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Permanent address:' Institute for Biomédical Research, Teijin Ltd., 4-3-2 Asahigaoka Hino, Tokyo 191, Japan.
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Permanent address:' Institute for Biomédical Research, Teijin Ltd., 4-3-2 Asahigaoka Hino, Tokyo 191, Japan.
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A polyisoxazole version of this approach is currently under investigation and will be reported in due course
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A polyisoxazole version of this approach is currently under investigation and will be reported in due course.
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note
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Note: a systematic numbering system is employed where the product number is derived from the compound numbers of its component precursors. Thus, referingto Scheme 1, combinatorial components 1, 2, 2, and 6 are employed to construct triisoxazoline 1226 (®1226 when polymer-bound) by the sequence 1 → ®1 + 2 → ®12 + 2 → ®122 + 6 → ®1226 -1226. Solution libraries (see Table 1) are lettered A-U; when polymer-bound, these same libraries are referred to as ®A→ ®U. Finally, oxidative elimination of selenium from ®12 gives olefin ®12a; likewise, oxidative elimination of selenium from library ®A gives library ®Aa. .The symbol ®denotes the resin (styrene/2% divinyl benzene copolymer).
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In a large library, it is quite probable that not all of the targets would be present see: (a)
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