The role of 5-HT1A receptors in the locomotor-suppressant effects of LSD: WAY-100635 studies of 8-OH-DPAT, DOI and LSD in rats

Behavioural Pharmacology

Volumn 7, Issue 6, 1996, Pages 551-559

  Krebs Thomson, K ^a   Geyer, M A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

8 OH DPAT; DOI; Hallucinogen; Locomotion; LSD; Rat; Serotonin; WAY 100635

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; LYSERGIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PSYCHEDELIC AGENT; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 2 AGONIST;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; DRUG SELECTIVITY; EXPLORATORY BEHAVIOR; LOCOMOTION; MALE; NONHUMAN; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030477053     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. 1A receptor agonists flesinoxan and 8-OH-DPAT in the rat. European Journal of Pharmacology, 200, 259-266.
2. 1A receptor agonists on patterns of rat motor activity in relation to effects on forebrain monoamine synthesis. Pharmacology and Toxicology, 72, 398-406.
3. 2 agonist DOI. European Journal of Pharmacology, 161, 45-51.
4. 1A receptors. British Journal of Pharmacology, 166, 793-799.
5. Berendsen HHG and Broekkamp CLE (1990) Behavioural evidence for functional interactions between 5-HT-receptor subtypes in rats and mice. British Journal of Pharmacology, 101, 667-673.
6. 1A receptor-mediated spontaneous tail-flicks in the rat. European Journal of Pharmacology, 191, 185-195.
7. Blanchard RJ, Shepherd JK, Armstrong J, Tsuda SF and Blanchard DC (1993) An ethopharmacological analysis of the behavioral effects of 8 OH-DPAT. Psychopharmacology, 112, 55-65.
8. 1A receptors. Journal of Medicinal Chemistry, 36, 1509-1510.
9. 1A receptor negatively linked to adenylate cyclase. European Journal of Pharmacology, 173, 189-192.
10. 1A receptor antagonist WAY100635. European Journal of Pharmacology, 264, 95-97.
11. 1A receptor antagonist WAY100135 and its enantiomers on 8-OH-DPAT-induced hyperglycemia in conscious rats. European Journal of Pharmacology, 254, 133-139.
12. 2 receptors? Pharmacology, Biochemistry and Behavior, 36, 901-906.
13. 2 receptors mediate discrete behaviors in the Mongolian gerbil. Pharmacology, Biochemistry and Behavior, 43, 131-137.
14. 1A receptor antagonists: utility as research tools and therapeutic agents. Trends in Pharmacological Sciences, 14, 41-48.
15. 1A receptors. European Journal of Pharmacology, 237, 283-291.
16. 1A receptor antagonist. Behavioural Brain Research, 73, 337-353.
17. 1A receptor function in the rat in vivo. European Journal of Pharmacology, 191, 391-400.
18. Geyer MA (1990) Approaches to the characterization of drug effects on locomotor activity in rodents. In: Modern Methods in Pharmacology: Testing and Evaluation of Drugs of Abuse (Eds. Adler MW and Cowan A), pp. 81-99. Wiley-Liss, New York.
19. Geyer MA and Krebs KM (1994) Serotonin receptor involvement in an animal model of the acute effects of hallucinogens. In: Hallucinogens: an Update (Ed Lin G), pp. 124-156. National Institute on Drug Abuse, Rockville, MD.
20. 2 involvement in the mechanism of action of hallucinogenic agents. Life Sciences, 35, 2505-2511.
21. 1A receptor agonists and antagonists: A comparison to adrenergic and dopaminergic neurons in rats. Journal of Pharmacology and Experimental Therapeutics, 273, 1032-1046.
22. Gozlan H, El Mestikawy S, Pichat L, Glowinski J and Hamon M (1983) Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT. Nature, 305, 140-142.
23. 1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. European Journal of Pharmacology, 211, 211-219.
24. Hillegaart V, Wadenberg ML and Ahlenius S (1989) Effects of 8-OH-DPAT on motor activity in the rat. Pharmacology, Biochemistry and Behavior, 32, 797-800.
25. 2A/C receptors in the expression of patterns of spontaneous motor activity in the rat. Society for Neuroscience Abstracts, 21, 1366.
26. 1A receptors: Behavioural and in vivo brain microdialysis studies. Life Sciences, 46, 955-963.
27. Hjorth S, Carlsson A, Lindberg P, Sanchez D, Wikström H, Arvidsson LE, Hacksell U and Nilsson JLG (1982) 8-Hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT-receptor stimulating activity. Journal of Neural Transmission, 55, 169-188.
28. Kalkman HO and Soar J (1990) Determination of the 5-HT receptor subtype involved in 8-OH-DPAT-induced hyperlocomotion: potential difficulties arising from inadequate pharmacological tools. European Journal of Pharmacology, 191, 383-390.
29. 1A receptor antagonist, to rat brain. Journal of Neurochemistry, 64, 2716-2726.
30. Krebs KM and Geyer MA (1994) Cross-tolerance studies of serotonin receptors involved in behavioral effects of LSD in rats. Psychopharmacology, 113, 429-437.
31. 2 agonist. Society for Neuroscience Abstracts, 21, 1694
32. Middlemiss DN and Tricklebank MD (1992) Centrally active 5-HT receptor agonists and antagonists. Neuroscience and Biobehavioral Reviews, 16, 75-82.
33. Mittman SM and Geyer MA (1991) Dissociation of multiple effects of acute LSD on exploratory behavior in rats by ritanserin and propranolol. Psychopharmacology, 105, 69-76.
34. 1A receptor antagonists on 8-OH-DPAT-induced hypothermia in rats and mice. European Journal of Pharmacology 193, 165-172.
35. 1A antagonists WAY100135 and SDZ 216-525 on 5-HT neuronal firing in the guinea-pig dorsal raphe nucleus. Neuropharmacology, 33, 61-66.
36. 2 receptors: low dose agonist-induced selective tolerance in the rat. Pharmacology, Biochemistry and Behavior, 39, 407-413.
37. 2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens. Psychopharmacology, 94, 213-216.
38. Tricklebank MD, Forler C and Fozard JR (1984) The involvement of subtypes of the 5HT1 receptor and of catecholaminergic systems in the behavioral response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat. European Journal of Pharmacology, 106, 271-272.
39. Wing LL, Tapson GS and Geyer MA (1990) 5-HT2 mediation of acute behavioral effects of hallucinogens in rats. Psychopharmacology, 100, 417-425.