structural Determinants of Putrescine Uptake Inhibition Produced by Cationic Diamidines in the Model of Trypanosomatid Crithidia fasciculata

Biological Chemistry Hoppe-Seyler

Volumn 377, Issue 12, 1996, Pages 833-836

  Navas, Isabel M ^a   García Fernández, Antonio J ^a   Johnson, Raoul A ^b   Reguera, Rosa M ^b   Balaña Fouce, Rafael ^b   Ordóñez, David ^b  

^a UNIVERSITY OF MURCIA   (Spain)

^b UNIVERSITY OF LEÓN   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; AMICARBALIDE; DIAMIDINE DERIVATIVE; DIBROMPROPAMIDINE; HYDROXYSTILBAMIDINE; PENTAMIDINE; PROPAMIDINE; PUTRESCINE; STILBAMIDINE; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; CRITHIDIA FASCICULATA; LEISHMANIA INFANTUM; MEMBRANE TRANSPORT; NONHUMAN; POLYAMINE METABOLISM; PRIORITY JOURNAL;

ANIMALS; BENZAMIDINES; CARBANILIDES; CRITHIDIA; INDOLES; LEISHMANIA; PENTAMIDINE; PUTRESCINE; STILBAMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS;

EID: 0030444145     PISSN: 01773593     EISSN: None     Source Type: Journal    
DOI: 10.1515/bchm3.1996.377.12.833     Document Type: Article

References (23)

1. Anonymous (1984). Pentamidine isethionate approved for Pneumocystis carinii pneumonia. FDA Drug Bull. 14,25–26.
2. Bacchi, C. J. (1981). Content, synthesis and functions of polyamines in Trypanosomatids: relationship to chemotherapy. J. Pro-tozool. 28,20–27.
3. Balaña-Fouce, R., Ordóñez, D., and Allinda, J. M. (1989). Putrescine transport system in Leishmania infantum promastigotes. Mol. Biochem. Parasitai. 35,43–50.
4. Balaña-Fouce, R., Escribano, M. I., and Alunda, J. M. (1991). Putrescine uptake regulation in response to alpha-difluoro-methylornithine treatment in Leishmania infantum promastigotes. Mol. Cell. Biochem. 107,127–133.
5. Byers, T., and Pegg, A. E. (1990). Regulation of polyamine transport in Chinese Hamster Ovary cells. J. Cell. Physiol. 143, 460–467.
6. Byers, T. L., Kameji, R., Rannels, D. F., and Pegg, A. E. (1987). Multiple pathways for uptake of paraquat, MGBG and polyamines. Am. J. Physiol. 252, 663–669.
7. Calonge, M., Cubría, J. C. Balaña-Fouce, R., and Ordóñez, D. (1996). Putrescine active uptake system in the Trypanosomatid Crithidia fasciculata. Biol. Chem. Hoppe Seyler 377, 233–238?.
8. Calonge, M., Johnson, R., Cubría, J. C., Balaña-Fouce, R., and Ordóñez, D. (1996). Effects of cationic diamidines on polyamine content and uptake on Leishmania infantum in vitro cultures. Biochem. Pharmacol. 52,835–841.
9. Gordonsmith, R. H., Smith, L. L., and Cohen, G. M. (1985). Pulmonary accumulation of methylglyoxal bis(guanylhydrazone) by the oligoamine uptake system. Biochem. Pharmacol. 34,1809–1816.
10. Khan, N. A., Quemerer, V., and Moulinoux, Ph. (1991). Polyamine membrane transport regulation. Cell. Biol. Int. Rep. 15,19–24.
11. Landham, S., and Godfrey, D. (1970). Isolation of salivarían trypanosomes from man and other mammals using DEAE-cel-lulose. Exp. Parasitol. 28,521–534.
12. Mitchell, J. L. A., Judd, G. G., Bareyal-Leyser, A., and Ling, S. Y. (1994). Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culturecells. Biochem. J. 299,19–22.
13. O'Sullivan, M. G., Golding, B. T., Smith, L., and Wyatt, I. (1991). Molecular features necessary for the uptake of diamines and related compounds by polyamine receptor of rat lung slices. Biochem. Pharmacol. 41,1839–1849.
14. Pearson, P. D., and Hewlett, E. L. (1985). Pentamidine for the treatment of Pneumocystis carinii pneumonia and other protozoan diseases. Ann. Intern. Med. 103,782–786?.
15. Pegg, A. E. (1988). Pölyämme metabolism and its importance in neoplastic growth and as a target for chemotherapy. Cancer Res. 4, 759–774.
16. Porter, C. W., Miller, J., and Bergeron, R. J. (1984). Aliphatic chain length specificity of the polyamine transport system in ascites L1210 leukemia cells. Cancer Res. 44,126–128.
17. Quemener, V., Blanchard, L. C., Chamaillard, R., Havouis, R., Cipolla, B., and Moulinoux, J. P. (1994). Polyamine deprivation: a new tool in cancer treatment. Anticancer Res. 14,443–448.
18. Reguera, M. R., Balaña-Fouce, R., Cubría, J. C., Alvarez-Bujidos, M. L., and Ordóñez, D. (1994). Putrescine uptake Inhibition by aromatic diamidines in Leishmania infantum promastigotes. Biochem. Pharmacol. 47,1859–1866.
19. Rinehart, C., and Chen, K. (1984). Characterization of the polyamine transport system in mouse neuroblastoma cells. J. Biol. Chem. 259,4750–4756.
20. Stanek, J., Caravatti, G., Capraro, H. G., Furet, P., Mett, H., Schneider, P., and Regenass, U. (1993). S-Adenosylmethionine decarboxylase inhibitors: New aryl and heteroaryl analogues of methylglyoxal bis(guanylhydrazone)? J. Med. Chem. 36, 46–54.
21. Seiler, N., and Dezeure, F. (1990). Polyamine transport in mammalian cells. Int. J. Biochem. 22,211–218.
22. Tyms, A. S., Williamson, J. D., and Bacchi, C. J. (1988). Polyamine inhibitors in antimicrobial chemotherapy. J. Antimicrob. Chemother. 22,403–427.
23. Van-Voorish, W. C. (1990). Therapy and prophylaxis of systemic protozoan infections. Drugs 40,176–202.