A hydrophilic Ω-loop (Tyr181 to Tyr188) in the nonsubstrate binding area of HIV-1 reverse transcriptase

Drug Design and Discovery

Volumn 14, Issue 3, 1996, Pages 225-239

  Mager, Peter P ^a   Walther, Horst ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

loop; Allosteric receptor sites; HIV 1 reverse transcriptase; Hydrophilicity of peptide segments; Molecular modelling; Mutations; Nonsubstrate (nonnucleoside) reverse transcriptase inhibitors (NNRTIs)

Indexed keywords

RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ARTICLE; BINDING SITE; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; HYDROPHILICITY; MOLECULAR MODEL; NONHUMAN; SITE DIRECTED MUTAGENESIS;

BINDING SITES; CHEMISTRY, PHYSICAL; HIV-1 REVERSE TRANSCRIPTASE; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; PROTEIN FOLDING; TYROSINE;

EID: 0030466559     PISSN: 10559612     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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