamieson GA, Michelson AD: Glycoprotein Ib (GPIb)-dependent and GPIb-independent pathways of thrombin-induced platelet activation. Blood 77:1740, 1991
14. Gralnick HR, Williams S, McKeown LP, Hansmann K, Fenton JW, Krutzsch H: High-affinity alpha-thrombin binding to platelet glycoprotein Ib alpha: identification of two binding domains. Proc Natl Acad Sci USA 91:6334, 1994
15. De Marco L, Mazzucato M, Masotti A, Ruggeri ZM: Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha. J Biol Chem 269:6478, 1994
16. Fox JEB: Identification of actin-binding protein as the protein linking the membrane skeleton to glycoproteins on platelet plasma membranes. J Biol Chem 260:11970, 1985
17. Fox JEB: Linkage of a membrane skeleton to integral membrane glycoproteins in human platelets. Identification of one of the glycoproteins as glycoprotein Ib. J Clin Invest 76:1673, 1985
18. Fox JEB, Berndt MC: Cyclic AMP-dependent phosphorylation of glycoprotein Ib inhibits collagen-induced polymerization of actin in platelets. J Biol Chem 264:9520, 1989
19. Molino M, Di Lallo M, Martelli N, de Gaetano G, Cerletti C: Effects of leukocyte-derived cathepsin G on platelet membrane glycoprotein Ib-IX and IIb-IIIa complexes: A comparison with thrombin. Blood 82:2442, 1993
20. LaRosa CA, Rohrer MJ, Benoit SE, Barnard MR, Michelson AD: Neutrophil cathepsin G modulates the platelet surface expression of the glycoprotein (GP) Ib-IX complex by proteolysis of the von Willebrand factor binding site on GPIbα and by a cytoskeletal-mediated redistribution of the remainder of the complex. Blood 84:158, 1994
21. Brower MS, Levin RI, Garry K: Human neutrophil elastase modulates platelet function by limited proteolysis of membrane glycoproteins. J Clin Invest 75:657, 1985
22. Wicki AN, Clemetson KJ: Structure and function of platelet membrane glycoproteins Ib and V. Effects of leukocyte elastase and other proteases on platelets response to von Willebrand factor and thrombin. Eur J Biochem 153:1, 1985
23. McGowan EB, Yeo K, Detwiler TC: The action of calcium-dependent protease on platelet surface glycoproteins. Arch Biochem Biophys 227:287, 1983
24. Hourdille P, Heilmann E, Combrie R, Winckler J, Clemetson KJ, Nurden AT: Thrombin induces a rapid redistribution of glycoprotein Ib-IX complexes within the membrane systems of activated human platelets. Blood 76:1503, 1990
25. Michelson AD, Ellis PA, Barnard MR, Matic GB, Viles AF, Kestin AS: Downregulation of the platelet surface glycoprotein Ib-IX complex in whole blood stimulated by thrombin, ADP or an in vivo wound. Blood 77:770, 1991
26. Lu H, Menashi S, Garcia I, Cramer EM, Li H, Tenza D, De Romeuf C, Soria J, Soria C: Reversibility of thrombin-induced decrease in platelet glycoprotein Ib function. Br J Haematol 85:116, 1993
27. Phillips DR, Agin PP: Platelet plasma membrane glycoproteins. Identification of a proteolytic substrate for thrombin. Biochem Biophys Res Commun 75:940, 1977
28. Berndt MC, Phillips DR: Purification and preliminary physicochemical characterization of human platelet membrane glycoprotein V. J Biol Chem 256:59, 1981
29. McGowan EB, Ding A, Detwiler TC: Correlation of thrombin-induced glycoprotein V hydrolysis and platelet activation. J Biol Chem 258:11243, 1983
30. Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA, Tedder TF, Todd RF: Leucocyte Typing V. Oxford, UK, Oxford, 1995
31. Coller BS: A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex. J Clin Invest 76:101, 1985
32. Gatter KC, Cordell JL, Turley H, Heryet A, Kieffer N, Anstee DJ, Mason DY: The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens. Histopathology 13:257, 1988
33. Shattil SJ, Cunningham M, Hoxie JA: Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. Blood 70:307, 1987
34. Michelson AD, Barnard MR: Plasmin-induced redistribution of platelet glycoprotein Ib. Blood 76:2005, 1990
35. Michelson AD, Benoit SE, Kroll MH, Li J, Rohrer MJ, Kestin AS, Barnard MR: The activation-induced decrease in the platelet surface expression of the glycoprotein Ib-IX complex is reversible. Blood 83:3562, 1994
36. Kestin AS, Valeri CR, Khuri SF, Loscalzo J, Ellis PA, MacGregor H, Birjiniuk V, Ouimet H, Pasche B, Nelson MJ, Benoit SE, Rodino LJ, Barnard MR, Michelson AD: The platelet function defect of cardiopulmonary bypass. Blood 82:107, 1993
37. Fox JEB, Phillips DR: Inhibition of actin polymerization in blood platelets by cytochalasins. Nature 292:650, 1981
38. Tokuyasu KT: A study of positive staining of ultrathin frozen sections. J Ultrastruct Res 63:287, 1978
39. Escolar G, Clemetson K, White JG: Persistence of mobile receptors on surfaceand suspension-activated platelets. J Lab Clin Med 123:536, 1994
40. Michelson AD, Barnard MR: Thrombin-induced changes in platelet membrane glycoproteins Ib, IX, and IIb-IIIa complex. Blood 70:1673, 1987
41. Hourdille P, Combrie R, Winckler J, Paponneau A, Lozano M, Pico M, Nurden A: Ultrastructural studies following the stimulation of normal and Bernard-Soulier platelets through the newly cloned thrombin receptor. Thromb Haemost 69:1148, 1993 (abstr)
42. Vu TH, Hung DT, Wheaton VI, Coughlin SR: Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64:1057, 1991
43. Chao BH, Kalkunte S, Maraganore JM, Stone SR: Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor. Biochemistry 31:6175, 1992
44. De Marco L, Mazzucato M, Masotti A, Fenton JW, Ruggeri ZM: Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombin. J Biol Chem 266:23776, 1991
45. Meyer SC, Fox JEB: Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells. J Biol Chem 270:14693, 1995
46. Li CQ, Dong J, Lanza F, Sanan DA, Sae-Tung G, Lopez JA: Expression of platelet glycoprotein (GP) V in heterologous cells and evidence for its association with GP Iba in forming a GP Ib-IX-V complex on the cell surface. J Biol Chem 27:16302, 1995
47. Behnke O, Bray D: Surface movements during the spreading of blood platelets Eur J Cell Biol 46:207, 1988
48. Honsberger M: Colloidal gold: A cytochemical marker for light and fluorescent microscopy and for transmission and scanning electron microscopy. Scan Electron Microsc 2:9, 1981
49. Shattil SJ, Hoxie JA, Cunningham M, Brass LF: Changes in the platelet membrane glycoprotein IIb-IIIa complex during platelet activation. J Biol Chem 260:11107, 1985
50. Phillips DR, Charo IF, Parise LV, Fitzgerald LA: The platelet membrane glycoprotein IIb-IIIa complex. Blood 71:831, 1988
51. Stenberg PE, McEver RP, Shuman MA, Jacques YV, Bainton DF: A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. J Cell Biol 101:880, 1985
52. Berman CL, Yeo EL, Wencel-Drake JD, Furie BC, Ginsberg MH, Furie B: A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation-dependent granule-external membrane protein. J Clin Invest 78:130, 1986
53. Larsen E, Celi A, Gilbert GE, Furie BC, Erbau JK, Bonfanti R, Wagner DD, Furie B: PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell 59:305, 1989
54. Hamburger SA, McEver RP: GMP-140 mediates adhesion of stimulated platelets to neutrophils. Blood 75:550, 1990
55. Palabrica T, Lobb R, Furie BC, Aronovitz M, Benjamin C, Hsu YM, Sajer SA, Furie B: Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature 359:848, 1992
56. Kestin AS, Ellis PA, Barnard MR, Errichetti A, Rosner BA, Michelson AD: The effect of strenuous exercise on platelet activation state and reactivity. Circulation 88:1502, 1993