Cysteine Conjugate β-Lyase-dependent Biotransformation of the Cysteine S-Conjugates of the Sevoflurane Degradation Product Compound A in Human, Nonhuman Primate, and Rat Kidney Cytosol and Mitochondria

Anesthesiology

Volumn 85, Issue 6, 1996, Pages 1454-1461

  Iyer, Ramaswamy A ^b   Anders, M W ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

^b NONE

Author keywords

Anesthetics, volatile: lyase, compound A, cysteine S conjugates, sevoflurane; Nephrotoxicity

Indexed keywords

2,2 DIFLUORO 1 (TRIFLUOROMETHYL)VINYL FLUOROMETHYL ETHER; 4 METHYLTHIO 2 OXOBUTYRIC ACID; AMINOOXYACETIC ACID; CYSTEINE CONJUGATE; CYSTEINE CONJUGATE BETA LYASE; CYSTEINE DERIVATIVE; SEVOFLURANE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOL; DRUG DEGRADATION; DRUG TRANSFORMATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; INHALATION ANESTHESIA; MALE; MITOCHONDRION; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANESTHETICS, INHALATION; ANIMALS; BIOTRANSFORMATION; CALLITHRIX; CARBON-SULFUR LYASES; ETHERS; HUMANS; HYDROCARBONS, FLUORINATED; KIDNEY; LYASES; MACACA FASCICULARIS; MACACA MULATTA; MALE; MITOCHONDRIA; RATS; RATS, INBRED F344; SPECIES SPECIFICITY;

EID: 0030457616     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199612000-00028     Document Type: Article

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