Neurotransmitters, signal transduction and second-messengers in Alzheimer's disease

Acta Neurologica Scandinavica

Volumn 94, Issue SUPPL.165, 1996, Pages 25-32

  Cowburn, Richard F ^a   Fowler, C J ^b   O'Neill, C ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

amyloid; Adenylyl cyclase; Alzheimer's disease; G protein; Neurotransmitters; Phospholipase C; Protein kinase C; Receptors

Indexed keywords

ADENYLATE CYCLASE; AMYLOID PRECURSOR PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHATIDYLINOSITOL; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS;

ALZHEIMER DISEASE; CONFERENCE PAPER; HUMAN; SIGNAL TRANSDUCTION; METABOLISM; REVIEW; SECOND MESSENGER;

ALZHEIMER DISEASE; HUMANS; NEUROTRANSMITTER AGENTS; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION;

EID: 0029687082     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.1996.tb05869.x     Document Type: Article

References (67)

1. Young AB, Penney JB Jr. Neurotransmitter receptors in Alzheimer disease. In: Terry RD, Katzman R., Bick KL, eds. Alzheimer disease. New York: Raven Press, 1994: 293-303.
2. Cowburn RF, Hardy JA, Roberts PJ. Neurotransmitter deficits in Alzheimer's disease. In: Davies DC, ed. Alzheimer's disease: towards an understanding of the aetiology and pathogenesis. London: John Libbey, 1989: 9-32.
3. Francis PT, Cross AJ, Bowen DM. Neurotransmitters and neuropeptides. In: Terry RD, Katzman R., Bick KL, eds. Alzheimer disease. New York: Raven Press, 1994: 247-61.
4. Horsburgh K., Saitoh T. Signal transduction in Alzheimer disease. In: Terry RD, Katzman R., Bick KL, eds. Alzheimer disease. New York: Raven Press, 1994: 369-86.
5. Tang WJ, Gilman AG. Adenylyl cyclases. Cell 1992: 70: 869-72.
6. Iyengar R. Molecular and functional diversity of mammalian Gs-stimulated adenylyl cyclases. FASEB J 1993: 7: 768-75.
7. Cowburn RF, Vestling M., Fowler CJ, Ravid R., Winblad B., O'Neill C. Disrupted β1-adrenoceptor-G-protein coupling in the temporal cortex of patients with Alzheimer's disease. Neurosci Lett 1993: 155: 163-66.
8. Wang HY, Friedman E. Receptor-mediated activation of G-proteins is reduced in postmortem brains from Alzheimer's disease patients. Neurosci Lett 1994: 173: 37-39.
9. Cowburn RF, O'Neill C., Ravid R., Alafuzoff I., Winblad B., Fowler CJ. Adenylyl cyclase activity in postmortem human brain: evidence of altered G protein mediation in Alzheimer's disease. J Neurochem 1992: 58: 1409-19.
10. O'Neill C., Wiehager B., Fowler CJ, Ravid R., Winblad B., Cowburn RF. Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain. Brain Res 1994: 636: 193-201.
11. Ohm TG, Bohl J., Lemmer B. Reduced basal and stimulated (isoprenaline, Gpp[NH]p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes. Brain Res 1991: 540: 229-36.
12. Schnecko A., Witte K., Bohl J., Ohm T., Lemmer B. Adenylyl cyclase activity in Alzheimer's disease brain: stimulatory and inhibitory signal transduction pathways are differentially affected. Brain Res 1994 644: 291-96.
13. 3H]forskolin binding sites in Alzheimer's disease: a quantitative autoradiographic study. Brain Res 1990: 511: 241-48.
14. Poat JA, Cripps HE, Iversen LL. Differences between high-affinity forskolin binding sites in dopamine-rich and other regions of rat brain. Proc Natl Acad Sci USA 1988: 85: 3216-20.
15. Ross BM, McLaughlin M., Roberts M., Milligan G., McCulloch J., Knowler JT. Alterations in the activity of adenylyl cyclase and high affinity GTPase in Alzheimer's disease. Brain Res 1993: 622: 35-42.
16. i-protein inhibited adenylyl cyclase activity in the brains of patients with Alzheimer's disease. Neurosci Lett 1992: 141: 16-20.
17. McLaughlin M., Ross BM, Milligan G., McCulloch J., Knowler JT. Robustness of G proteins in Alzheimer's disease: an immunoblot study. J Neurochem 1991: 57: 9-14.
18. sα) mRNA in hippocampal and cortical neurons. Mol Brain Res 1991: 10: 71-81.
19. sα mRNA in human and rat brain. J Neurochem 1991: 57: 1019-23.
20. O'Neill C., Fowler CJ, Wiehager B., Cowburn RF, Alafuzoff I., Winblad B. Coupling of human brain cerebral cortical α2-adrenoceptors to GTP-binding proteins in Alzheimer's disease. Brain Res 1991: 563: 39-43.
21. 1A receptor-G protein interactions in the cerebral cortex of patients with Alzheimer's disease. Neurosci Lett 1991: 133: 15-19.
22. 1 receptors to G proteins in Alzheimer hippocampus: a quantitative autoradiographic study. Neuroscience 1993: 52: 843-54.
23. Bergström L., Garlind A., Nilsson L., Alafuzoff I., Fowler CJ, Winblad B., Cowburn RF. Regional distribution of somatostatin receptor binding and modulation of adenylyl cyclase in Alzheimer's disease brain. J Neurol Sci 1991: 105: 225-33.
24. 3H]oxotremorine-M binding in normal and Alzheimer's disease parietal cortex: an index of muscarinic receptor G-protein coupling. Biochem Soc Trans 1989: 17: 202-3.
25. Hernandez-Hernandez A., Adem A., Ravid R., Cowburn RF. Preservation of acetylcholine muscarinic M2 receptor G-protein interactions in the neocortex of patients with Alzheimer's disease. Neurosci Lett 1995: 186: 57-60.
26. Slama A., Heidet V., Cervera P., Hirsch E., Javoy-Agid F., Epelbaum J. Preservation of somatostatin receptors coupled to the inhibition of adenylate cyclase in the cortex and hippocampus in senile dementia of the Alzheimer type. Dementia 1991: 2: 88-94.
27. Jones DT, Reed RR. Molecular cloning of five GTP-binding protein cDNA species from rat olfactory epithelium. J Biol Chem 1987: 262: 14241-49.
28. i2. Biochem J 1990: 267: 391-98.
29. Kato K., Kurobe N., Suzuki F. et al. Concentrations of several proteins characteristic of nervous tissue in cerebral cortex of patients with Alzheimer's disease. J Mol Neurosci 1991: 3: 95-99.
30. Brown DA. G-proteins and potassium currents in neurons. Annu Rev Physiol 1990: 52: 215-42.
31. Huang HM, Gibson GE. Altered β-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors. J Biol Chem 1993: 268: 14616-21.
32. Sternweis PC, Smrcka AV. Regulation of phospholipase C by G proteins. Trends Biochem Sci 1992: 17: 502-6.
33. Nishizuka Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 1988: 334: 661-65.
34. Irvine RF. Inositol lipids in cell signalling. Curr Opin Cell Biol 1992: 4: 212-19.
35. Smith CJ, Perry EK, Perry RH, Fairbairn AF, Birdsall NJM. Guanine nucleotide modulation of muscarinic cholinergic receptor binding in postmortem human brain- a preliminary study in Alzheimer's disease. Neurosci Lett 1987: 82: 227-32.
36. 1 muscarinic receptors in Alzheimer's disease: implications for the failure of cholinergic replacement therapies. Ann Neurol 1991: 29: 256-62.
37. Warpman U., Alafuzoff I., Nordberg A. Coupling of muscarinic receptors to GTP proteins in postmortem human brain: alterations in Alzheimer's disease. Neurosci Lett 1993: 150: 39-43.
38. 1 muscarinic receptors to G-protein in Alzheimer's disease. Alzheimer Dis Assoc Disord 1991: 5: 163-72.
39. Ogawa N., Mizukawa K., Asanuma M., Kanazawa I. Abnormalities in muscarinic cholinergic receptors and their G-protein coupling systems in the cerebral frontal cortex in Alzheimer's disease. Arch Gerontol Geriatr 1993: 17: 77-89.
40. 3H]-PIP2 hydrolysis in Alzheimer's disease. Life Sci 1993: 53: 439-44.
41. Stokes CE, Hawthorne JN. Reduced phosphoinositide concentrations in anterior temporal cortex of Alzheimer-diseased brains. J Neurochem 1987: 48: 1018-21.
42. Jolles J., Bothmer J., Markerink M., Ravid R. Phosphatidylinositol kinase is reduced in Alzheimer's disease. J Neurochem 1992: 58: 2326-29.
43. Bothmer J., Markerink M., Jolles J. Evidence for a selective decrease in type 1 phosphatidylinositol kinase activity in brains of patients with Alzheimer's disease. Dementia 1994: 5: 6-11.
44. 3H]inositol 1, 4, 5-trisphosphate binding in Alzheimer's disease. Neurosci Lett 1988: 94: 198-202.
45. 4) binding in Alzheimer's disease brain. Brain Res 1995: 681: 160-66.
46. 2+ channel. FEBS Lett 1993: 323: 229-32.
47. Saito K-I, Elce JS, Hamos JE, Nixon RA. Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proc Natl Acad Sci USA 1993: 90: 2628-32.
48. Cole G., Dobkins KR, Hansen LA, Terry RD, Saitoh T. Decreased levels of protein kinase C in Alzheimer brain. Brain Res 1988: 452: 165-74.
49. Masliah E., Cole GM, Shimohama S. et al. Differential involvement of protein kinase C isozymes in Alzheimer's disease. J Neurosci 1990: 10: 2113-24.
50. Masliah E., Cole GM, Hansen LA et al. Protein kinase C alteration is an early biochemical marker in Alzheimer's disease. J Neurosci 1991: 11: 2759-67.
51. 3H]phorbol ester binding sites in Alzheimer's and Parkinson's disease: an autoradiographic study. In: Corain B., Iqbal K., Nicolini M., Winblad B., Wisniewski H., Zatta P., eds. Alzheimer's disease: advances in clinical and basic research. Chichester: John Wiley and Sons Ltd, 1993: 341-48.
52. 3H]phorbol 12, 13-dibutyrate binding to protein kinase C in Alzheimer's disease. J Neurochem 1991: 56: 1121-29.
53. Van Huynh T., Cole G., Katzman R., Huang KP, Saitoh T. Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts. Arch Neurol 1989: 46: 1195-99.
54. Bruel A., Cherqui G., Columelli S. et al. Reduced protein kinase C activity in sporadic Alzheimer's disease fibroblasts. Neurosci Lett 1991: 133: 89-92.
55. Govoni S., Bergamaschi S., Racchi M. et al. Cytosol protein kinase C downregulation in fibroblasts from Alzheimer's disease patients. Neurology 1993: 43: 2581-86.
56. Winblad B., Messamore E., O'Neill C., Cowburn RF. Biochemical pathology and treatment strategies in Alzheimer's disease: emphasis on the cholinergic system. Acta Neurol Scand 1993: 149 (Suppl): 4-6.
57. Joachim CL, Selkoe DJ. The seminal role of β-amyloid in the pathogenesis of Alzheimer's disease. Alz Dis Assoc Disord 1992: 6: 7-34.
58. Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992: 256: 184-85.
59. Gillespie SL, Golde TE, Younkin SG. Secretory processing of the Alzheimer amyloid β/A4 protein precursor is increased by protein phosphorylation. Biochem Biophys Res Commun 1992: 187: 1285-90.
60. Hung AY, Haas C., Nitsch R. et al. Activation of protein kinase C inhibits cellular production of the amyloid β-protein. J Biol Chem 1993: 268: 22959-62.
61. Gabuzda D., Busciglio J., Yankner BA. Inhibition of β-amyloid production by activation of protein kinase C. J Neurochem 1993: 61: 2326-29.
62. Buxbaum JD, Koo EH, Greengard P. Protein phosphorylation inhibits production of Alzheimer amyloid β/A4 peptide. Proc Natl Acad Sci USA 1993: 90: 9195-98.
63. Nitsch RM, Slack BE, Wurtman RJ, Growdon JH. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 1992: 258: 304-7.
64. Buxbaum JD, Oishi M., Chen HI et al. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor. Proc Natl Acad Sci USA 1992: 89: 10075-78.
65. Nitsch RM, Farber SA, Growdon JH, Wurtman RJ. Release of amyloid β-protein precursor derivatives by electrical depolarization of rat hippocampal slices. Proc Natl Acad Sci USA 1993: 90: 5191-93.
66. Nitsch RM, Growdon JH. Role of neurotransmission in the regulation of amyloid β-protein precursor processing. Biochem Pharmacol 1994: 47: 1275-84.
67. Efthimiopoulos S., Felsenstein KM, Sambamurti K., Robakis NK, Refolo LM. Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein. J Neurosci Res 1994: 38: 81-90.