Mutagenicity study of a new antineoplastic agent S-1 and its components, CDHP, and OXO

Journal of Toxicological Sciences

Volumn 21, Issue SUPPL. 3, 1996, Pages 675-689

  Ohuchida, Akinobu ^a   Kouchi, Yasuhide ^a   Sato, Sachiko ^a   Maeda, Yasuhiro ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 CHLORO 2,4 DIHYDROXYPYRIDINE; 5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; ANTINEOPLASTIC AGENT; FLUOROPYRIMIDINE DERIVATIVE; FLUOROURACIL; OXONIC ACID; PYRIDINE DERIVATIVE; TEGAFUR;

ANIMAL CELL; ARTICLE; BACTERIAL MUTATION; CHINESE HAMSTER; CHROMOSOME ABERRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ESCHERICHIA COLI; LUNG ALVEOLUS CELL; METABOLIC ACTIVATION; MUTAGEN TESTING; NONHUMAN; SALMONELLA TYPHIMURIUM;

ANIMALIA; BACTERIA (MICROORGANISMS); CRICETINAE; CRICETULUS GRISEUS; ESCHERICHIA COLI; MAMMALIA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0030482694     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.21.supplementiii_675     Document Type: Article

References (10)

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2. Shibahara, T., Kaneko, E., Itoh, T., Awogi, T., Tsushimoto, G., Takahashi, N., Marshall, R. R. and Kirkland, D. J. (1993) : Mutagenic and clastogenic properties of (3-[3-(6-beozoyloxy-3-cyano-2-pyridyloxycarbonyl) benzoyl]-1-ethoxymethyl-5-fluorouracil) (BOF-A2), a new 5-fluorouracil derivative with anti-tumour activity. J. Toxicol. Sci., 18, Suppl., III, 11-19. with anti-tumour activity. J. Toxicol. Sci., 18, Suppl., III, 11-19.
3. Shirasaka, T., Shimamoto, Y., Ohshima, H., Yamaguchi, M., Kato, T., Yonekura, K. and Fukushima, M. (1996) : Development of a novel form of an oral 5-fluorouracil derivative directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anti-Cancer Drugs, 7, 548-557.
4. Yajima, N., Kondo, K. and Morita, K. (1981) : Reverse mutation test in Salmonella typhimurium and chromosomal aberration tests in mammalian cells in culture on fluorinated pyrimidine derivatives. Mutation Res., 88, 241-254.