Molecular simulation of 5,6-substituted 1-[(2-hydroxyethoxy)methyl]uracils with anti-HIV-1 activity

European Journal of Medicinal Chemistry

Volumn 31, Issue 9, 1996, Pages 701-712

  Mager, P P ^a   De Clercq, E ^b   Takashima, H ^c   Ubasawa, M ^c   Sekiya, K ^c   Baba, M ^d   Walther, H ^a  

^a Rudolf Boehm Institute of Pharmacology and Toxicology   (Germany)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c MITSUBISHI CHEMICAL CORPORATION   (Japan)

^d KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

1 (2 hydroxyethoxy)methyl 6 (phenylthio)thymine; Anti HIV 1 activity; Cluster analysis; Molecular modelling; Non least squares (NLS) regression; Non nucleoside HIV 1 reverse transcriptase inhibitor; QSAR

Indexed keywords

3 [2 (2 BENZOXAZOLYL)ETHYL] 5 ETHYL 6 METHYL 2(1H) PYRIDONE; 9 CHLORO 4,5,6,7 TETRAHYDRO 5 METHYL 6 (3 METHYL 2 BUTENYL)IMIDAZO[4,5,1 JK][1,4]BENZODIAZEPINE 2(1H) THIONE; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; URACIL DERIVATIVE; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LIPOPHILICITY; MOLECULAR MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 0029786954     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/0223-5234(96)85879-X     Document Type: Article

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