Mouse liver microsomal metabolism of chloral hydrate, trichloroacetic acid, and trichloroethanol leading to induction of lipid peroxidation via a free radical mechanism

Drug Metabolism and Disposition

Volumn 24, Issue 1, 1996, Pages 81-90

  Ni, Yi Chang ^a   Wong, Tit Yee ^a   Lloyd, Roger V ^b   Heinze, Thomas M ^a   Shelton, Sharon ^a   Casciano, Daniel ^a   Kadlubar, Fred F ^a   Fu, Peter P ^a,c  

^a UNIVERSITY OF MEMPHIS   (United States)

^b University of Memphis   (United States)

^c NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,4 DICHLORO 6 PHENYLPHENOXY)ETHYLAMINE; ACETALDEHYDE; ALLOPURINOL; CHLORAL HYDRATE; CYTOCHROME P450; DRUG METABOLITE; FORMALDEHYDE; FREE RADICAL; HORSERADISH PEROXIDASE; LIPID PEROXIDE; MALONALDEHYDE; PROPIONALDEHYDE; PROSTAGLANDIN SYNTHASE; PYRAZOLE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRICHLOROACETIC ACID; TRICHLOROETHANOL; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG CYTOTOXICITY; DRUG METABOLISM; ENZYME INDUCTION; GENE LOCUS; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LIPID PEROXIDATION; LIVER CELL CARCINOMA; LIVER MICROSOME; LYMPHOBLASTOID CELL; MALE; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL;

ALLOPURINOL; ANIMALS; CATALYSIS; CELL LINE; CHLORAL HYDRATE; ETHYLENE CHLOROHYDRIN; FREE RADICALS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HORSERADISH PEROXIDASE; HUMANS; LIPID PEROXIDATION; MALE; MICE; MICROSOMES, LIVER; NAD; NADP; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; TRICHLOROACETIC ACID; XANTHINE OXIDASE;

ANIMALIA; ARMORACIA RUSTICANA;

EID: 0030067740     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

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