Oxidative inactivation of thioredoxin as a cellular growth factor and protection by a Cys73→Ser mutation

Biochemical Pharmacology

Volumn 52, Issue 11, 1996, Pages 1741-1747

  Gasdaska, John R ^a   Kirkpatrick, D Lynn ^b   Montfort, William ^c   Kuperus, Miles ^b   Hill, Simon R ^a   Berggren, Margareta ^a   Powis, Garth ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF REGINA   (Canada)

^c University of Arizona   (United States)

Author keywords

growth factor; homodimer; oxidation; thioredoxin

Indexed keywords

CYSTEINE; DIMER; DITHIOTHREITOL; GROWTH FACTOR; MONOMER; MUTANT PROTEIN; OXIDIZING AGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SERINE; THIOREDOXIN; THIOREDOXIN REDUCTASE;

ARTICLE; CELL GROWTH; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; OXIDATION; OXIDATION REDUCTION STATE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN MODIFICATION; REDUCTION;

GROWTH SUBSTANCES; HUMANS; OXIDATION-REDUCTION; POINT MUTATION; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOREDOXIN; TUMOR CELLS, CULTURED;

EID: 0030582835     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00595-3     Document Type: Article

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