EMF and current cancer concepts

Bioelectromagnetics

Volumn 17, Issue 5, 1996, Pages 339-357

  Kavet, Robert ^a  

^a ELECTRIC POWER RESEARCH INSTITUTE   (United States)

Author keywords

Animal bioassays; Cancer models; Cell proliferation

Indexed keywords

DISEASES; MAMMALS; PATHOLOGY;

ANIMAL BIOASSAY; CANCER BIOLOGY; CANCER MODELS; CARCINOGENESES; ELECTRIC AND MAGNETIC FIELDS; EPIDEMIOLOGIC-STUDY; GENOTOXIC; MAGNETIC CURRENTS; POWER FREQUENCY ELECTRIC AND MAGNETIC FIELDS; TARGET CELLS;

CELL PROLIFERATION;

ANIMALIA; RODENTIA;

CELL SURFACE RECEPTOR;

ANIMAL; BIOASSAY; BIOLOGY; CELL DIVISION; COCARCINOGENESIS; DISEASE MODEL; ELECTRICITY; ELECTROMAGNETIC FIELD; ENVIRONMENTAL EXPOSURE; EPIDEMIOLOGY; EXPERIMENTAL NEOPLASM; GENETICS; HUMAN; MAGNETISM; NEOPLASM; PHYSIOLOGY; REVIEW; RODENT;

ANIMALS; BIOLOGICAL ASSAY; BIOLOGY; CELL DIVISION; COCARCINOGENESIS; DISEASE MODELS, ANIMAL; ELECTRICITY; ELECTROMAGNETIC FIELDS; ENVIRONMENTAL EXPOSURE; EPIDEMIOLOGIC METHODS; HUMANS; MAGNETICS; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; RECEPTORS, CELL SURFACE; RODENTIA;

EID: 0030337526     PISSN: 01978462     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-186X(1996)17:5<339::AID-BEM1>3.0.CO;2-4     Document Type: Article

References (197)

1. Adams JM, Cory S (1991) Transgenic models of tumor development. Science 254.1161-1167.
2. Andersen ME, Mills JJ, Gargas ML, Kedderis L. Birnbaum LS, Neubert D, Greenlee WF (1993): Modeling receptor-mediated processes with dioxin: Implications for pharmacokinctics and risk assessment Risk Anal 13:25-36.
3. Anderson LE, Sasser LB, Morris JE (1994): Large granular lymphocytic (LGL) leukemia in rats exposed to 60-Hz magnetic fields: Preliminary studies and protocol (EPRI report TR-104577). Palo Alto, CA: Electric Power Research Institute.
4. Ashby J, Morrod RS (1991). Detection of human carcinogens. Nature 352:185-186.
5. Aubert C, Janiaud P, Lecalvez J (1980): Effect of pinealectomy and melatonin on mammary tumor growth in Sprague-Dawley rats under different conditions of lighting. J Neural Trans 47:121-130.
6. Babbitt JT, Kharazi AI, Taylor JMG, Bonds CB, Mirell SG, Hahn TJM (1994): Lymphoma/leukemia in mice exposed to 60 Hz magnetic fields. Presented at the Annual Review of Research on Biological Effects From the Generation, Delivery and Use of Electricity. Albuquerque, NM, November 6-10, 1994. Frederick, MD: W/L Associates, Ltd., pp 114-115.
7. Bading H, Ginty DD, Greenberg ME (1993): Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science 260:181-186.
8. Bannasch P (1986): Preneoplastic lesions as end points in carcinogenicity testing. I. Hepatic preneoplasia. Carcinogenesis 7:689-695.
9. Barrett JC (1993): Mechanisms of multistep carcinogenesis and carcinogen risk assessment. Environ Health Perspect 100:9-20.
10. Bassctt CAL (1993): Beneficial effects of electromagnetic fields. J Cell Biochem 51:387-393.
11. Baum A, Mevissen M, Kamino K, Mohr U, Löscher W (1995): A histopathological study on alterations in DMBA-induced mammary carcinogenesis in rats with 50 Hz, 100 μT magnetic field exposure. Carcinogenesis 16:119-125.
12. Beniashvili DS, Bilanishvili VG, Menabde MZ (1991): Low-frequency electromagnetic radiation enhances the induction of rat mammary tumors by nitrosomethyl urea. Cancer Lett 61:75-79.
13. Bishop JM (1987): The molecular genetics of cancer. Science 235.305-311.
14. Blackman CF, Benane SG, Rabinowitz JR, House DE, Joines WT (1985): A role for the magnetic field in the radiation-induced efflux of calcium ions from brain tissue in vitro. Bioelectromagnetics 6:327-337.
15. Blackman CF, Benane SG, House DE, Eliot DJ (1990): Importance of alignment between local dc magnetic field and an oscillating magnetic field in responses of brain tissue in vitro and in vivo. Bioclectromagnetics 16 48-59.
16. Blackman CF, Benane SG, House DE (1993a): Evidence for direct effect of magnetic fields on neunte outgrowth. FASEB J 7:801-806.
17. Blackman CF, Benane SG, House DE, Pollock MM (1993b): Action of 50 Hz magnetic fields on neunte outgrowth in pheochromocytoma cells. Bioelectromagnetics 14:273-286.
18. Blanchard JP, Blackman CF (1994): Clarification and application of an ion parametric resonance model for magnetic field interactions with biological systems. Bioelectromagnetics 15:217-238.
19. Blask DE, Hill SM, Orstead KM, Massa JS (1986): Inhibitory effects of the pineal hormone melatonin and underfeeding during the promotional phase of 7, 12-dimethylbenzanthracene (DMBA)-induced mammary tumorigenesis. J Neural Trans 67:125-138.
20. Boorman GA, Maronpot RR, Eustis SL (1994): Rodent carcinogenicity bioassay. Past, present, and future. Toxicol Pathol 22:105-111.
21. Bos JL (1988): The ras family and human carcinogenesis. Mutat Res 195:255-271.
22. Bowman JD, Thomas DC, London SJ, Peters JM (1995): Hypothesis: The risk of childhood leukemia is related to combinations of power-frequency and static magnetic fields. Bioelectromagnetics 16:48-59.
23. Breuer M, Slebos R, Verbeek S, Van Lohuizen M, Wientjens E, Berns A (1989): Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice. Nature 340:61-63.
24. Breuer M, Wientjens E, Verbeek S, Slebos R, Berns A (1991): Carcinogen-induced lymphomagenesis in pirn-1 transgenic mice: Dose dependence and involvement of myc and ras. Cancer Res 51:958-963.
25. Butterworth BE, Popp JA, Conolly RB, Goldsworthy TL (1992): Chemically induced cell proliferation in carcinogenesis, In Vanio H, Magee PH, McGregor DB, McMichael AJ (eds): "Mechanisms of Carcinogenesis in Risk Identification." IARC Scientific Publication No. 116. Lyon, France: IARC, pp 279-305.
26. Byus CV, Stuchly MA (1995): The ability of magnetic fields to serve as a co-promotional stimulus to the development of papillomas on the skin of the mouse. Presented at the 17th Annual Bioelectromagnetics Society Meeting, Boston, MA, June 18-22, p 79.
27. Byus CV, Pieper SE, Adey R (1987): The effects of low-energy 60-Hz environmental electromagnetic fields upon the growthrelated enzyme ornithine decarboxylase. Carcinogenesis 8:1385-1389.
28. Caelles C, Helmberg A, Karin M (1994): p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370:220-223.
29. Carfagna MA, Held SD, Kedderis GL (1993): Furan-induced cytolethality in isolated rat hepatocytes: Correspondence with in vivo dosimetry. Toxicol Appl Pharmacol 123:265-273.
30. Cavenee WK, Dryja TP, Phillips RA, Benedict WF, Godbout R, Gallie BL, Murphree AL, Strong LC, White RL (1983): Expression of recessive alleles by chromosomal mechanisms in retinoblastoina. Nature 305:779-784.
31. Chaloupka K, Santostefano M, Goldfarb IS, Liu G, Myers MJ, Tsyrolv IB, Gelboin HV, Krishnan V, Safe S (1994): Aryl hydrocarbon (Ah) receptor-independent induction of Cyp1a2 gene expression by acenaphthylene and related compounds in B6C3F1 mice. Carcinogenesis 15:2835-2840.
32. Chhabra RS, Huff JE, Schwetz BS, Selkirk J (1990): An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program. Environ Health Pcrspcct 86:313-321.
33. Cohen MM, Kunska A, Astemborski JA, McCulloch D, Paskewitz PA (1986): Effect of low-level, 60-Hz electromagnetic fields on human lymphoid cells: I. Mitotic rate and chromosome breakage in human peripheral lymphocytes. Bioelectromagnetics 7:415-423.
34. Cohen SM, Ellwein LB (1990): Cell proliferation in carcinogenesis. Science 249:1007-1011.
35. Cohen SM, Ellwein LB (1991): Genetic errors, cell proliferation, and carcinogenesis. Cancer Res 51:6493-6505.
36. Corcoran GB, Fix L, Jones DP, Moslen MT, Nicotera P, Oberhammer FA, Buttyan R (1994): Apoptosis: Molecular control point in toxicity. Toxicol Appl Pharmacol 128:169-181.
37. DeGerlache J, Lans M, Préat V, Taper H, Roberfroid M (1984): Comparison of different models of rat liver carcinogenesis: Conclusions from a systemic analysis Toxicol Pathol 12:374-382.
38. Demers PA, Thomas DB, Rosenblatt KA, Jimenez LM, McTiernan A, Stalsberg H, Stemhagen A, Thompson WD, Curnen MGM. Satariano W, Austin DF, Isacson P, Greenberg RS, Key C, Kolonel LN, West DW (1991): Occupational exposure to electromagnetic fields and breast cancer in men. Am J Epidemiol 134:340-347.
39. DiGiovanni J (1992): Multistage carcinogenesis in mouse skin. Pharmacol Ther 54:63-128
40. Donehower LA, Harvey M, Slagle BL, McArthur MK, Montgomery CA Jr, Butel JS, Bradley A (1992): Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356:215-221.
41. Dragan YP, Pilot HC (1992): Commentary: The role of the stages of initiation and promotion in phenotypic diversity during hepatocarcinogenesis in the rat. Carcinogenesis 13:739-750.
42. 1 male mice. Polycyclic Arom Comp 7:183-189.
43. Eddy M (1993): The use of transgenic mice for environmental health research. Environ Health Perspect 101:298-300.
44. Eliyahu D, Raz A, Gruss P, Givol D, Oren M (1984): Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature 312:646-649.
45. EPA (1986): Environmental Protection Agency guidelines for carcinogen risk assessment. Fed Register 51( 185):33995-34012.
46. 2u -globulin: Association with chemically induced renal toxicity and neoplasia in the male rat. Environmental Protection Agency report 525/3-91/019F, September, 1991.
47. Ewing MW, Conti CJ, Kruszewski FH, Slaga TJ, DiGiovanni J (1988): Tumor progression in Sencar mouse skin as a function of initiator dose and promoter dose, duration, and type. Cancer Res 48:7048-7054.
48. Farber E (1973): Hyperplastic liver nodules, methods. Cancer Res 7:345-375.
49. Farber E (1990): Commentary: Clonal adaptation during carcinogenesis. Biochem Pharmacol 39:1837-1846.
50. Farrow SN, White JHM, Martinou I, Raven T, Pun K-T, Grinham CJ, Martinou J-C, Brown R (1995): Cloning of a bcl-2 homologue by interaction with adenovirus EIB 19K. Nature 374:731-733.
51. Feychting M, Ahlbom A (1993): Magnetic fields and cancer in children residing near Swedish high-voltage power lines. Am J Epidemiol 138:467-481.
52. Feychting M, Ahlbom A (1995): Childhood leukemia and residential exposure to weak extremely low frequency magnetic fields. Environ Health Perspect 103(Suppl 2):59-62.
53. Fidler I (1986): Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis, Cancer Metast Rev 5 29-49.
54. Fitzsimmons RJ, Farley JR, Adey WR, Baylink DJ (1989): Frequency dependence of increased cell proliferation, in vitro, in exposures to a low-amplitude, low frequency electric field: Evidence for dependence on increased mitogen activity released into culture medium, J Cell Physiol 139:586-591.
55. Floderus B, Persson T, Stenlund C, Wennberg A, Ost Å, Knave B (1993): Occupational exposure to electromagnetic fields in relation to leukemia and brain tumors: A case-control study in Sweden. Cancer Causes Control 4:465-476.
56. Goldfarb S, Zak FG (1961): Role of injury and hyperplasia in the induction of hepatocellular carcinoma. J Am Med Assoc 178:729-731.
57. Goldsworthy TL, HC Pilot (1985): An approach to the development of a short term whole-animal bioassay to distinguish initiating agents (incomplete carcinogens), promoting agents, complete carcinogens, and noncarcinogens in rat liver. J Toxicol Environ Health 16:389-402
58. Goldsworthy TL, Recio L, Brown K, Donehower LA, Mirsalis JC, Tennant R, Purchase IFH (1994): Symposium overview: Transgenic animals in toxicology. Fund Appl Toxicol 22:8-19.
59. Gossner VW, Friedrich-Freksa H (1964): Histochemische untersuchungen über die glucose-6-phosphatase in der rattcnlcber während der kanzerisierung durch nitrosamine, Z Naturforsch 19:862-864.
60. Graham C, Cohen HD, Cook MR (1990): Irmnunological and biochemical effects of 60-Hz electric and magnetic fields in humans. Final report, U.S. Department of Energy contract DEFC01-84-CE-76246, MRI project RA-338-C. Kansas City, MO: Midwest Research Institute, January 30, 1990.
61. Graham C, Cook MR, Riffle DW, Gerkovich MM: Nocturnal melatonin levels in human volunteers exposed to 60-Hz magnetic fields. Bioelectromagnetics (in press).
62. Greaves MF, Alexander FE (1993): An infectious etiology for common acute lymphoblastic leukemia in childhood. Leukemia 7:349-360.
63. Greenhalgh DA, Welty DJ, Player A, Yuspa SH (1990): Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma Proc Natl Acad Sci USA 87:643-647.
64. Groffen J, Voncken J-W, van Schaik H, Heisterkamp N (1992): Animal models for chronic myeloid leukemia and acute lymphoblastic leukemia. Leukemia 6(Suppl 1):44-46.
65. Grota LJ, Reiter RJ, Keng P, Michaelson S (1994): Electric field exposure alters serum melatonin but not pineal melatonin synthesis in male rats. Bioelectromagnetics 15:427-437.
66. Hanahan D (1989): Transgenic mice as probes into complex systems. Science 246:1265-1275.
67. Hanson DJ (1994): EPA to revise cancer guidelines to incorporate more than tumors. Chem Eng News, September 26, pp 21-22.
68. Hard GC, Rodgers SV, Baetcke KP, Richards WL, McGaughy RE, Valcovic LR (1993): Hazard evaluation of chemicals that cause accumulation of a2m-globulin hyaline droplet nephropathy, and tubule neoplasia in the kidneys of male rats. Environ Health Perspect 100:313-349.
69. Harris CC (1991): Chemical and physical carcinogenesis: Advances and perspectives for the 1990s. Cancer Res 51:5023s-5044s.
70. Hengartner MO, Horvitz HR (1994): Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in bcl-2. Nature 369:318-323.
71. Hennings H, Michael D, Cheng C, Steinert P, Holbrook K, Yuspa SH (1980): Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19:245-254.
72. Hennings H, Shores R, Wenk ML, Spangler EF, Tarone R, Yuspa SH (1983): Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters. Nature 304:67-69.
73. Hennings H, Robinson VA, Michael DM, Pettit GR, Jung R, Yuspa SH (1990): Development of an in vitro analogue of initiated mouse epidermis to study tumor promoters and antipromoters. Cancer Res 50:4794-4800.
74. Herren SL, Pereira MA, Britt AL, Khoury MK (1982): Initiation/ promotion assay for chemical carcinogens in rat liver. Toxicol Lett 12:143-150.
75. Holder JW, Elmore E, Barrett JC (1993): Gap junction function and cancer. Cancer Res 53:3475-3485.
76. Hollstein M, Didransky D, Vogelstein B, Harris CC (1991): p53 Mutations in human cancers. Science 253:49-53.
77. Holmberg B (1995): Magnetic fields and cancer: Animal and cellular evidence - An overview. Environ Health Perspect 103(Suppl 2):63-67.
78. Holmberg B, Rannug A (1995): Magnetic fields and cancer development in animal models. Radio Sci 30:223-231.
79. Huff J (1993): Chemicals and cancer in humans: First evidence in experimental animals. Environ Health Perspect 100:201-210.
80. Huff J, Haseman J (1991): Long-term chemical carcinogenesis experiments for identifying potential human cancer hazards: Collective database of the National Cancer Institute and National Toxicology Program (1976-1991). Environ Health Perspect 96:23-31.
81. Huggins C, Yang NC (1962): Induction and extinction of mammary cancer: A striking effect of hydrocarbons permits analysis of mechanisms of causes and cure of breast cancer. Science 137:257-262.
82. Ito N, Tsuda H, Tatematsu M, Inoue T, Tagawa Y, et al (1988): Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione-S-transferase placental form positive foci in rats - An approach for a new medium-term bioassay system. Carcinogenesis 9:387-394.
83. Kato M, Honma K, Shigemitsu T, Shiga Y (1993): Effects of exposure to a circularly polarized 50-Hz magnetic field on plasma and pineal melatonin levels in rats. Bioelectromagnetics 14:97-116.
84. Kato M, Honma K, Shigemitsu T, Shiga Y (1994): Recovery of nocturnal melatonin concentration takes place within 1 week following cessation of 50 Hz circularly polarized magnetic field exposure for six weeks. Bioelectromagnetics 15:489-492
85. Kavet R (1992): A brief perspective on biological effects from intermittent E/MF exposure. In: "Future Epidemiologic Studies of Health Effects of Electric and Magnetic Fields." EPRI report TR-1011175, Palo Alto, CA: Electric Power Research Institute, pp A47-A53.
86. Kavet R (1993): "Proceedings of the EPRI Cancer Workshop II on Laboratory Research." EPRI report TR-101749. Palo Alto, CA: Electric Power Research Institute.
87. Kavet R (1995): Magnetic field exposure assessment. In Blank M (ed): "Electromagnetic Fields: Biological Interactions and Mechanisms." Washington, DC; American Chemical Society, pp 191-223
88. Kedderis GL, Carfagna MA, Held SD, Batra R, Murphy JE, Gargas ML (1993): Kinetic analysis of furan biotransformation by F344 rats in vivo and in vitro. Toxicol Appl Pharmacol 123:274-282.
89. Kirschvink JL, Kobayashi-Kirschvink A, Diaz-Ricci JC, Kirschvink SJ (1992): Magnetite in human tissues: A mechanism for the biological effects of weak ELF magnetic fields. Bioelectromagnetics Suppl 1:101-113.
90. Klaunig JE, Ruch RJ (1990): Role of inhibition of intercellular communication in carcinogenesis. Lab Invest 62:135-146.
91. Lacy-Hulbert A, Wilkins RC, Hesketh TR, Mctcalfe JC (1995): No effect of 60 Hz electromagnetic fields on MYC or B-actin expression in human leukemic cells. Radiat Res 144:9-17.
92. Land H, Parada LF, Weinberg RA (1983): Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 304:596-602.
93. Larson JL, Wolf DC, Butterworth BE (1994): Induced cytotoxicity and cell proliferation in the hepatocarcinogenicity of chloroform in female B6C3F1 mice: Comparison of administration by gavage in corn oil vs. ad libitum in drinking water. Fund Appl Toxicol 22:90-102.
94. Lednev VV (1991). Possible mechanism for the influence of weak magnetic fields on biological systems. Bioelectromagnetics 12:71-75.
95. Lee JM Jr, Stonnshak F, Thompson JM, Thinesen P, Painter LJ, Olenchek EG, Hess DL, Forbes R, Foster DL (1993): Melatonin secretion and puberty in female lambs exposed to environmental electric and magnetic fields. Biol Reprod 49:857-864.
96. Lee JM Jr, Stormshak F, Thompson JM, Hess DL, Foster DL (1995): Melatonin and puberty in female lambs exposed to EMF: A replicate study. Bioelectromagnetics 16:119-123.
97. Lerchl A, Nonaka KO, Stokkan K-A, Reiter RJ (1990): Marked rapid alterations in nocturnal pineal serotonin metabolism in mice and rats exposed to weak intermittent magnetic fields. Biochem Biophys Res Commun 169:102-108.
98. Lerchl LA, Honaka KO, Reiter RJ (1991): Pineal gland "magnetosensitivity" to static magnetic fields is a consequence of induced electric currents (eddy currents). J Pineal Res 10:109-116.
99. Liboff AR, Williams T, Strong DM, Wistar R (1984): Time varying magnetic fields: Effect on DNA synthesis. Science 223:818-820.
100. Linet MS (1985): "The Leukemias." New York: Oxford University Press.
101. Litovitz TA, Krause D, Mullms JM (1991): Effect of coherence time of the applied magnetic field on ornithine decarboxylase activity. Biochem Biophys Res Commun 178:862-865.
102. Litovitz TA, Montrose CJ, Doinov P, Brown KM, Barber M (1994): Temporally incoherent magnetic fields mitigate the response of biological systems to temporally coherent magnetic fields. Bioelectromagnetics 15:399-409.
103. Livingston GK, Witt KL, Gandhi OP, Chatterjee I, Roti Roti JL (1991): Reproductive integrity of mammalian cells exposed to power frequency electromagnetic fields. Environ Mol Mutagen 17:49-58.
104. London SJ, Thomas DC, Bowman JD, Sobel E, Cheng T-C, Peters JM (1991): Exposure to residential electric and magnetic fields and risk of childhood leukemia. Am J Epidemiol 134:923-937.
105. Löscher W, Mevissen M (1994): Minireview: Animal studies on the role of 50/60 Hertz magnetic fields in carcinogenesis. Life Sci 54:1531-1543.
106. Loscher W, Mevissen M, Lehmacher W, Stamm A (1993): Tumor promotion in a breast cancer model by exposure to a weak alternating magnetic field Cancer Lett 71:75-81.
107. Löscher W, Wahnschaffe U, Mevissen M, Lerchl A, Stamm A (1994): Effects of weak alternating magnetic fields on nocturnal melatonin production and mammary carcinogenesis in rats. Oncology 51:288-295.
108. Luben RA (1991): Effects of low-energy electromagnetic fields (pulsed and DC) on membrane signal transduction processes in biological systems. Health Phys 61:15-28.
109. Lucier GW (1992): Receptor-mediated carcinogenesis. In Vainio H, Magee PN, McGregor DB, McMichael AJ (eds): "Mechanisms of Carcinogenesis in Risk Identification." IARC Scientific Publications No. 116. Lyon, France: IARC, pp 87-112.
110. MacDonald JS, Lankas GR, Morrissey RE (1994): Toxicokinetic and mechanistic considerations in the interpretation of the rodent bioassay. Toxicol Pathol 22:124-140.
111. Mandeville R (1995): Ongoing Canadian research program on the potential carcinogenicity of 60 Hz magnetic fields on Fischer rats (unpublished report). Presented at the 1995 EPRI EMF Seminar, Understanding and Integrating the Science, Santa Clara, CA, March 20-22.
112. Mandeville R, Mercier G, Oth D, Descôteaux J-P, Lis M, Franco E (1994): A unique model for the study of the effects of 60 Hz magnetic fields on brain tumor promotion in Fischer rats Presented at The Annual Review of Research on Biological Effects From the Generation, Delivery and Use of Electricity, Albuquerque, NM, November 6-10, 1994. Frederick, MD: W/L Associates, Ltd., pp 114-115.
113. McCann J, Dietrich F, Rafferty C, Martin AO (1993): A critical review of the genotoxic potential of electric and magnetic fields. Mutat Res 297:61-95.
114. McCann J, Kavet R, Rafferty CN (1997): Testing EMF for potential carcinogenic activity: A critical review of animal models. Environ Health Perspect, in press.
115. McCormick DL, Gauger JR, Boorman GA (1994a): Studies to evaluate the toxic and carcinogenic potential of 60 Hz magnetic fields in laboratory animals. Proceedings of the 4th Annual IEEE Dual-Use Technologies Conference, Vol 1, 553-560.
116. McCormick DL, Cahill MA, Harder JB, Ryan BM, Findlay JC, Pomerantz LE, Szymanski RR, Boorman GA (1994b): Pineal function assessment F344 rats and B6C3F1 mice exposed to 60 Hz magnetic fields. Presented at the 16th Annual Bioelectromagnelics Meeting, Copenhagen, Denmark, June 12-17. Frederick, MD: Bioelectromagnetics Society, p 50.
117. McCormick DL, Ryan BM, Findlay JC, Boorman GA (1994c): Exposure to 60 Hz magnetic fields and lymphoma development in pim transgenic mice, Presented at the Annual Review of Research on Biological Effects From the Generation, Delivery and Use of Electricity, Albuquerque, NM, November 6-10. Frederick, MD: W/L Associates, Ltd., pp 44-45.
118. McCormick F (1993): How receptors turn ras on. Nature 363:15-16.
119. McLean JRN, Stuchly MA, Mitchel REJ, Wilkinson D, Yang H, Goddard M, Lecuyer DW, Schunk M, Callary E, Morrison D (1991): Cancer promotion in a mouse-skin model by a 60-Hz magnetic field: II. Tumor development and immune response. Bioelectromagnetics 12:273-287.
120. McLean JRN, Thansandote A, Lecuyer DW, Kim J (1995): The effect of 60 Hz magnetic fields on copromotion of chemically induced skin tumours on SENCAR mice. Presented at the 17th Annual Bioelectromagnetics Meeting, Boston, MA. June 18-22. Frederick, MD: Bioelectromagnetics Society, p 212.
121. McLeod KJ (1992): Microelectrode measurements of low frequency electric field effects in cells and tissues. Bioelectromagnetics Suppl 1:161-178
122. McLeod KJ, Rubin CT (1992): The effect of low-frequency electrical fields on osteogenesis. J Bone Joint Surg 74A:920-929.
123. Mevissen M, Stamm A, Buntenkötter S, Zwingelberg R, Wahnschaffe U, Löscher W (1993): Effects of magnetic fields on mammary tumor development induced by 7,12-dimethylbenz(a)anthracene in rats. Bioelectromagnetics 14:131-143.
124. Miller DR, Viaje A, Aldaz CM Conti CJ, Slaga TJ (1987): Terminal differentiation-resistant epidermal cells in mice undergoing two-stage carcinogenesis. Cancer Res 47:1935-1940.
125. Moolgavkar SH (1988): Biologically motivated two-stage model for cancer risk assessment. Toxicol Lett 43:139-150.
126. Moolgavkar SH, Knudson AG (1981): Mutation and cancer: A model for human carcinogenesis. JNCI 66:1037-1052.
127. Morris JF, Sasscr JE, Miller DL, Mitchell CE, Anderson LE, Kavet RI, Johnston DA, and DiGiovanni J (1995): Evaluation of a skin cancer model for study of carcinogenesis in a magnetic field exposure system. Presented at the 17th Annual Bioelectromagnetics Meeting, Boston, MA, June 18-22. Frederick, MD: Bioelectromagnetics Society, p 131
128. Nishizuka Y (1989): Studies and prospectives of the protein kinase C family for cellular regulation. Cancer 63:1892-1903.
129. NRPB (1992). "Electromagnetic Fields and the Risk of Cancer." National Radiological Protection Board, Chilton, UK.
130. Peraino C, Richards WL, Stevens FJ (1982): Multistage hepatocarcinogenesis. In Slaga TJ (ed): "Mechanisms of Tumor Promotion. Tumor Promotion in Internal Organs." Boca Raton, FL: CRC Press, pp 1-53.
131. Pereira MAJ (1982): Rat liver foci bioassay. J Am Coll Toxicol 1:101-117.
132. Phillips JL (1993): Effects of electromagnetic field exposure on gene transcription. J Cell Biochem 51:381-386.
133. Pike MC, Spicer DV, Dahmoush L, Press MF (1993): Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Am J Epidemiol 15:17-35.
134. Pilot HC (1990): Altered hepatic foci: Their role in murine hepatocarcinogenesis. Annu Rev Pharmacol Toxicol 30:465-500.
135. Polk C (1992): Dosimetry of extremely-low-frequency magnetic fields. Bioelectromagnetics Suppl 1:209-235.
136. Polk C (1993): Physical mechanisms for biological effects of ELF low-intensity electric and magnetic fields: Thermal noise limit and eounterion polarization. In Blank M (ed): "Electricity and Magnetism in Biology and Medicine." San Francisco: San Francisco Press, pp 543-546.
137. Raff MC, Barres BA, Burne JF, Coles HS, Ishizaki Y, Jacobson MD (1993): Programmed cell death and the control of cell survival: Lessons from the nervous system. Science 262:695-700.
138. Rannug A, Hkström T, Mild KH, Holmberg B, Gimenez-Conti I, Slaga TJ (1993a): A study on skin tumor formation in mice with 50 Hz magnetic field exposure. Carcinogenesis 14:573-578.
139. Rannug A, Holmberg B, Mild KH (1993b): A rat liver foci promotion study with 50-Hz magnetic fields. Environ Res 62:223-229.
140. Rannug A, Holmberg B, Ekström T, Mild KH (1993c): Rat liver foci study on coexposure with 50 Hz magnetic fields and known carcinogens. Bioelectromagnetics 14:17-27.
141. Rannug A, Holmberg B, Ekström T, Mild KH, Gimenez-Conti I, Slaga TJ (1994). Intermittent 50 Hz magnetic field and skin tumor promotion in SENCAR mice. Carcinogenesis 15:153-157.
142. Rasmussen H (1986): The calcium messenger system N Engl J Med 314:1094-1101, 1164-1170.
143. Reiter RJ (1989): The pineal gland. In DeGroot LJ (ed): "DeGroot's Endocrinology " Philadelphia: W B Saunders, pp 240-253.
144. Reiter RJ (1990): Effects of light and stress in pineal function. In Wilson BW, Stevens RG, Anderson LE (eds): "Extremely Low Frequency Electromagnetic Fields: The Question of Cancer." Richland, WA: Battelle Press, pp 87-107.
145. Reiter RJ, Anderson LE, Buschbom RL, Wilson BW (1988): Reduction in the nocturnal rise in pineal melatonin levels in rats exposed to 60-Hz electric fields in utero and for 23 days after birth. Life Sci 42.2203-2206.
146. Reiter RJ, Poeggeler B, Chen LD, Manchester LC, Hara M, OlatomijiBello Y (1994a): Nocturnal pineal serotonin metabolism in male rats subjected to short duration pulsed static magnetic fields. Presented at the Annual Review of Research on Biological Effects From the Generation, Delivery and Use of Electricity, Albuquerque. NM, November 6-10. Frederick, MD: W/ L Associates, Ltd., pp 39-41
147. Reiter RJ, Tan D, Poeggeler B, Chen L, Menendez-Pelaez A (1994b): Melatonin, free radicals and cancer initiation. In Maestroni GJM, Conti A, Reiter RJ (eds): "Advances in Pineal Research, Vol 7." pp 211-228. John Libbey & Co., London, UK.
148. Reiter RJ, Tan D, Poeggeler B, Menendez-Pelaez A, Chen L, Saarela S (1994c): Melatonin as a free radical scavenger. Implications for aging and age-related diseases. Ann NY Acad Sci 719:1-12.
149. Repacholi M, Basten A, Harris A, Noonan D, Finnie J, Gebski V, Kuchel T, Bangay M (1995): Carcinogenicity from exposure to 50 Hz magnetic fields: A transgenic mouse study. Presented at the 17th Annual Bioelectromagnetics Meeting, Boston, MA, June 18-22. Frederick, MD: Bioelectromagnetics Society, p 173.
150. Roberts R, Gallagher J, Spooncer E, Allen TD, Bloomfield F, Dexter TM (1988): Heparan sulphate bound growth factors: A mechanism for stromal cell mediated haemopoiesis. Nature 332:376-378
151. Ross SM (1990): Combined DC and ELF magnetic fields can alter cell proliferation. Bioelectromagnetics 11:27-36.
152. Rubin CT, McLeod KJ, Lanyon LE (1989): Prevention of osteoporosis by pulsed electromagnetic fields. J Bone Joint Surg 71A:411-417.
153. Russo J, Gusterson BA, Rogers AE, Russo IH, Wellings SR, van Zwieten MJ (1990): Biology of disease: Comparative study of human and rat mammary tumorigenesis. Lab Invest 62:244-278.
154. Saffer J, Thurston SJ (1995): Short exposures to 60-Hz magnetic fields do not alter MYC expression in HL60 or Daudi cells. Radiat Res 144:18-25
155. Sahl JD, Kelsh MA, Greenland S (1993): Cohort and nested casecontrol studies of hematopoietic cancers and brain cancer among electric utility workers. Epidemiology 4:104-114.
156. Sasser LB, Morris JE, Buschbom RL, Miller DL, Anderson LE (1991): Effect of 60 Hz electric fields on pineal melatonin during various times of the dark period. Presented at the Annual Review of Research on Biological Effects of 50 and 60 Hz Electric and Magnetic Fields, November 3-7. Milwaukee, WI: U.S. Department of Energy.
157. Sasser LB, Morris JE, Miller DL, Wilson BW, Anderson LE (1992): Pineal function in rats acutely exposed to magnetic fields. Presented at the Annual Review of Research on Biological Effects From the Generation. Delivery and Use of Electricity. San Diego, CA. November 8-12. Frederick, MD: W/L Associates, Ltd., p A23.
158. Savitz DA, Loomis DP (1995): Magnetic field exposure in relation to leukemia and brain mortality among electric utility workers. Am J Epidemiol 141:123-134.
159. Savitz DA, Wachtel H, Barries FA, John EM, Tvrdik JG (1988): Casecontrol study of childhood cancer and exposure to 60-Hertz magnetic fields. Am J Epidemiol 128:21-38.
160. Sawyers CL, Denny CT, Witte ON (1991): Leukemia and the disruption of normal hematopoiesis. Cell 64:337-350.
161. Schulte-Hennann R, Timmermann-Trosiener I, Barthel G, Bursch W (1990): DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion. Cancer Res 50:5127-5135.
162. Shah PN, Mhatre MC, Kothari LS (1984): Effect of melatonin on mammary carcinogenesis in intact pinealectomized rats in varying photoperiods. Cancer Res 44:3403-3407.
163. Shaw IC, Jones HB (1994): Mechanisms of nongenotoxic carcinogenesis. Trends Pharmacol Sci 15:89-93.
164. Sisken BF, Walker J, Orgel MJ (1993): Prospects on clinical applications of electrical stimulation for nerve regeneration. Cell Biochem 52:404-409.
165. Stevens RG (1987): Electric power use and breast cancer: A hypothesis. Am J Epidemiol 125:556-561.
166. Strickland JE, Ueda M, Hennings H, Yuspa SH (1992): Model for initiated mouse skin: Suppression of papilloma but not carcinoma formation by normal epidermal cells in grafts on athymic nude mice. Cancer Res 52:1439-1444.
167. Stuchly MA., Lecuyer DW, McLean J (1991): Cancer promotion in a mouse-skin model by 60-Hz magnetic fields: I. Experimental design and exposure system. Biôëlectromagnetics 12:261-271.
168. Stuchly MA, McLean JRN, Burnett R, Goddard M, Lecuyer DW, Mitchel REJ (1992): Modification of tumor promotion in the mouse skin by exposure to an alternating field. Cancer Lett 65:1-7.
169. Tamarkin L, Cohen M, Roselle D, Reichert C, Lippman M, Chabner B (1981): Melatonin inhibition and pinealectomy enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in the rat. Cancer Res 41:4432-4436.
170. Tamarkin L, Baird CJ, Almeida OFX (1985): Melatonin: A coordinating signal for mammalian reproduction. Science 227:714-720.
171. Tennant RW (1993): Stratification of rodent carcinogenicity bioassay results to reflect relative human hazard. Mutat Res 286:111-118.
172. Thériault G, Goldberg M, Miller AB, Armstrong B, Guénel P, Deadman J, Imbernon E, To T, Chevalier A, Cyr D, Wall C (1994): Cancer risks associated with occupational exposure to magnetic fields among electric utility workers in Ontario and Quebec, Canada, and France: 1970-1989. Am J Epidemiol 139:550-572.
173. Trosko JE, Chang CC, Madhukar BV (1987): Chemical and oncogene modulation of intercellular communication in tumor promotion. In Milman HA, Elmore E (eds): "Biochemical Mechanisms and Regulation of Intercellular Communication." Princeton, NJ: Princeton Scientific Publ, pp 209-236.
174. Trosko JE, Chang CC, Madhukar BV (1990): Modulation of intercellular communication during radiation and chemical carcinogenesis. Radiat Res 123:241-251.
175. Tsuda H, Lee G, Farber E (1980): The induction of resistant hepatocytes as a new principle for a possible short term in vivo test for carcinogens. Cancer Res 40:1157-1164.
176. Vainio H, Magee PN, McGregor DB, McMichael AJ (eds; 1992): "Mechanisms of Carcinogenesis in Risk Identification." IARC Scientific Publication 116. Lyon, France: IARC.
177. Vesselinovitch SD, Kyriazis AP, Mihailovich N, Rao KVN (1975): Conditions modifying development of tumors in mice at various sites by benzo(a)pyrene. Cancer Res 35:2948-2953.
178. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AMM, Bos JL (1988): Genetic alterations during colorectal-tumor development. N Engl J Med 319:525-532.
179. Walleczek J (1992): Electromagnetic field effects on cells of the immune system: The role of calcium signaling. FASEB J 6:3177-3185.
180. Weaver JC, Astumian RJD (1990): The response of living cells to very weak electric fields: The thermal noise limit. Science 247:459-462.
181. Weaver JC, Astumian RD (1992): Estimates for ELF effects: Noisebased thresholds and the number of experimental conditions required for empirical searches. Bioelectromagnetics Suppl 1:209-235.
182. Weinberg RA (1989): Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis. Cancer Res 49:3713-3721.
183. Weinstein IB (1988): The origins of human cancer: Molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment. 27th G.H.A. Clowes Memorial Award Lecture. Cancer Res 48:4135-4143.
184. Welsch CW (1985): Host factors affecting the growth of carcinogeninduced rat mammary carcinomas: A review and tribute to Charles Brenton Huggins. Cancer Res 45:3415-3443.
185. Wertheimer N, Leeper E (1979): Electrical wiring configurations and childhood cancer. Am J Epidemiol 109:273-284
186. Wilson BW, Anderson LE, Hilton DI, Phillips RD (1981): Chronicexposure to 60-Hz electric fields: Effects on pineal function in the rat. Bioelectromagnetics 2:371-380.
187. Wilson BW, Anderson LE, Hilton DI, Phillips RD (1983): Erratum: Chronic exposure to 60-Hz electric fields: Effects on pineal function in the rat. Bioelectromagnetics 4:293.
188. Wilson BW, Chess EK, Anderson LE (1986): 60-Hz electric-field effects on pineal melatonin rhythms: Time course for onset and recovery. Bioelectromagnetics 7:239-242.
189. Wilson BW, Matt KS, Morris JE, Sasser LB, Miller DL, Anderson LE (1995): Effects of acute and subchronic exposure to magnetic fields on the hypothalamic pituitary-gonadal axis in the Siberian hamster. Presented at the Seventeenth Annual Bioelectromagnetics Meeting, Boston, MA, June 18-22. Frederick, MD: Bioelectromagnetics Society, p 169.
190. Yamasaki H (1990) Gap junctional intercellular communication and carcinogenesis. Carcinogenesis 11:1051-1058.
191. Yamasaki H, Hollstein M, Cabrai JRP, Tomatis L (1989): Role of oncogene activation during prenatal (transplacental) initiation and postnatal promotion in mouse skin tuinours. In Napalkov NP, Rice JM, Tomatis L, Yamasaki H (eds): "Perinatal and Multigeneration Carcinogenesis." Lyon, France: IARC, pp 221-237.
192. Yellon SM (1994a): Acute 60 Hz magnetic field exposure effects on the melatonin rhythm in the pineal gland and circulation of the adult Djungarian hamster. J Pineal Res 16:136-144.
193. Yellon SM (1994b): Studies of acute and daily 60 Hz magnetic field exposures on the nighttime melatonin rhythm in adult Djungarian hamsters in short days. Presented at the Annual Review of Research on Biological Effects From the Generation, Delivery and Use of Electricity. Albuquerque, NM, November 6-10. Frederick, MD: W/L Associates, Ltd., pp 41-42.
194. Yuspa SH (1994): The pathogenesis of squamous cell cancer: Lessons learned from studies of skin carcinogenesis. 33rd G.H.A. Clowes Memorial Award Lecture. Cancer Res 54:1178-1189.
195. Yuspa SH, Kilkenny AE, Steinert PM, Roop DR (1989): Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro. J Cell Biol 109:1207-1217.
196. Zaffanella LE (1993): Survey of Residential Magnetic Field Sources. EPRITR-102759-V1, EPRI TR-102759-V2, Final Report. Palo Alto, CA: Electric Power Research Institute.
197. Zwingelberg R, Obe G, Rosenthal M, Mcvisscn M, Buntenkötter S, Löscher W (1993). Exposure of rats to a 50-Hz, 30-mT magnetic field influences neither the frequencies of sister-chromatid exchanges nor proliferation characteristics of cultured peripheral lymphocytes. Mutat Res 302:39-44.