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1
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0027407108
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Dominance and crypticity of T cell antigenic determinants
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Sercarz EE, Lehmann PV, Ametani Benichou G, Miller A, Moudqil K. Dominance and crypticity of T cell antigenic determinants. Annu Rev Immunol. 11:1993;729-766.
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Sercarz, E.E.1
Lehmann, P.V.2
Ametani Benichou, G.3
Miller, A.4
Moudqil, K.5
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2
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0029198108
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Alteration of signal transduction in T cells from cancer patients
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V.T. De Vita, S. Hellman, Rosenberg S.A. Phildelphia: JB Lippincott Company
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Ochoa A, Longo DL. Alteration of signal transduction in T cells from cancer patients. De Vita VT, Hellman S, Rosenberg SA. Important Advances in Oncology. 1995;43-54 JB Lippincott Company, Phildelphia.
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Important Advances in Oncology
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Ochoa, A.1
Longo, D.L.2
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3
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Tumor eradication by adoptive transfer of cytotoxic T lymphocytes
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Melief CJM. Tumor eradication by adoptive transfer of cytotoxic T lymphocytes. Adv Cancer Res. 58:1992;143-175.
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Adv Cancer Res
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Melief, C.J.M.1
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0029055849
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Induction of anti-self immunity to cure cancer
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Nanda Nk, Sercarz EE. Induction of anti-self immunity to cure cancer. Cell. 82:1995;13-17.
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Cell
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Nanda Nk1
Sercarz, E.E.2
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5
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0029078313
-
Synergy between T cell immunity and inhibition of paracrine stimulation causes tumor rejection
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of special interest. Paracrine factor produced by tumor cells counteracts tumor eradication by T lymphocytes. The factor attracts granulocytes that make the tumor cells grow faster, outsmarting the T lymphocytes
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Seung LP, Rowley DA, Dubey P, Schreiber H. Synergy between T cell immunity and inhibition of paracrine stimulation causes tumor rejection. of special interest Proc Natl Acad Sci USA. 92:1995;6254-6258 Paracrine factor produced by tumor cells counteracts tumor eradication by T lymphocytes. The factor attracts granulocytes that make the tumor cells grow faster, outsmarting the T lymphocytes.
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Proc Natl Acad Sci USA
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Seung, L.P.1
Rowley, D.A.2
Dubey, P.3
Schreiber, H.4
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6
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0030005902
-
Anti-angiogenic therapy of transgenic mice impairs de novo tumor growth
-
of special interest. Antiangiogenic therapy may eventually be used synergistically with T cell therapy. Who wants to try it first?
-
Parangi S, O'Reilly M, Christophori G, Holmgren L, Grosfeld J, Folkman J, Hanahan D. Anti-angiogenic therapy of transgenic mice impairs de novo tumor growth. of special interest Proc Natl Acad Sci USA. 93:1996;2002-2007 Antiangiogenic therapy may eventually be used synergistically with T cell therapy. Who wants to try it first?
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Proc Natl Acad Sci USA
, vol.93
, pp. 2002-2007
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Parangi, S.1
O'Reilly, M.2
Christophori, G.3
Holmgren, L.4
Grosfeld, J.5
Folkman, J.6
Hanahan, D.7
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7
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0028686018
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Prospects for T cell immunotherapy of tumors by vaccination with immunodominant and subdominant peptides
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Chichester: John Wiley & Sons
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Melief CJM, Kast WM. Prospects for T cell immunotherapy of tumors by vaccination with immunodominant and subdominant peptides. Vaccines against Virally Induced Cancers (Ciba Symposium 189). 1994;97-102 John Wiley & Sons, Chichester.
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Vaccines against Virally Induced Cancers (Ciba Symposium 189)
, pp. 97-102
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Melief, C.J.M.1
Kast, W.M.2
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8
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0029310528
-
T cell immunotherapy by adoptive transfer of cytotoxic T lymphocytes and by vaccination with minimal essential epitopes
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Melief CJM, Kast WM. T cell immunotherapy by adoptive transfer of cytotoxic T lymphocytes and by vaccination with minimal essential epitopes. Immunol Rev. 145:1995;167-177.
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(1995)
Immunol Rev
, vol.145
, pp. 167-177
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Melief, C.J.M.1
Kast, W.M.2
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9
-
-
0029053611
-
Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein: Coordinate up-regulation of peptide transporters and HLA class I antigen expression
-
of special interest. EBV LMP may restore some of the antigen processing and presentation defects in Burkitt's lymphoma cells
-
Rowe M, Khanna R, Jacob CA, Argaet V, Kelly A, Powis S, Belich M, Croom-Carter D, Lee S, Burrows SR, et al. Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein: coordinate up-regulation of peptide transporters and HLA class I antigen expression. of special interest Eur J Immunol. 25:1995;1374-1384 EBV LMP may restore some of the antigen processing and presentation defects in Burkitt's lymphoma cells.
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(1995)
Eur J Immunol
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, pp. 1374-1384
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Rowe, M.1
Khanna, R.2
Jacob, C.A.3
Argaet, V.4
Kelly, A.5
Powis, S.6
Belich, M.7
Croom-Carter, D.8
Lee, S.9
Burrows, S.R.10
-
10
-
-
0029003999
-
Inhibition of antigen processing by the internal repeat region of the EBV EBNA-1 antigen
-
of outstanding interest. A starting stratery of the viral gene product. Cis-acting failure of MHC class I processing and presentation of EBNA-1 CTL epitopes by an EBNA-1 internal repeat region
-
Levitskaya J, Coram M, Levitsky V, Imveh S, Steiger Wald-Mullen PM, Klein G, Kurilla MG, Masucci MG. inhibition of antigen processing by the internal repeat region of the EBV EBNA-1 antigen. of outstanding interest Nature. 375:1995;685-688 A starting stratery of the viral gene product. Cis-acting failure of MHC class I processing and presentation of EBNA-1 CTL epitopes by an EBNA-1 internal repeat region.
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(1995)
Nature
, vol.375
, pp. 685-688
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Levitskaya, J.1
Coram, M.2
Levitsky, V.3
Imveh, S.4
Steiger Wald-Mullen, P.M.5
Klein, G.6
Kurilla, M.G.7
Masucci, M.G.8
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11
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0029035637
-
*0201 binding peptides
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+ healthy donors
-
+ healthy donors.
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(1995)
J Immunol
, vol.154
, pp. 5934-5943
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Ressing, M.E.1
Sette, A.2
Brand, R.M.P.3
Rappert, J.4
Wentworth, P.A.5
Hartman, M.6
Oseroff, C.7
Grey, H.M.8
Melief, C.J.M.9
Kast, W.M.10
-
12
-
-
0028295047
-
A Role of HLA-A motifs in identification of potential CTL epitopes in human paillomavirus type 16 E6 and E7 proteins
-
Kast WM, Brandt RPM, Sidney J, Drifthout JW, Kubo RF, Grey HM, Melief CJM, Sette A. A Role of HLA-A motifs in identification of potential CTL epitopes in human paillomavirus type 16 E6 and E7 proteins. J Immunol. 152:1994;3904-3912.
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(1994)
J Immunol
, vol.152
, pp. 3904-3912
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Kast, W.M.1
Brandt, R.P.M.2
Sidney, J.3
Drifthout, J.W.4
Kubo, R.F.5
Grey, H.M.6
Melief, C.J.M.7
Sette, A.8
-
13
-
-
0030020476
-
*0201 restricted E7 encoded epitope
-
*0201-binding peptides. This demonstrates that such patients do not react to all possible viral epitopes and that vaccination might be beneficial for the large majority of patients
-
*0201-binding peptides. This demonstrates that such patients do not react to all possible viral epitopes and that vaccination might be beneficial for the large majority of patients.
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(1996)
Cancer Res
, vol.56
, pp. 582-588
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Ressing, M.E.1
Van Driel, W.2
Celis, E.3
Sette, A.4
Brandt, R.M.P.5
Hartman, M.6
Anholts, J.D.H.7
Schreuder, G.M.T.8
Ter Harmsel, W.B.9
Fleuren, G.J.10
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14
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-
0029924107
-
Human tumor antigens recognized by T lymphocytes
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of outstanding interest. One of the first clinical vaccination trials against a tumor associated self antigen shows that T cell tolerance can be broken by deliberate vaccination. No clinical benefit was observed in this study, however
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Boon T, Van der Bruggen P. Human tumor antigens recognized by T lymphocytes. of outstanding interest J Exp Med. 183:1995;725-729 One of the first clinical vaccination trials against a tumor associated self antigen shows that T cell tolerance can be broken by deliberate vaccination. No clinical benefit was observed in this study, however.
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(1995)
J Exp Med
, vol.183
, pp. 725-729
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Boon, T.1
Van der Bruggen, P.2
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15
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0029042336
-
Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia CEA vaccine
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of outstanding interest. One of the first clinical vaccination tirals against a tumor-associated self antigen shows that T cell tolerance can be broken by deliberate vaccination. No clinical benefit was observed in this study, however
-
Tsang KY, Zaremba S, Nieroda CA, Zhu MZ, Hamilton JM, Schlom J. Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia CEA vaccine. of outstanding interest J Natl Cancer Inst. 87:1995;982-993 One of the first clinical vaccination tirals against a tumor-associated self antigen shows that T cell tolerance can be broken by deliberate vaccination. No clinical benefit was observed in this study, however.
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(1995)
J Natl Cancer Inst
, vol.87
, pp. 982-993
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Tsang, K.Y.1
Zaremba, S.2
Nieroda, C.A.3
Zhu, M.Z.4
Hamilton, J.M.5
Schlom, J.6
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18
-
-
0028330866
-
In vitro generation of human CTLs specific for peptides derived from the HER-2/neu protooncogene protein
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Disis ML, Smith HW, Murphy AE, Chen W, Cheever MA. in vitro generation of human CTLs specific for peptides derived from the HER-2/neu protooncogene protein. Cancer Res. 54:1994;1071-1076.
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Cancer Res
, vol.54
, pp. 1071-1076
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Disis, M.L.1
Smith, H.W.2
Murphy, A.E.3
Chen, W.4
Cheever, M.A.5
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19
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0027303111
-
In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild type p53
-
Houbiers JGA, Nijman HW, Van der Burg SH, Drijfhout JW, Kenemans P, Van de Velde CJM, Brand A, Momberg F, Kast WM, Melief CJM. in vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild type p53. Immunology. 23:1993;2072-2077.
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Immunology
, vol.23
, pp. 2072-2077
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Houbiers, J.G.A.1
Nijman, H.W.2
Van der Burg, S.H.3
Drijfhout, J.W.4
Kenemans, P.5
Van de Velde, C.J.M.6
Brand, A.7
Momberg, F.8
Kast, W.M.9
Melief, C.J.M.10
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20
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0028178285
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P53, a potential target for tumor-directed T cells
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Nijman HW, Van der Burg SH, Vierboom MPM, Houbiers JGA, Kast WM, Melief CJM. p53, a potential target for tumor-directed T cells. Immunol Lett. 40:1994;171-178.
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Immunol Lett
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Nijman, H.W.1
Van der Burg, S.H.2
Vierboom, M.P.M.3
Houbiers, J.G.A.4
Kast, W.M.5
Melief, C.J.M.6
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22
-
-
0029967001
-
+ T cells elicited by primary in vitro immunization with a BCR-ABL breakpoint peptide
-
of outstanding interest
-
+ T cells elicited by primary in vitro immunization with a BCR-ABL breakpoint peptide. of outstanding interest Blood. 1996; First demonstration that T cells directed against a chromosomal breakpoint peptide recognize human cancer cells.
-
(1996)
Blood
-
-
Ten Bosch, G.J.A.1
Joosten, A.M.2
Kessler, J.H.3
Melief, C.J.M.4
Leeksma, O.C.5
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23
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85099488659
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A synthetic peptide derived from the tumor-associated protein mdm2 can stimulate autoreactive, high avidity CTLs that recognise naturally processed protein
-
of outstanding interest
-
Dahl AM, Beverly P, Stauss HJ. A synthetic peptide derived from the tumor-associated protein mdm2 can stimulate autoreactive, high avidity CTLs that recognise naturally processed protein. of outstanding interest J Immunol. 1996; Autoreactive CTLs raised in mice against an mdm2 peptide lyse cells bearing processed mdm2.
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(1996)
J Immunol
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-
Dahl, A.M.1
Beverly, P.2
Stauss, H.J.3
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24
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-
0029608719
-
Targeting p53 as a general tumor antigen
-
of outstanding interest. CTLs raised against in HLA-A2-transgenic mice against a wild-type p53 peptide can lyse human tumor cells
-
Theobald M, Biggs J, Dittmer D, Levine AJ, Sherman LA. Targeting p53 as a general tumor antigen. of outstanding interest Proc Natl Acad Sci USA. 92:1995;11993-11997 CTLs raised against in HLA-A2-transgenic mice against a wild-type p53 peptide can lyse human tumor cells.
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(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 11993-11997
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-
Theobald, M.1
Biggs, J.2
Dittmer, D.3
Levine, A.J.4
Sherman, L.A.5
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25
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0029866282
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Human minor histocompatibility antigens
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Goulmy E. Human minor histocompatibility antigens. Curr Opin Immunol. 8:1996;75-81.
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(1996)
Curr Opin Immunol
, vol.8
, pp. 75-81
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Goulmy, E.1
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26
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0029027351
-
Identification of graft versus host disease associated human minor histocompatibility antigen
-
of outstanding interest. First molecular identification of a human minor histocompatibility antigen by tandem mass spectrometry
-
Den Haan JMM, Sherman NE, Blokland E, Huckzo E, Koning F, Drifthout JW, Shabanowitz J, Hunt DF, Engelhard VH, Goulmy E. Identification of graft versus host disease associated human minor histocompatibility antigen. of outstanding interest Science. 268:1995;1478-1480 First molecular identification of a human minor histocompatibility antigen by tandem mass spectrometry.
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(1995)
Science
, vol.268
, pp. 1478-1480
-
-
Den Haan, J.M.M.1
Sherman, N.E.2
Blokland, E.3
Huckzo, E.4
Koning, F.5
Drifthout, J.W.6
Shabanowitz, J.7
Hunt, D.F.8
Engelhard, V.H.9
Goulmy, E.10
-
27
-
-
0029092140
-
Human H-Y: A male-specific histocompatibility antigen derived from the SMCY protein
-
of special interest. Second human minor histocompatibility antigen characterized molecularly: the long sought after 'male-antigen'. Human minor H antigens could serve as target antigent for cancer therapy under various circumstances
-
Wang W, Meadows LR, Den Haan JMM, Sherman NE, Chen Y, Blokland E, Shabanowitz J, Agulnik AI, Hendrikson RC, Bishop CE, et al. Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein. of special interest Science. 269:1995;1588-1590 Second human minor histocompatibility antigen characterized molecularly: the long sought after 'male-antigen'. Human minor H antigens could serve as target antigent for cancer therapy under various circumstances.
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(1995)
Science
, vol.269
, pp. 1588-1590
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-
Wang, W.1
Meadows, L.R.2
Den Haan, J.M.M.3
Sherman, N.E.4
Chen, Y.5
Blokland, E.6
Shabanowitz, J.7
Agulnik, A.I.8
Hendrikson, R.C.9
Bishop, C.E.10
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28
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85046111964
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Functions of the proteasome in antigen presentation
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Goldberg AL, Gaczynska M, Grant E, Michalik M, Rock KL. Functions of the proteasome in antigen presentation. Cold Spring Harb Symp Quant Biol. 50:1995;47-61.
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(1995)
Cold Spring Harb Symp Quant Biol
, vol.50
, pp. 47-61
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Goldberg, A.L.1
Gaczynska, M.2
Grant, E.3
Michalik, M.4
Rock, K.L.5
-
29
-
-
0028968217
-
Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules
-
of special interest. This paper, along with [30], documents that CTL epitope hierarchy is strongly influenced by proteasome cleavage patterns
-
Niedermann G, Butz S, Ihlenfeldt HG, Grimm R, Lucchiari M, Hoschützki H, Jung G, Masier B, Eichmann K. Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules. of special interest Immunity. 2:1995;289-299 This paper, along with [30], documents that CTL epitope hierarchy is strongly influenced by proteasome cleavage patterns.
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(1995)
Immunity
, vol.2
, pp. 289-299
-
-
Niedermann, G.1
Butz, S.2
Ihlenfeldt, H.G.3
Grimm, R.4
Lucchiari, M.5
Hoschützki, H.6
Jung, G.7
Masier, B.8
Eichmann, K.9
-
30
-
-
0028817874
-
The cleavage preference of the proteasome governs the yield of antigenic peptides
-
of special interest. See annotation [29]
-
Eggers M, Boes-Fabian B, Ruppert T, Kloetzel PM, Koszinowski UH. The cleavage preference of the proteasome governs the yield of antigenic peptides. of special interest J Exp Med. 182:1995;1865-1870 See annotation [29].
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(1995)
J Exp Med
, vol.182
, pp. 1865-1870
-
-
Eggers, M.1
Boes-Fabian, B.2
Ruppert, T.3
Kloetzel, P.M.4
Koszinowski, U.H.5
-
31
-
-
16044372545
-
A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation
-
Demonstrating that a virus-encoded dominant CTL epitope in a tumor can be destroyed prematurely by mutation at a single amino acid position in the epitope that results accelerated proteasomal degradation.
-
Ossendorp F, Eggers M, Neisig A, Ruppert T, Groettrap M, Sijts A, Mengedé E, Kloetzel PM, Neafjes J, Koszinowski UH, Melief CJM. A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation of outstanding interest Immunity. 1996; Demonstrating that a virus-encoded dominant CTL epitope in a tumor can be destroyed prematurely by mutation at a single amino acid position in the epitope that results accelerated proteasomal degradation.
-
(1996)
Immunity
-
-
Ossendorp, F.1
Eggers, M.2
Neisig, A.3
Ruppert, T.4
Groettrap, M.5
Sijts, A.6
Mengedé, E.7
Kloetzel, P.M.8
Neafjes, J.9
Koszinowski, U.H.10
Melief, C.J.M.11
-
32
-
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0028829908
-
Major difference in TAP dependent translocation of MHC presentable peptides and the effect of flanking sequences
-
of special interest. Demonstration that TAP-dependent translocantion can sometimes depend on amino acids flanking the actual MHC binding epitope
-
Neisig A, Roelse J, Sijts AJAM, Ossendorp F, Eeltkamp MCW, Kast WM, Melief CJM, Neefjes JJ. Major difference in TAP dependent translocation of MHC presentable peptides and the effect of flanking sequences. of special interest J Immunol. 154:1995;1273-1276 Demonstration that TAP-dependent translocantion can sometimes depend on amino acids flanking the actual MHC binding epitope.
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(1995)
J Immunol
, vol.154
, pp. 1273-1276
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-
Neisig, A.1
Roelse, J.2
Sijts, A.J.A.M.3
Ossendorp, F.4
Eeltkamp, M.C.W.5
Kast, W.M.6
Melief, C.J.M.7
Neefjes, J.J.8
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34
-
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0026057983
-
Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with an unbound peptide
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Kast WM, Roux L, Curren J, Blom HJJ, Voordouw AC, Meloen RH, Kolakovsky D, Melief CJM. Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with an unbound peptide. Proc Natl Sci USA. 88:1991;2283-2287.
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(1991)
Proc Natl Sci USA
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, pp. 2283-2287
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Kast, W.M.1
Roux, L.2
Curren, J.3
Blom, H.J.J.4
Voordouw, A.C.5
Meloen, R.H.6
Kolakovsky, D.7
Melief, C.J.M.8
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35
-
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0027480311
-
Strict peptide length is not required for the induction of the cytotoxic T lymphocyte-mediated antiviral protection by peptide vaccination
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Kast WM, RMP Brandt, Melief CJM. Strict peptide length is not required for the induction of the cytotoxic T lymphocyte-mediated antiviral protection by peptide vaccination. Eur J Immunol. 23:1993;1189-1192.
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(1993)
Eur J Immunol
, vol.23
, pp. 1189-1192
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Kast, W.M.1
RMP Brandt2
Melief, C.J.M.3
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36
-
-
0028075608
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The MHC class I restricted T-cell response to Sendai virus in C57BL/6 mice: A single immunodominant epitope elicits an extremely diverse repertoire of T-cells
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Cole GA, Hogg TL, Woodland DI. The MHC class I restricted T-cell response to Sendai virus in C57BL/6 mice: a single immunodominant epitope elicits an extremely diverse repertoire of T-cells. Int Immunol. 6:1994;1767-1775.
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(1994)
Int Immunol
, vol.6
, pp. 1767-1775
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Cole, G.A.1
Hogg, T.L.2
Woodland, D.I.3
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37
-
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0027320440
-
Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells
-
Feltkamp MCW, Smits HL, Vierboom MPM, Minnaar RP, De Jongh BM, Drijfhout JW, Ter Schegget J, Melief CJM, Kast WM. Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells. Eur J Immunol. 23:1993;2242-2249.
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(1993)
Eur J Immunol
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, pp. 2242-2249
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Feltkamp, M.C.W.1
Smits, H.L.2
Vierboom, M.P.M.3
Minnaar, R.P.4
De Jongh, B.M.5
Drijfhout, J.W.6
Ter Schegget, J.7
Melief, C.J.M.8
Kast, W.M.9
-
38
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0028326766
-
CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma
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Mandelboim O, Berke G, Fridkin M, Feldman M, Eisenstein M, Eisenbach L. CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma. Nature. 369:1994;67-71.
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(1994)
Nature
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, pp. 67-71
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Mandelboim, O.1
Berke, G.2
Fridkin, M.3
Feldman, M.4
Eisenstein, M.5
Eisenbach, L.6
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39
-
-
0028884728
-
Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides
-
of outstanding interest. The peptide identified in [38] can be used as a peptide vaccine to cause regression of metastatic tumors
-
Mandelboim O, VAdai E, Fridkin M, Katz-Hillel A, Feldman M, Berke G, Eisenbach L. Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides. of outstanding interest Nat Med. 1:1995;1179-1183 The peptide identified in [38] can be used as a peptide vaccine to cause regression of metastatic tumors.
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(1995)
Nat Med
, vol.1
, pp. 1179-1183
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-
Mandelboim, O.1
VAdai, E.2
Fridkin, M.3
Katz-Hillel, A.4
Feldman, M.5
Berke, G.6
Eisenbach, L.7
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40
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0028876917
-
Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection I: Induction of a primary cytotoxic T lymphocyte response in humans
-
of outstanding interest. First application of an MHC class I binding peptide vaccine in humans. An HBV-derived peptide induces a vigorous CTL response in healthy volunteers capable of lysing HBV-infected target cells
-
dVitiello A, Ishioka G, Grey HM, Rose R, Farness P, LaFond R, Yuan L, Chisari FV, Urze J, Barholomeuz R, Chestnut RW. Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection I: induction of a primary cytotoxic T lymphocyte response in humans. of outstanding interest J Clin Invest. 95:1995;341-345 First application of an MHC class I binding peptide vaccine in humans. An HBV-derived peptide induces a vigorous CTL response in healthy volunteers capable of lysing HBV-infected target cells.
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(1995)
J Clin Invest
, vol.95
, pp. 341-345
-
-
DVitiello, A.1
Ishioka, G.2
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41
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0025836774
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Fine specificity of cytotoxic T lymphocytes primed in vivo either with virus or synthetic lipopeptide vaccine or primed in vitro with peptide
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Schild H, Norma M, Deres K, Falk K, Rötschke O, Wiesmüller KH, Jung G, Rammensee HG. Fine specificity of cytotoxic T lymphocytes primed in vivo either with virus or synthetic lipopeptide vaccine or primed in vitro with peptide. J Exp Med. 174:1991;1665-1669.
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42
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0029006188
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T cell priming versus T-cell tolerance induced by synthetic peptides
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of outstanding interest. High dose peptide in IFA, repeatedly injected intraperitoneally in mice, cause tolerance rather than immunity
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Aichele P, Brduscha-Riem, Zinkernagel RM, Hengartner H, Pricher H. T cell priming versus T-cell tolerance induced by synthetic peptides. of outstanding interest J Exp Med. 182:1995;261-266 High dose peptide in IFA, repeatedly injected intraperitoneally in mice, cause tolerance rather than immunity.
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Aichele, P.1
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Aichele P, Kybarz D, Ohashi PS, Odermatt B, Zinkernagel RM, Hengartner H, Pircher H. Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model. Proc Natl Acad Sci USA. 91:1994;444-448.
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44
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0024466940
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Eradication of adenovirus E1 induced tumors by E1A-specific cytotoxic T lymphocytes
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Kast WM, Offringa R, Peters PJ, Voordouw A, Meloen RH, Van der Eb AJ, Melief CJM. Eradication of adenovirus E1 induced tumors by E1A-specific cytotoxic T lymphocytes. Cell. 59:1989;603-614.
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45
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0028942630
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An adenovirus type 5 early region 1 B-encoded CTL epitope mediating tumr eradication by CTL clones is down-modulated by an activated ras oncogene
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Toes REM, Offringa R, Blom RJJ, Brandt RMP, Van der Eb AJ, Melief CJM, Kast WM. An adenovirus type 5 early region 1 B-encoded CTL epitope mediating tumr eradication by CTL clones is down-modulated by an activated ras oncogene. J Immunol. 154:1995;3396-3405.
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46
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0029935569
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Functional deletion of tumor-specific CTLs induced by peptide vaccination can lead to the inability to reject tumours
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of outstanding interest. CTL tolerance associated with enhanced tumor outgrowth can also be achieved by a single injection of low dose immunodominant peptide in IFA Excellent protection is achieved if the same epitope is presented by Ads
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Toes REM, Blom RJJ, Offringa R, Kast WM, Melief CJM. Functional deletion of tumor-specific CTLs induced by peptide vaccination can lead to the inability to reject tumours. of outstanding interest J Immunol. 156:1996;3911-3918 CTL tolerance associated with enhanced tumor outgrowth can also be achieved by a single injection of low dose immunodominant peptide in IFA Excellent protection is achieved if the same epitope is presented by Ads.
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Toes, R.E.M.1
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47
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0029798058
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Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction
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Toes REM, Offringa R, Blom RJJ, Melief CJM, Kast WM. Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction. of special interest Proc Natl Acad Sci USA. 1996; Same results as in [49] but with a different CTL epitope.
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Proc Natl Acad Sci USA
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Toes, R.E.M.1
Offringa, R.2
Blom, R.J.J.3
Melief, C.J.M.4
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48
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of outstanding interest Matzinger P. Tolenrance, danger, and the extended family. Annu Rev Immunol. 12:1994;991-1045.
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Matzinger, P.1
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49
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0030048724
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Peptide pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity
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of special interest. Dendritic cells are a potent delivery system in CTL epitope vaccination
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of special interest Celluzzi CM, Mayordomo JI, Storkus WJ, Lotze MT, Falo LD. Peptide pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity. J Exp Med. 183:1996;283-287 Dendritic cells are a potent delivery system in CTL epitope vaccination.
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Celluzzi, C.M.1
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Lotze, M.T.4
Falo, L.D.5
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50
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0028793675
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Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic anti-lumour immunity
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of outstanding interest. Peptide-pulsed DCs can even eradicate (small) established tumours
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of outstanding interest Mayordomo JI, Zorma T, Storkus WJ, Zitvogel L, Celluzzi C, Falo LD, Melief CJM, Ildstad ST, Kast WM, Deleo AB, Lotze MT. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic anti-lumour immunity. Nat Med. 1:1995;1297-1302 Peptide-pulsed DCs can even eradicate (small) established tumours.
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Mayordomo, J.I.1
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Falo, L.D.6
Melief, C.J.M.7
Ildstad, S.T.8
Kast, W.M.9
Deleo, A.B.10
Lotze, M.T.11
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51
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0030058647
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Therapy of murine tumours with peptide-pulsed dendritic cells: Dependence on T-cells, B7 costimulation, and T helper cell 1-associated cytokines
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of special interest. Nonidentified peptides, eluted from MHC class I molecules on tumors at low pH, can serve as an efficient preventive vaccine, if delivered on activated DCs
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of special interest Zitvogel L, Mayordomo JI, Tjandrawan T, Deleo AB, Clarke MR, Lotze MT, Storkus WJ. Therapy of murine tumours with peptide-pulsed dendritic cells: dependence on T-cells, B7 costimulation, and T helper cell 1-associated cytokines. J Exp Med. 183:1996;87-97 Nonidentified peptides, eluted from MHC class I molecules on tumors at low pH, can serve as an efficient preventive vaccine, if delivered on activated DCs.
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J Exp Med
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Zitvogel, L.1
Mayordomo, J.I.2
Tjandrawan, T.3
Deleo, A.B.4
Clarke, M.R.5
Lotze, M.T.6
Storkus, W.J.7
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53
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0029911677
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Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccines
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of outstanding interest. Both mutant and wild-type p53 MHC class I binding peptides delivered on DCs protect against tumor outgrowth
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of outstanding interest Mayordomo JI, Loftus DJ, Sakamoto H, De Cesare CM, Appasany PM, Lotze MT, Storkus WJ, Appella E, Deleo AB. Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccines. J Exp Med. 183:1996;1357-1365 Both mutant and wild-type p53 MHC class I binding peptides delivered on DCs protect against tumor outgrowth.
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Mayordomo, J.I.1
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Sakamoto, H.3
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Appasany, P.M.5
Lotze, M.T.6
Storkus, W.J.7
Appella, E.8
Deleo, A.B.9
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54
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0029642252
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Tumore regression responses in melanoma patients treated with a peptide encoded by gene MAGE-3
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of outstanding interest. Free peptides delivered without adjuvant to patients with metastatic melanoma cause complete remission in two patients
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of outstanding interest Marchand M, Wegmants P, Rankin E, Arienti F, Belli F, Parmiani G, Cascinelli N, Bourlond A, VanWijck R, Humblet Y, et al. Tumore regression responses in melanoma patients treated with a peptide encoded by gene MAGE-3. Int CAncer. 63:1995;883-885 Free peptides delivered without adjuvant to patients with metastatic melanoma cause complete remission in two patients.
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Marchand, M.1
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55
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Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells
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Mukherji B, Chakraborty NG, Yamasaki S, Okino T, Yamase H, Sporn JR, Kurtzman SK, Ergrin MT, Ozols J, Meehan J, Mauri F. Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells. Proc Natl Acad Sci USA. 92:1995;8078-8082.
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Mukherji, B.1
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56
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Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor associated antigen
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Wang M, Bronte V, Chen PW, Gritz L, Panicali D, Rosenberg SA, Restifo NP. Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor associated antigen. J Immunol. 154:1995;4685-4692.
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Wang, M.1
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57
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0028930719
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Minimal determinant expressed by recombinant vaccinia virus elicits therapeutic anti tumor cytolytic T lymphocyte responses
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McCabe BJ, Irvine KR, Nishimura MI, Yang JC, Spiess PJ, Shulman EP, Rosenberg SA, Restifo NP. Minimal determinant expressed by recombinant vaccinia virus elicits therapeutic anti tumor cytolytic T lymphocyte responses. Cancer Res. 55:1995;1741-1747.
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McCabe, B.J.1
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Rosenberg, S.A.7
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58
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Antigen processing in vivo and the elicitation of primary CTL responses
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+ CTLs.
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Restifo, N.P.1
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Irvine, K.R.3
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Anderson, R.W.6
Eisenlohr, L.C.7
Rosenberg, S.A.8
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59
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A 'string of-beads' vaccine, comprising linked minigenes, confers protection form lethal-dose virus challenge
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Whitton JL, Sheng N, Oldstone MBA, McKee TA. A 'string of-beads' vaccine, comprising linked minigenes, confers protection form lethal-dose virus challenge. J Virol. 67:1993;348-352.
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60
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Anti-viral protective immunity induced by major histocompatibility complex class I molecule restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins
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of special interest. First demonstration of protective effect of CTL epitope string-of-beads protein construct
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of special interest Weidt G, Deppert W, Buchhop S, Dralle H, Lehmann-Grube F. Anti-viral protective immunity induced by major histocompatibility complex class I molecule restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins. J Virol. 69:1995;2654-2658 First demonstration of protective effect of CTL epitope string-of-beads protein construct.
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Weidt, G.1
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65
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0029783148
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of special interest Toes REM, Blom RJJ, Van der Voort EIH, Offringa R, Melief CJM, Kast WM. Protective anti-tumor immunity induced by immunization with completely allogeneic tumor cells. Cancer Res. 1996; Protective vaccination induced by immunication with completely allogeneic tumor cells is associated with CTL memory to viral antigens processed by host APCs.
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Toes, R.E.M.1
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Offringa, R.4
Melief, C.J.M.5
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Pardoll, D.M.1
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