Neurotransmitter receptor/G-protein mediated signal transduction in Alzheimer's disease brain

Neurodegeneration

Volumn 5, Issue 4, 1996, Pages 483-488

  Cowburn, Richard F ^a,d   Fowler, Christopher J ^b   O'Neill, Cora ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c UNIVERSITY COLLEGE CORK   (Ireland)

^d KFC   (Sweden)

Author keywords

Adenylyl cyclase; Alzheimer's disease; G protein; Neurotransmission; Phospholipase C; Protein kinase C; amyloid

Indexed keywords

ADENYLATE CYCLASE; AMYLOID BETA PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROTRANSMITTER RECEPTOR; PHOSPHATIDYLINOSITOL; PHOSPHOLIPASE C; PROTEIN KINASE C;

ALZHEIMER DISEASE; AUTOPSY; BRAIN; CONFERENCE PAPER; HUMAN; HYDROLYSIS; NEUROCHEMISTRY; PATHOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0030483685     PISSN: 10558330     EISSN: None     Source Type: Journal    
DOI: 10.1006/neur.1996.0067     Document Type: Conference Paper

References (37)

1. Alder JT, Chessell IP, Bowen DM (1995) A neurochemical approach for studying response to acetylcholine in Alzheimer's disease. Neurochem Res 20:769-771
2. Bonkale WL, Fastbom J, Wiehager B, Ravid R, Winblad B, Cowburn RF (1996) Impaired G-protein stimulated adenylyl cyclase activity in Alzheimer's disease brain is not accompanied by reduced cyclic-AMP dependent protein kinase activity. Brain Res. In press
3. Cashman RE, Grammas P (1995) cAMP-dependent protein kinase in cerebral microvessels in aging and Alzheimer's disease, Mol Chem Neuropathol 26:247-258
4. Clark EA, Leach KL, Trojanowski JQ, Lee VM-Y (1991) Characterisation and differential distribution of the three major human protein kinase C isozymes (PKCα, PKCβ and PKCγ) of the central nervous system in normal and Alzheimer's disease brains. Lab Invest 64:35-44
5. Cole G, Dobkins K, Hansen LA, Terry RD, Saitoh T (1988) Decreased levels of protein kinase C in Alzheimer brain. Brain Res 452:165-174
6. Cowburn RF, O'Neill C, Ravid R, Alafuzoff I, Winblad B, Fowler CJ (1992) Adenylyl cyclase activity in post-mortem human brain: evidence of altered G protein mediation in Alzheimer's disease. J Neurochem 58:1409-1419
7. Cowburn RF, Vestling M, Fowler CJ, Ravid R, Winblad B, O'Neill C (1993) Disrupted β1-adrenoceptor-G-protein coupling in the temporal cortex of patients with Alzheimer's disease. Neurosci Lett 155:163-166
8. 35S]GTPγS binding shows regional selective changes in Alzheimer's disease postmortem brain. Neurodegeneration 5:19-26
9. Cowburn RF, Fowler CJ, O'Neill C (1996b) Neurotransmitters, signal transduction and second messengers in Alzheimer 's Disease. Acta Neurol Scand (Suppl). 165:25-32
10. Crews FT, Kurian P, Freund G (1994) Cholinergic and serotonergic stimulation of phosphoinositide hydrolysis is decreased in Alzheimer's disease. Life Sci 55:1992-2002
11. m GTPase activity in aging and Alzheimer's disease: implications for altered signal transduction. Brain Res 664:54-60
12. 2 hydrolysis in Alzheimer's disease. Life Sci 53:439-444
13. Flynn DD, Weinstein DA, Mash DC (1991) Loss of high-affinity agonist binding to M1 muscarinic receptors in Alzheimer's disease: implications for the failure of cholinergic replacement therapies. Ann Neurol 29:256-262
14. 4 binding in Alzheimer's disease brain. Brain Res 681:160-166
15. Greenwood AF, Powers RTE, Jope RS (1995) Phosphoinositide hydrolysis, Gq alpha, phosholipase C, and protein kinase C in post mortem human brain: Effects of post mortem interval, subject age, and Alzheimer's disease. Neuroscience 69:125-138
16. Haug L-S, Østvold AC, Cowburn RF, Garlind A, Winblad B, Walaas SI (1996) Decreased inositol(1,4,5)trisphosphate receptor levels in Alzheimer's disease cerebral cortex: selectivity of changes and correlation to pathological severity. Neurodegeneration 5:169-176
17. Hérnandez-Hérnandez A, Adem A, Ravid R, Cowburn RF (1995) Preservation of acetylcholine muscarinic M2 receptor G-protein interactions in the neocortex of patients with Alzheimer's disease. Neurosci Letts 186:57-60
18. Jope RS, Song L, Li X, Powers R (1994) Impaired phosphoinositide hydrolysis in Alzheimer's disease brain. Neurobiol Aging 15: 221-226
19. Ladner CJ, Celesia CG, Magnuson DJ, Lee JM (1995) Regional alterations in M1 muscarinic receptor-G-protein coupling in Alzheimer's disease. J Neuropathol Exp Neurol 54:783-789
20. Li X, Greenwood AF, Powers R, Jope RS (1996) Effects of postmortem interval, age and Alzheimer's disease on G-proteins in human brain. Neurobiol Aging 17:115-122
21. Masliah E, Cole GM, Shimohama S, Hansen LA, DeTeresa R, Terry RD, Saitoh T (1990) Differential involvement of protein kinase C isozymes in Alzheimer's disease. J Neurosci 10:2113-2124
22. Masliah E, Cole GM, Hansen LA, Mallory M, Allbright T, Terry RD, Saitoh T (1991) Protein kinase C alteration is an early biochemical marker in Alzheimer's disease. J Neurosci 11:2759-2767
23. McLaughlin M, Ross BM, Milligan G, McCulloch J, Knowler JT (1991) Robustness of G proteins in Alzheimer's disease: an immunoblot study. J Neurochem 57:9-14
24. Meier-Ruge W, Iwangoff P, Reichlmeier K (1984) Neurochemical enzyme changes in Alzheimer's and Pick's disease, Arch Gerontol Geriatr 3:161-165
25. Ohm TG, Bohl J, Lemmer B (1991) Reduced basal and stimulated (isoprenaline, Gpp[NH]p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes. Brain Res 540:229-236
26. O'Neill C, Fowler CJ, Wiehager B, Ravid R, Winblad B, Cowburn RF (1994) Region selective alterations in G-protein subunit levels in the Alzheimer's disease brain. Brain Res 636:193-201
27. Parks KM, Sugar JE, Haroutunian V, Bierer L, Perl D, Wallace WC (1991) Reduced in vitro phosphorylation of synapsin (site 1) in Alzheimer's disease postmortem tissues, Mol Brain Res 9:125-134
28. Ross BM, Mclaughlin M, Roberts M, Milligan G, McCulloch J, Knowler JT (1993) Alterations in the activity of adenylyl cyclase and high affinity GTPase in Alzheimer's disease. Brain Res 622:35-42
29. qa in control and Alzheimer's disease brains. Biochem Soc Trans 23:363S
30. Schnecko A, Witte K. Bolh J, Ohm T, Lemmer B (1994) Adenylyl cyclase activity in Alzheimer's disease brain: stimulatory and inhibitory signal transduction pathways are differentially affected. Brain Res 644:291-296
31. Shimohama S, Narita M, Matsushima H, Kimura J, Kameyama M, Hagiwara M, Hidaka H, Taniguchi T (1993) Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease. Neurology 43:1407-1413
32. Smith CJ, Perry EK Perry RH, Fairbairn AF, Birdsall NJM (1987) Guanine nucleotide modulation of muscarinic cholinergic receptor binding in postmortem human brain - a preliminary study in Alzheimer's disease. Neurosci Lett 82:227-232
33. Wallace MA, Claro E (1993) Transmembrane signalling through phospholipase C in human cortical membranes. Neurochem Res 18:139-145
34. Wang H-Y, Friedmann E (1994) Receptor-mediated activation of G-proteins is reduced in postmortem brains from Alzheimer's disease patients. Neurosci Lett 173:37-39
35. Wang H-Y, Pisano MR, Friedman E (1994) Attenuation of protein kinase C activity and translocation in Alzheimer's disease brain. Neurobiol Aging 15:293-298
36. Young AB, Penney JB (1994) Neurotransmitter receptors in Alzheimer's disease. In Terry RD, Katzman R, Bick KL. Alzheimer's disease. Raven Press, New York, pp 293-303
37. 3H]inositol 1,4,5-trisphosphate binding in Alzheimer's disease. Neurosci Lett 94:198-202