A comparative study of thromboxane (TP) receptor mimetics and antagonists on isolated human umbilical artery and myometrium

Advances in Experimental Medicine and Biology

Volumn 407, Issue , 1996, Pages 219-230

  Abbas, Farhat ^a   Amin, Zayheda ^a   Burk, Robert M ^b   Krauss, Achim H P ^b   Marshall, Kay ^a   Senior, Judith ^a   Woodward, David F ^b  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b ALLERGAN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; 7 [3 [3 HYDROXY 4 (4 IODOPHENOXY) 1 BUTENYL] 7 OXABICYCLO[2.2.1]HEPTAN 2 YL] 5 HEPTENOIC ACID; 7 [7 (3 HYDROXY 1 OCTENYL) 3 OXO 2,4 DIOXABICYCLO[3.2.1]OCT 6 YL] 5 HEPTENOIC ACID; 7 [7 (3 HYDROXY 1 OCTENYL) 3 OXO 2,4 DIOXABICYCLO[3.2.1]OCT 6 YL] 5 HEPTENOL; RAMATROBAN; THROMBOXANE RECEPTOR; THROMBOXANE RECEPTOR BLOCKING AGENT; THROMBOXANE RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ARTERY CONSTRICTION; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; MYOMETRIUM; PRIORITY JOURNAL; UMBILICAL ARTERY; UTERUS CONTRACTION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; BICYCLO COMPOUNDS, HETEROCYCLIC; CARBAZOLES; FATTY ACIDS, UNSATURATED; FEMALE; HUMANS; HYDRAZINES; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; MYOMETRIUM; RECEPTORS, THROMBOXANE; SULFONAMIDES; THROMBOXANE A2; UMBILICAL ARTERIES;

EID: 0030395411     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (20)

1. Arunlakshana, O. & Schild, H.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol. Chemother. 14, 48-58.
2. 2α on human umbilical cord vessels. Prostaglandins, 8, 411-416.
3. Burk, R.M., Gac, T.S., Krauss, A.M., Woodward, D.W. (1994). Synthesis of a novel series of 3-oxo-2,4-dioxo-bicyclo [3.2.1] octanes. Pharmacological evidence for two thromboxane receptor subtypes. In Abstracts for the 9th international conference on prostaglandins and related substances, p. 43. Fondazione Giovanni Lorenzini.
4. Clayton, J.K., Marshall, K., Sangha, R., Kennedy, F. & Senior, J. (1994). Comparison of uterine thromboxane receptors. In Abstracts for the 9th international conference on prostaglandins and related substances, p. 110, Fondazione Giovanni Lorenzini.
5. Coleman, R.A., Humphrey, P.P.A., Kennedy, I., Lumley, P. (1984). Prostanoid receptors - The development of a working classification. TIPS, 303-306
6. Davingdon, J., Lorenz, R.R. & Shepherd, J.T. (1965). Response of human umbilical artery to changes in transmural pressure. Am. J. Physiol. 209, 51-59.
7. 2α on isolated human umbilical and placental vessels. Br. J. Obs. Gynaec., 180, 363-385.
8. Kennedy, I., Coleman, R.A., Humphrey, P.P.A., Levy, G.P. & Lumley, P. (1982). Studies on the characterisation of prostanoid receptors: A proposed classification. Prostaglandins, 24, 667-689.
9. 2α. Br. J. Pharmacol., (in press).
10. Lumley, P., Humphrey, P.P.A., Kennedy, I. & Coleman, R.A. (1982). Comparison of the potencies of some prostaglandins as vasodilators in three vascular beds of the anaesthetised dog. Eur. J. Pharmacol., 81, 421-430.
11. 2 analogs in platelets and blood vessels. Eur. J. Pharmacol. 148, 309-315.
12. 2 receptor antagonist on airway smooth muscle in vitro. Br. J. Pharmacol., 104, 579-590.
13. 2 receptors: Evidence for different subclasses in the rat. Biochem Pharmacol., 42, 537-544.
14. Ogletree, M.L., Harris, D.N., Greenberg, R., Haslanger, M.F. & Nakane, M. (1985). Pharmacological actions of SQ 29548, a novel selective thromboxane antagonist. J. Pharmacol. Exp. Ther. 234, 435-441.
15. Pickles, V.R. (1967). The myometrial action of six prostaglandins: Consideration of a Receptor Hypothesis: The Nobel Symposium, Vol 2: Prostaglandins ed. Bergstrom, S. & Samuelsson, B. pp. 79-83. Stockholm: Almquist and Wiksell.
16. Piper, P.J. & Vane, J.R. (1971). The release of prostaglandins from lung and other tissues. Annals. N.Y. Acad. Sci., 180, 363-385.
17. Senior, J., Marshall, K., Sangha, R., Baxter, G.S. & Clayton, J.K. (1991). In vitro characterization of prostanoid EP-receptors in the non-pregnant human myometrium. Br. J. Pharmacol., 102, 747-753.
18. 2 (TP-) receptors: Evidence from antagonist potency measurements. Br. J. Pharmacol., 102, 607-614.
19. von Euler, U.S. (1938). Action of adrenaline, acetylcholine and other substances on nerve free vessels (human placenta). J. Physiol. 93, 129-143.
20. Wulf, H. (1964). The oxygen and carbon dioxide tension gradients in the human placenta at term. Am. J. Obs. Gynaec. 88(1), 38-44.