C2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 12, 1996, Pages 2055-2069

  Qian, Xinhua ^a   Morís Varas, Francisco ^a   Fitzgerald, Michael C ^a   Wong, Chi Huey ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4,5,6 TETRAHYDROXYAZEPANE; 3,6 BIS(3 FLUOROBENZYL) 3,4,5,6 TETRAHYDROXY 1 METHYLAZEPANE; ALPHA GALACTOSIDASE; ALPHA GLUCOSIDASE; ALPHA LEVO FUCOSIDASE; ALPHA MANNOSIDASE; AZEPINE DERIVATIVE; BETA GALACTOSIDASE; BETA GLUCOSIDASE; GLYCOSIDASE; GLYCOSIDASE INHIBITOR; N ACETYL BETA GLUCOSAMINIDASE; POLYOL; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; 3,4,5,6-TETRAHYDROXYAZEPANE; ASPARTIC PROTEINASE; ENZYME INHIBITOR; FIV PROTEASE; IMINOSUGAR; ISOFAGOMINE; N BENZYL 3,4,5,6 TETRAHYDROXYAZEPANE; N-BENZYL-3,4,5,6-TETRAHYDROXYAZEPANE; PIPERIDINE DERIVATIVE;

ARTICLE; ASPERGILLUS NIGER; CATTLE; COMPUTER SIMULATION; CRYSTAL STRUCTURE; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FELINE IMMUNODEFICIENCY VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; KIDNEY; MOLECULAR DYNAMICS; NONHUMAN; PLANT; STEREOCHEMISTRY; YEAST; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ASPARTIC ENDOPEPTIDASES; AZEPINES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GLYCOSIDE HYDROLASES; HIV PROTEASE INHIBITORS; IMINO PYRANOSES; MODELS, MOLECULAR; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030299794     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(96)00218-0     Document Type: Article

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