Rearrangement and expression of Vγ1, Vγ2 and Vγ3 TCR γ genes in C57BL/6 mice

International Immunology

Volumn 8, Issue 1, 1996, Pages 83-90

  Pereira, Pablo ^a   Gerber, David ^c   Regnault, Armelle ^b   Huang, Shu Ying ^c   Hermitte, Véronique ^a   Coutinho, Antonio ^a   Tonegawa, Susumu ^c  

^a INSTITUT PASTEUR   (France)

^b INSERM   (France)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Gene rearrangement; Intraepithelial lymphocytes; J region; TCR gene; T cells

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; COMPLEMENTARY DNA; MESSENGER RNA; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; C57BL MOUSE; CHEMISTRY; COMPARATIVE STUDY; GENE EXPRESSION; GENE REARRANGEMENT; GENETICS; IMMUNOLOGY; MALE; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; T LYMPHOCYTE; ANIMAL CELL; CELL POPULATION; CELL SELECTION; CELL SURFACE; CONTROLLED STUDY; DNA SEQUENCE; GENE SEQUENCE; GENETIC TRANSCRIPTION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; GENE EXPRESSION; GENE REARRANGEMENT, GAMMA-CHAIN T-CELL ANTIGEN RECEPTOR; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SEQUENCE ANALYSIS; T-LYMPHOCYTES;

EID: 0029666481     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.1.83     Document Type: Article

References (32)

1. Raulet, D. H. 1989 The structure, function, and molecular genetics of the γδ T cell receptor Annu. Rev. Immunol 7:175.
2. Iwamoto, A, Rupp, F, Ohashi, P S., Walker, C. L, Pircher, H , Jono, R , Hengartner, H. and Mak, T. W 1986 T-cell-specrfic γ genes in C57BL/10 mice, sequence and expression of new constant and variable region genes J Exp Med. 163:203.
3. Owen, F L , Taylor, B A., Zweidler. A and Seidman, J G 1986. The murine γ-chain of the T cell receptor is closely linked to a spermatocyte specific histone gene and the beige coat color locus on chromosome 13 J Immunol 137:1044
4. Mayday, A C , Saito, H , Gillies, S. D , Kranz, D M , Tanigawa, G , Eisen, H N. and Tonegawa, S. 1985. Structure, organization, and somatic rearrangement of T cell receptor γ genes Cell. 40:259.
5. Traunecker, A, Oliven, F., Allen, N. and Karjalainen, K. 1986. Normal T cell development is possible without 'functional' γ chain genes. EMBO J 5 1589.
6. Haas, W., Pereira, P. and Tonegawa, S. 1993. Gamma/delta cells. Annu. Rev. Immunol. 11:637
7. Happ, M. P., Kubo, R. T., Palmer, E., Born, W. K. and O'Brien, R. L 1989. Limited receptor repertoire in a mycobacterta-reactive subset of γδ cells. Nature 342 696.
8. O'Brien, R. L , Fu, Y X., Cranfill, R , Dallas, A., Ellis, C., Reardon, C., Lang, J., Cardig, S. R., Kubo R. and Born, W. 1992 Heat shock protein Hsp60-reactive γδ cells: a large diversified T lymphocyte subset with highly focused specificity. Proc. Natl Acad. Sci. USA 89:4348.
9. δ6 T cells in the skin. Eur. J. Immunol. 22:595.
10. Whetsell, M , Mosley, R L., Whetsell, L., Schaefer, F. V., Miller, K. S., and Klein, J R. 1991. Rearrangement and junctional-site sequence analyses of T-cell receptor γ genes in intestinal intraepttheliai lymphocytes from murine athymic chimeras. Mol Cell. Biol. 11:5902.
11. Mosley, R. L., Whetsell, M., Stickney, D., Whetsell, L., Schaefer, F. V., Miller, K. S. and Klein. J. R. 1994 Phenotype and TCR γδ variable gene repertoire of intestinal intraepithelial lymphocytes in wild mice (Musmusculus domesticus): abundance of Vγ1 transcripts and extensive δ gene diversity, Int Immunol. 6:231.
12. Ishikawa, H , Li, Y, Yamarnoto, S., Kaufmann, S. H. E. and Tonegawa, S. 1993. Cytotoxic and Interferon γ producing activities of γδ cells in the mouse intestinal epithelium is strain dependent. Proc. Natl Acad. Sci. USA 90:8204.
13. Kubo, R., Born, W., Kappler, J. W., Marrack, P and Pigeon, M. 1989 Characterization of a monoclonal antibody which detects all murine alpha, beta T cell receptors J Immunol. 142:2736.
14. Itohara, S., Nakanishi, N , Kanagawa, O., Kubo, R. and Tonegawa, S. 1989 Monoclonal antibodies specific to native murine T-cell receptor γδ. analysis of γδ cells during thymic ontogeny and in the peripheral lymphoid organs. Proc. Natl Acad. Sci. USA 86:5094.
15. Chirwing, J. M., Przybyla, A. E., MacDonald, R J and Rutter, W J. 1979 Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294.
16. Pannetier, C., Cochet, M., Darche, S, Casrouge, A., Zöller, M. and Kourilsky, P 1993. The sizes of the CDR3 hypervariable regions of the murine T-ceil receptor β chains vary as a function of the recombined germ-line segments Proc Natl Acad Sci USA 90 4319
17. Asarnow, D M, Goodman, T., Lefrançois, L and Allison, J P. 1989 Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells Nature 341:60
18. Kyes, S , Carew, E , Cardig, S R., Janeway, C A and Hayday, A. 1989. Diversity in T-cell receptor γ gene usage in intestinal epithelium. Proc. Natl Acad. Sci USA 86:5527
19. Takagaki, Y, Decloux, A., Bonneville, M. and Tonegawa, S 1989. Diversity of γδ T cell receptors on murine intestinal intraepithelial lymphocytes. Nature 339:712.
20. Goodman, T. and Lefrançois, L. 1989. Inraepithelial lymphocytes: anatomical site, not T cell receptor from dictates phenotype and function. J. Exp. Med 170:1569.
21. Regnault, A, Cumano, A., Vassali, P. Guy-Grand D and Kourilsky, P. 1994. Oligoclonal repertoire of the CD8αα and the CD8αβ TCRαβ murine intestinal intraepithelial lymphocytes: evidence for the random emergence of T cells J. Exp. Meet 180:1345
22. Balk, S P, Ebert, E. C., Blumenthal. R. L, McDermott, F V, Wurcherpfenning, K. W., Landau, S. B and Blumberg, RS 1991 Oligocional expansion and CD1 recognition by human intestmal intraepithetial lymphocytes. Science 253:1411
23. VanKerckhove, C, Russel, G. J., Deutsch, K, Reich, K , Bhan, A. K., DerSimonian, H. and Brenner, M B 1992 Oligocionality of human intestinal intraepithelial T cells J. Exp Med 175:57.
24. Blumberg, R S., Yockey, C. E., Gross, G. G., Ebert, E. C. and Balk, S. P 1993. Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple Vβ T cell receptor genes. J. Immunol 150:5144
25. Gross, G G., Schwartz, V. L, Stevens, C, Ebert, E C. Blumberg, R. S. and Balk, S. P 1994. Distribution of dominant αβ T cell clones in human intestinal mucosa. J. Exp. Med. 180 1337
26. Chowers, Y., Holtmeier, W., Harwood, J., Morzycka-Wroblewska, E. and Kagnoff, M F. 1994. The Vδ1 T cell receptor repertoire in human small intestine and colon J Exp Med 180:183
27. Houlden, B A., Cron, R Q , Coligan, J E. and Bluestone. J A 1988. Systematic development of distinct T cell receptor-γδ T cell subsets during fetal ontogeny. J. Immunol. 141:3753
28. γ4 T cell receptors and lack of isotype exclusion by dendritic epidermal T cell lines. J Immunol 141:2057
29. Ezquerra, A., Wilde, D. B, McConnell, T. J., Sturmhofel K., Valas, R. B., Shevach, E. M. and Coligan, J E. 1992 Mouse autoreactive γδ T cells. II. Molecular characterization of the T cell receptor. Eur J Immunol 22:491.
30. Matis, L A , Ffy, A. M., Cron, R Q , Cotterman, M. M , Dick, R F and Bluestone, J A 1989 Structure and specificity of a class II MHC alloreactive γδ Tcell receptor heterodimer Science 245:746
31. Rellahan, B. L., Bluestone, J A , Houlden, B A , Cotterman, M M. and Matis, L. A. 1991 Junctional sequences influence the specificity of γδ T cell receptors J Exp. Med. 173:503
32. γ1-expressing γδ lymphocytes in normal mice J Exp Med. in press