Biosynthesis of taxol: Enzymatic acetylation of 10-deacetylbaccatin-III to baccatin-lII in crude extracts from roots of Taxus baccata

Biochemical and Biophysical Research Communications

Volumn 229, Issue 1, 1996, Pages 16-20

  Zocher, Rainer ^a   Weckwerth, Wolfram ^a   Hacker, Christine ^a   Kammer, Bettina ^a   Hornbogen, Till ^a   Ewald, Dietrich ^b  

^a TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^b Federal Research Centre for Forestry and Forest Products   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ACETYL COENZYME A; BACCATIN III; CARBON 14; PACLITAXEL; PLANT EXTRACT; TRITIUM;

ACETYLATION; ARTICLE; BIOSYNTHESIS; ISOTOPE LABELING; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY; TREE; ULTRAVIOLET SPECTROSCOPY;

TAXUS BACCATA; TRITIUM;

EID: 0030569547     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1996.1751     Document Type: Article

References (8)

1. 1. Kingston, D. G. I. (1991) Pharmac. Ther. 52, 1-34.
2. 2. Floss, H. G., and Mocek, V. (1995) in Taxol: Science and Applications (Suffness, M., Ed.), pp. 191-208, CRC Press, Boca Raton, FL.
3. 3. Mehri, H., Lewis, G. N., and Croteau, R. (1995) Arch. Biochem. Biophys. 322(2), 437-444.
4. 4. Koepp, A. E., Mehri, H., Zajicek, J., Stofer Vogel, B., LaFever, R. E., Lewis, G. N., and Croteau, R. (1995) J. Biol. Chem. 270, No. 15, 8686-8690.
5. 5. Lin, X., Mehri, H., Koepp, A. E., Floss, H. G., and Croteau, R. (1996) Biochemistry 35, 2968-2977.
6. 6. Wildung, M. R., and Croteau, R. (1996) J. Biol Chem. 271(16), 9201-9204.
7. 7. Hefner, J., Rubenstein, S. M., Ketchum, R. E. B., Gibson, D. M., Williams, R. M., and Croteau, R. (1996) Chemistry & Biology 3, 479-489.
8. 8. Miller, R. W., Powell, R. G., and Smith, Jr., C. R. (1981) J. Org. Chem. 46, 1469-1474.