Crossing the hydrophobic barrier: Insertion of membrane proteins

Science

Volumn 274, Issue 5294, 1996, Pages 1850-1851

  Engelman, Donald M ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLICIN A; HEMOLYSIN; MEMBRANE PROTEIN;

DRUG DESIGN; HYDROGEN BOND; LIPID BILAYER; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; REVIEW;

BACTERIAL TOXINS; COLICINS; HEMOLYSIN PROTEINS; HYDROGEN BONDING; LIPID BILAYERS; MEMBRANE PROTEINS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY;

EID: 0030448915     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.274.5294.1850     Document Type: Review

References (13)

1. L. Song et al., Science 274, 1859 (1996).
2. R. Henderson and N. Unwin, Nature 257, 28 (1975).
3. J. Deisenhofer, O. Epp, K. Miki, R. Huber, H. Michel, ibid, 318, 618 (1985).
4. M S. Weiss et al., Science 254, 1627 (1991).
5. S. W. Cowan et al., Nature 358, 727 (1992).
6. D. M. Engelman and T. A, Steitz, Cell 23, 411 (1981).
7. M. W. Parker, F. Pattus, A. D. Tucker, D. Tsernoglou, Nature 337, 93 (1989).
8. M. W. Parker et al., ibid 367, 292 (1994).
9. T. Surrey and F. Jähnig, Proc. Natl. Acad. Sci. U.S.A. 89, 7457 (1992).
10. S, Bhakdi et al., Arch. Microbiol. 165, 73 (1996).
11. B. Walker, O. Braha, S. Cheley, H. Bayley, Chem. Biol. 2, 99 (1995).
12. B. A. Lewis and D. M. Engelman, J. Mol. Biol. 166, 211 (1983).
13. We thank K. MacKenzie and J. Murphy for comments and assistance, and the NIH, NSF, and National Foundation for Cancer Research for support.