Coupling protein design and in vitro selection strategies: Improving specificity and affinity of a designed β-protein IL-6 antagonist

Journal of Molecular Biology

Volumn 255, Issue 1, 1996, Pages 86-97

  Martin, Franck ^a   Toniatti, Carlo ^a   Salvati, Anna Laura ^a   Ciliberto, Gennaro ^a   Cortese, Riccardo ^a   Sollazzo, Maurizio ^a  

^a IRBM   (Italy)

Author keywords

Affinity selection; Hypervariable regions; Interleukin 6 antagonist; Phage display; Protein engineering

Indexed keywords

INTERLEUKIN 6;

ARTICLE; DRUG BINDING SITE; DRUG POTENCY; DRUG SPECIFICITY; GENETIC ENGINEERING; PRIORITY JOURNAL;

EID: 0029994999     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0008     Document Type: Article

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