Developmental regulation of expression of GABA(A) receptor α1 and α6 subunits in cultured rat cerebellar granule cells

Neuropharmacology

Volumn 35, Issue 9-10, 1996, Pages 1337-1346

  Thompson, C L ^a   Pollard, S ^a   Stephenson, F A ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Benzodiazepine; Cerebellar granule cell; Development; GABA(A) receptor

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; DIAZEPAM; DIZOCILPINE; FLUNITRAZEPAM; GABAERGIC RECEPTOR AFFECTING AGENT; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; IONOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RADIOLIGAND; RECEPTOR SUBUNIT;

AFFINITY CHROMATOGRAPHY; AGE; ANIMAL CELL; ARTICLE; BRAIN DEVELOPMENT; CEREBELLUM; CONTROLLED STUDY; GRANULE CELL; IMMUNOBLOTTING; IMMUNOREACTIVITY; LIGAND BINDING; MOLECULAR WEIGHT; NERVE CELL CULTURE; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CEREBELLUM; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUTAMIC ACID; NERVE TISSUE PROTEINS; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, GABA-A; RECEPTORS, GLUTAMATE; TRANSCRIPTION, GENETIC;

EID: 0030471003     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00114-1     Document Type: Article

References (31)

1. A receptor mRNA expression in cultured cerebellar granule neurons. J. Neurosci. 13:1994;1784-1792.
2. A receptor mRNAs in cultured cerebellar granuleneurons is dependent on developmental signals. Neurosci. Abstr. 472. 7.
3. Biggs C.S., Pearce B.R., Fowler L.J., Whitton P.S. The effect of sodium valproate on extracellular GABA and other amino acids in the ventral hippocampus: an in vivo microdialysis study. Brain Res. 594:1992;138-142.
4. Burgoyne R.D., Cambray-Deakin M.A. The cellular neurobiology of neuronal development of the cerebellar granule cell. Brain Dev. Rev. 13:1988;77-101.
5. Chazot P., Coleman S.K., Cik M., Stephenson F.A. Molecular characterisation of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the co-existence of three subunit types within a discrete receptor molecule. J. Biol. Chem. 269:1994;24,403-24,409.
6. Connolly C.N., Krishek B.J., McDonald B.J., Smart T.G., Moss S.J. Assembly and cell surface expression of heteromeric and homomeric γ-aminobutyric acid type A receptors. J. Biol. Chem. 271:1996;89-96.
7. D'Angelo E., Rossi P., Taglietti V. Different proportions of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor currents at the mossy fibre-granule cell synapse of developing rat cerebellum. Neuroscience. 53:1993;121-130.
8. A receptor α subunit iso-oligomers: demonstration of receptor populations containing α1α2, α1α3, and α2α3 subunit pairs. J. Biol. Chem. 266:1991;24,778-24,784.
9. Dutton D.R. Isolation, culture, and use of viable central nervous system perikarya. Meths Neurosci. 2:1990;87-102.
10. A-receptor subunit expression. Dev. Brain Res. 88:1995;1-16.
11. Harris B.T., Charlton M.E., Costa E., Grayson D.R. Quantiative changes in α1 and α5 γ-aminobutyric acid type-A receptor subunit mRNAs and proteins after a single treatment of cerebellar granule neurons with N-methyl-D-aspartate. Molec. Pharmac. 45:1994;647-648.
12. Hatten M.E., Heintz N. Mechanisms of neuronal patterning and specification in the developing cerebellum. Ann. Rev. Neurosci. 18:1995;385-408.
13. A receptor subtypes in developing hippocampal neurons. Neuron. 7:1991;927-936.
14. 3H]Ro 15-4513 binding sites. Neuroscience. 53:1993;483-488.
15. A receptor mRNAs in the rat brain. III. Embryonic and postnatal development J. Neurosci. 12:1992;4151-4172.
16. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
17. A receptor selective for a behavioural alcohol antagonist. Nature. 346:1990;648-651.
18. A receptor channels. Ann. Rev. Neurosci. 17:1994;569-602.
19. A receptor α-subunits in rat brain during development. Fedn Eur. Biochem. Soc. Letts. 286:1991;44-46.
20. A receptor structure and physiological properties in cultured cerebellar granule neurons. Neuron. 13:1994;149-158.
21. A receptor complex in an inhibitory synaptic circuit in the rat cerebellum. Dev. Brain Res. 55:1990;73-86.
22. A receptor subunit expression by activation of N-methyl-D-aspartate-selective glutamate receptors. Molec. Pharmac. 39:1991;599-603.
23. A receptor subpopulations. J. Biol. Chem. 268:1993;3753-3757.
24. A receptors of adult rat cerebellum demonstrates two alpha subunits per receptor oligomer. J. Biol. Chem. 270:1995;21,285-21,290.
25. Santi M.R., Ikonomovic S., Wroblewski J.T., Grayson D.R. Temporal and depolarisation-induced changes in the absolute amounts of mRNAs encoding metabotropic glutamate receptors in cerebellar granule neurons in vitro. J. Neurochem. 63:1994;1207-1217.
26. A receptors. Biochem. J. 310:1995;1-9.
27. A receptor α5 and α6 subunit-like immunoreactivity in rat brain. Neurosci. Lett. 144:1992;53-56.
28. A receptor α1 and α6 subunit expression by a cAMP-mediated signalling mechanism in cerebellar granule cells in primary culture. J. Neurochem. 67:1996;434-438.
29. A receptor subtypes expressed in cerebellar granule cells: A developmental study. J. Neurochem. 62:1994;2037-2044.
30. Turner J.D., Bodewitz G., Thompson C.L. and Stephenson F.A. (1993) Immunohistochemical mapping of gamma-aminobutyric acid type-A receptor alpha subunits in rat central nervous system. In: Anxiolytic β-carbolines: From Molecular Biology to the Clinic (Stephens D.N., Ed.), Psychopharmacology Series, Vol. 11, pp. 29-49. Springer, Berlin.
31. A receptor α6 subunit mRNA occurs only after cerebellar granule cell migration. Dev. Brain Res. 75:1993;91-104.