A 13-week oral repeated dose toxicity study of a new antineoplastic agent S-1 in rats

Journal of Toxicological Sciences

Volumn 21, Issue SUPPL. 3, 1996, Pages 505-526

  Hayashi, Taiji ^a   Hasegawa, Hiroyuki ^a   Tanaka, Gotaro ^a   Ohmae, Sigeo ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

13 week repeated dose study; Antineoplastic agent; Rat; S 1

Indexed keywords

5 CHLORO 2,4 DIHYDROXYPYRIDINE; 5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; ANTINEOPLASTIC AGENT; FLUOROPYRIMIDINE DERIVATIVE; OXONIC ACID; PYRIDINE DERIVATIVE; TEGAFUR;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD TOXICITY; CONTROLLED STUDY; DEATH; DOSE RESPONSE; DRUG TOXICITY; EDEMA; FEMALE; HISTOPATHOLOGY; KERATOSIS; MALE; MOTOR DYSFUNCTION; NEPHROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SEX DIFFERENCE;

ANIMALIA;

EID: 0030482723     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.21.supplementiii_505     Document Type: Article

References (9)

1. Shirasaka, T., Shimamoto, Y., Ohshima, H., Yamaguchi, M., Kato, T., Yonekura, K. and Fukushima, M. (1996) : Development of a novel form of an oral 5-fluorouracil derivative directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anti-Cancer Drugs, 7, 548-557.
2. Spicer, E. J. F., Swigart, J. L., Drafta, R. E., Blair, M. and Kinoshita, H. (1994) : Toxicity study of emitefur, a new antineoplastic agent (II) ; 13-week oral toxicity study in rats. Jpn. Pharmacol. Then, 22, 1, 87-107.