Recovery phase of acute experimental autoimmune encephalomyelitis in rats corresponds to development of endothelial cell unresponsiveness to interferon gamma activation

Journal of Neuroscience Research

Volumn 44, Issue 3, 1996, Pages 223-234

  Dore Duffy, P ^a,c   Balabanov, R ^a   Rafols, J ^b   Swanborg, R H ^c  

^a Division of Neuroimmunology   (United States)

^b Department of Anatomy ^*

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

EAE; endothelial cells; pericytes; TGF 1

Indexed keywords

GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; INFLAMMATION; LEUKOCYTE MIGRATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROVASCULATURE; NONHUMAN; PATHOPHYSIOLOGY; PERICYTE; PRIORITY JOURNAL; RAT; SCORING SYSTEM;

ANIMALS; CAPILLARIES; CELLS, CULTURED; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; RATS; RATS, INBRED F344; TRANSFORMING GROWTH FACTOR BETA;

EID: 0029958899     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960501)44:3<223::AID-JNR3>3.0.CO;2-I     Document Type: Article

References (49)

1. Barmudez L (1993): Production of transforming growth factor beta by Mycobacterium avium-infected human macrophages is associated with unresponsiveness to IFN gamma. J. Immunol 150:1838-1845.
2. Bernard CCA (1977): Suppressor cells prevent experimental autoimmune encephalomyelitis in mice. Clin Exp Immunol 29:100-111.
3. Bowman PD, Betz AJ, Ard D, Wolinsky JS, Penney JB, Shivers RR, Goldstein GW (1981): Primary culture of capillary endothelium from rat brain. In Vitro 17:353-362.
4. Chan BM, Kassner PD, Schiro JA, Byers HR, Kupper TS, Hemler ME (1992): Distinct cellular functions mediated by different VLA integrins α subunit cytoplasmic domains. Cell 68:1051-1060.
5. Cotran RS, Gimbrone MA, Bevilacqua MP, Mendrick ML, Pober JS (1986): Induction and detection of a human endothelial activation antigen in vivo. J Exp Med 164:661-666.
6. Cragg RI, Webster H de F (1985) la antigens in the normal rat nervous system and in lesions of experimental allergic encephalomyelitis. Acta Neuropathol (Berl) 68:263-272.
7. Dore-Duffy P, Balabanov R, Washington R, Swanborg R (1994a): Transforming growth factor beta-1 inhibits cytokine-Induced CNS endothelial cell activation. Mol Chem Neuropathol 22:161-175.
8. Dore-Duffy P, Washington R, Balabanov R (1994b): Cytokine-mediated activation of cultured CNS microvessels: a system for examining antigenic modulation of CNS endothelial cells, and evidence for long-term expression of the adhesion protein E-selectin. J Cereb Blood How Metab 22:16-175.
9. Dore-Duffy P, Balabanov R, Washington R (1994c): CNS pericytes have immune potential. Expression of macrophage antigens and production of eicosanoids. Neurology [Suppl] 43:A163.
10. Fabry H, Topham DJ, Fee D, Herlein J, Carlino JA, Hart MN, Sriram S (1995): TGF-β2 decreases migration of lymphocytes in vitro and homing of cells into the central nervous system in vivo. J Immunol 155:325-332.
11. Herman I, D'Amore PA (1985): Microvascular pericytes contain muscle and nonmuscle actins. J Cell Biol 101:43-52.
12. Hickey WF, Kimuru H (1988): Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 239:290-292.
13. Hickey WF, Osborn JP, Kirby WM (1985): Expression of Ia molecules by astrocytes during acute experimental allergic encephalomyelitis in the Lewis rat. Cell Immunol 91:528-535.
14. Holda JH, Swanborg RH (1980): Susceptibility of Lewis rats to experimental autoimmune encephalomyelitis after recovery from passively induced disease. Immunol Commun 9(4):33-340.
15. Johns LD, Sriram S (1993): Experimental allergic encephalomyelitis: neutralizing antibody to TGFβ1 enhances the clinical severity of the disease. J Neuroimmunol 47:1-7.
16. Johns LD, Flanders KC, Rangers GE, Sriram S (1991): Successful treatment of experimental allergic encephalomyelitis with transforming growth factor beta-1. J Immunol 147:1792-1796.
17. Joo F, Karnushina I (1973): A procedure for the isolation of capillaries from rat brain. Cytobios 8:41-48.
18. Karpus WJ, Swanborg RH (1989): CD4+ suppressor cells differentially affect the production of IFNγ by effector cells of experimental autoimmune encephalomyelitis. J Immunol 143:3492-3501.
19. Karpus WJ, Swanborg RH (1991): CD4+ suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor beta. J Immunol 146:1163-1168.
20. Kuruvilla AP, Shah R, Hochwald GM, Liggitt HD, Palladino MA, Thorbecke GJ (1991): Protective effect of transforming growth factor beta 1 on experimental autoimmune disease in mice. Proc Natl Acad Sci USA 88:2918-2922.
21. Massaque J (1990): The transforming growth factor-β family. Annu Rev Cell Biol 6:597-620.
22. Matsumoto Y, Fujiwara M (1986): In situ detection of class I and II major histocompatibility complex antigens in the rat central nervous system during experimental allergic encephalomyelitis. An immunohistochemical study. J Neuroimmunol 12:265-277.
23. McCarron, RM, Ranke M, Spatz M, McFarlin FE (1991): Cerebral vascular endothelial cells are effective targets for in vitro lysis by encephalitogenic T lymphocytes. J Immunol 147:503-508.
24. McCarron RM, Wang L, Racke MK, McFarlin FE, Spatz M (1993): Cytokine-regulated adhesion between encephalitogenic T lymphocytes and cerebrovascular endothelial cells. J Neuroimmunol 43:23-30.
25. Miller A, Lider O, Roberts AB, Sporn MB, Weiner HL (1992): Suppressor T cells generated by oral toleration to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β after antigen-specific triggering. Proc Natl Acad Sci USA 89:421-425.
26. Miller A, Al-Sabfaagh A, Santos LM, Das MP, Weiner HL (1993): Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression. J Immunol 15:7307-7315.
27. Moiradian DL, Diglio CA (1991): Production of transforming growth factor-β-like growth factor by RSV-transformed rat cerebral microvascular endothelial cells. Tumor Biol 12:171-179.
28. Mustafa M, Vingsbo C, Olsson T, Issazadeh J, Ljungdahl A, Holmdahl R (1994): Protective influences on experimental autoimmune encephalomyelitis by MHC Class I and Class II alleles. J Immunol 153:3337-3344.
29. Paterson PY, Swanborg RH (1988): Demyelinating diseases of the central and peripheral nervous systems. In M. Samster (ed): "Immunological Diseases," 4th ed., Little Brown, pp 1877.
30. Racke MK, Dhib-Jalbut S, Canella B, Albert PS, McFarlin DE (1991): Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis. J Immunol 146:3012-3016.
31. Racke MK, Cannella B, Albert P, Sporn M, Raine CS, McFarlin DE (1992): Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis. Int Immunol 5:615-620.
32. Sakuda H, Nakashima Y, Kuriyama S, Sveishi K (1992): Media conditioned by smooth muscle cells cultured in a variety of hypoxic environments stimulates in vitro angiogenesis. A relationship of transforming growth factor beta 1. Am J Pathol 141:1507-1516.
33. Santambrogio L, Hochwald GM, Leu CH, Thorbecke GJ (1993a): Antagonistic effects of endogenous and exogenous TGF-beta and TNF on auto-immune diseases in mice. Immunopharmacol Immunotoxicol 15:461-478.
34. Santambrogio L, Hochwald GM, Saxena B, Leu CH, Martz JE, Carlino JA, Ruddle NH, Palladino MA, Gold LI, Thorbecke GJ (1993b): Studies of the mechanisms by which transforming growth factor-beta (TGFβ) protects against allergic encephalomyelitis. Antagonism between TGFβ and tumor necrosis factor. J Immunol 151:7307-7315.
35. Santos LM, Al-Sabbagh A, Londono A, Weiner HL (1994): Oral tolerance to myelin basic protein induces regulatory TGF-beta-secreting T-cells in Peyer's patches of SJL mice. Cell Immunol 157:439-447.
36. Sato Y, Tsuboi R, Lyons R, Moses H, Rifrin DB (1990): Characterization of the activation of latent TGFβ by Co-cultures of en-dothelial cells and pericytes or smooth muscle cells: a self-regulation system. J Cell Biol 111:757-703.
37. 2with identical immunosuppressive effects and a potential role in the regulation of autoimmune T cell function. J Neuroimmunol 24:249-257.
38. Shimizu Y, Shaw S. (1991): Lymphocyte interactions with extracellular matrix. FASEB J 5:2292-2299.
39. Sobel RA, Blanchette BW, Bhan AK, Colvin RB (1984): The immunopathology of experimental allergic encephalomyelitis. II. Endothelial cell Ia increases prior to inflammatory cell infiltration. J Immunol 132:2402-2407.
40. Sobel RA, Natale JM, Schneeberger JE (1987): The immunopathology of acute experimental allergic encephalomyelitis. IV. An ultrastructural immunocytochemical study of class II major histocompatibility complex molecule (Ia) expression. J Neuropathol Exp Neurol 46:239-249.
41. Stevens DB, Gould KE, Swanborg RH (1994): Transforming growth factor-β1 inhibits tumor necrosis factor-α/lymphotoxin production and adoptive transfer of disease by effector cells of autoimmune encephalomyelitis. 51:77-83.
42. Swanborg RH (1988): Experimental allergic encephalomyelitis. Methods Enzymol 162:413-428.
43. Traugott U (1989): Detailed analysis of early immunopathologic events during lesion formation in acute experimental encephalomyelitis. Cell Immunol 119:114-129.
44. Uitdehaag BMJ, de Groot CJA, Kreike A, van der Meide PH, Polman CH, Dijkstra CD (1993): The significance of in situ Ia antigen expression in the pathogenesis of autoimmune central nervous system disease. J Autoimmun 6:323-335.
45. Vass K, Lassmann H, Wekerle H, Wisniewski HM (1986): The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis. Acta Neuropathol (Berl) 70:149-160.
46. Washington R, Burton J, Todd RF, Newman W, Dragov L, Dore-Duffy P (1994): Expression of Immunologically relevant endothelial cell activation antigens on isolated central nervous system microvessels from patients with multiple sclerosis. Ann Neurol 35(1):89-97.
47. Wekerle H (1984): The lesion of acute experimental autoimmune encephalomyelitis. Isolation and membrane phenotypes of perivascular infiltrates from encephalitic rat brain white matter. Lab Invest 51:199-205.
48. Willenborg DO (1979): Experimental allergic encephalomyelitis in the Lewis rat: studies on the mechanism of recovery from disease and acquired resistance to reinduction. J Immunol 123(3):1145-1150.
49. Zamvil SS, Steinman L (1990): The T lymphocyte in experimental allergic encephalomyelitis. Annu Rev Immunol 8:579-632.