The scid Mutation Does Not Affect Slowly Repairing Potentially Lethal Damage That Is Sensitive to 0.23 M NaCl

Journal of Radiation Research

Volumn 37, Issue 4, 1996, Pages 247-255

  Kimura, Hiroshi ^a   Ikebuchi, Makoto ^a   Fushiki, Masato ^a   Komatsu, Kenshi ^b  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

DNA dependent protein kinase; High salt concentration; PLD repair; Radiation sensitivity; Scid cells

Indexed keywords

CELLS; CYTOLOGY; SODIUM CHLORIDE;

0.5 M NACL; DAMAGE REPAIR; DNA-DEPENDENT PROTEIN KINASE; HIGH SALT CONCENTRATION; HUMAN CHROMOSOMES; POTENTIALLY LETHAL DAMAGE REPAIR; RADIATION SENSITIVITY; SCID CELL; WILD TYPES;

REPAIR;

ULEX EUROPAEUS;

SODIUM CHLORIDE;

ANIMAL; ARTICLE; CELL LINE; CELL STRAIN 3T3; DNA DAMAGE; DNA REPAIR; DRUG EFFECT; GENETICS; HUMAN; MOUSE; MOUSE MUTANT; MUTATION; RADIATION DOSE;

3T3 CELLS; ANIMALS; CELL LINE; DNA DAMAGE; DNA REPAIR; HUMANS; MICE; MICE, SCID; MUTATION; RADIATION TOLERANCE; SODIUM CHLORIDE;

EID: 0030322779     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.37.247     Document Type: Article

References (23)

1. Raaphorst, G. P. and Dewey, W. C. (1979) A study of the repair of potentially lethal and sublethal radiation damage in Chinese hamster cells exposed to extremely hypo- or hypertonic NaCl solutions. Radiat. Res. 77: 325-340.
2. Utsumi, H. and Elkind, M. M. (1985) Two forms of potentially lethal damage have similar repair kinetics in plateau-and log-phase cells. Int. J. Radiat. Biol. 47: 569-580.
3. Iliakis, G. P., Bryant, E. and Ngo, F. Q. H. (1985) Independent forms of potentially lethal damage fixed in plateau-phase Chinese hamster cells by postirradiation treatment in hypertonic salt solution or araA. Radiat. Res. 104: 329-345.
4. Ikebuchi, M., Kimura, H., Hill, C. K. and Aoyama, T. (1995) Are three forms of potentially lethal damage expressed after X irradiation by treatment with hypertonic solutions in Chinese hamster V79 cell? Radiat. Res. 141: 19-27.
5. Okayasu, R., Varlotto, J. and Iliakis, G. (1993) Hypertonic treatment does not affect the radiation yield of interphase chromosome breaks in DNA double-strand break repair-deficient xrs-5 cells. Radiat. Res. 135: 171-177.
6. Okayasu, R. and Iliakis, G. (1994) Evidence that the product of the xrs gene is predominantly involved in the repair of a subset of radiation-induced interphase chromosome breaks rejoining with fast kinetics. Radiat. Res. 138: 34-43.
7. Kimura, H., Terado, T., Komatsu, K., Nozawa, A., Ikebuchi, M. and Aoyama, T. (1995) Cultured cells from a severe combined immunodeficient mouse have a slower than normal rate of repair of potentially lethal damage sensitive to hypertonic treatment. Radiat. Res. 142: 176-180.
8. Getts, R. C. and Stamato, T. D. (1994) Absence of a Ku-like DNA end binding activity in the xrs double-stranded DNA repair-deficient mutant. J. Biol. Chem. 269: 15981-15984.
9. Taccioli, G. E., Gottlieb, T. M., Blunt, T., Priestley, A., Demengeot, J., Mizuta, R., Lehman, A. R., Alt, F. W., Jackson, S. P. and Jeggo, P. A. (1994) Ku80: Product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 265: 1442-1445.
10. Smider, V., Rathmell, W. K., Lieber, M. R. and Chu, G. (1994) Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science 266: 288-291.
11. Rathmell, W. K. and Chu, G. (1994) A DNA end-binding factor involved in double-strand break repair and V(D)J recombination. Mol. Cell. Biol. 14: 4741-4748.
12. Finnie, N. J., Gottlieb, T. M., Blunt, T. P., Jeggo, A. and Jackson, S. P. (1995) DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA double-strand break repair. Proc. Natl. Acad. Sci. USA 92: 320-324.
13. Kirchgessner, C. U., Patil, C. K., Evans, J. W., Cuomo, C. A., Fried, L. M., Carter, T., Oettinger, M. A. and Brown, J. M. (1995) DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267: 1178-1183.
14. Blunt, T., Finnie, N. J., Taccioli, G. E., Smith, G. C. M., Demengeot, J., Gottlieb, T. M., Mizuta, R., Varghese, A. J., Alt, F. W., Jeggo, P. A. and Jackson, S. P. (1995) Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with murine scid mutation. Cell 80: 831-823.
15. Iliakis, G. (1988) Radiation-induced potentially lethal damage: DNA lesions susceptible to fixation. Int. J. Radiat. Biol. 53: 541-584.
16. Waldren, C. A. and Rasko, I. (1978) Caffeine enhancement of X-ray killing in cultured human and rodent cells. Radiat. Res. 73: 95-110.
17. Biedermann, K. A., Sun, J., Giaccia, A. J., Tosto, L. M. and Brown, J. M. (1991) scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc. Natl. Acad. Sci. USA 88: 1394-1397.
18. Nagasawa, H., Chen, D. J. and Strniste, G. F. (1989) Response of X-ray-sensitive CHO mutant cells to γ radiation. I. Effects of low dose rates and the process of repair of potentially lethal damage in G1 phase. Radiat. Res. 118: 559-567.
19. Iliakis, G. E. and Okayasu, R. (1990) Radiosensitivity throughout the cell cycle and repair of potentially lethal damage and DNA double-strand breaks in an X-ray-sensitive CHO mutant. Int. J. Radiat. Biol. 57: 1195-1211.
20. Komatsu, K., Ohta, T., Jinno, Y., Niikawa, N. and Okumura, Y. (1993) Functional complementation in mouse-human radiation hybrids assigns the putative murine scid gene to the pericentric region of human chromosome 8. Hum. Mol. Genet. 2: 1031-1034.
21. Okayasu, R. and Iliakis, G. (1993) Ionizing radiation induces two forms of interphase chromosome breaks in Chinese hamster ovary cells that rejoin with different kinetics and show different sensitivity to treatment in hypertonic medium or β-araA. Radiat. Res. 136: 262-270.
22. Gottlieb, T. M. and Jackson, S. P. (1993) The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen. Cell 72: 131-142.
23. Evans, J. W., Liu, X. F., Kirchgessner, C. U. and Martin Brown, J. (1996) Induction and repair of chromosome aberrations in scid cells measured by premature chromosome condensation. Radiat. Res. 145: 39-46.