Synthetic routes for the generation of 7,7-dialkyl azepin-2-ones

Tetrahedron Letters

Volumn 37, Issue 50, 1996, Pages 8985-8988

  Robl, Jeffrey A ^a   Sieber McMaster, Ellen ^a   Sulsky, Richard ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZEPINE DERIVATIVE;

ALKYLATION; ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; METHODOLOGY; REACTION ANALYSIS;

EID: 0030577486     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(96)02109-0     Document Type: Article

References (14)

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2. b) Robl, J. A.; Cimarusti, M.; Simpkins, Ligaya M.; Brown, B.; Ryono, D.; Bird, J. E.; Asaad, M. M.; Schaeffer, T. R.; Tripoddo, N. J. Med. Chem. 1996, 39, 494
3. c) Robl, J. A.; Cimarusti, M. Tetrahedron Lett. 1994, 35, 1393.
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11. 4) and evaporated. Purification by flash chromatography (5 × 15 cm column, 3:7 ethyl acetate/hexanes) provided 20 as white solid, mp 62-64 °C, 1.012 g, 84% yield.
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14. 3).