Reproductive and developmental toxicity study of a new antineoplastic agent, S-1 (II) - Teratological study in rats by oral administration

Journal of Toxicological Sciences

Volumn 21, Issue SUPPL. 3, 1996, Pages 603-618

  Yukiyama, Shiro ^a   Shinomiya, Mitsuhiro ^a   Ikebuchi, Kazuya ^a   Sato, Toshikazu ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Antineoplastic agent; Rats; S 1; Teratological study

Indexed keywords

5 CHLORO 2,4 DIHYDROXYPYRIDINE; 5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; ANTINEOPLASTIC AGENT; OXONIC ACID; PYRIDINE DERIVATIVE; TEGAFUR;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; FEMALE; FETUS; FETUS DEVELOPMENT; FOOD INTAKE; HYDROCEPHALUS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PROGENY; RAT; REPRODUCTIVE TOXICITY; SKELETON MALFORMATION; STILLBIRTH; TERATOGENESIS; WEIGHT REDUCTION;

ANIMALIA;

EID: 0030454270     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.21.supplementiii_603     Document Type: Article

References (9)

1. Inouye, M. (1976) : Differential staining of cartilage and bone in fetal mouse skeleton by Aldan Blue and Alizarin Red S. Cong. Anom., 16, 171-173.
2. Shirasaka, T., Shimamoto, Y., Ohshima, H., Yamaguchi, M., Kato, K., Yonekura, K. and Fukushima, M. (1996) : Development of a novel form of an oral 5-fluorouracil derivative directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anti-cancer Drugs, 7, 548-557.
3. Wilson, J. G. (1965) : Teratology, Principles and Techniques, pp. 262-277, Univ. of Chicago, Illinois.