Action potential variation in canine ventricle: A modeling study

Computers in Cardiology

Volumn 0, Issue 0, 1996, Pages 221-224

  Demir, Semahat S ^a,b   O'Rourke, Brian ^a   Tomaselli, Gordon F ^a   Marban, Eduardo ^a   Winslow, Raimond L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR SYSTEM; CELLS; COMPUTER SIMULATION; ELECTRIC CURRENTS; EQUIVALENT CIRCUITS; MATHEMATICAL MODELS; MEDICAL PROBLEMS;

ACTION POTENTIAL; CANINE VENTRICLE; MYOCYTES; VOLTAGE CLAMP;

BIOELECTRIC POTENTIALS;

EID: 0030381156     PISSN: 02766574     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Article

References (21)

1. Liu D.-W., Gintant G., and Antzelevitch C. Ionic bases for electrophysiological distinctions among epicardial, midmyocardial and endocardial myocytes from the free wall of the canine left ventricle. Circ. Res., 1993, 72(3):671-687.
2. K3) in canine ventricular epicardial, midmyocardial, and endocardial myocytes. Circ. Res., 1995, 76(3):351-365.
3. Zygmunt A. Intracellular calcium activates a chloride current in canine ventricular myocytes. Am. J. Physiol., 1994, 363:1984-1995.
4. Nabauer M., Beuckelmann D., Uberfuhr P., and Steinbeck G. Regional differences in current density and rate dependence properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation, 1996, 93:168-177.
5. Kaab S., Nuss H., Chiamvimonvat N., O'Rourke B., Pak P., Kass D., Marban E., and Tomaselli G. F. Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ. Res., 1996, 78:262-273.
6. Gintant G. Two components of delayed rectifier current in canine atrium and ventricle. Circ. Res., 1996, 78:26-37.
7. Colatsky T. Voltage clamp measurements of sodium channel properties in rabbit cardiac Purkinje fibers. J. Physiol, 1980, 305:215-234.
8. Tseng G.-N., Robinson R., and Hoffman B. Passive properties and membrane currents of canine ventricular myocytes. J. G. Physiol., 1987, 90:671-701.
9. 2+ currents in single canine purkinje cells. Circ. Res., 1989, 65(6):1735-1750.
10. Shibasaki T. Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. J. Physiol., 1987, 387:227-250.
11. 2+ in canine ventricular myocytes. Circ. Res., 1996, 78:936-944.
12. Yue D. and Marban E. A novel cardiac potassium channel that is active and conductive at depolarized potentials. Pflugers Arch., 1988, 413:127-133.
13. Backx P. and Marban E. Background potassium current active during the plateau of the action potential in guinea pig ventricular myocytes. Circ. Res., 1993, 72(4):890-900.
14. Gadsby D. and Nakao M. Steady-state current-voltage relationship of the Na/K pump in guinea pig ventricular myocytes. J. Gen. Physiol., 1989, 94:511-537.
15. Nakao M. and Gadsby D. [Na] and [K] dependence of the Na/K pump current-voltage relationship in guniea pig ventricular myocytes. J. Gen. Physiol., 1989, 94:539-565.
16. Matsuoka S. and Hilgemann D. Steady-state and dynamic properties of cardiac sodium-calcium exchange. J. Gen. Physiol., 1992, 100:963-1001.
17. Page E. Quantitative ultrastructrual analysis in cardiac membrane physiology. Am. J. Physiol., 1978, 235:C147-C158.
18. 2+. Biophys. J., 1981, 34:559-569.
19. 2+ binding to troponin. Biophy. J., 1982, 37:43A.
20. Hilgemann D. and Noble D. Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of basic cellular mechanisms. Phil. Trans. R. Soc. Lond.(B), 1987, 230:163-205.
21. Demir S., Clark J., Murphey C., and Giles W. A mathematical model of a rabbit sinoatrial node cell. Amer. J. Physiol., 1994, 266:C832-C852.