Time Course of Changes in Brain Energy Metabolism of the Rat after Microsphere-Induced Cerebral Embolism

The Japanese Journal of Pharmacology

Volumn 55, Issue 2, 1991, Pages 197-209

  Takeo, Satoshi ^a   Miyake, Keiko ^a   Tanonaka, Kouichi ^a   Tanonaka, Reiko ^a   Taguchi, Taku ^a   Okano, Kikumi ^b   Inoue, Kiyoshi ^b   Ohga, Yuko ^b   Kishimoto, Yoriko ^b  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b FUKUYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; LACTIC ACID; MICROSPHERE; PYRUVIC ACID;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN MITOCHONDRION; CONTROLLED STUDY; ENERGY METABOLISM; MALE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ANIMAL; BRAIN; BRAIN CHEMISTRY; BRAIN ISCHEMIA; ENERGY METABOLISM; INTRACRANIAL EMBOLISM AND THROMBOSIS; MALE; MICROSPHERES; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; RATS; RATS, INBRED STRAINS;

EID: 0026026681     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.55.197     Document Type: Article

References (42)

1. Lowry, O.H., Passonneau, J.V., Hassellberger, F.X. and Schultz, D.W.: Effect of ischemia on known substrates and cofactors of the glycolytic pathway in brain. J. Biol. Chem. 239, 18-30 (1964)
2. Broniszewska-Ardelt, B. and Wroblewska, J.T.: The activity of phosphofructokinase, pyruvate kinase and lactate dehydrogenase in guinea pig and rat brains in normal and hypoxic conditions. Bull. Acad. Pol. Sci. Ser. Sci. Biol. 21, 505-512 (1975)
3. Folbergrova, J., Nordberg, K., Quistorff, B. and Siesjo, B.K.: Carbohydrate and amino acid metabolism in rat cerebral cortex in moderate and extreme hypercapnia. J. Neurochem. 9S, 457-462 (1975)
4. Norberg, K., Quistorff, B. and Siesjo, B.K.: Effect of hypoxia of 10-45 seconds duration on energy metabolism in the cerebral cortex of unanesthetized and anesthetized rats. Acta Physiol: Scand, 95, 301-310 (1975)
5. Borgstrom, L., Norberg, K. and Siesjo, B.K.: Glucose consumption in rat cerebral cortex in nor-moxia, hypoxia and hypercapnia. Acta Physiol. Scand. 96, 569-574 (1976)
6. Sikorska, M. and Broniszewska-Ardelt, B.: The activity of adenylate cyclase, hexokinase, phosphofructokinase, glucose-6-phosphate dehydrogenase and pyruvate kinase in rat brain after experimental carbon monoxide intoxication. Bull. Acad. Sci. Biol. Ser. Sci. Biol. 24, 429-435 (1976)
7. Villa, R.F.: Brain enzymes and ischemia. Eur. Neurol. 20, 245-252 (1981)
8. Villa, R.F., Marzatico, F. and Benzi, G.: Changes induced by ischemia on some cerebral enzymatic activities related to energy transduction and amino acid metabolism. Neurochem. Res. 8, 269-290 (1983)
9. Brooks, S.P.J., and Storey, K.B.: Anoxic brain function: molecular mechanisms of metabolic depression. FEBS Lett. 232, 214-216 (1988)
10. Welsh, F.A., Ginsberg, M.D., Rieder, W. and Budd, W.W.: Diffuse cerebral ischemia in the cat: II Regional metabolites during severe ischemia and recirculation. Ann. Neurol. 3, 493-501 (1978)
11. Kogure, K., Busto, R. and Scheinberg, P.: Energy metabolites and water content in rat brain during the early stage of development of cerebral infarction. Brain 97, 103-114 (1974)
12. Sugi, T., Schuier, F.J., Hossmann, K.-A. and Zulch, K.-J.: The effect of mild microembolia injury on the energy metabolism of the cat brain. J. Neurol. 223, 255-292 (1984)
13. Bralet, J., Beley, P., Bralet, A.-M. and Beley, A.: Comparison of the effects of hypertonic glycerol and urea on brain edema, energy metabolism and blood flow following cerebral microembolism in the rat. Deleterious effect of glycerol treatment. Stroke 14, 597-604 (1983)
14. Wilms, F.J., Garcia, J.H., Conger, K.A. and Chui-Wilmes, E.: Mechanisms of blood-brain barrier breakdown after microembolization of the cat's brain. J. Neuropathol. Exp. Neurol. 42, 421-438 (1983)
15. Wiersperger, N., Gygax, P. and Hofmann, A.: Calcium antagonists PY-108068: Demonstration of its efficacy in various types of experimental brain ischemia. Stroke 15, 679-685 (1984)
16. Hegedus, K., Fekete, I., Tury, F. and Molnar, L.: Experimental focal cerebral ischemia in rabbits. J. Neurol- 232, 223-230 (1985)
17. Kiyota, T., Hamajo, K., Miyamoto, M. and Nagaoka, A.: Effect of idebenone (CV-2619) on memory impairment observed in passive avoidance task in rats with cerebral embolism. Japan. J. Pharmacol. 37, 300-302 (1985)
18. Narumi, S., Kiyota, Y. and Nagaoka, A.: Cerebral embolization impairs memory function and reduces cholinergic marker enzyme activities in various brain regions in rats. Pharmacol. Biochem. Behav. 24, 1729-1731 (1986)
19. Furlow, T. and Bass, N.H.: Arachidonate-induced cerebrovascular occlusion in the rat. Neurology 26, 297-304(1976)
20. McGraw, C.P.: Experimental cerebral infarction. Effect of pentobarbital in Mongolian gerbils. Arch, Neurol. 34, 334-336 (1977)
21. Bucher, T.: Über ein Phosphatübertragendes Garumsferment. Biochem. Biophys. Acta 1, 292-314 (1947)
22. Lowry, O.H. and Passonneau, J.V.: A collection of metabolic assays. In A Flexible System of Enzymatic Analysis, Edited by Lowry, O.H. and Passonneau, J.V., p. 146-156, Academic Press, New York (1972)
23. Gutmann, I. and Wahlefeld, A.W.: L-(+)-Lac-tate. In Methods of Enzymatic Analysis, Edited by Bergmeyer, H.U., p. 1464-1468, Verlag Chemie and Academic Press, New York and London (1974)
24. Czok, R. and Lamprecht, W.: Pyruvate, phosphoenolpyruvate and D-glucerate-2-phosphate. In Methods of Enzymatic Analysis, 2nd English edition, Edited by Bergmeyer, H.U., p. 1446-1451, Verlag Chemie and Academic Press, New York and London (1974)
25. Sordahl, L.A., Johnson, C., Blailock, Z.R. and Schwartz, A.: The mitochondrion. In Methods in Pharmacology, Vol. 1, Edited by Schwartz, A., p. 247-286, Appleton-Century-Crafts, New York (1971)
26. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randal, R.J.: Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275 (1951)
27. Veech, R.L., Harris, R.L., Veloso, D. and Veech, E.H.: Freeze-blowing: a new technique for the study of brain in vivo. J. Neurochem. 20, 183-188 (1973)
28. Ponten, U., Rate he son, R.A., Salford, L.G. and Siesjo, B.K.: Optical freezing conditions for cerebral metabolites in rats. J. Neurochem. 21, 1127-1138 (1973)
29. Edoute, Y., Kotze, J.C.N., and Lochner, A.: Oxidative phosphorylation rate: index for evaluation of mitochondrial function in myocardial ischemia. J. Mol. Cell. Cardiol. 11, 831-833 (1979)
30. Rehncrona, S., Rosen, I. and Siesjo, B.K.: Brain lactic acidosis and ischemic cell damage: 1. Biochemistry and neurophysiology. J. Cell. Blood Flow Metabol. 1, 297-311 (1981)
31. Hillered, L., Smith, M.-J. and Siesjo, B.K.: Lactic acidosis and recovery of mitochondrial function following forebrain ischemia in the rat. J. Cerebr, Blood Flow Metabol. 5, 259-266 (1985)
32. Welsh, F.A., Sakamoto, T., McKee, A.E. and Sims, R.E.: Effect of lactacidosis on pyridine nucleotide stability during ischemia in mouse brain. J. Neurochem. 49, 846-851 (1987)
33. Ljunggren, B., Schutz, H. and Siesjo, B.K.: Changes in energy state and acid base parameters of the rat brain during complete compression ischemia. Brain Res. 73, 277-289 (1974)
34. Takeo, S., Miyake, K., Minematsu, R., Tanonaka, K. and Konishi, M.: In vitro effect of naftidrofuryl oxalate on cerebral mitochondria impaired by microsphere-induced embolism in rats. J. Pharmacol. Exp. Ther. 248, 1207-1214 (1989)
35. Chance, B., Cohen, P., Jobsis, F. and Schoener, B.: Intracellular oxidation-reduction states in vivo. Science 137, 499-508 (1962)
36. Welsh, F.A., Durity, F. and Langfitt, T.W.: The appearance of regional variations in metabolism at a critical level of diffuse cerebral oligemia. J. Neurochem. 28, 71-79 (1977)
37. Mela, L.: Mitochondrial function in cerebral ischemia and hypoxia: Comparison of inhibitory and adaptive responses. Neurol. Res. 1, 51-63 (1979)
38. Schultz, H., Silverstein, P.R. and Vapalahti, M.: Brain mitochondrial function after ischemia and hypoxia. Arch. Neurol. 29, 408-416 (1973)
39. Duffy, T.E., Nelson, S.R. and Lowry, O.H.: Cerebral carbohydrate metabolism during acute hypoxia and recovery. J. Neurochem. 19, 959-977 (1972)
40. Siesjo, B.K. and Zwetmow, N.N.: Effects of increased cerebrospiral fluid pressure upon adenine nucleotides and upon lactate and pyruvate in rat brain tissue. Acta Neurol. Scand. 46, 187-202 (1972)
41. MacMillan, V. and Siesjo, B.K.: Critical oxygen tensions in the brain. Acta Physiol. Scand. 82, 412-414 (1971)
42. Bralet, A.-M., Beley, A. and Bralet, J.: Brain edema and blood-brain barrier permeability following quantitative cerebral microembolism. Stroke 14, 34-38 (1983)