2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline synthesis via a [3 + 2] cycloaddition

Tetrahedron Letters

Volumn 37, Issue 41, 1996, Pages 7343-7344

  Bernotas, Ronald C ^a   Adams, Ginette ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PYRAZINE DERIVATIVE; QUINOLINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0030573984     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01641-3     Document Type: Article

References (10)

1. 1. Bernotas, R. C., Adams, G. Tetrahedron Lett., proceeding communication.
2. 2. Nijhuis, W. H. N.; Verboorn, W.; Reinhoudt, D. N. Synthesis 1987, 641-645.
3. 13C NMR, CIMS, IR spectral data.
4. 4. Cicchi, S.; Goti, A.; Brandi, A.; Guarna, A.; De Sarlo, F. Tetrahedron Lett. 1990, 31, 3351-3354.
5. 5. Melting point of 5-hydrochloride: 191-192°C; literature: 192-194°C (see reference 6d).
6. 6. For other syntheses of this ring system: (a) Rupe, H.; Thommen, W. Helv. Chim. Acta 1947, 30, 920-931;
7. (b) Baxter, C. A. R.; Richards, H. C. J. Med. Chem. 1972, 15, 351-356;
8. (c) Huff, J. R.; King, S. W.; Saari, W. S.; Springer, J. P.; Martin, G. E.; Williams, M. J. Med. Chem. 1985, 25, 945-948;
9. (d) Rossi, A; Sury, E., South African Patent 67 05 766, 1967; Chem. Abstr. 1969, 70, 47502a; and
10. (e) ref. 2.