Oral single-dose toxicity study of a new antineoplastic agent S-1, and its components, CDHP, and Oxo

Journal of Toxicological Sciences

Volumn 21, Issue SUPPL. 3, 1996, Pages 495-504

  Hayashi, Taiji ^a   Tanaka, Gotaro ^a   Irimura, Kenji ^a   Hirota, Tomio ^a   Ohmae, Sigeo ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Antineoplastic agent; Dog; Mouse; Oral single dose toxicity study; Rat; S 1

Indexed keywords

5 CHLORO 2,4 DIHYDROXYPYRIDINE; 5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; ANTINEOPLASTIC AGENT; FLUOROPYRIMIDINE DERIVATIVE; FLUOROURACIL; OXONIC ACID; PYRIDINE DERIVATIVE; TEGAFUR;

ALOPECIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRADYPNEA; CONTROLLED STUDY; DEATH; DOG; DOSE RESPONSE; DRUG FORMULATION; DRUG TOXICITY; FEMALE; GASTROINTESTINAL TOXICITY; LD 50; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SALIVATION; SPECIES DIFFERENCE; WEIGHT REDUCTION;

ANIMALIA; CANIS FAMILIARIS;

EID: 0030481144     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Koenig, H. and Patel, A. (1970) : Biochemical basis for fluorouracil neurotoxicity. Arch. Neurol., 23, 155-160.
2. Pattison, F. L. M. and Peters, R. A. (1966) : Monofluoro Aliphatic Compounds, Handbook of Experimental Pharmacology, 20, Part 1, 387-458.
3. Shirasaka, T., Shimamoto, Y., Ohshima, H., Yamaguchi, M., Kato, T., Yonekura, K. and Fukushima, M. (1996) : Development of a novel form of an oral 5-fluorouracil derivative directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anti-Cancer Drugs, 7, 548-557.