Congenital hypothyroid goiter with deficient thyroglobulin: Identification of an endoplasmic reticulum storage disease with induction of molecular chaperones

Journal of Clinical Investigation

Volumn 98, Issue 12, 1996, Pages 2838-2844

  Medelros Neto, Geraldo ^a   Kim, Paul S ^b   Yoo, Sung E ^b   Vono, Jussara ^b   Targovnik, Hector M ^a   Camargo, Rosalinda ^a   Hossain, S Abu ^b   Arvan, Peter ^b,c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b HARVARD MEDICAL SCHOOL   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

BiP; GRP94; Intracellular transport; Protein folding; Thyroid

Indexed keywords

CHAPERONE; THYROGLOBULIN;

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASE REPORT; CONGENITAL HYPOTHYROIDISM; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GOITER; GOLGI COMPLEX; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; SIBLING; STORAGE DISEASE; THYROID FOLLICLE;

ANIMALS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GLYCOSYLATION; GOITER; HSP70 HEAT-SHOCK PROTEINS; HUMANS; HYPOTHYROIDISM; IMMUNOASSAY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MICE; MICE, INBRED STRAINS; MICROSCOPY, ELECTRON; MOLECULAR CHAPERONES; MUTATION; THYROGLOBULIN; THYROID GLAND; THYROTROPIN;

EID: 0030481624     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/jci119112     Document Type: Article

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