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Volumn 118, Issue 49, 1996, Pages 12322-12330

Sapphyrin-oligonucleotide conjugates. Novel sequence-specific DNA photomodifying agents with increased binding affinity

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; OLIGONUCLEOTIDE; PORPHYRIN DERIVATIVE; SAPPHYRIN; UNCLASSIFIED DRUG;

EID: 0030443575     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja961672l     Document Type: Article
Times cited : (51)

References (78)
  • 2
    • 0004244327 scopus 로고
    • Crooke, S. T., Lebleu, B., Eds.; CRC Press: Boca Raton, FL
    • (b) Antisense Research and Applications; Crooke, S. T., Lebleu, B., Eds.; CRC Press: Boca Raton, FL, 1993.
    • (1993) Antisense Research and Applications
  • 52
    • 33847465810 scopus 로고
    • U.S. Patent No. 5,194,949
    • Poulsen, L. L.; Ziegler, D. M. U.S. Patent No. 5,194,949, 1993.
    • (1993)
    • Poulsen, L.L.1    Ziegler, D.M.2
  • 56
    • 33847432968 scopus 로고    scopus 로고
    • 2 is necessary to keep the macrocycle monomeric.
    • 2 is necessary to keep the macrocycle monomeric.
  • 59
    • 33847459436 scopus 로고    scopus 로고
    • The low reaction temperature (5 °C) was chosen to maximize duplex formation.
    • The low reaction temperature (5 °C) was chosen to maximize duplex formation.
  • 60
    • 33744562376 scopus 로고    scopus 로고
    • note
    • Cleavage at six guanine residues, namely, G5, G7, G9, G24, G26, and G28, was analyzed by gel densitometry. Densitometry measurements involving G30 could not be made accurately.
  • 61
    • 33847426734 scopus 로고    scopus 로고
    • Background cleavage was minor, being observed to be less than 2% of the intact substrate strand.
    • Background cleavage was minor, being observed to be less than 2% of the intact substrate strand.
  • 62
    • 0003458038 scopus 로고
    • SpringerVerlag: New York
    • The increased stability is thought to be a consequence of the decline in the repulsive interactions between the negatively charged phosphodiester backbones: Saenger, W. Principles of Nucleic Acids Structure; SpringerVerlag: New York, 1984; p 145.
    • (1984) Principles of Nucleic Acids Structure , pp. 145
    • Saenger, W.1
  • 65
    • 0014434394 scopus 로고
    • (a) Foote, C. S. Science 1968, 162, 963-970.
    • (1968) Science , vol.162 , pp. 963-970
    • Foote, C.S.1
  • 67
    • 33744594250 scopus 로고    scopus 로고
    • note
    • 2d
  • 72
    • 33744712232 scopus 로고    scopus 로고
    • note
    • Cleavage at the 5′ end of the substrate may also be attributed to triple helix formation, although this mechanism is not favored; see the text.
  • 77
    • 33744571299 scopus 로고    scopus 로고
    • note
    • Poly(A) was used in these studies to illustrate how sapphyrin conjugates might be useful in binding RNA substrates, common single-stranded oligonucleotide therapeutic targets.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.