An oral repeated dose toxicity study of a new antineoplastic agent S-1 in dogs: I . A 13-week repeated dose toxicity study - II . An ophthalmologic toxicity recovery study

Journal of Toxicological Sciences

Volumn 21, Issue SUPPL. 3, 1996, Pages 527-544

  Hayashi, Taiji ^a   Yamaguchi, Shuji ^a   Kito, Suguru ^a   Tanaka, Gotaro ^a   Kurokawa, Kyoko ^a   Hirota, Tomio ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 CHLORO 2,4 DIHYDROXYPYRIDINE; 5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; ANTINEOPLASTIC AGENT; CHLORIDE; CREATININE; FLUOROPYRIMIDINE DERIVATIVE; LACTATE DEHYDROGENASE; OXONIC ACID; PYRIDINE DERIVATIVE; TEGAFUR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEATH; DOG; DOSE RESPONSE; DRUG TOXICITY; EYE TOXICITY; FEMALE; HISTOPATHOLOGY; LYMPHATIC SYSTEM DISEASE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PIGMENTATION; REPRODUCTIVE TOXICITY;

ANIMALIA; CANIS FAMILIARIS;

EID: 0030479647     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.21.supplementiii_527     Document Type: Article

References (13)

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2. Patitsas, C., Meisler, D. M. Rockword, E. J. and McMahon, J. T. (1991) : Infectious crystalline keratopathy occurring in an eye subsequent to glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil. Ophthalmic Surg., 22, 7, 412-413.
3. Shirasaka, T., Shimamoto, Y., Ohshima, H., Yamaguchi, M., Kato, T., Yonekura, K. and Fukushima, M. (1996) : Development of a novel form of an oral 5-fluorouracil derivative directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anti-Cancer Drugs, 7, 548-557.
4. Tsuchiya, M., Hayasaka, S. and Mizuno, K. (1987) : Affinity of ocular acid-insoluble melanin for drugs in vitro. Invest. Ophthalmol. Vis. Sci., 28, 822-825.