Drug targets in the embryo. Studies on the cocaine- and antidepressant-sensitive serotonin transporter

Annals of the New York Academy of Sciences

Volumn 801, Issue , 1996, Pages 239-255

  Schroeter, Sally ^a   Blakely, Randy D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CITALOPRAM; COCAINE; COMPLEMENTARY DNA; FLUOXETINE; IMIPRAMINE; MESSENGER RNA; NEUROTRANSMITTER; PAROXETINE; SEROTONIN; SERTRALINE; TRYPTOPHAN HYDROXYLASE;

AMINE TRANSPORT; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; DRUG ABUSE; DRUG TARGETING; EMBRYO DEVELOPMENT; HUMAN; IN SITU HYBRIDIZATION; MOLECULAR CLONING; MORPHOGENESIS; NERVE CELL DIFFERENTIATION; NONHUMAN; PRESYNAPTIC NERVE; RAPHE NUCLEUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNAPSE;

EID: 0030450424     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb17446.x     Document Type: Conference Paper

References (83)

1. WESSELLS, N. K. 1977. Tissue Interactions and Development. W. A. Benjamin, Inc. Menlo Park, CA.
2. LAUDER, J. M. 1988. Neurotransmitters as morphogens. Prog. Brain Res. 73: 365-387.
3. COOKE, J. 1995. Morphogens in vertebrate development: how do they work? BioEssays 17(2): 93-96.
4. WOLPERT, L. 1969. Positional information and the spatial pattern of cellular formation. J. Theor. Biol. 25: 1-47.
5. DRIEVER, W., V. SIEGEL & C. NÜSSLEIN-VOLHARD. 1990. Autonomous determination of anterior structures in the early Drosophila embryo by the bicoid morphogen. Development 109: 811-820.
6. THALLER, C. & G. EICHELE. 1987. Identification and spatial distribution of retinoids in the developing chick limb bud. Nature 327: 625-628.
7. GREEN, J. B. A., H. NEW & J. C. SMITH. 1992. Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 71: 731-739.
8. CHRISTIAN, J. L. & R. T. MOON. 1993. Building a frog: the role of Xenopus Wnts in patterning the embryonic mesoderm. In Molecular Basis of Morphogenesis. M. Bernfield, Ed. 35-48. Wiley-Liss, Inc. New York.
9. COOPER, J. R., F. E. BLOOM & R. H. ROTH. 1991. The Biochemical Basis of Neuropharmacology. 6th edit. Oxford University Press, New York.
10. AMARA, S. G. & M. J. KUHAR. 1993. Neurotransmitter transporters: recent progress. Ann. Rev. Neurosci. 16: 73-93.
11. CLARK, J. & G. RUDNICK. 1993. From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters. Biochim. Biophys. Acta 1144: 249-263.
12. IVERSEN, L. L. 1975. Uptake processes for biogenic amines. In Handbook of Psychopharmacology. L. L. Iversen, S. D. Iversen & S. H. Snyder, Eds. 381-442. Plenum Press. New York.
13. DARVAS, Z., R. SWYDAN & G. CSABA. 1985. Influence of benzodiazepine (diazepam) by single and repeated treatment on the growth of Tetrahymena. Biomed. Biochim. Acta 44(11/12): S1725-1728.
14. CASTRODAD, F. A., F. L. RENAUD, J. ORTIZ & D. M. PHILIPS. 1988. Biogenic amines stimulate regeneration of cilia in Tetrahymena thermophila. J. Protozool. 35(2): 260-264.
15. PIENKOWSKI, M. M. 1980. Modulation of cell proliferation in cultured postimplantation embryos by cyclic AMP. Biol. Reprod. 22(3): 582-586.
16. BUZNIKOV, G. A. 1984. The action of neurotransmitters and related substances on early embryogenesis. Pharmacol. Ther. 25: 23-59.
17. WALLACE, J. A. 1982. Monoamines in the early chick embryo: demonstration of serotonin synthesis and the regional distribution of serotonin-concentrating cells during morphogenesis. Am. J. Anat. 165: 261-276.
18. STRUDEL, G., M. RECASENS & P. MANDEL. 1977. Identification de catécholamines et de sérotonine dans les chordes d'embryons de poulet. C.R. Acad. Sc. Paris - Serie D. 284: 967-969.
19. GODIN, I. 1986. Explanted and implanted notochord of amphibian anuran embryos. Histofluorescence study on the ability to synthesize catecholamines. Anat. Embryol. 173: 393-399.
20. IC-receptor expression on cell proliferation control in hamster fibroblasts: serotonin fails to induce a transformed phenotype. Exp. Cell Res. 200(2): 523-527.
21. LAUDER, J. M., J. A. WALLACE & H. KREBS. 1981. Roles for serotonin in neuroembryogenesis. Adv. Exp. Med. Biol. 133: 477-506.
22. SCHMIDT, M. J. & E. SANDERS-BUSH. 1971. Tryptophan hydroxylase activity in developing rat brain. J. Neurochem. 18: 2549-2551.
23. WAPNIR, R. A., R. L. HAWKINS & J. H. STEVENSON. 1971. Ontogenesis of phenylalanine and tryptophan hydroxylation in rat brain and liver. Biol. Neonat. 18: 85-93.
24. ZHOU, Q-Y., C. J. QUALFE & R. D. PALMITER. 1995. Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 374(6523): 640-643.
25. BRUNNER, H. G., M. NELEN, X. O. BREAKEFIELD, H. H. ROPERS & B. A. VANOOST. 1993. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262: 578-580.
26. COLLINS, F. A., D. L. MURPHY, A. L. REISS, K. B. SIMS, J. G. LEWIS, L. FREUND, F. KAROUM, D. ZHU, I. H. MAUMENEE & S. E. ANTONARAKIS. 1992. Clinical, biochemical, and neuropsychiatric evaluation of a patient with a contiguous gene syndrome due to a microdeletion Xp11.3 including the Norrie disease locus and monoamine oxidase (MAOA and MAOB) genes. Am. J. Med. Genet. 42(1): 127-134.
27. BALKOVETZ, D. F., C. TIRUPPATHI, F. H. LEIBACH, V. B. MAHESH & V. GANAPATHY. 1989. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J. Biol. Chem. 264: 2195-2198.
28. GANAPATHY, V. & F. H. LEIBACH. 1995. Placental biogenic amines and their transporters. In Placental Toxicology. B. V. Rama Sastry, Ed. 161-174. CRC Press, Inc. Boca Raton.
29. RAMAMOORTHY, S., A. L. BAUMAN, K. R. MOORE, H. HAN, T. YANG-FENG, A. S. CHANG, V. GANAPATHY & R. D. BLAKELY. 1993. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc. Natl. Acad. Sci. USA 90: 2542-2546.
30. YAVARONE, M. S., D. L. SHUEY, T. W. SADLER & J. M. LAUDER. 1993. Serotonin uptake in the ectoplacental cone and placenta of the mouse. Placenta 14: 149-161.
31. BLAKELY, R. D., H. E. BERSON, J. R. T. FREMEAU, M. G. CARON, M. M. PEEK, H. K. PRINCE & C. C. BRADLEY. 1991. Molecular cloning and functional expression of a rat brain serotonin transporter. Nature 354: 66-70.
32. PRASAD, P. D., F. H. LEIBACH, V. B. MAHESH & V. GANAPATHY. 1994. Human placenta as a target organ for cocaine action: interaction of cocaine with the placental serotonin transporter. Placenta 15: 267-278.
33. BOESS, F. G. & I. L. MARTIN. 1994. Molecular biology of 5-HT receptors. Neuropharmacology 33: 275-317.
34. LESLIE, M. J., C. A. BENNETT-CLARKE & R. W. RHOADES. 1992. Serotonin 1B receptors form a transient vibrissa-related pattern in the primary somatosensory cortex of the developing rat. Dev. Brain Res. 69: 143-148.
35. BENNETT-CLARKE, C. A., M. J. LESLIE, N. L. CHIAIA & R. W. RHOADES. 1993. Serotonin 1B receptors in the developing somatosensory and visual cortices are located on thalamocortical axons. Proc. Natl. Acad. Sci. USA 90: 153-157.
36. HELLENDALL, R. P., U. B. SCHAMBRA, J. P. LIU & J. M. LAUDER. 1993. Prenatal expression of 5-HT1C and 5-HT2 receptors in the rat central nervous system. Exp. Neurol. 120: 186-201.
37. LAUDER, J. M. & H. KREBS. 1978. Serotonin as a differentiation signal in early neurogenesis. Dev. Neurosci. 1: 15-30.
38. LEE, S-L., S. W. WAN, B. J. MOORE & B. L. FANBURG. 1991. Dual effect of serotonin on growth of bovine pulmonary artery smooth muscle cells in culture. Circ. Res. 68: 1362-1368.
39. NEMECEK, G. M., S. R. COUGLIN, D. A. HANDLEY & M. A. MOSKOWITZ. 1986. Stimulation of aortic smooth muscle cell mitogenesis by serotonin. Proc. Natl. Acad. Sci. USA 83: 674-678.
40. TAKUWA, N., M. GANZ, Y. TAKUWA, R. B. STERZEL & H. RASMUSSEN. 1989. Studies of the mitogenic effect of serotonin in rat renal mesangial cells. Am. J. Physiol. 257: F431-F439.
41. i-protein. Nature 335: 254-256.
42. SEUWEN, K. & J. POUYSSÉGUR. 1990. Serotonin as a growth factor. Biochem. Pharmacol. 39: 985-990.
43. EMANUELSSON, H., M. CARLBERG & B. LOWKVIST. 1988. Presence of serotonin in early chick embryos. Cell Diff. 24: 191-200.
44. YAVARONE, M. S., D. L. SHUEY, H. TAMIR, T. W. SADLER & J. M. LAUDER. 1993. Serotonin and cardiac morphogenesis in the mouse embryo. Teratology 47: 573-584.
45. MOISEIWITSCH, J. R. D., T. W. SADLER & J. M. LAUDER. 1992. Serotonin and craniofacial development. Teratology 45: 491.
46. BOTTARO, D., D. SHEPRO, S. PETERSON & H. B. HECHTMAN. 1985. Serotonin, histamine, and norepinephrine mediation of endothelial and vascular smooth muscle cell movement. Am. J. Physiol. 248: 252-257.
47. ZIMMERMAN, E. F., R. L. CLARK, S. GANGULI & K. VENKATASUBRAMANIAN. 1983. Serotonin regulation of palatal cell motility. J. Craniofacial Genet. Dev. Biol. 3: 371-385.
48. LAWRENCE, I. E., JR. & H. W. BURDEN. 1973. Catecholamines and morphogenesis of the chick neural tube and notochord. Am. J. Anat. 137: 199-208.
49. WALLACE, J. A. 1988. Neurotransmitters and early embryogenesis. In Amino Acid Availability and Brain Function in Health and Disease. G. Huether, Ed. 431-439. Springer-Verlag. Berlin, Heidelberg.
50. SHUEY, D. L., M. YAVARONE, T. W. SADLER & J. M. LAUDER. 1990. Serotonin and morphogenesis in the cultured mouse embryo. In Molecular Aspects of Development and Aging of the Nervous System. J. M. Lauder, Ed. 205-214. Plenum Press. New York.
51. LAUDER, J. M., H. TAMIR & T. W. SADLER. 1988. Serotonin and morphogenesis I. Sites of serotonin uptake and binding protein immunoreactivity in the midgestation mouse embryo. Development 102: 709-720.
52. LAUDER, J. M. & E. F. ZIMMERMAN. 1988. Sites of serotonin uptake in epithelia of the developing mouse palate, oral cavity, and face: possible role in morphogenesis. J. Craniofacial Genet. Dev. Biol. 8: 265-276.
53. SHUEY, D. L., T. W. SADLER, H. TAMIR & J. M. LAUDER. 1992. Serotonin and morphogenesis. II. Transient expression of serotonin uptake and binding protein during craniofacial morphogenesis in the mouse during craniofacial morphogenesis in the mouse. Anat. Embryol. 187: 75-85.
54. SHUEY, D. L., T. W. SADLER, H. TAMIR & J. M. LAUDER. 1993. Serotonin and morphogenesis: transient expression of serotonin uptake and binding protein during craniofacial morphogenesis in the mouse. Anat. Embryol. 187: 75-85.
55. IGNARRO, L. J. & F. E. SHIDEMAN. 1968. Norepinephrine and epinephrine in the embryo and embryonic heart of the chick: uptake and subcellular distribution. J. Pharmacol. Exp. Ther. 159(1): 49-58.
56. SHUEY, D. L., T. W. SADLER & J. M. LAUDER. 1992. Serotonin as a regulator of craniofacial morphogenesis: site-specific malformations following exposure to serotonin uptake inhibitors. Teratology 46: 367-378.
57. SHUEY, D. L. 1990. Developmental toxicity of sertraline, a selective serotonin uptake inhibitor in mouse whole embryo culture. Teratology 41: 591.
58. 3H-imipramine binding sites in rat cerebral cortex after prenatal exposure to antidepressants. Life Sci. 46(22): 1619-1626.
59. STANFORD, M. S. & J. H. PATTON. 1993. In utero exposure to fluoxetine HCl increases hematoma frequency at birth. Pharmacol. Biochem. Behav. 45: 959-962.
60. ROMERO, G., E. TOSCANO & J. DEL RIO. 1994. Effect of prenatal exposure to antidepressants on 5-HT-stimulated phosphoinositide hydrolysis and 5-HT2 receptors in rat brain. Gen. Pharmacol. 25(5): 851-856.
61. BYRD, R. A. & J. K. MARKHAM. 1994. Developmental toxicology studies of fluoxetine hydrochloride administered orally to rats and rabbits. Fundam. Appl. Toxicol. 22: 511-518.
62. PASTUSZAK, A., B. SCHICK-BOSCHETTO, C. ZUBER, M. FELDKAMP, M. PINELLI, S. SIHN, A. DONNENFELD, M. MCCORMACK, M. LEEN-MITCHELL, C. WOODLAND, A. GARDNER, M. HOM & G. KOREN. 1993. Pregnancy outcome following first-trimester exposure to fluoxetine (Prozac). JAMA 269(17): 2246-2248.
63. BARKER, E. L. & R. D. BLAKELY. 1995. Norepinephrine and serotonin transporters. Molecular targets of antidepressant drugs. In Psychopharmacology: the Fourth Generation of Progress. F. E. Bloom & D. J. Kupfer, Eds. 321-333. Raven Press, Ltd. New York.
64. BLAKELY, R. D., L. J. DEFELICE & H. C. HARTZELL. 1994. Molecular physiology of norepinephrine and serotonin transporters. J. Exp. Biol. 196: 263-281.
65. HOFFMAN, B. J., E. MEZEY & M. J. BROWNSTEIN. 1991. Cloning of a serotonin transporter affected by antidepressants. Science 254(579-580): 579-580.
66. CHANG, A. S., S. M. CHANG, D. M. STARNES, S. SCHROETER & R. D. BLAKELY. 1996. Cloning and expression of the mouse brain serotonin transporter. Mol. Brain Res. In press.
67. BLAKELY, R. D. 1992. Advances in molecular biology of neurotransmitter transporters. Curr. Opin. Psychol. 5: 69-73.
68. TATE, C. G. & R. D. BLAKELY. 1994. The effect of N-linked glycosylation on activity of the Na(+)- and Cl(-)-dependent serotonin transporter expressed using recombinant baculovirus in insect cells. J. Biol. Chem. 269(42): 26303-26310.
69. FOZARD, J., ED. 1989. Peripheral Actions of 5-Hydroxytryptamine. Oxford University Press. New York.
70. LESCH, K. P., B. L. WOLOZIN, H. C. ESTLER, D. L. MURPHY & P. RIEDERER. 1993. Isolation of a cDNA encoding the human brain serotonin transporter. J. Neural Transm. Gen. Sect. 91(1): 67.
71. LESCH, K. P., B. L. WOLOZIN, D. L. MURPHY & P. REIDERER. 1993. Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J. Neurochem. 60(6): 2319-2322.
72. SCHROETER, S., J. M. LAUDER & R. D. BLAKELY. 1994. Ontogeny of the mouse serotonin transporter. Soc. Neurosci. Abstr. 20: 1317.
73. 125I]RTI-55 autoradiography, in situ hybridization, and immunocytochemistry. Soc. Neurosci. Abstr. 21: 866.
74. BLAKELY, R. D., K. R. WISE & S. SCHROETER. 1995. Localization of the serotonin transporter to rodent adrenal chromaffin cells: support for a role of 5-HT in adrenal physiology. Soc. Neurosci. Abstr. 21: 781.
75. HOFFMAN, B. J. 1994. Expression cloning of a serotonin transporter: a new way to study antidepressant drugs. Pharmacopsychiatry 27: 16-22.
76. HOGAN, B., R. BEDDINGTON, F. CONSTANTINI & E. LACY. 1994. Manipulating the Mouse Embryo. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY.
77. MELIKIAN, H. E., J. K. MCDONALD, H. GU, G. RUDNICK, K. R. MOORE & R. D. BLAKELY. 1993. Human norepinephrine transporter: biosynthetic studies using a site-directed polyclonal antibody. J. Biol. Chem. 269(16): 12290-12297.
78. QIAN, Y., H. E. MELIKIAN, D. B. RYE, A. I. LEVEY & R. D. BLAKELY. 1995. Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. J. Neurosci. 15(2): 1261-1274.
79. 125I]RTI-55 to dopamine and serotonin transporters in rat brain. Synapse 12(1): 27-36.
80. LAMBRACHT-HALL, M., A. D. KONSTANTINIDOU & T. C. THEOHARIDES. 1990. Serotonin release from rat brain mast cells in vitro. Neuroscience 39(1): 199-207.
81. LAUDER, J. M. 1993. Neurotransmitters as growth regulatory signals: role of receptors and second messengers. TINS 16(6): 233-240.
82. THOMAS, S. A., A. M. MATSUMOTO & R. D. PALMITER. 1995. Noradrenaline is essential for mouse fetal development. Nature 374(6523): 643-546.
83. CASES, O., I. SEIF, J. GRIMSBY, P. GASPAR, K. CHEN, S. POURNIN, U. MULLER, M. AGUET, C. BABINET, J. C. SHIH & E. DEMAEYER. 1995. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 268(5218): 1763-1766.