Changes in labile energy metabolites, redox state and intracellular pH in postischemic brain of normo- and hyperglycemic rats

Brain Research

Volumn 726, Issue 1-2, 1996, Pages 57-63

  Katsura, Ken ichiro ^a,b   Folbergrová, Jaroslava ^a,c   Siesjö, Bo K ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

Cerebral ischemia; Energy metabolism; Hyperglycemia; Intracellular pH; Postischemic alkalinization

Indexed keywords

CARBON 14; CREATINE KINASE; CREATINE PHOSPHATE; DIMETHADIONE; GLUCOSE; GLYCOGEN;

ALKALOSIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN METABOLISM; CELL PH; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; ENERGY METABOLISM; GLUCOSE BLOOD LEVEL; GLYCOGEN METABOLISM; HYPERGLYCEMIA; NEOCORTEX; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RAT;

EID: 0030575295     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00317-4     Document Type: Article

References (53)

1. [1] Bengtsson, F., Boris-Möller, F., Hansen, A.J. and Siesjö, B.K., Extracellular pH in the rat brain during hypoglycemic coma and recovery, J. Cereb. Blood Flow Metab., 10 (1990) 262-269.
2. [2] Cardell, M., Bingren, H., Wieloch, T., Zivin, J. and Saitoh, T., Protein kinase C is translocated to cell membranes during cerebral ischemia, Neurosci. Lett., 119 (1990) 228-232.
3. [3] Chen, H., Chopp, M., Vande Linde, A.M.Q., Dereski, M.O., Garcia, J.H. and Welch, K.M.A., The effects of post-ischemic hypothermia on the neuronal injury and brain metabolism after forebrain ischemia in the rat, J. Neurol, Sci., 107 (1992) 191-198.
4. [4] Chopp, M., Welch, K.M.A., Tidwell, C.D. and Helpern, J.A., Global cerebral ischemia and intracellular pH during hyperglycemia and hypoglycemia in cats., Stroke, 19 (1988) 1383-1387.
5. [5] Chopp, M., Chen, H., Vande Linde, A.M.Q., Brown, E. and Welch, K.M.A., Time course of postischemic intracellular alkalosis reflects the duration of ischemia, J. Cereb. Blood Flow Metab., 10 (1990) 860-865.
6. [6] Chopp, M., Vande Linde, A.M.Q., Chen, H., Knight, R., Helpern, J.A. and Welch, K.M.A., Chronic cerebral intracellular alkalosis following forebrain ischemic insult in rats, Stroke, 21 (1990) 463-466.
7. [7] de Courten-Myers, G., Myers, R.E. and Schoolfield, L., Hyperglycemia enlarges infarct size in cerebrovascular occlusion in cats, Stroke, 19 (1988) 623-630.
8. [8] Deshpande, J.K., Siesjö, B.K. and Wieloch, T., Calcium accumulation and neuronal damage in the rat hippocampus following cerebral ischemia. J. Cereb. Blood Flow Metab., 7 (1987) 89-95.
9. [9] Duchen, M., McGuinness, O., Brown, L., Crompton, M., On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury, Cardiovasc. Res., 21 (1993) 1790-1794.
10. [10] Dux, E., Mies, G., Hossmann, K.-A. and Siklos, L., Calcim in the mitochondria following brief ischemia of gerbil brain, Neurosci. Lett., 78 (1987) 295-300.
11. [11] Ekholm, A., Kristián, T. and Siesjö, B.K., Influence of hyperglycemia and of hypercapnia on cellular calcium transients during reversible brain ischemia, Exp. Brain Res., 104 (1995) 462-466.
12. [12] Ereciñska, M. and Silver, I., ATP and brain function, J. Cereb. Blood Flow Metab., 9 (1989) 2-19.
13. [13] Folbergrová, J., MacMillan, V. and Siesjö, B.K., The effect of hypercapnic acidosis upon some glycolytic and Krebs cycle-associated intermediates in the rat brain, J. Neurochem., 19 (1972) 2507-2517.
14. + ratio of the rat brain, J. Neurochem., 19 (1972) 2497-2505.
15. [15] Folbergrová, J., Katsura, K. and Siesjö, B.K., Glycogen accumulated in the brain following insults is not degraded during a subsequent period of ischemia, J. Neurol. Sci., 137 (1996) 7-13.
16. [16] Frelin, C., Vigne, P., Ladoux, A. and Lazdunski, M., The regulation of the intracellular pH in cells from vertebrates, Eur. J. Biochem., 174 (1988) 3-14.
17. [17] Giffard, R.G., Monyer, H., Christine, C.W. and Choi, D.W., Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures, Brain Res., 506 (1990) 339-342.
18. + exchanger: Topical review, J. Membrane Biol., 90 (1986) 1-12.
19. [19] Hillered, L., Smith, M.-L. and Siesjö, B.K., Lactic acidosis and recovery of mitochondrial function following forebrain ischemia in the rat, J. Cereb. Blood Flow Metab., 5 (1985) 259-266.
20. [20] Iijima, T., Ciani, S. and Hagiwara, S., Effects of the external pH on Ca channels: experimental studies and theoretical considerations using a two-site, two-ion model, Proc. Natl. Acad. Sci. USA, 83 (1986) 654-658.
21. [21] Inamura, K., Smith, M.-L., Hansen, A.J. and Siesjö, B.K., Seizure-induced damage to substantia nigra and globus pallidus is accompanied by pronounced intra-and extracellular acidosis, J. Cereb. Blood Flow Metab., 9 (1989) 821-829.
22. [22] Katsura, K., Asplund, B., Ekholm, A. and Siesjö, B.K., Extra-and intracellular pH in the brain during ischemia, related to tissue lactate content in normo-and hypercapnic rats. Euro. J. Neurosci., 4 (1992) 166-176.
23. + transport, and changes in extra-and intracellular pH, J. Cereb. Blood Flow Metab., 13 (1993) 820-826.
24. [24] Katsura, K., Kristián, T., Smith, M.-L. and Siesjö, B.K., Acidosis induced by hypercapnia exaggerates ischemic brain damage, J. Cereb. Blood Flow Metab., 14 (1994) 243-250.
25. [25] Kobatake, K., Sako, K., Izawa, M., Yamamoto, Y. and Hakim, A., Autoradiographic determination of brain pH following middle cerebral artery occlusion in the rat, Stroke, 15 (1984) 540-547.
26. [26] Kozuka, M., Smith, M.-L. and Siesjö, B.K., Preischemic hyperglycemia enhances postischemic depression of cerebral metabolic rate, J. Cereb. Blood Flow Metab., 9 (1989) 478-490.
27. [27] Kraig, R.P., Pulsinelli, W.A. and Plum, F., Carbonic acid buffer changes during complete brain ischemia, Am. J. Physiol., 250 (1986) R348-R357.
28. eq of the creatine kinase reaction and other phsphate hydrolyses and phosphate transfer reactions, J. Biol. Chem., 254 (1979) 6528-6537.
29. [29] Mabe, H., Blomqvist, P. and Siesjö, B.K., Intercellular pH in the brain following transient ischemia. J. Cereb. Blood Flow Metab., 3 (1983) 109-114.
30. 0, Soc. Neurosci. Abstr. 14 (1988) 791.
31. [31] Pontén, U., Ratcheson, R.A., Salford, L.G. and Siesjö, B.K., Optimal freezing conditions for cerebral metabolites in rats, J. Neurochem, 21 (1973) 1127-1138.
32. [32] Pulsinelli, W.A. and Duffy, T.E., Regional energy balance in rat brain after transient forebrain ischemia, J. Neurochem., 40 (1983) 1500-1503.
33. [33] Pulsinelli, W.A., Levy, D.E. and Duffy, T.E., Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia, Ann. Neurol., 11 (1982) 499-509.
34. [34] Richter, C., Gogvadze, V., Laffranchi, R., Schlapbach, R., Schweizer, M., Suter, M., Walter, P., Yaffee, M., Oxidants in mitochondria: from physiology to diseases, Biochim. Biophys. Acta, 1271 (1995) 67-74.
35. [35] Siemkowicz, E. and Hansen, A., Clinical restitution following cerebral ischemia in hypo-, normo-, and hyperglycemic rats., Acta Neurol. Scand., 58 (1978) 1-8.
36. [36] Siesjö, B.K., Brain Energy Metabolism, John Wiley, Chichester, New York, 1978.
37. [37] Siesjö, B.K., Mechanisms of ischemic brain damage, Crit. Care. Med., 16 (1988) 954-963.
38. [38] Siesjö, B.K., Folbergrová, J. and MacMillan, V., The effect of hypercapnia upon intracellular pH in the brain, evaluated by the bicarbonate-carbonic acid method and from the creatine phosphokinase equilibrium, J. Neurochem., 19 (1972) 2483-2495.
39. [39] Siesjö, B.K., Von Hanwehr, R., Nergelius, G., Nevander, G. and Ingvar, M., Extra-and intracellular pH in the brain during seizures and in the recovery period following the arrest of seizure activity, J. Cereb. Blood Flow Metab., 5 (1985) 47-57.
40. [40] Siesjö, B.K., Katsura, K., Mellergård, P., Ekholm, A., Lundgren, J. and Smith, M.-L., Acidosis-related brain damage; Neurobiology of ischemic brain damage. In K. Kogure, Hossmann and Siesjö (Eds.), Progress in Brain Research, Elsevier, Amsterdam, 1993.
41. [41] Siesjö, B.K. and Siesjö, P., Mechanisms of secondary brain injury, J. Eur. Anesthesiol., 13 (1996) in press.
42. + in the hippocampus during recovery from short-term, transient ischemia, J. Cereb. Blood Flow Metab., 12 (1992) 759-772.
43. [43] Sims, N.R., Selective impairment of respiration in mitochondria isoloated from brain subregions following transient forebrain ischemia in the rat, J. Neurochem., 56 (1991) 1836-1844.
44. [44] Sims, N.R. and Pulsinelli, W.A., Altered mitochoadrial respiration in selectively vulnerable brain subregions following transient forebrain ischemia in the rat, J. Neurochem., 49 (1987) 1367-1374.
45. [45] Smith, M.-L., Bendek, G., Dahlgren, N., Rosén, I., Wieloch, T. and Siesjö, B.K., Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model, Acta Neurol. Scand., 69 (1984) 385-401.
46. [46] Smith, M.-L., Von Hanwehr, R. and Siesjö, B.K., Changes in extraand intracellular pH in the brain during and following ischemia in hyperglycemic and in moderately hypoglycemic rats, J. Cereb. Blood Flow Metab., 6 (1986) 574-583.
47. [47] Smith, M.-L., Kalimo, H., Warner, D.S. and Siesjö, B.K., Morphological lesions in the brain preceding the development of postischemic seizures, Acta Neuropathol. (Berl.), 76 (1988) 253-264.
48. [48] Tombaugh, G.C. and Sapolsky, R.M., Evolving concepts about the role of acidosis in ischemic neuropathology, J. Neurochem., 61 (1993) 793-803.
49. [49] Traynelis, S. and Cull-Candy, S., Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons., Nature, 345 (1990) 347-350.
50. [50] Vyklický, L., Vlachová, V. and Krusěk, J., The effect of external pH changes on responses to excitatory amino acids in mouse hippocampal neurones, J. Physiol, 430 (1990) 497-517.
51. [51] Warner, D.S., Smith, M.-L. and Siesjö, B.K., Ischemia in normo-and hyperglycemic rats: effects on brain water and electrolytes, Stroke, 18 (1987) 464-471.
52. [52] Zaidan, E. and Sims, N.R., The calcium content of mitochondria from brain subregions following short-term forebrain ischemia and recirculation, J. Neurochem., 63 (1994) 1812-1819.
53. [53] Zoratti, M. and Szabó, I., The mitochondrial permeability transition, Biochim. Biophys. Acta, 1241 (1995) 139-176.