Bioactive Conformation of 1-Arylpiperazines at Central Serotonin Receptors

Journal of Medicinal Chemistry

Volumn 28, Issue 7, 1985, Pages 945-948

  Huff, Joel R ^a   King, Stella W ^a   Saari, Walfred S ^a   Springer, J P ^a   Martin, Gregory E ^a   Williams, Michael ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1 (6 CHLORO 2 PYRAZINYL)PIPERAZINE; 1 (6 TRIFLUOROMETHYL 2 PYRAZINYL)PIPERAZINE; 1 ARYLPIPERAZINE DERIVATIVE; 2,3,4,4A,5,6 HEXAHYDRO 9 TRIFLUOROMETHYL 1H PYRAZINO[1,2 A]QUINOLINE; DRUG; PIPERAZINE DERIVATIVE; RADIOISOTOPE; SEROTONIN H 3; SEROTONIN RECEPTOR; SPIPERONE H 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; DRUG ANALYSIS; DRUG ANTAGONISM; DRUG COMPARISON; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHARMACOKINETICS; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CENTRAL NERVOUS SYSTEM; CHEMISTRY; FEMALE; FRONTAL LOBE; MICE; MOLECULAR CONFORMATION; PIPERAZINES; POSTURE; PYRAZINES; QUINOLINES; RATS; RECEPTORS, SEROTONIN; SEROTONIN; SPIPERONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0021800534     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00145a017     Document Type: Article

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