Ca2+ signaling and intracellular Ca2+ binding proteins

Journal of Biochemistry

Volumn 120, Issue 4, 1996, Pages 685-698

  Niki, Ichiro ^a   Yokokura, Hisayuki ^a   Sudo, Toshiki ^a   Kato, Masumi ^a   Hidaka, Hiroyoshi ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Annexins; C2 region proteins; Ca2+ signaling; Ca2+ storage proteins; EF hand proteins

Indexed keywords

CALCIUM BINDING PROTEIN; CALCIUM ION; PHOSPHOLIPID BINDING PROTEIN; TROPONIN C; ANNEXIN; CALCIUM; CALMODULIN; CALSEQUESTRIN; PHOSPHOLIPID;

CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL COMMUNICATION; CELLULAR DISTRIBUTION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; CELL; CHEMISTRY; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE; ULTRASTRUCTURE;

ANIMALS; ANNEXINS; CALCIUM; CALCIUM-BINDING PROTEINS; CALMODULIN; CALSEQUESTRIN; CELLS; HUMANS; PHOSPHOLIPIDS; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

EID: 0030254309     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a021466     Document Type: Review

References (222)

1. Kretsinger, R.H. (1980) Structure and evolution of calcium-modulated proteins. CSC Crit. Rev. Biochem. 8, 119-174
2. Moncrief, N.D., Kretsinger, R.H., and Goodman, M. (1990) Evolution of EF-hand calcium-modulated proteins. I. Relationships based on amino acid sequences. J. Mol. Evol. 30, 522-562
3. Nakayama, S., Moncrief, N.D., and Kretsinger, R.H. (1992) Evolution of EF- and calcium-modulated proteins. II. Domains of several subfamilies have diverse evolutionary histories. J. Mol. Evol. 34, 416-448
4. Ikura, M. (1996) Calcium binding and conformational response in EF-hand proteins. Trends Biol. Sci. 21, 14-17
5. Rogers, J.H. (1987) Calretinin: A gene for a novel calcium-binding protein expressed principally in neurons, J. Cell Biol. 105, 1343-1353
6. Takagi, T., Nojiri, M., Konishi, K., Maruyama, K., and Nonomura, Y. (1986) Amino acid sequence of vitamin D-dependent calcium binding protein from bovine cerebellum. FEES Lett. 201, 41-45
7. Luan, Y., Matsuura, I., Yazawa, M., Nakamura, T., and Yagi, K. (1987) Yeast calmodulin: Structural and functional differences compared with vertebrate calmodulin. J. Biochem. 102, 1531-1537
8. Gerke, V. and Weber, K. (1985) The regulatory chain in the p36-kD substrate complex of viral tyrosine- specific protein kinases is related in sequence to the S-100 protein of glial cells. EMBO J. 4, 2917-2920
9. Farah, C.S. and Reinach, F.C. (1995) The troponin complex and regulation of muscle contraction. FASEB J. 9, 755-767
10. Kakiuchi, S., Yamazaki, R., and Nakajima, H. (1970) Properties of a heat-stable phosphodiesterase activating factor isolated from brain extract. Proc. Jpn. Acad. 48B, 587-592
11. Kakiuchi, S. and Yamazaki, R. (1970) Calcium dependent phosphodiesterase activity and its activating factor (PAF) from brain. Studies on cyclic 3′,5′-nucleotide phosphodiesterase (III). Biochem. Biophys. Res. Commun. 41, 1104-1110
12. Cheung, W.Y. (1970) Cyclic 3′,5′-nucleotide phosphodiesterase. Demonstration of an activator. Biochem Biophys. Res. Commun. 38, 533-538
13. James, P., Vorherr, T., and Carafoli, E. (1995) Calmodulin-binding domains: Just two faced or multi-faced? Trends Biol. Sci. 20, 38-42
14. 2+ binding sites. J. Biol. Chem. 268, 20096-20104
15. Crivici, A. and Ikura, M. (1995) Molecular and structural basis of target recognition by calmodulin. Annu. Rev, Biophys, Biomol. Struct. 24, 85-116
16. Means, A.B. (1994) Calcium, calmodulin and cell cycle regulation. FEES Lett. 347, 1-4
17. Means, A.R., Tash, J.S., and Chafouleas, J.G. (1982) Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells. Physiol, Rev. 62, 1-39
18. Ohya, Y. and Anraku, Y. (1992) Yeast calmodulin: Structural and functional elements essential for the cell cycle. Cell Calcium 13, 445-455
19. 2+/calmodulin-dependent protein kinase : Domain structure and regulation. Trends Biochem. SCi. 14, 62-66
20. Walaas, S.I. and Greengard, P. (1991) Protein phosphorylation and neuronal function. Pharmacol. Rev. 43, 299-349
21. Nairn, A.C. and Picciotto, M.R. (1994) Calcium/calmodulin-dependent protein kinases. Cancer Biol. 15, 295-303
22. Dabrowska, R., Aromatorio, D., Sherry, J.M.F., and Hartshorne, D. J. (1978) Modulator protein as a component of the myosin light chain kinase from chicken gizzard. Biochemistry 17, 253-258
23. 2+/calmodulin-dependent protein kinase V and I may form a family of isoforms. Biochem. Biophys. Res. Commun. 201, 1561-1566
24. 2+/calmodulin-dependent protein kinase kinase cascade. Biochem. Biophys. Res. Commun. 203, 694-701
25. 2+/ calmodulin-dependent protein kinase IV. J. Biol. Chem. 269, 28640-28647
26. 2+Vcalmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinases. J. Biol. Chem. 270, 19320-19324
27. Hidaka, H., Asano, M., Iwadare, S., Matsumoto, I., Totsuka, T., and Aoki, N. (1978) A novel vascular relaxing agent, N-(6-aminohexyl)-5-chloro-l-naphthalenesulfonamide which affects vascular smooth muscle actomyosin. J. Pharmacol. Exp. Ther. 207, 8-15
28. 2+ / calmodulin-dependent protein kinase II. J. Biol. Chem. 265, 4315-4320
29. Hidaka, H. and Yokokura, H. (1996) Molecular and cellular pharmacology of a calcium/calmodulin-dependent protein kinase II (CaM kinase II) inhibitor, KN-62, and proposal of CaM kinase phosphorylation cascades. Adv. Pharmacol 36, 193-219
30. Hidaka, H. and Kobayashi, R. (1993) Use of protein (serine/ threonine) kinase activators and inhibitors to study protein phosphorylation in Protein Phosphorylation, a Practical Approach (Hardie, D.G., ed.) pp. 87-107, Oxford University Press, New York
31. Tanaka, T. and Hidaka, H. (1980) Hydrophobic regions function in calmodulin-enzyme(s) interactions. J. Biol. Chem. 266, 11078-11080
32. Serratosa, J., Pujol, M.J., Bachs, O., and Carafoli, E. (1988) Rearrangement of nuclear calmodulin during proliferative liver cell activation. Biochem. Biophys. Res. Commun. 160, 1162-1169
33. Wong, E.C.C., Saffitz, J.E., and Mcdonald, J.M. (1991) Association of calmodulin with isolated nuclei from rat hepatocytes. Biochem. Biophys. Res. Commun. 181, 1548-1556
34. Bachs, O., Agell, N., and Carafoli, E. (1994) Calmodulin and calmodulin-binding proteins in the nucleus. Cell Calcium 16, 289-296
35. 2+-regulated dynamic compartmentalization of calmodulin in living smooth muscle cells. J. Biol. Chem. 270, 21532-21538
36. Tan, J.L., Ravid, S., and Spudich, J.A. (1992) Control of nonmuscle myosins by phosphorylation. Annu. Rev. Biochem. 61, 721-759
37. Kanda, K., Sobue, K., and Kakiuchi, S. (1985) Phosphorylation of myosin light chain and the actin-activated ATPase activity of adrenal medullary myosin. J. Biochem. 97, 961-964
38. Kumakura, K., Sasaki, K., Sakurai, T., Ohara-Imaizumi, M., Misonou, H., Nakamura, S., Matsuda, Y., and Nonomura, Y. (1994) Essential role of myosin light chain kinase in the mechanism for MgATP-dependent priming of exocytosis in adrenal chromaffin cells. J. Neurosci. 14, 7695-7703
39. Lee, V.D. and Huang, B. (1993) Molecular cloning and centrosomal localization of human caltractin, Proc. Natl. Acad. Sci. USA 90, 11039-11043
40. 2+-binding protein: Homology in its protein sequence with calmodulin and the yeast CDC31 gene product. J. Cell Biol. 107, 133-140
41. Klee, C.B., Draetta, G.F., and Hubbard, M.J. (1988) Calcineurin. Adv. Enzymol. 61, 149-200
42. Perrino, B.A., Ng, L.Y., and Soderling, T.R. (1995) Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin. J. Biol. Chem. 270, 340-346
43. Kunz, J. and Hall, M.N. (1993) Cyclosporin A, FK506 and rapamycin: More than just immunosuppression, Trends Biochem. Sci. 18, 334-338
44. Milan, D., Griffith, J., Su, M., Price, E.R., and McKeon, F. (1994) The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation. Cell 79, 437-447
45. Sorimachi, H., Imajoh, S., Emori, Y., Kawasaki, H., Ohno, S., Minami, Y., and Suzuki, K. (1989) Molecular cloning of a novel mammalian calcium-dependent protease distinct from both mand μ -types. Specific expression of the mRNA in skeletal muscle. J. Biol. Chem. 284, 20106-20111
46. Suzuki, K. (1987) Calcium activated neutral pro tease: domain structure and activity regulation. Trends Biochem. Sci. 12, 103-105
47. Murachi, T. (1989) Intracellular regulatory system involving calpain and calpastatin. Biochem. Int. 18, 263-294
48. Saido, T.C., Sorimachi, H., and Suzuki, K. (1994) Calpain: New perspectives in molecular diversity and physiological-pathological involvement. FASEB J. 8, 814-822
49. Kretsinger, R.H. and Nockolds, C.E. (1973) Carp muscle calcium-binding protein. II. Structure determination and general description. J. Biol. Chem. 248, 3313-3326
50. Mutus, B., Karuppiah, N., Sharma, R.K., and MacManus, J.P. (1985) The differential stimulation of brain and heart cyclic-AMP phosphodiesterase by oncomodulin, Biochem. Biophys. Res. Commun. 131, 500-506
51. MacManus, J.P. (1979) Occurrence of a low-molecular-weight calcium-binding protein in neoplastic liver. Cancer Res, 39, 3000-3005
52. MacManus, J.P., Whitfteld, J.F., Boynton, A.L., Durkin, J.P., and Swierenga, S.H.H. (1982) Oncomodulin-a widely distributed, tumour-specific, calcium-binding protein. Oncodeu. Biol. Med. 3, 79-90
53. MacManus, J.P., Brewer, L.M., and Whitfield, J.F. (1985) The widely-distributed tumour protein, oncomodulin is a normal constituent of human and rodent placentas. Cancer Lett. 27, 145-151
54. Inouye, S., Noguchi, M., Sakaki, Y., Takagi, Y., Miyata, T., Iwanaga, S., Miyata, T., and Tsuji, F.I. (1985) Cloning and sequence analysis of cDNA for the luminescent protein aequorin. Proc. Natl. Acad. Sci. USA 82, 3154-3158
55. Shimomura, O., Johnson, F.H., and Saiga, Y. (1962) Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan, Aequorea, J. Cell Comp. Physiol. 59, 223-239
56. Ridgway, E.B. and Ashley, C.C. (1967) Calcium transients in single muscle fibers. Biochem. Biophys. Res. Commun. 29, 229-234
57. Ridgway, E.B., Gilkey, J.C., and Jaffe, L.F. (1977) Free calcium increases explosively in activating medaka eggs. Proc. Natl. Acad. Sci. USA 74, 623-627
58. Nakatani, K. and Yan, K.-W. (1988) Calcium and light adaptation in retinal rods and cones. Nature 334, 69-71
59. Matthews, H.R., Murphy, R.L.W., Fain, G.L., and Lamb, T.D. (1988) Photoreceptor light adaptation is mediated by cytoplasmic calcium concentration. Nature 334, 67-69
60. 2+ was withdrawn (see Hurley, J.B., Dizhoor, A.M., Ray, S., and Stryer, L. (1993) Science 260, 740.)]
61. 2+ was withdrawn (see Hurley, J.B., Dizhoor, A.M., Ray, S., and Stryer, L. (1993) Science 260, 740.)]
62. Kawamura, S. (1993) Rhodopsin phosphorylation as a mechanism of cyclic GMP phosphodiesterase regulation by S-modulin. Nature 362, 855-657
63. Kawamura, S., Hisatomi, O., Kayada, S., Tokunaga, F., and Kuo, C.-H. (1993) Recoverin has S-modulin activity in frog rods. J. Biol. Chem. 268, 14579-14582
64. Gorodovikova, E.N., Gimelbrant, A.A., Senin, I.I., and Philippov, S.P.P. (1994) Recoverin mediates the calcium effect upon rhodopsin phosphorylation and cGMP hydrolysis in bovine retina rod cells. FEES Lett. 349, 187-190
65. Klenchin, V.A., Calvert, P.D., and Bownds, M.D. (1995) Inhibition of rhodopsin kinase by recoverin. Further evidence for a negative feedback system in phototransduction. J. Biol. Chem. 270, 16147-16152
66. De Castro, E., Nef, S., Fiumelli, H., Lenz, S.E., Kawamura, S., and Nef, P. (1995) Regulation of rhodopsin phosphorylation by a family of neuronal calcium sensors. Biochem. Biophys. Res. Commun. 216, 133-140
67. 2+-dependent interaction of recoverin with rhodopsin kinase. J. Biol. Chem. 270, 18060-18066
68. Nakano, A., Terasawa, M., Watanabe, M., Usuda, N., Monta, T., and Hidaka, H. (1992) Neurocalcin, a novel calcium binding protein with three EF-hand domains, expressed in retinal amacrine cells and ganglion cells. Biochem. Biophys. Res. Commun. 186, 1207-1211
69. Iino, S., Kobayashi, S., Okazaki, K., and Hidaka, H. (1995) Neurocalcin-immunoreactive receptor cells in the rat olfactory epithelium and vomeronasal organ. Neurosci. Lett. 191, 91-94
70. 2+-binding protein that associates with membranes and inhibits in vitro phosphorylation of bovine rhodopsin. J. Biol. Chem. 271, 10256-10262
71. Moore, B.W. (1965) A soluble protein characteristic of the nervous system. Biochem. Biophys. Res. Commun. 19, 739-744
72. Schäfer, B.W. and Heizmann, C.W. (1996) The S100 family of EF-hand calcium-binding proteins: Functions and pathology, Trends Biochem. Sci. 21, 134-140
73. Zimmer, D.B., Cornwall, E.H., Lander, A., and Song, W. (1995) The S100 protein family: History, function, and expression. Brain Res. Bull. 37, 417-429
74. Glenney, J.R., Jr., Kindy, M.S., and Zokas, L. (1989) Isolation of a new member of the S100 protein family: Amino acid sequence, tissue, and subcellular distribution. J. Cell Biol. 108, 569-578
75. Marshak, D.R. (1990) S100β as a neurotrophic factor. Prog. Brain Res. 86, 169-181
76. Marks, A., Petsche, D., O'Hanlon, D., Kwong, P.C., Stead, R., Dunn, R., Baumal, R., and Liao, S.-K. (1990) S100 protein expression in human melanoma cells: comparison of levels of expression among different cell lines and individual cells in different phases of the cell cycle. Exp. Cell Res. 187, 59-64
77. 0 (αα) protein in tumor tissues and in sera of patients with renal cell carcinoma. Jpn. J. Cancer Res. 76, 856-862
78. Nagasaka, A., Umekawa, H., Hidaka, H., Iwase, K., Nakai, A., Ariyoshi, Y., Ohyama, T., Aono, T., Nakagawa, H., Ohtani, S., Shinoda, S., Miyakawa, S., Kawase, K., and Miura, K. (1987) Increase in S-100b protein content in thyroid carcinoma. Metabolism 36, 388-391
79. Lee, S.W., Tomasetto, C., Swisshelm, K., Keyomarsi, K., and Sager, R. (1992) Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment. Proc. Natl. Acad. Sci. USA 89, 2504-2508
80. Kligman, D. and Marshak, D.R. (1985) Purification and characterization of a neunte extension factor from bovine brain. Proc. Natl. Acad. Sci. USA 82, 7136-7139
81. Winningham-Major, F., Staecker, J.L., Barger, S.W., Coats, S., and Van Eldik, L.J. (1989) Neurite extension and neuronal survival activities of recombinant S100β proteins that differ in the content and position of cysteine residues. J. Cell Biol. 109, 3063-3071
82. Selinfreund, R.H., Barger, S.W., Pledger, W.J., and Van Eldik, L.J. (1991) Neurotrophic protein S100β stimulates glial cell proliferation. Proc. Natl. Acad. Sci. USA 88, 3554-3558
83. Marshak, D.R., Pesce, S.A., Stanley, L.C., and Griffin, S.T. (1991) Increased S100β neurotrophic activity in Alzheimer's disease temporal lobe, Neurobiol. Aging 13, 1-7
84. Stanley, L.C., Mrak, R.E., Woody, R.C., Perrot, L.J., Zhang, S.X., Marshak, D.R., Nelson, S.J., and Griffin, W.S.T. (1994) Glial cytokines as neuropathogenic factors in HIV infection: Pathogenic similarities to Alzheimer's disease. J. Neuropathol. Exp. Neural. 53, 231-238
85. 2+-binding proteins of neutrophils and monocytes. J. Leukocyte Biol. 63, 197-204
86. Tokunaga, K., Nakamura, Y., Sakiyama, S., Hasegawa, Y., and Sato, K, (1991) Binding of pEL98, an S100-related calcium-binding protein to nonmuscle tropomyosin, J. Cell Biol. 124, 757-768
87. 2+-dependent insulin release from the pancreatic β cell. J. Biol. Chem. 269, 6149-6152
88. Regnouf, F., Sagot, L, Delouche, B., Devilliers, G., Cartaud, J., Henry, J.-P., and Pradel, L.-A. (1995) "In vitro" phosphorylation of annexin 2 heterotetramer by protein kinase C. J. Biol. Chem. 270, 27143-27150
89. Donato, R, (1987) Quantitative analysis of the interaction between S-100 proteins and brain tubulin. Cell Calcium 8, 283-297
90. Roth, J., Burwinkel, F., van den Bos, C., Goebeler, M., Vollmer, E., and Sorg, C. (1993) MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner. Blood 82, 1875-1883
91. 2+-dependent manner. J. Biol. Chem. 268, 12669-12674
92. Baudier, J., Mochly-Rosen, D., Newton, A., Lee, S-H., Koshland, D.E., Jr., and Cole, R.D. (1987) Comparison of S100b protein with calmodulin: Interactions with melittin and microtubule-associated τ proteins and inhibition of phosphorylation of τ proteins by protein kinase C, Biochemistry 26, 2886-2893
93. 2+ calmodulin-dependent protein kinase II. J. Biol. Chem. 263, 5876-5883
94. Patel, J., Marangos, P.J., Heydorn, W.E., Chang, G., Verma, A., and Jacobowitz, D. (1983) S-100-mediated inhibition of brain protein phosphorylation. J. Neurochem. 41, 1040-1045
95. Marshak, D.R., Watterson, D.M., and Van Eldik, L.J. (1981) Calcium-dependent interaction of S100b, troponin C, and calmodulin with an immobilized phenothiazine. Proc. Natl. Acad. Sci. USA 78, 6793-6797
96. Tokumitsu, H., Kobayashi, R., and Hidaka, H. (1991) A calciumbinding protein from rabbit lung cytosol identified as the product of growth-regulated gene (2A9) and its binding proteins, Arch. Biochem. Biophys. 288, 202-207
97. Terasawa, M., Nakano, A., Kobayashi, R., and Hidaka, H. (1992) Neurocalcin: A novel calcium-binding protein from bovine brain. J. Biol. Chem. 267, 19596-19599
98. Baudier, J., Delphin, C., Grunwald, D., Khochbin, S., and Lawrence, J. (1992) Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein. Prot Natl. Acad Sci. USA 89, 11627-11631
99. Murao, S., Collart, F.R., and Huberman, E. (1989) A protein containing the cystic flbrosis antigen is an inhibitor of protein kinases. J. Biol. Chem. 264, 8356-8360
100. 2-terminal tail of the 36-κDa heavy chain. J. Biol. Chem. 261, 10485-10488
101. Becker, T., Weber, K., and Johnsson, N. (1990) Protein-protein recognition via short amphiphilic helices; a mutational analysis of the binding site of annexin II for p11. EMBO J. 9, 4207-4213
102. Minami, H., Tokumitsu, H., Mizutani, A., Watanabe, Y., Watanabe, M., and Hidaka, H. (1992) Specific binding of CAP-50 to calcyclin. FEES Lett. 305, 217-219
103. Mailliard, W.S., Haigler, H.T., and Schlaepfer, D.D, (1996) Calcium-dependent binding of S100C to the N-terminal domain of annexin I. J. Biol. Chem. 271, 719-725
104. Zimmer, D.B. and Van Eldik, L.J. (1986) Identification of a molecular target for the calcium-modulated protein S100, J. Biol. Chem. 261, 11424-11428
105. Zimmer, D.B. and Dubuisson, J.G. (1993) Identification of an S100 target protein: Glycogen phosphorylase. Cell Calcium 14, 323-332
106. Raynal, P. and Pollard, H.B. (1994) Annexins: The problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins. Biochim. Biophys. Acta 1197, 63-93
107. Smith, V.L. and Dedman, J.R. (1986) An immunological comparison of several novel calcium-binding proteins. J. Biol. Chem. 261, 15815-15818
108. 2+-binding proteins related to Torpedo calelectrin. EMBO J. 3, 2969-2974
109. 2+ and lipid-binding proteins. FEES Lett. 203, 99-103
110. 2+-regulated-phospholipid binding protein. Biosci. Rep. 7, 289-298
111. Varticovski, L., Chahwala, S.B., Whitman, M., Cantley, L., Schindler, D., Chow, E.P., Sinclair, L.K., and Pepinsky, R.B. (1988) Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinasee and protein kinases A and C. Biochemistry 27, 3682-3690
112. Kretsinger, R.H. and Creutz, C.E. (1986) Consensus in exocytosis. Nature 320, 573
113. Saris, C.J.M., Tack, B.F., Kristensen, T., Glenney, J.R., Jr., and Hunter, T. (1986) The cONA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats. Cell 46, 201-212
114. 2+ and phospholipids. Trends Biochem. Sci. 11, 420-423
115. Burgoyne, R.D. and Geisow, M.J. (1989) The annexin family of calcium-binding proteins. Cell Calcium 10, 1-10
116. Creutz, C.E. (1992) The annexing and exocytosis. Science 268, 924-931
117. 2+-binding protein of lymphocyte plasma membrane. Biochem. J. 21B, 309-316
118. 2+-dependent membrane-binding proteins. Nature 320, 636-638
119. Turnay, J., Pfannmuller, E., Lizarbe, M.A., Bertling, W.M., and Mark, K.V.D. (1995) Collagen binding activity of recombinant and N-terminally modified annexin V (anchorin Cll). J. Cell. Biochem. 68, 208-220
120. 2+-binding protein. Biochem. J. 238, 49-54
121. Raynal, P., van Bergen en Henegouwen, P.M.P., Hullin, F., Ragab-Thomas, J.M.F., Fauvel, J., Verkleij, A., and Chap, H. (1992) Morphological and biochemical evidence for partial nuclear localization of annexin 1 in endothelial cells. Biochem. Biophys. Res. Commun. 186, 432-439
122. Sun, J., Salem, H., and Bird, P. (1992) Nuclear and cytoplasmic localization of annexin V. FEBS Lett. 314, 425-429
123. Kuijpers, G.A., Lee, G., and Pollard, H.B. (1992) Immunolocalization of synexin (annexin VII) in adrenal chromaffin granules and chromaffin cells: Evidence for a dynamic role in the secretory process. Cell Tissue Res. 269, 323-330
124. Morgan, R.O. and Fernández, M.-P. (1995) Molecular phytogeny of annexins and identification of a primitive homologue in Giardia lamblia. Mol. Biol. Evol. 12, 967-979
125. Südhof, T.C., Walker, J.H., and Obrocki, J. (1982) Calelectrin self-aggregates and promotes membrane aggregation in the presence of calcium. EMBO J. 1, 1167-1170
126. Meers, P., Mealy, T., Pavlosky, N., and Tauber, A.I. (1992) Annexin I-mediated vesicular aggregation: Mechanism and role in human neutrophils. Biochemistry 31, 6372-6382
127. Meers, P., Mealy, T., and Tauber, A.I. (1993) Annexin I interactions with human neutrophil specific granules: Fusogenicity and coaggregation with plasma membrane vesicles. Biochim. Biophys. Acta 1147, 177-184
128. Creuz, A.E., Pazoleg, C.J., and Pollard, H.B. (1978) Identification and purification of an adrenal medullary protein (synexin) that causes calcium-dependent aggregation of isolated chromaffln granules. J. Biol. Chem. 263, 2858-2866
129. Ali, S.M., Geisow, M.J., and Burgoyne, R.D. (1989) A role for calpaction in calcium dependent exocytosis in adrenal chromaffin cells, Nature 340, 313-315
130. Ohnishi, M., Tokuda, M., Masaki, T., Fujimura, T., Tai, Y., Itano, T., Matsui, H., Ishida, T., Konishi, R., Takahara, J., and Hatase, O. (1995) Involvement of annexin-I in glucose-induced insulin secretion in rat pancreatic islets. Endocrinology 136, 2421-2426
131. Liu, L., Fisher, A.B., and Zimmerman, U.-J.P. (1995) Lung annexin II promotes fusion of isolated lamellar bodies with liposomes. Biochim. Biophys. Acta 1259, 166-172
132. Rojas, E., Pollard, H.B., Haigier, H.T., Parra, C., and Burns, A.L. (1990) Calcium-activated endonexin II forms calcium channels across acidic phospholipid bilayer membranes. J. Biol. Chem. 265, 21207-21215
133. 2+ channels in phosphatidylserine bilayer membranes. Proc. Natl. Acad. Sci. USA 85, 2974-2978
134. Rojas, E., Arispe, N., Haigier, H.T., Burns, A.L., and Pollard, H.B. (1992) Identification of annexins as calcium channels in biological membranes. Bone Mineral 17, 214-218
135. Blackwell, G.J., Flower, R.J., Nijkamp, F.P., and Vane, J.R. (1978) Phospholipase A2 activity of guinea-pig isolated perfused lungs: Stimulation, and inhibition by anti-inflammatory steroids. Brit. J. Pharmacol. 62, 79-89
136. 2 by "lipocortins" and calpactins. An effect of binding to phospholipids. J. Biol Chem. 262, 1698-1705
137. z activity of endonexin. FEES Lett. 216, 45-50
138. 2 inhibitory protein in rabbit neutrophils induced by glucocorticoids. Proc. Natl. Acad. Sci. USA 77, 2533-2536
139. McLeod, J.D., Goodall, A., Jelic, P., and Bolton, C. (1995) Changes in the cellular distribution of lipocortin-1 (Annexin-1) in C6 glioma cells after exposure to dexamethasone, Biochem. Pharmacol. 50, 1103-1107
140. 2 by picomolar concentrations of recombinant human lipocortin I. Brit. J. Dermatol. 121, 155-160
141. Flower, R.J. and Rothwell, N.J. (1994) Lipocortin-1: Cellular mechanisms and clinical relevance. Trends Pharmacol. Sci. 15, 71-76
142. 2 is substrate concentration dependent. FEBS Lett. 219, 176-180
143. Ravanat, C., Archipoff, G., Beretz, A., Freund, G., Cazenave, J.-P., and Freyssinet, J.-M. (1992) Use of annexin-V to demonstrate the role of phosphatidylserine exposure in the maintenance of haemostatic balance by endothelial cells. Biochem. J. 282, 7-13
144. Rothhut, B., Cornera, C., Cortial, S., Haumont, P.-Y., Diep-Le, K.H., Cavadore, J.-C., Conard, J., Russo-Marie, F., and Lederer, F. (1989) A 32 κDa lipocortin from human mononuclear cells appears to be identical with the placental inhibitor of blood coagulation. Biochem. J. 263, 929-935
145. Thiagarajan, P. and Tait, J.F. (1990) Binding of annexin V/ placental anticoagulant protein into platelets. Evidence for phosphatidylserine exposure in the procoagulant response of activated platelets. J. Biol. Chem. 266, 17420-17423
146. Goulding, N.J., Jefferiss, C.M., Pan, L., Rigby, W.F.C., and Guyre, P.M. (1992) Specific binding of lipocortin-1 (annexin I) to monocytes and neutrophils is decreased in rheumatoid arthritis, Arthritis Rheumatism 35, 1395-1397
147. Morand, E.F., Jefferiss, C.M., Dixey, J., Mitra, D., and Goulding, N.J. (1994) Impaired glucocorticoid induction of mononuclear leukocyte lipocortin-1 in rheumatoid arthritis. Arthritis Rheumatism 37, 207-211
148. van Venrooij, W.J., Wodzig, K.W., Habets, W.J., de Rooij, D.J., and van de Putte, L.B. (1989) Anti-56K, a novel, frequently occurring autoantibody specificity in connective tissue disease. Clin. Exp. Rheumatol. 7, 277-282
149. Misaki, Y., Pruijn, G.J.M., van der Kemp, A.W.C.M., and van Venrooij, W.J. (1994) The 56K autoantigen is identical to human annexin XI, J. Biol. Chem. 269, 4240-4246
150. 2+/phospholipid-binding proteins, annexin family. J. Biol. Chem. 267, 8919-8924
151. Misaki, Y., Venrooij, Van W.J., and Pruijn, G.J.M. (1995) Prevalence and characteristics of anti-56k/annexin XI autoantibodies in systemic autoimmune diseases. J. Rheumatol. 22, 97-102
152. Campos-Gonzalez, R., Kanemitsu, M., and Boynton, A.L. (1990) Epidermal growth factor induces the accumulation of calpactin II on the cell surface during membrane ruffling. Cell Motil Cytoskeleton 15, 34-40
153. Radke, K., Gilmore, T., and Martin, G.S. (1980) Transformation by Rous sarcoma virus: A cellular substrate for transformation-specific protein phosphorylation contains phosphotyrosine. Cell 21, 821-828
154. 2 inhibitor lipocortin. Biochemistry 25, 4497-4503
155. Gould, K.L., Woodgett, J.R., Isacke, C.M., and Hunter, T. (1986) The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo. Mol. Cell. Biol. 6, 2738-2744
156. 2+-modulated lipid-binding proteins. EMBO J. 6, 1599-1604
157. Mizutani, A., Tokumitsu, H., Kobayashi, R., and Hidaka, H. (1993) Phosphorylation of annexin XI (CAP-50) in SR-3Y1 cells. J. Biol. Chem. 268, 15517-15522
158. Rothhut, B., Dubois, T., Feliers, D., Russo-Marie, F., and Oudinet, J.-P, (1995) Inhibitory effect of annexin V on protein kinase C activity in mesangial cell lysates. Eur. J. Biochem. 232, 865-872
159. Nishizuka, Y. (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 268, 607-614
160. Baker, M.E. (1989) Similarity between phospholipase C and the regulatory domain of protein kinase C. Mol. Cell. Endocrinol. 61, 129-131
161. 2+-dependent translocation domain with homology to PKC and GAP, Cell 65, 1043-1051
162. Perin, M.S., Fried, V.A., Mignery, G.A., Jahn, R., and Sudhof, T.C. (1990) Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. Nature 345, 260-263
163. 2+/phospholipid-binding fold. Cell 80, 929-938
164. Takai, Y., Kishimoto, A., Iwase, Y., Kawahara, Y., Mon, T., and Nishizuka, Y. (1979) Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids, J. Biol. Chem. 254, 3692-3695
165. Takai, Y., Kishimoto, A., Kikkawa, U., Mon, T., and Nishizuka, Y. (1979) Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system, Biochem. Biophys. Res. Commun. 91, 1218-1224
166. Coussens, L., Parker, P.J., Rhee, L., Yang-Feng, T.L., Chen, E., Waterfield, M.D., Francke, U., and Ullrich, A. (1986) Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science 233, 859-866
167. Osada, S., Mizuno, K., Saido, T.C., Suzuki, K., Kuroki, T., and Ohno, S. (1992) A new member of the protein kinase C family, nPKCθ, predominantly expressed in skeletal muscle. Mol. Cell. Biol. 12, 3930-3938
168. Chang, J.D., Xu, Y., Raychowdhury, M.K., and Ware, J.A. (1993) Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). J. Biol Chem. 268, 14208-14214
169. May, W.S., Jr., Sahyoun, N., Wolf, M., and Cuatrecasas, P. (1985) Role of intracellular calcium mobilization in the regulation of protein kinase C-mediated membrane processes. Nature 317, 549-551
170. Akita, Y., Ohno, S., Konno, Y., Yano, A., and Suzuki, K. (1990) Expression and properties of two distinct classes of the phorbol ester receptor family, four conventional protein kinase C types, and a novel protein kinase C. J. Biol. Chem. 265, 354-362
171. Mochly-Rosen, D., Khaner, H., and Lopez, J. (1991) Identification of intracellular receptor proteins for activated protein kinase C. Proc. Natl. Acad. Sci. USA 88, 3997-4000
172. Mochly-Rosen, D., Miller, K.G., ScheUer, R.H., Khaner, H., Lopez, J., and Smith, B.L. (1992) p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C. Biochemistry 31, 8120-8124
173. Disatnik, M.-H., Hernandez-Sotomayor, S.M., Jones, G., Carpenter, G., and Mochly-Rosen, D. (1994) Phospholipase C-γl binding to intracellular
174. Nishizuka, Y. (1986) Studies and perspectives of protein kinase C. Science 233, 305-312
175. Fagaro, A. and Nishizuka, Y. (1990) Protein kinase C in transmembrane signalling. FEES Lett. 268, 350-354
176. Matthew, W.D., Tsavaler, L., and Reichardt, L.F. (1981) Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. J. Cell Biol. 91, 257-269
177. Mizuta, M., Inagaki, N., Nemoto, Y., Matsukura, S., Takahashi, M., and Seino, S. (1994) Synaptotagmin III is a novel isoform of rat synaptotagmin expressed in endocrine and neuronal cells. J. Biol. Chem. 269, 11675-11678
178. Hudson, A.W. and Birnbaum, M.J. (1995) Identification of a nonneuronal isoform of synaptotagmin, Proc. Natl. Acad. Sci. USA 92, 5895-5899
179. Marquèze, B., Boudier, J.A., Mizuta, M., Inagaki, N., Seino, S., and Seagar, M. (1995) Cellular localization of synaptotagmin I, II, and III mRNAs in the central nervous system and pituitary and adrenal glands of the rat. J. Neurom. 15, 4906-4917
180. 2+-dependent and -independent activities of neural and non-neural synaptotagmins. Nature 375, 594-599
181. Mikoshiba, K., Fukuda, M., Moreira, J.E., Lewis, F.M.T., Sugimori, M., Niinobe, M., and Llinas, R. (1995) Role of the C2A domain of synaptotagmin in transmitter release as determined by specific antibody injection into the squid giant synapse preterminal. Proc. Natl. Acad. Sci USA 92, 10703-10707
182. Fukuda, M., Moreira, J.E., Lewis, F.M.T., Sugimori, M., Niinobe, M., Mikoshiba, K., and Llinas, R. (1995) Role of C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into the squid giant synapse preterminal. Proc. Natl. Acad. Sci. USA 92, 10708-10712
183. Südhof, T.C. (1995) The synaptic vesicle cycle: A cascade of protein-protein interactions. Nature 375, 645-653
184. 2+-dependent manner. Trends Neurosci. 18, 177-183
185. 2(s); comparison of arachidonoyl-selective and -nonselective enzymes. FASEB J. 7, 339-348
186. 2 with membrane in the macrophage cell line RAW 264.7. J. Biol. Chem. 265, 5409-5413
187. Marshall, L.A. and McCarte-Roshak, A. (1992) Demonstration of similar calcium dependencies by mammalian high and low molecular mass phospholipase A, Biochem. Pharmacol. 44, 1849-1858
188. Balsinde, J., Diez, E., Schuiier, A., and Mollinedo, F. (1988) Phospholipase A2 activity in resting and activated human neutrophils. Substrate specificity, pH dependence, and subcellular localization. J. Biol. Chem. 263, 1929-1936
189. 2 is a 100-κDa protein in human monoblast U937 cells. J. Biol. Chem. 266, 5268-5272
190. Glasier, K.B. (1995) Regulation of phospholipase A2 enzymes: Selective inhibitors and their pharmacological potential. Adv. Pharmacol. 32, 31-66
191. 2+ for membrane binding but not for catalytic activity, Biochem. Biophys. Res. Commun. 184, 118-124
192. 2. Biochim. Biophys. Acta. 878, 394-403
193. Stahl, M.L., Ferenz, C.R., Kelleher, K.L., Kriz, R.W., and Knopf, J.L. (1988) Sequence similarity of phospholipase C with the non-catalytic region of arc. Nature 332, 269-272
194. Essen, L.-O., Perisic, O., Cheung, M., and Williams, R.L. (1996) Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ. Nature 380, 595-602
195. Yang, L.J., Rhee, S.G., and Williamson, J.R. (1994) Epidermal growth factor-induced activation and translocation of phospholipase C- γ 1 to the cytoskeleton in rat hepatocytes. J. Biol. Chem. 269, 7156-7162
196. Vogel, U.S., Dixon, R.A.F., Schaber, M.D., Diehl, R.E., Marshall, M.S., Scolnick, E.M., Sigal, I.S., and Gibbs, J.B. (1988) Cloning of bovine GAP and its interaction with oncogenic ras p21. Nature 336, 90-93
197. Shirataki, H., Kaibuchi, K., Sakoda, T., Kishida, S., Yamaguchi, T., Wada, K., Miyazaki, M., and Takai, Y. (1993) Rabphilin-3A, a putative target protein for smgp25A/ra63A p25 small GTP-binding protein related to synaptotagmin. Mol. Cell. Biol. 13, 2061-2068
198. 2+-binding domains. J. Biol. Chem. 268, 27164-27170
199. Kishida, S., Shirataki, H., Sasaki, T., Kato, M., Kaibuchi, K., and Takai, Y. (1993) Rab3A GTPase-activating protein-inhibiting activity of rabphilin-3A, a putative Rab3A target protein, J. Biol. Chem. 268, 22259-22261
200. Novick, P. and Brennwald, P. (1993) Friends and family: The role of the Rab GTPases in vesicular traffic. Cell 75, 597-601
201. 2+ spiking in single smooth muscle cells. EMBO J. 12, 5287-5291
202. Milner, R.E., Baksh, S., Shemanko, C., Carpenter, M.R., Smillie, L., Vance, J.E., Opas, M., and Michalak, M. (1991) Calreticulin and not calsequestrin, is the major calcium binding protein of smooth muscle sarcoplasmic reticulum and liver endoplasmic reticulum. J. Biol. Chem. 266, 7155-7165
203. Michalak, M., Milner, R.E., Burns, K., and Opas, M. (1992) Calreticulin. Biochem. J. 286, 681-692
204. Ostwald, T.J. and MacLennan, D.H. (1974) Isolation of a high affinity calcium-binding protein from sarcoplasmic reticulum. J. Biol. Chem. 249, 974-979
205. 2+-storage compartments (calciosomes) of liver and brain. Biochem. J. 271, 473-480
206. 2+ store of nonmuscle cells? Proc. Natl. Acad. Sci. USA 85, 1091-1095
207. Fliegel, L., Ohuishi, M., Carpenter, M.R., Khanna, V.K., Reithmeier, R.A.F., and MacLennan, D.H. (1987) Amino acid sequence of rabbit fast-twitch skeletal muscle calsequestrin deduced from cDNA and peptide sequencing. Proc. Natl. Acad. Sci. USA. 84, 1167-1171
208. Fliegel, L., Burns, K., MacLennan, D.H., Reithmeier, R.A.F., and Michalak, M. (1989) Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal sarcoplasmic reticulum. J. Biol. Chem. 264, 21522-21528
209. Van, P.N., Peter, F., and Soling, H.-D. (1989) Four intracisternal calcium-binding glycoproteins from rat liver microsomes with high affinity for calcium. No indication for calsequestrin-like proteins in inositol 1,4,5-trisphosphate-sensitive calcium sequestering rat liver vesicles. J. Biol. Chem. 264, 17494-17501
210. 2+ binding domains. J. Biol. Chem. 266, 21458-21465
211. Somlyo, A.P., Bond, M., and Somlyo, A.V. (1985) Calcium content of mitochondria and endoplasmic reticulum in liver frozen rapidly in vivo. Nature 314, 622-625
212. Kamier, B., Lebeche, D., and Lucero, H. (1994) Calcium storage by the endoplaatic reticulum of the sea urchin egg. in Calcium as Cell Signal (Maruyama, K., Nonomura, S., and Kohama, K., eds.) pp. 133-140, Igaku-Shoin, Tokyo/New York
213. 2+-binding protein with multiple EF-hand motifs and a carboxyl-terminal HDEL sequence. J. Biol. Chem, 268, 699-705
214. Weis, K., Griffiths, G., and Lamond, A.I. (1994) The endoplasmic reticulum calcium-binding protein of 55kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl terminal His-Asp-Glu-Leu motif. J. Biol. Chem. 269, 19142-19150
215. Lucero, H.A., Lebeche, D., and Kaminer, B. (1994) ER calcistorin/protein disulfide isomerase (PDI). Sequence determination and expression of a cDNA clone encoding a calcium storage protein with PDI activity from endoplasmic reticulum of the sea urchin egg. J. Biol. Chem. 269, 23112-23119
216. Oberdorf, J.A., Lebeche, D., Head, J.F., and Kammer, B. (1988) Identification of a calsequestrin-like protein form sea urchin eggs. J. Biol. Chem. 263, 6806-6809
217. Opas, M., Dziak, E.Z., Fliegel, L., and Michalak, M. (1991) Regulation of expression and intracellular distribution of calreticulin, a major calcium binding protein of nonmuscle cells. J. Cell. Physiol. 149, 160-171
218. Rojiani, M.V., Finlay, B.B., Gray, V., and Dedhar, S. (1991) In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin a subunits. Biochemistry 30, 9859-9866
219. Dedhar, S., Rennie, P.S., Shago, M., Hagesteijin, C.-Y.L., Yang, H., Filmus, J., Hawley, R.G., Bruchovsky, N., Cheng, H., Matusik, R.J., and Giguére, V. (1994) Inhibition of nuclear hormone receptor activity by calreticulin. Nature 367, 480-483
220. Burns, K., Duggan, B., Atkinson, E.A., Famulski, K.S., Nemer, M., Bleackley, R.C., and Michalak, M. (1994) Modulation of gene expression by calreticulin binding to the glucocorticoid receptor. Nature 367, 476-480
221. Dedhar, S. (1994) Novel functions for calreticulin: Interaction with integrins and modulation of gene expression? Trends Biochem. Sci. 19, 269-271
222. Koch, G., Smith, M., Macer, D., Webster, P., and Mortara, R. (1986) Endoplasmic reticulum contains a common, abundant calcium-binding glycoprotein, endoplasmin. J. Cell Sci. 86, 217-232