Evidence for magnesium deficiency in the pathogenesis of bronchopulmonary dysplasia (BPD)

Magnesium Research

Volumn 9, Issue 3, 1996, Pages 205-216

  Caddell, Joan L ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Bronchopulmonary dysplasia (BPD); Inflammatory cytokines; Magnesium; Magnesium deficiency; Oxygen; Oxygen free radicals; Thromboxane A2; Very low birth weight (VLBW) infant

Indexed keywords

15 HYDROXY 5,8,11,13 ICOSATETRAENOIC ACID; 15-HYDROXY-5,8,11,13-EICOSATETRAENOIC ACID; CHEMOKINE; ENDOTHELIN 1; FREE RADICAL; HYDROXYICOSATETRAENOIC ACID; IMMUNOGLOBULIN; NITRIC OXIDE; SUBSTANCE P; THROMBOXANE A2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; HUMAN; LUNG DYSPLASIA; MAGNESIUM DEFICIENCY; METABOLISM; NEWBORN; PATHOPHYSIOLOGY; REVIEW; VERY LOW BIRTH WEIGHT;

ANIMALS; BRONCHOPULMONARY DYSPLASIA; CHEMOKINES; ENDOTHELIN-1; FREE RADICALS; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; IMMUNOGLOBULINS; INFANT, NEWBORN; INFANT, VERY LOW BIRTH WEIGHT; MAGNESIUM DEFICIENCY; NITRIC OXIDE; SUBSTANCE P; THROMBOXANE A2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030253035     PISSN: 09531424     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (116)

1. Northway, H.W., Rosan, R.C. & Porter, D.Y. (1967): Pulmonary disease following therapy of hyaline membrane disease. Bronchopulmonary dysplasia. N. Engl. J. Med. 276, 357-368.
2. Zimmerman, J.J. (1995): Bronchoalveolar inflammatory pathophysiology of bronchopulmonary dysplasia. Clin. Perinatol. 22, 429-456.
3. Avery, M.E. & First, L.R. (1989): Pediatric medicine, pp. 170-174. Baltimore: Williams & Wilkins.
4. Pierce, M.R. & Bancalari, E. (1995): The role of inflammation in the pathogenesis of bronchopulmonary dysplasia. Pediatr. Pulmonol. 19, 371-378.
5. Bancalari, E. & Gerhardt, T. (1986): Bronchopulmonary dysplasia. Pediatr. Clin. North. Am. 33, 1-23.
6. Roberts, R.J. (1986): Pharmacologic approaches to the prevention and treatment of bronchopulmonary dysplasia. Respir. Care 31, 581-590.
7. Bonikos, D.S., Bensch, K.G. & Northway, W.H. [1976): Oxygen toxicity in the newborn. The effect of chronic continuous 100 percent oxygen exposure on the lungs of newborn mice. Am. J. Pathol. 85, 623-650.
8. Walti, H., Paris-Llado, J., Breart, G. & Couchard, M. and the French Collaborative Multicentre Study Group (1995): Porcine surfactant replacement therapy in newborns of 25-31 weeks' gestation: a randomized, multicentre trial of prophylaxis versus rescue with multiple low doses. Acta Paediatr. 84, 913-921.
9. Tucker, L., Hoff, C., Peevy, K., Brost, B., Holland, S & Calhoun, B.C. (1995): The effects of antenatal steroid use in premature rupture of membranes. Aust. N. Z. J. Obstet. Gynaecol. 35, 390-392.
10. Shinwell, E.S., Karplus, M., Zmora, E., Reich, D., Rothschild, A., Blazer, S., Bader, D., Yurman, S., Dolfin, T., Kuint, J., Milbaeur, B., Kohelet, D., Goldberg, M., Armon, Y., Davidson, S., Sirota, L., Amitai, M., Zaretsky, A., Barak, M. & Gottfried, S. (1996): Failure of early postnatal dexamethasone to prevent chronic lung disease in infants with respiratory distress syndrome. Arch. Dis. Child. 74 (1 Special Issue SI), F33-F37.
11. Hansen, T. & Corbet, A. (1991): Chronic lung disease - bronchopulmonary dysplasia. In: Schaffer and Avery's diseases of the newborn, 6th ed., eds. H.W. Taeusch, R.A. Ballard, & M.E. Avery, pp. 519-526, Philadelphia: W.B. Saunders.
12. American Society of Hospital Pharmacists (1991): Theophyllines. American Hospital Formulary Service (AHFS). pp. 2196-2198.
13. Larvor P. & Rayssiguier, Y. (1972): Hypomagnesaemia following theophylline or furosemide injection in ewes: renal versus extrarenal effect. J. Physiol. (Lond) 227, 365-375.
14. Guignard, J.P., Dubourg, L. & Gouyon, J.B. (1995): [Diuretics in the neonatal period] [Review] Rev. Med. Suisse Romande 115, 583-590.
15. Willson, R.L. (1987): Vitamin, selenium, zinc, and copper interactions in free radical protection against ill-placed iron. Proc. Nutr. Soc. 46, 27-34.
16. Wispe, J.R. & Roberts, R.J. (1988): Development of antioxidant systems. In: Bronchopulmonary dysplasia, eds. T.A. Merritt, W.H. Northway, & B.R. Boynton, pp. 103-116. Boston: Blackwell.
17. Zachman, R.D., Samuels, D.P., Brand, J.M., Winston, J.F. & Pi, J.-T. (1996): Use of the intramuscular relative-dose-response test to predict bronchopulmonary dysplasia in premature infants. Am. J. Clin. Nutr. 63, 123-129.
18. Sosenko, I.R.S. & Frank, L. (1991): Oxidants and antioxidants. In: Basic mechanisms of pediatric respiratory disease. Cellular and integrative, eds. V. Chernick & R.B. Mellins, pp 315-327. Philadelphia: B.C. Decker.
19. Russell G.A. & Cooke, R.W.I. (1995): Randomised controlled trial of allopurinol prophylaxis in very preterm infants. Arch. Dis. Child. 73, F27-F31.
20. Rosenfeld, W.N., Davis, J.M., Parton, L., Richter, S.E., Price, A., Flaster, E. & Kassem, N. (1996): Safety and pharmacokinetics of recombinant human superoxide dismutase administered intratheceally to premature neonates with respiratory distress syndrome. Pediatrics 97, (6 Part 1) 811-817.
21. Darlow, B.A., Inder, T.E., Graham, P.J., Sluis, K.B., Malpas, T.J., Taylor, B.J. & Winterbourn, C.C. (1995): The relationship of selenium status to respiratory outcome in the very low birth weight infant. Pediatrics 96, (2 Pt 1) 314-319.
22. Lonnqvist, P.A., Jonsson, B., Winberg, P. & Frostell, C.G. (1995): Inhaled nitric oxide in infants with developing or established chronic lung disease. Acta Paediatr. 84, 1188-1192.
23. Heffner, J.E. & Repine, J.E. (1989): Pulmonary strategies of antioxidant defense. Rev. Respir. Dis. 140, 531-554.
24. Koo, W.W. K. & Tsang, R.C. (1993): Calcium, magnesium, phosphorus and vitamin D. In: Nutritional needs of the preterm infant, eds. R.C. Tsang, A. Lucas, R. Uauy & S. Zlotkin, pp. 135-155. Baltimore: Williams & Wilkins.
25. Peterson, D.R., van Belle, G. & Chinn, N.M. (1979): Epidemiologic comparisons of the sudden infant death syndrome with other major components of infant mortality. Am. J. Epidemiol. 110, 699-707.
26. National Research Council (1989): Recommended dietary allowances, 10th ed., pp. 187-194 and Table pp. 284ff, Washington, D.C.: National Academy Press.
27. Dancis, J., Springer, D., Cohlan, S.A. (1971): Fetal homeostasis in maternal nutrition. II. Magnesium deprivation. Pediatr. Res. 5, 131-136.
28. Caddell, J.L. (1988): Magnesium therapy in premature neonates with apnea neonatorum. J. Am. Coll. Nutr. 7, 5-16.
29. Tanuma, S., Fukui, K. Suzuki, H., Kondo, E., Tsunematsu, K. & Sakuma, Y. (1989): Magnesium metabolism in neonate-lymphocytic magnesium value and prognosis of low birth weight infant. In: Magnesium in health and disease, eds. Y. Itokawa & J. Durlach, pp. 367-374. London: John Libbey.
30. Munoz, R., Khuilnani, P, Ziegler, J., Salem, M., Catlin, E.A., Nussbaum, S., Todres, I.D. & Chernow, B. (1994): Ultrafilterable hypomagnesemia in neonates admitted to the neonatal intensive care unit. Crit. Care Med. 22, 815-820.
31. Widdowson, E.M. & McCance, R.A. (1965): The metabolism of calcium, phosphorus, magnesium, and strontium. Pediatr. Clin. North Am. 12, 595-614.
32. Uauy, R., Mena, P. & Warshaw, J.B. (1994): Growth and metabolic adaptation of the fetus and newborn. In: Principles and practice of pediatrics. 2nd ed, eds F.A. Oski, C.D. De Angelis, R.B. Feigin, J.A. McMilian & J.B. Warshaw, pp. 279-281. Philadelphia, J. B. Lippincott.
33. Dirks, J.H. (1983): The kidney and magnesium regulation. Kidney Int. 23, 771-777.
34. Thoren, L. (1963): Magnesium deficiency in gastrointestinal fluid loss. Acta Chir. Scand. Suppl. 306, 1-65.
35. Peabody, J.L. & Lewis, K. (1985): Consequences of newborn intensive care. In: Infant stress under intensive care. Environmental neonatology, eds. A. W. Gottfried & J.L. Gaiter, pp. 199-226. Baltimore: University Park Press.
36. Durlach, J. (1988): Magnesium deficits secondary to stress. In: Magnesium in clinical medicine, pp. 140-147, London: John Libbey.
37. Classen, H.G. (1990): Systemic stress and the role of magnesium. In: Metal ions in biological systems, eds. H. Sigel & A. Sigel, pp. 321-339. New York: Marcel Dekker.
38. Gunther, T., Ising, H. & Merker, H.J. (1978): Elektrolyt und Kollagengehalt im Rattenherzen bei chronischem Magnesium-Mangel und Stress. J. Clin. Chem. Clin. Biochem. 16, 293-297.
39. Caddell, J.L., Kupiecki, R. Proxmire, D.L., Satoh, P & Hutchinson, B. (1986): Plasma catecholamines in acute magnesium deficiency in weanling rats. J. Nutr. 116, 1896-1901.
40. Ryrfeldt, A., Bannenberg, G. & Moldeus, P. (1993): Free radicals and lung disease. Br. Med. Bull. 49, 588-603.
41. Cheeseman, K.H. & Slater, T.F. (1993): An introduction to free radical biochemistry. Br. Med. Bull. 49, 481-493.
42. Contreras, M., Hariharan, N., Lewandoski, J.R., Clesielski, W., Koscik, R. & Zimmerman, J.J. (1996): Bronchoalveolar oxyradical inflammatory elements herald bronchopulmonary dysplasia. Crit. Care Med. 24, 29-37.
43. Pitkanen, O.M., Hallman, M. & Andersson, S.M. (1990): Correlation of free oxygen radical-induced lipid peroxidation with outcome in very low birth weight infants. J. Pediatr. 116, 760-764.
44. Varsila, E., Pesonen, E. & Andersson, A. (1995): Early protein oxidation in the neonatal lung is related to development of chronic lung disease. Acta Paediatr. 84, 1296-1299.
45. Ogihara, T., Okamoto, R., Kim, H.S., Nagai, A., Morinobu, T., Moji, H., Kamegai, H., Hirano, K., Ogihara, H., Tamai, H. & Mino, M. (1996): New evidence for the involvement of oxygen radicals in triggering neonatal chronic lung disease. Pediatr Res. 30, 117-119.
46. Benatar, A., Clarke, J. & Silverman, M. (1995): Pulmonary hypertension in infants with chronic lung disease: non-invasive evaluation and short term effect of oxygen treatment. Arch. Dis. Child. 72, F14-F19.
47. Kelly, F.J. (1993): Free radical disorders of preterm infants. Br. Med. Bull. 49, 668-678.
48. Evans, P.H. (1993): Free radicals in brain metabolism and pathology. Br. Med. Bull. 49, 577-585.
49. Halliwell, B. & Gutteridge, J.M.C. (1990): Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol. 86, 1-85.
50. Flink, E.B., Dedhia, H.V., Dinsmore, J., Doshi, H.M., Banks, D. & Hshieh, P. (1992): High-dose magnesium sulfate attenuates pulmonary oxygen toxicity. Crit. Care Med. 20, 1692-1698.
51. Robertson, B. (1989): The evolution of neonatal respiratory distress syndrome into chronic lung disease. Eur. Respir. J. 2 (suppl 3), 33s-37s.
52. Weglicki, W.B., Phillips, T.M., Mak, I.T., Cassidy, M.M., Dickens, B.F., Stafford, R. & Kramer, J.H. (1994): Cytokines, neuropeptides, and reperfusion injury during magnesium deficiency. Ann. N.Y. Acad. Sci. 723, 246-257.
53. Dickens, B.F., Weglicki, W.B., Li, Y.S. & Mak, I.T. (1992): Magnesium deficiency in vitro enhances free radical induced intracellular oxidation and cytotoxicity in endothelial cells. FEBS Lett. 311, 187-191.
54. Rayssiguier, Y., Durlach, J., Gueux, E., Rock, E. & Mazur, A. (1993): Magnesium and ageing. Experimental data: importance of oxidative damage. Magnes. Res. 6, 369-378.
55. Gueux, E., Azais-Braesco, V., Bussiere, L., Grolier, P., Mazur, A. & Rayssiguier, Y. (1995): Effect of magnesium deficiency on triglyceride-rich lipoproteins and tissue susceptibility to peroxidation in relation to vitamin E content. Br. J. Nutr. 74, 849-856.
56. Mahfouz, M.M. & Kummerow, F.A. (1989): Effect of magnesium deficiency on 6-desaturase activity and fatty acid composition of rat liver microsomes. Lipids 24, 727-732.
57. Freedman, A.M., Mak, I.T., Stafford, R.E., Dickens, B F., Cassidy, M.M., Muesing, R.A. & Weglicki, W.B. (1992): Erythrocytes from magnesium deficient hamsters display an enhanced susceptibility to oxidative stress. Am. J. Physiol. 262, C1371-C1375.
58. Brown, L.A.S., Perez, J.A., Harris, F.L. & Clark, R.H. (1996): Glutathione supplements protect preterm rabbits from oxidative lung injury. Am. J. Physiol. (Cell. Mol. Physiol.) 14, L446-L451.
59. Mills, B.J., Linderman, R.D. & Lang, C.A. (1986): Magnesium deficiency inhibits biosynthesis of blood glutathione and tumor growth in the rat. (42260) Proc. Soc. Exp. Biol. Med. 181, 687-695.
60. Thordstein, M. Bagenholm, R. Thiringer, K. & Kjellmer, I. (1993): Scavengers of free oxygen radicals in combination with magnesium ameliorate perinatal hypoxic-ischemic brain damage in the rat. Pediatr. Res. 34, 23-26.
61. FitzGerald, G.A. (1992): Prostaglandins and related compounds. In: Cecil textbook of medicine, 19th ed., eds. J.B. Wyngaarden, L.H. Smith, & J.C. Bennett, pp. 1206-1212. Philadelphia: W.B. Saunders.
62. Stenmark, K.R., Eyzaguirre, M., Westcott, J.Y., Henson, P.M. & Murphy, R.C. (1987): Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia. Am. Rev. Respir. Dis. 136, 770-772.
63. Christman, B.W., McPherson, C.D., Newman, J.H., King, G. A., Bernard, G.R., Groves, B.M. & Loyd, J.E. (1992): An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N. Engl. J. Med. 327, 70-75.
64. Nadler, J.L., Buchanan, T., Natarajan, R., Antonipillai, I., Bergman, R., & Rude, R. (1993): Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension 21, 1024-1029.
65. Nigam, S., Averdunk, R. & Gunther, T. (1986): Alteration of prostanoid metabolism in rats with magnesium deficiency. Prostaglandins Leukotrienes Med. 123, 1-10.
66. Gunther, T., Schumann, K. & Vormann, J. (1995): Tumor necrosis factor-alpha, prostanoids and immunoglobulins in magnesium deficiency. Magnes. Bull. 17, 109-114.
67. Watson, K.V., Moldow, C.F., Ogburn, P.L. & Jacob, H.S. (1986): Magnesium sulfate: rationale for its use in preeclampsia. Proc. Natl. Acad. Sci. USA 83, 1075-1078.
68. Nadler, J.L., Goodson , S. & Rude, R.K. (1987): Evidence that prostacyclin mediates the vascular action of magnesium in humans. Hypertension 9, 379-383.
69. Caddell, J.L. (1995): Hypothesis - The role of magnesium and possibly copper in the pathogenesis of chronic lung disease of the premature infant. Pediatr. Asthma Allergy Immunol. 9, 87-101.
70. Burhop, K.E., Selig, W.M., & Malik, A.B. (1988): Monohydroxyeicosatetraenoic acids (5-HETE and 15-HETE) induce pulmonary vasoconstriction and edema. Circ. Res. 62, 687-698.
71. Kawamura, K. & Kummerow, F.A. (1992): Effect of magnesium deficiency on 15-hydroxyeicosatetraenoic acid in cultured human umbilical arterial endothelial cells. Magnes. Res. 5, 109-113.
72. Wang, E.E.L., Ohlsson, A. & Kellner, J.D. (1995): Association of Ureaplasma Urealyticum colonization with chronic lung disease of prematurity-results of a metaanalysis. J. Pediatr. 127, 640-644.
73. McCoy, H. & Kenney, M.A. (1992): Magnesium and immune function: recent findings. Magnes. Res. 5: 281-293.
74. Groneck, P. & Speer, C.P. (1995): Pathogenesis of bronchopulmonaiy dysplasia. Z. Geburtshilfe Neonatol. 199, 181-189.
75. Groneck, P., Gotze-Speer, B., Oppermann, M., Eiffert, H. & Speer, C.P. (1994): Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: a sequential analysis of inflammatory mediators in respiratory fluids of high-risk preterm neonates. Pediatrics 93, 712-718.
76. Bagchi, A., Viscardi, R.M., Taciak, V., Ensor, J.E., McCrea, K.A. & Hasday, J.D. (1994): Increased activity of interleukin-6 but not tumor necrosis factor-alpha in lung lavage of premature infants is associated with the development of bronchopulmonary dysplasia. Pediatr. Res. 36, 244-252.
77. Jones, C.A., Cayabyab, R.G., Kwong, K.Y.C., Stotts, C., Wong, B., Hamdan, H., Minoo, P. & de Lemos, R.A. (1996): Undetectable interleukin (IL)-10 and persistent IL-8 expression early in hyaline membrane disease: a possible developmental basis for the predisposition to chronic lung inflammation in preterm newborns. Pediatr. Res. 39, 966-975.
78. LoMonaco, M.B., Barber, C.M. & Sinkin, R.A. (1996): Differential cytokine mRNA expression by neonatal pulmonary cells. Pediatr. Res. 39, 248-252.
79. Watterberg, K.L., Demers, L.M., Scott, S.M. & Murphy, S. (1996): Chorioamnionitis and early lung inflammation in infants in whom bronchopulonary dysplasia develops. Pediatrics 97, 210-215.
80. Rayssiguier, Y., Malpeuch, C., Nowacki, W., Davaud, M., Lebreton, J.P., Rock, E., Mazur, A. & Durlach, J. (1994): Evaluation of the inflammatory state during magnesium deficiency in the rat. Magnes. Res. 7, Suppl. 1, 51 (Abstr.)
81. Weglicki, W.B. & Phillips, T.M. (1992): Pathobiology of magnesium deficiency, a cytokine/neurogenic inflammation hypothesis. Am. J. Physiol. 263, R734-R737.
82. Weglicki, W.B., Phillips, T.M., Freedman, A.M., Cassidy, M.M. & Dickens, B.F. (1992): Magnesium deficiency elevates circulating levels of inflammatory cytokines and endothelin. Mol. Cell Biochem. 110, 169-173.
83. Tullus, K., Noack, G.W., Burman, L.G., Nilsson, R., Wretlind, B. & Brauner, A. (1996): Elevated cytokine levels in tracheobronchial aspirate fluids from ventilator treated neonates with bronchopulmonary dysplasia. Eur. J. Pediatr. 155, 112-116.
84. Vassalli, P. (1992): The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10, 411-452.
85. Giaid, A., Yanagisawa, M., Langleben, D., Michel, R.P., Levy, R., Shennib, H., Kimura, S., Masaki, T., Duguid, W.P. & Stewart, D.J. (1993): Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. 328, 1732-1739.
86. Stewart, D.J., Levy, R.D., Cernacek, P., & Langleben, D. (1991): Increased plasma endothelin-1 in pulmonary hypertension: Marker or mediator of disease? Ann. Intern. Med. 114, 464-469.
87. Kojima, T., Isozaki-Fukuda, Y., Takedatsu, M., Ono, A., Hirata, Y. & Kobayashi, Y. (1992): Plasma endothelin-like immunoreactivity levels in neonates. Eur. J. Pediatr. 151, 913-915.
88. Kojima, T., Hattori, K., Hirata, Y., Aoki, T., Sasaitakedatsu, M., Kino, M. & Kobayashi, Y. (1996): Endothelin-1 has a priming effect on production of superoxide anion by alveolar macrophages - its possible correlation with bronchopulmonary dysplasia. Pediatr. Res. 39, 112-116.
89. 2+ deficiency by substance P receptor inhibition. Circ. Res. 74, 1009-1013.
90. Rock, E., Astler, C., Lab, C., Malpeuch, C., Nowacki, W., Gueux, E., Mazur, A. & Rayssiguier, Y. (1995): Magnesium deficiency in rats induces a rise in plasma nitric oxide. Magnes. Res. 8, 237-242.
91. Milner, A.D. (1994): Nitric oxide. Eur. J. Pediatr. 153 (9 suppl 2): S7-S11.
92. Bois, P., Gascon, A., Beaulnes, A. (1963): Histamine-liberating effect of magnesium deficiency in the rat. Nature, 197, 501-502.
93. Itokawa, Y., Kimura, C., Inagaki, C. & Tanaka, C. (1974): Effect of thiamine on serotonin oxidation in magnesium deficient rats. J. Nutr. Sci. Vitaminol. (Tokyo) 20, 27-33.
94. Garrison, J.C. (1990): Histamine, bradykinin, 5-hydroxytryptamine, and their antagonists. In: Goodman and Gilman's the pharmacological basis of therapeutics, eds. A. G. Goodman, T.W. Rall, A.S. Nies & P. Taylor. 8th ed., pp. 575-599. New York: Pergamon Press.
95. Gunther, T., Vormann, J., Hollriegel, V., Disch, G. & Classen, H.G. (1992): Role of lipid peroxidation and vitamin E in magnesium deficiency. Magnes. Bull. 14, 57-66.
96. Rayssiguier, Y., Gueux, E., Bussiere, L. Durlach, J. & Mazur, A. (1993): Dietary magnesium affects susceptibility of lipoproteins and tissues to peroxidation in rats. J. Am. Coll. Nutr. 12, 133-137.
97. Stocker, J.T. (1986): Pathologic features of long-standing 'healed' bronchopulmonary dysplasia: A study of 28 3-to 40-month-old infants. Hum. Pathol. 17, 943-961.
98. O'Brodovich, H.M. & Mellins, R.B. (1985): Bronchopulmonary dysplasia. Unresolved neonatal acute lung injury. Am. Rev. Respir. Dis. 132, 694-7090.
99. Abman, S.H., Burchell, M.F., Schaeffer, M.S. & Rosenberg, A.A. (1989): Late sudden unexpected deaths in hospitalized infants with bronchopulmonary dysplasia. Am. J. Dis. Child. 143, 815-819.
100. Werthammer, J., Brown, E.R., Neff, R.K. & Taeusch, H.W. (1982): Sudden infant death syndrome in infants with bronchopulmonary dysplasia. Pediatrics 69, 301-304.
101. Kruse, H.D., Orent, E.R., McCollum, E.V (1932): Studies in magnesium deficiency in animals. I. Symptomatology resulting from magnesium deprivation. Ant. J. Physiol. 101, 454-461.
102. Caddell, J.L. (1978): Exploring the magnesium-deficient weanling rat as an animal model for the sudden infant death syndrome: Physical, biochemical, electrocardiographic, and gross pathologic changes. Pediatr. Res. 12, 1157-1166.
103. Caddell, J.L. (1972): Hypothesis: Magnesium deprivation in sudden unexpected infant death. Lancet ii, 258-262.
104. Durlach, J., Durlach, V., Rayssiguier, Y., Ricquier, D., Goubern, M., Bertin, R., Bara, M., Guiet-Bara, A., Olive, G., & Mettey, R. (1991): Magnesium and thermoregulation. I. Newborn and infant. Is sudden infant death syndrome a magnesium-dependent disease of the transition from chemical to physical thermoregulation? Magnes. Res. 4, 137-152.
105. Caddell, J.L. (1992): Hypothesis: new concepts concerning the pathophysiology of the sudden infant death syndrome due to magnesium deficiency shock. Magnes. Res. 5, 165-172.
106. Durlach, J., Durlach, V., Bac, P., Bara, M. & Guiet-Bara, A. (1994): Magnesium and therapeutics. Magnes. Res. 7, 313-328.
107. Mordes, J.P. & Wacker, W.E.C. (1978): Excess magnesium. Pharmacol. Rev. 29, 273-300.
108. Rude, R.K. & Singer, F.R. (1981): Magnesium deficiency and excess. Ann. Rev. Med. 32, 245-259.
109. Green, K.W., Key, T.C., Coen, R. & Resnik, R. (1983): The effects of maternally administered magnesium sulfate on the neonate. Am. J. Obstet. Gynecol. 146, 29-33.
110. Stone, S.R. & Pritchard, J.A. (1970): Effect of maternally administered magnesium sulfate on the neonate. Obstet. Gynecol. 35, 574-577.
111. Dudley, D., Gagnon, D. & Varner, M. (1989): Long-term tocolysis with intravenous magnesium sulfate. Obstet. Gynecol. 73, 373-378.
112. Molloy, D.W., Dhingra, S., Solven, F., Wilson, A. & McCarthy, D.S. (1984): Hypomagnesemia and respiratory muscle power. Am. Rev. Respir. Dis. 129, 497-498.
113. Skobeloff, E.M., Spivey, W.H., McNamara, R.M. & Greenspon, L. (1989): Intravenous magnesium sulfate for the treatment of acute asthma in the emergency department. JAMA 262, 1210-1213.
114. Spivey, W.H., Skobeloff, E.M. & Levin, R.M. (1990): Effect of magnesium chloride on rabbit bronchial smooth muscle. Ann. Emerg. Med. 19, 1107-1112.
115. 2+ entry. Am. J. Physiol. 270, L469-L474.
116. Koumbourlis, A.C., Motoyama, E.K., Mutich, R.L., Mallory, G.B., Walczak, S.A. & Fertal, K. (1996): Longitudinal follow-up of lung function from childhood to adolescence in prematurely born patients with neonatal chronic lung disease. Pediatr. Pulmonol. 21, 28-34.