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Yoshida S, Akizuki M, Mimori T, Yamagata H, Inada S, Homma M: The precipitating antibody to an acidic nuclear protein antigen, the Jo-1, in connective tissue diseases: a marker for a subset of polymyositis with interstitial pulmonary fibrosis. Arthritis Rheum 1983, 26:604-611.
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A subluxing arthropathy associated with the anti-Jo-1 antibody in polymyositis/dermatomyositis
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Weidensaul D, Imam T, Holyst M-M, King PD, McMurray RW: Polymyositis, pulmonary fibrosis, and hepatitis C. Arthritis Rheum 1995, 38:437-439. This paper describes a new association involving a patient with hepatitis C virus infection and anti-Jo-1-positive polymyositis with interstitial lung disease.
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Autoantibodies to a transfer RNA-associated protein in a murine model of chronic graft versus host disease
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Gelpi C, Martinez MA, Vidal S, Targoff IN, Rodriguez-Sanchez JL: Autoantibodies to a transfer RNA-associated protein in a murine model of chronic graft versus host disease. J Immunol 1994, 152:1989-1999.
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11
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0028923294
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Myositis: Immunologic contributions to understanding cause, pathogenesis, and therapy
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Rotz PH, Rider LG, Targoff IN, Raben N, et al.: Myositis: immunologic contributions to understanding cause, pathogenesis, and therapy. Ann Intern Med 1995, 122:715-724.
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Clinical manifestations in patients with antibody to PL-12 antigen (alanyl-tRNA synthetase)
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Targoff IN, Amett FC: Clinical manifestations in patients with antibody to PL-12 antigen (alanyl-tRNA synthetase). Am J Med 1990, 88:241-251.
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Hirakata M, Nakamura K, Okano Y, Suwa A, Inada S, Akizuki M, Hardin JA: Anti-alanyl tRNA synthetase (PL-12) antibodies are associated with interstitial lung diseases in Japanese patients [abstract]. Arthritis Rheum 1995, 38:8321.
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Reaction of anti-OJ autoantibodies with components of the multi-enzyme complex of aminoacyl-tRNA synthetases in addition to isoleucyl-tRNA synthetase
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Targoff IN, Trieu EP, Miller FW: Reaction of anti-OJ autoantibodies with components of the multi-enzyme complex of aminoacyl-tRNA synthetases in addition to isoleucyl-tRNA synthetase. J Clin Invest 1993, 91:2556-2564.
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Antibodies to glycyl-transfer RNA synthetase in patients with myositis and interstitial lung disease
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Targoff IN, Trieu EP, Plotz PH, Miller FW: Antibodies to glycyl-transfer RNA synthetase in patients with myositis and interstitial lung disease. Arthritis Rheum 1992, 35:821-830.
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Autoantibodies to glycyl-transfer RNA synthetase in myositis: Association with dermatomyositis and immunologic heterogeneity
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Hirakata M, Suwa A, Takeda Y, Matsuoka Y, Irimajiri S, Targoff IN, Hardin JA, Craft J: Autoantibodies to glycyl-transfer RNA synthetase in myositis: association with dermatomyositis and immunologic heterogeneity. Arthritis Rheum 1996, 39:146-150. Immunologic heterogeneity of anti-EJ (glycyl-tRNA synthetase) antibodies is described. One patient serum sample with anti-EJ antibodies immunoprecipitated a 75-kD protein along with only one of four associated tRNAs, and this serum sample lacked inhibition of glycylation for the cognate tRNA, suggesting different epitope specificities among anti-EJ sera.
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Hirakata, M.1
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Hirakata M, Nakamura K, Fujii T, Okano Y, Mimori T, Takeda Y, Hardin JA, Akizuki M: Clinical and immunogenetic features of anti-SRP autoantibodies in Japanese patients [abstract]. Arthritis Rheum 1995, 38:8321.
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Hirakata, M.1
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Targoff IN, Reichlin M: The association between Mi-2 antibodies and dermatomyositis. Arthritis Rheum 1985, 28:796-803.
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A broadened spectrum of juvenile myositis: Myositis-specific autoantibodies in children
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Rider L, Miller FW, Targoff IN, Sherry DD, Samayoa E, Lindahl M, Wener MH, Pachman LM, Plotz PH: A broadened spectrum of juvenile myositis: myositis-specific autoantibodies in children. Arthritis Rheum 1994, 37:1534-1538.
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Rider, L.1
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Lindahl, M.6
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The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation
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Seelig HP, Moosbrugger I, Ehrfeld H, Fink T, Renz M, Genth E: The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation. Arthritis Rheum 1995, 38:1389-1399. The authors isolated a full-length cDNA encoding the major Mi-2 antigen. This study demonstrated that the Mi-2 antigen was a 218-kD protein encoded on chromosome 12 and that it had a structural similarity to members of the helicase family.
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Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen
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Ge Q, Nilasena DS, O'Brien CA, Frank MB, Targoff IN: Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen. J Clin Invest 1995, 96:1730-1737. Another molecular cloning study of the Mi-2 antigen. The sequence of an apparent partial cDNA encoding the 240-kD Mi-2 antigen contained four potential zinc-linger motifs. The authors claim that the 240-kD Mi-2 is a novel protein.
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Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositisscleroderma overlap
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Taccioli, G.E.1
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Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA
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Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line
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Lees-Miller SP, Godbout R, Chan DW, Weinfeld M, Day RS III, Barron GM, Allalunis-Turner J: Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science 1995, 267:1183-1185. This paper reports that the radiosensitive human malignant glioma cell line is defective in DNA double-strand breaks and fails to express DNA-PKcs, suggesting that DNA-PK activity is involved in DNA repair.
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Science
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Lees-Miller, S.P.1
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41
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0028816760
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Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-stranded break repair mutants by the p86 Ku autoantigen
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Boubnov NV, Hall KT, Wills Z, Lee SE, He DM, Benjamin DM, Pulaski CR, Band H, Reeves W, Hendrickson EA, Weaver DT: Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-stranded break repair mutants by the p86 Ku autoantigen. Proc Natl Acad Sci U S A 1995, 92:890-894. This paper reports that introduction of the Ku(p86) gene to radiation-sensitive mutant cell lines that have low expression levels of p86 mRNA normalized defective DNA repair and V(D)J recombination, suggesting that the Ku(p86) protein is essential for DNA repair and V(D)J recombination.
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Boubnov, N.V.1
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0028953951
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DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect
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Kirchgessner CU, Patil CK, Evans JW, Cuomo CA, Fried LM, Carter T, Oettiinger MA, Brown JM: DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect Science 1995, 267:1178-1183. This paper claims that the defect of the gene encoding DNA-PKcs explains the SCID mouse, because protein levels of DNA-PKcs are extremely reduced in cells from the SCID mouse, and because chromosomal fragments expressing DNA-PKcs complement the SCID phenotype.
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Science
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Kirchgessner, C.U.1
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Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation
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Blunt T, Finnie NJ, Taccioli GE, Smith GCM, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ, Alt FW, Jeggo PA, Jackson SP: Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 1995, 80:813-832. Cells from the SCID mouse and from the V3 mutant hamster lack DNA-PK activity because of defects in DNA-PKcs. Yeast artificial chromosomes containing the DNA-PKcs gene complement the DNA repair and V(D)J recombination deficiencies of these cells.
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Cell
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Blunt, T.1
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Mizuta, R.7
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44
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0029156599
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DNA-dependent protein kinase catalytic subunit: A relative of phosphatidyl-inositol 3-kinase and the ataxia telanglectasia gene product
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Hartley KS, Gell D, Smith GCM, Zhang H, Divecha N, Connelly MA, Admon A, Lees-Miller SP, Anderson CW, Jackson SP: DNA-dependent protein kinase catalytic subunit: a relative of phosphatidyl-inositol 3-kinase and the ataxia telanglectasia gene product Cell 1995, 82:849-856. Complementary DNA encoding for 460-kD DNA-PKcs was identified. The structure of DNA-PKcs was found to be related to the phosphatidyl inositol-3-kinase family and the product of the ataxia-telangiectasia gene.
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Cell
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