Glycogen accumulated in the brain following insults is not degraded during a subsequent period of ischemia

Journal of the Neurological Sciences

Volumn 137, Issue 1, 1996, Pages 7-13

  Folbergrová, Jaroslava ^a,b   Katsura, Ken Ichiro ^a,c   Siesjö, Bo K ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^c NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Complete ischemia; Glycogen degradation; Hypoglycemic coma; Methionine sulphoximine seizure; Transient ischemia

Indexed keywords

GLYCOGEN; METHIONINE SULFOXIMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; HYPOGLYCEMIA; MALE; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

EID: 0029912179     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-510X(96)82226-X     Document Type: Article

References (43)

1. Abdul-Rahman, A., Siesjö, B.K. (1980) Local cerebral glucose consumption during insulin-induced hypoglycemia, and in the recovery period following glucose administration. Acta Physiol. Scand. 110: 149-159.
2. Breckenridge, B.M., Norman, J.H. (1962) Glycogen phosphorylase in brain. J. Neurochem. 9: 383-392.
3. Cammermeyer, J., Fenton, I.M. (1981) Improved preservation of neuronal glycogen by fixation with iodoacetic acid-containing solutions. Exp. Neurol. 72: 429-445.
4. Cardell, M., Koide, T., Wieloch, T. (1989) Pyruvate dehydrogenase activity in the rat cerebral cortex following cerebral ischemia. J. Cereb. Blood Flow Metab. 9: 350-357.
5. Cardell, M., Siesjö, B.K., Wieloch, T. (1991) Changes in pyruvate dehydrogenase complex activity during and following severe insulin-induced hypoglycemia. J. Cereb. Blood Flow Metab. 11: 122-128.
6. Cataldo, A.M., Broadwell, R.D. (1986) Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions: I. Neurons and glia. J. Elect. Microscopy Tech. 3: 413-437.
7. Cohen, P. (1978). The role of cyclic AMP dependent protein kinase in the regulation of glycogen metabolism in mammalian skeletal muscle. In: Current Topics in Cellular Regulation Vol. 14 (BL Horecker, ER Stadtman, eds), New York, Academic Press, pp 117-195.
8. Delorme, P., Hevor, T.K. (1985) Glycogen particles in methionine sulfoximine epileptogenic rodent brain and liver after the administration of methionine and actinomycin D. Neuropathol. Appl. Neurobiol. 11 : 117-128.
9. Folbergrová, J., Passonneau, J.V., Lowry, O.H., Schulz, D.W. (1969) Glycogen, ammonia and related metabolites in the brain during seizures evoked by methionine sulphoximine. J. Neurochem. 16: 191-203.
10. + ratio of the rat brain. J. Neurochem. 19: 2497-2505.
11. Folbergrová, J. (1973) Glycogen and glycogen phosphorylase in the cerebral cortex of mice under the influence of methionine sulphoximine. J. Neurochem. 20: 547-557.
12. Goldberg, N.D., O'Toole, A.G. (1969) The properties of glycogen synthetase and regulation of glycogen biosynthesis in rat brain. J. Biol. Chem. 244: 3053-3061.
13. Guth, L., Watson, P.K. (1968) A correlated histochemical and quantitative study on cerebral glycogen after brain injury in the rat. Exp. Neurol. 22: 590-602.
14. Gutierrez, J.A., Norenberg, M.D. (1977) Ultrastructural study of methionine suIfoximine-induced Alzheimer type II astrocytosis. Am. J. Pathol. 86: 285-300.
15. Hevor, T.K., Delorme, P., Gayet, J. (1985) Glycogen content and fructose-1,6,-biphosphatase activity in methionine sulfoximine epileptogenic mouse brain and liver after protein synthesis inhibition. Neurophathol. Appl. Neurobiol. 11: 129-139.
16. Hevor, T.K., Delorme, P., Beauvillain, J.C. (1986) Glycogen synthesis and immunocytochemical study of fructose-1,6-biphosphatase in methionine sulfoximine epileptogenic rodent brain. J. Cereb. Blood Flow Metab. 6: 292-297.
17. Ibrahim, M.Z.M., (Ed.) (1975) Glycogen and its Related Enzymes of Metabolism in the Central Nervous System. New York, Berlin, Heidelberg, Springer-Verlag, pp. 6-84.
18. Inoue, N., Matsukado, Y., Goto, S., Miyamoto, E. (1988) Localization of glycogen synthase in brain. J. Neurochem. 50: 400-405.
19. Katsura, K., Ekholm, A., Asplund, B., Siesjö, B.K. (1991) Extracellular pH in the brain during ischemia: relationship to the severity of lactic acidosis. J. Cereb. Blood Flow Metab. 11: 597-599.
20. Katsura, K., Asplund, B., Ekholm, A., Siesjö, B.K. (1992) Extra- and intracellular pH in the brain during ischemia, related to tissue lactate content in normo- and hypercapnic rats. Euro. J. Neurosci. 4: 166-176.
21. Katsura, K., Folbergrová, J., Gidö, G., Siesjö, B.K. (1994) Functional, metabolic, and circulatory changes associated with seizure activity in the postischemic brain. J. Neurochem. 62: 1511-1515.
22. Kozuka, M., Smith, M-L., Siesjö, B.K. (1989) Preischemic hyperglycemia enhances postischemic depression of cerebral metabolic rate. J. Cereb. Blood Flow Metab. 9: 478-490.
23. Kraig, R.P., Pulsinelli, W.A., Plum, F. (1985) Hydrogen ion buffering during complete brain ischemia. Brain Res. 342: 281-290.
24. Kraig, R.P., Chesler, M. (1990) Astrocytic acidosis in hyperglycemic and complete ischemia. J. Cereb. Blood Flow Metab 10: 104-114.
25. Lamer, J., Villar-Palasi, C., Goldberg, N.D., Bishop, J.S., Huijing, F., Wenger, J.I., Sasko, H., Brown, N.B. (1968) Hormonal and nonhormonal control of glycogen synthesis-control of transferase phosphatase and transferase I kinase. In: W.J. Whelan (Ed.), Control of Glycogen Metabolism, New York, Academic Press, pp 1-18.
26. Ljunggren, B., Schutz, H., Siesjö, B.K. (1974) Changes in energy state and acid-base parameters of the rat brain during complete compression ischemia. Brain Res. 73: 277-289.
27. Lowry, O.H., Passonneau, J.V., eds. (1972) A Flexible System of Enzymatic Analysis. New York, Academic Press.
28. Mrsulja, B.B., Lust, W.D., Mrsulja, B.J., Passonneau, J.V., Klaizo, I. (1976) Brain glycogen following experimental cerebral ischemia in gerbils (Meriones unguiculatus). Experientia 32: 732-734.
29. Petito, C.K., Babiak, T. (1982) Early proliferative changes in astrocytes in postischemic noninfarcted rat brain. Ann. Neurol. 11: 510-518.
30. Petito, C.K., Pulsinelli, W.A., Jacobson, G., Plum, F. (1982) Edema and vascular permeability in ischemia: Comparison between ischemic neuronal damage and infarction. J. Neuropathol. Exp. Neurol. 41 : 423-436.
31. Pfeiffer, B., Elmer, K., Roggendorf, W., Reinhart, P.H., Hamprecht, B. (1990) Immunohistochemical demonstration of glycogen phosphorylase in rat brain slices. Histochemistry 94: 73-80.
32. Pfeiffer, B., Meyermann, R., Hamprecht, B. (1992) Immunohistochemical co-localization of glycogen phosphorylase with the astroglial markers glial fibrillary acidic protein and S-100 protein in rat brain sections. Histochemistry 97: 405-412.
33. Phelps, C.H. (1972) Barbiturate-induced glycogen accumulation in brain. An electron microscopic study. Brain Res. 39: 225-234.
34. Phelps, C.H. (1975) An uttrastructural study of methionine sulphoximine-induced glycogen accumulation in astrocytes of the mouse cerebral cortex. J. Neurocytol. 4: 479-490.
35. Plum, F. (1983) What causes infarction in ischemic brain?: The Robert Wartenburg lecture. Neurology 33: 222-233.
36. Pontén, U., Ratcheson, R.A., Salford, L.G., Siesjö, B.K. (1973) Optimal freezing conditions for cerebral metabolites in rats. J. Neurochem 21: 1127-1138.
37. Pulsinelli, W.A., Levy, D.E., Duffy, T.E. (1982) Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia. Ann. Neurol. 11: 499-509.
38. Siesjö, B.K., eds. (1978) Brain Energy Metabolism. Chichester, New York, John Wiley and Sons, Ltd.
39. Siesjö, B.K. (1988) Acidosis and ischemic brain damage. Neurochem Pathol 9: 31-88.
40. Siesjö, B.K., Katsura, K., Mellergård, P., Ekholm, A., Lundgren, J., Smith, M-.L. (1993) Acidosis-related brain damage; Neurobiology of ischemic brain damage. In: K. Kogure, K-A Hossmann, B.K. Siesjö (Eds.), Progress in Brain Research, Amsterdam, Elsevier, pp 23-48.
41. Smith, M-.L., Bendek, G., Dahlgren, N., Rosén, I., Wieloch, T., Siesjö, B.K. (1984) Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model. Acta Neurol. Scand. 69: 385-401.
42. Smith, M-.L., von Hanwehr, R., Siesjö, B.K. (1986) Changes in extra- and intracellular pH in the brain during and following ischemia in hyperglycemic and in moderately hypoglycemic rats. J. Cereb. Blood Flow Metab. 6: 574-583.
43. Söderling, T.R., Park, C.R. (1974). Recent advances in glycogen metabolism. In: P. Greengard, G.A. Robinson (Eds.), Advances in Cyclic Nucleotide Research, Vol. 4, New York, Raven Press, pp 284-333.