Macrophage mediated processing of an exogenous antigenic fluorescent probe: Time-dependent elucidation of the processing pathway

Biology of the Cell

Volumn 87, Issue 1-2, 1996, Pages 95-104

  Weaver Jr , Donald J ^a   Cherukuri, Anu ^a   Carrero, Jenny ^a   Coelho Sampaio, Tatiana ^b   Durack, Gary ^a   Voss Jr , Edward W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Antigen processing; FITC BSA; Haptens; Protease

Indexed keywords

FLUORESCENT DYE;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; ENDOCYTOSIS; FLOW CYTOMETRY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0030464127     PISSN: 02484900     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0248-4900(97)89841-3     Document Type: Article

References (38)

1. 1 Allen PM, Unanue ER (1984) Differential requirements for antigen processing by macrophages for lysozyme specific T cell hybridomas. J Immunol 132, 1077-1079
2. 2 Bakke O, Dobberstein B (1990) MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell 63, 707-716
3. 3 Benjamin DC, Berzofsky JA, East IJ, Gurd FRN, Hannum C, Leach SJ, Margoliash E, Michael JG, Miller A, Prager EM, Secarz EE, Smith-Gill SJ, Todd PE, Wilson AC (1984) The antigenic structure of proteins: A reappraisal. Annu Rev Immunol 2, 67-101
4. 4 Blum JS, Fiani ML, Stahl PD (1991) Proteolytic cleavage of ricin A chain in endosomal vesicles. Evidence for the action of endosomal proteases at both neutral and acidic pH. J Biol Chem 266, 22091-22095
5. 5 Bond JS, Butler EP (1987) Intracellular proteases. Annu Rev Biochem 56, 333-364
6. 6 Bowser R, Murphy RF (1990) Kinetics of hydrolysis of endocytosed substrates by mammalian cultured cells: early introduction of lysosomal enzymes into the endocytic pathway. J Cell Physiol 143, 110-117
7. 7 Brodsky FM, Guagliardi LE (1991) The cell biology of antigen processing and presentation. Annu Rev Immunol 9, 707-744
8. 8 Buus S, Sette A, Colon SM, Jenis DM, Grey HM (1986) Isolation and characterization of antigen-Ia complexes involved in T cell recognition. Cell 47, 1071-1077
9. 9 Buus S, Werdelin O (1986) A group-specific inhibitor of lysosomal cysteine proteinases selectively inhibits both proteolytic degradation and presentation of the antigen dinitrophenyl-poly-L-lysine by guinea pig accessory cells to T cells. J Immunol 136, 452-458
10. 10 Collins DS, Unanue ER, Harding CV (1991) Reduction of disulfide bonds within lysosomes is a key step in antigen processing. J Immunol 147, 4054-4059
11. 11 Diment S, Stahl P (1985) Macrophage endosomes contain proteases which degrade endocytosed protein ligands. J Biol Chem 260, 15311-15317
12. 12 Diment S, Leech MS, Stahl PD (1988) Cathepsin D is membrane-associated in macrophage endosomes. J Biol Chem 263, 6901-6907
13. 13 Diment S (1990) Different roles for thiol and aspartyl proteases in antigen presentation of ovalbumin. J Immunol 145, 417-422
14. 14 Diment S (1993) Proteolytic processing for MHC class II antigen presentation. Cienciae Cultura 45, 305-312
15. 15 Fox MH, Delohery TM (1987) Membrane fluidity measured by fluorescence polarization using an EPICS V cell sorter. Cytometry 8, 20-25
16. 16 Goetzl EJ, Banda MJ, Leppert D (1996) Matrix metalloproteinases in immunity. J Immunol 156, 1-4
17. 17 Gottschalk S, Waheed A, Schmidt B, Laidler P, von Figura K (1989) Sequential processing of lysosomal acid phosphatase by a cytoplasmic thiol proteinase and a lysosomal aspartyl proteinase. EMBO J 8, 3215-3219
18. 18 Gradehandt G, Ruede E (1991) The endo/lysosomal protease cathepsin B is able to process conalbumin fragments for presentation to T cells. Immunology 74, 393-398
19. 19 Green JM, DeMars R, Xu X, Pierce SK (1995) The intracellular transport of MHC class II molecules in the absence of HLA-DM. J Immunol 155, 3759-3768
20. 20 Jensen PE (1990) Regulation of antigen presentation by acidic pH. J Exp Med 171, 1779-1784
21. 21 Jensen PE (1992) Acidification and reduction can be sufficient to allow proteins to bind class II MHC. J Immunol 150, 3347-3356
22. 22 Jensen PE, Sherman MA, Runnels HA, Tompkins SM (1994) Regulation of antigen/class II MHC complex formation. In: Antigen Processing and Presentation (Humphreys RE, Pierce SK, eds) Academic Press Inc, San Diego, 67-79
23. 23 Mego JL (1984) Role of thiols, pH, and cathepsin D in the lysosomal catabolism of serum albumin. Biochem J 218, 775-783
24. 24 McCoy K, Gal S, Schwartz RH, Gottesman MM (1988) An acidic protease secreted by transformed cells interferes with antigen processing. J Cell Biol 106, 1879-1884
25. 25 Neefjes JJ, Stollorz V, Peters PJ, Geuze HJ, Ploegh HL (1990) The biosynthetic pathway of MHC class II but not class I molecules intersect the endocytic route. Cell 61, 171-183
26. 26 Puri J, Factorovich Y (1988) Selective inhibition of antigen presentation to cloned T cells by protease inhibitors. J Immunol 141, 3313-3317
27. 27 Qiu Y, Xu X, Wandiger-Ness A, Dalke DP, Pierce SK (1994) Separation of subcellular compartments containing distinct functional forms of MHC class II. J Cell Biol 125, 595-605
28. 28 Rodriguez GM, Diment S (1992) Role of cathepsin D in antigen presentation of ovalbumin. J Immunol 149, 2894-2898
29. 29 Sette A, Adorni L, Colon SM, Buus S, Grey HM (1989) Capacity of intact proteins to bind to MHC class II molecules. J Immunol 143, 1265-1267
30. 30 Streicher HZ, Berkower IJ, Busch M, Gurd FRN, Berzofsky JA (1984) Antigen conformation determines processing requirements for T-cell activation. Proc Natl Acad Sci USA 81, 6831-6839
31. 31 Takahashi H, Cease KB, Berzofsky JA (1989) Identification of proteases that process distinct epitopes on the same protein. J Immunol 142, 2221-2229
32. 32 Van Buskirk A, Crump BL, Margoliash E, Pierce SK (1989) A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family. J Exp Med 170, 1799-1809
33. 33 van Noort JM, van der Drift ACM (1989) The selectivity of cathepsin D suggests an involvement of the enzyme in the generation of T-cell epitopes. J Biol Chem 264, 14159-14164
34. 34 van Noort JM, Boon J, van der Drift ACM, Wagenaar JPA, Boots AMH, Boog CJP (1991) Antigen processing by endosomal proteases determines which sites of sperm-whale myoglobin are eventually recognized by T cells. Eur J Immunol 21, 1989-1996
35. 35 van Noort JM, Jacobs MJM (1994) Cathepsin D, but not cathepsin B, releases T cell stimulatory fragments from lysozyme that are functional in the context of multiple murine class II MHC molecules. Eur J Immunol 24, 2175-2180
36. 36 Voss EW Jr, Workman CJ, Mummert ME (1996) Detection of protease activity using a fluorescence-enhancement globular substrate. BioTechniques 20, 286-291
37. 37 Xu X, Song W, Cho H, Qiu Y, Pierce SK (1995) Intracellular transport of invariant chain-MHC class II complexes to the peptide loading compartment. J Immunol 155, 2984-2992
38. 38 Ziegler HK, Unanue ER (1982) Decrease in macrophage catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells. Proc Natl Acad Sci USA 79, 175-178