Pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites in streptozocin-induced diabetic rayts

General Pharmacology

Volumn 27, Issue 5, 1996, Pages 803-807

  Coudore F ^a   Besson, A ^a   Courteix, C ^a   Eschalier, A ^a   Lavarenne, J ^a   Fialip, J ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

Amitriptyline; Demethylated and hydroxylated metabolites; Diabetic; Kinetics; Rat

Indexed keywords

10 HYDROXYAMITRIPTYLINE; 10 HYDROXYNORTRIPTYLINE; AMITRIPTYLINE; DINORAMITRIPTYLINE; DRUG METABOLITE; NORTRIPTYLINE; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG ELIMINATION; DRUG HYDROXYLATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

EID: 0030198608     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(95)02082-9     Document Type: Article

References (33)

1. Attal N., Jazat F., Kayser V. and Guilbaud G. (1990) Further evidence for "pain-related̂ behaviors in a model of unilateral peripheral mononeuropathy. Pain 41, 235-251.
2. Bechtel C. Y., Joanne C., Grandmottet M. and Bechtel R. P. (1988) The influence of insulin-dependent diabetes on the metabolism of caffeine and the expression of the debrisoquin oxidation phenotype. Clin. Pharmacol. Ther. 44, 408-417.
3. Bennett G. J. and Zie Y. K. (1988) A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33, 87-107.
4. Coudoré F., Ardid D., Eschalier A. Fialip J. and Lavarenne J. (1992) High-performance liquid chromatographic determination of amitriptyline and its main metabolites using a silica column with reversed-phase eluent. J. Chromatogr. Biomed. Applic. 584, 249-255.
5. Coudoré F., Fialip J., Eschalier A. and Lavarenne J. (1994) Mice plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after half-life repeated administration. Comparison with acute administration. Fundam. Clin. Pharmacol. 8, 525-531.
6. Coudoré F., Besson A., Eschalier A., Fialip J. and Lavarenne J. (1996) Plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after acute and repeated administration to rats. Gen. Pharmacol. 27, 803-807.
7. Courteix C., Eschalier A. and Lavarenne J. (1993) Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain. Pain 53, 81-88.
8. Courteix C., Bardin M., Chantelauze C., Lavarenne J. and Eschalier A. (1994) Study of the sensibility of the diabetes-induced pain model in rats to a range of analgesics. Pain 57, 153-160.
9. Dahl M. L. and Bertilsson L. (1993) Genetically variable metabolism of antidepressants and neuroleptic drugs in man. Pharmacogenetics 3, 61-70.
10. Dawling S, Braithwaite R., McAuley R. and Montgomery S. (1979) Single oral-dose pharmacokinetics of amitriptyline and maprotiline in depressed patients - prediction of steady-state plasma concentrations. Br. J. Clin. pract. 33, 28-33.
11. Dixon R. L., Hart L. G. and Fouts J. R. (1961) The metabolism of drugs by liver microsomes from alloxan-diabetic rats. J. Pharmacol. Exp. Ther. 133, 7-11.
12. Eschalier A., Fialip J., Varoquaux O., Makambila M. C., Marty H. and Bastide P. (1988) Pharmacokinetic patterns of repeated administration of antidepressants in animals. I. Implications for antinociceptive action of clomipramine in mice. J. Pharmac. Exp. Ther. 245, 963-968.
13. Favreau L. V. and Schenkman J. B. (1988) Composition changes in hepatic microsomal cytochrome P-450 during onset of streptozocin-induced diabetes and during insulin treatment. Diabetes 37, 576-584.
14. Ghersi-Egea J. F., Minn A. and Siest G. (1988) A new aspect of the protective function of the blood-brain barrier: activities of four drug-metabolizing enzymes in isolated rat brain microvessels. Life Sci. 42, 2515-1523.
15. Hyttel J., CNDRistensen A. V. and Fjalland B. (1980) Neuropharmacological properties of amitriptyline, nortriptyline and their metabolites. Acta Pharmac. Toxic. 47, 53-57.
16. Kapitulnik J., Gelboin H. G., Guengerich F. P. and Jakobovitz D. M. (1987) Immuno-histochemical localization of cytochrome P450 in rat brain. Neuroscience 20, 829-833.
17. LeQuesne P. M. and Fowler C. J. (1986) A study of pain threshold in diabetic with neuropathic foot lesions. J. Neurol. Neurosurg. Psychiat. 49, 1191-1194.
18. Minn A., Ghersi-Egea J. F., Perrin R., Leininger B. and Siest G. (1991) Drug metabolizing enzymes in the rat brain and cerebral microvessels Brain Res. Rev. 16, 65-82.
19. Miyake K., Fukuchi H., Kitaura T., Kimura M., Sarai K. and Nakahara T. (1990) Pharmacokinetics of amitriptyline and its demethylated metabolite in serum and specific brain regions of rats after acute and chronic administration of amitriptyline. J. Pharm. Sci. 79, 288-192.
20. Past M. R. and Cook D. E. (1982) Drug metabolism in a reconstituted system by diabetes dependent hepatic cytochrome P-450. Res. Comm. Chem. Pathol. Pharm 37, 81-90.
21. Potter W. Z., Rudorfer M. V. and Lane E. A. (1984) Frontiers in Biochemical and Pharmacological Research in Depression pp. 373-390, Raven Press, New York.
22. Reinke L. A., Stohs S. J., and Rosenberg H. (1978) Altered activity of hepatic mixed-function monooxygenase enzymes in streptozotocin-induced diabetic rats. Xenobiotica 8, 611-619.
23. Rouer E., Beaune P. and Leroux J. P. (1986) Immunoquantitation of some cytochrome P-450 in liver microsomes from streptozotocin-diabetic rats. Experientia 42, 1162-1163.
24. Schultz P., Dick P., Blaschke T. F. and Hollister L. (1985) Discrepancies between pharmacokinetic studies of amitriptyline. Clin. Pharmacokin. 10, 257-258.
25. Seltzer Z., Dubner R. and Shir Y. (1990) A novel behavioural model of neuropathic pain disorders produced by partial sciatic nerve injury. Pain 43, 205-215.
26. Shimojo N. (1994) Cytochrome P450 changes in rats with streptozocin-induced diabetes. Int. J. Biochem. 26, 1261-1268.
27. Shimojo N., Ishizaki T., Imaoka S., Funae Y., Fujii S. and Okuda K. (1993) Changes in amounts of cytochrome P450 isozymes and levels of catalytic activities in hepatic and renal microsomes of rats with streptozocin-induced diabetes. Biochem. Pharmac. 46, 621-627.
28. Sindrup S. H. (1994) Antidepressants in the treatment of diabetic neuropathy symptoms. Danish Med. Bull. 41, 66-78.
29. Skett P. and Joels L. A. (1985) Different effects of acute and chronic diabetes mellitus on hepatic drug metabolism in the rat. Biochem. Pharmac. 34, 287-289.
30. Watkins J. (1990) Natural history of the diabetic neuropathy. Quart. J. Med. New series 77, 284, 1209-1218.
31. Young R. J. and Clarke B. F. (1985) Pain relief in diabetic neuropathy: the effectiveness of imipramine and related drugs. Diabetic Med. 2, 363-366.
32. Young R. C. (1991) Hydroxylated metabolites of antidepressants. Psychopharmac. Bull. 27, 521.
33. Ziegler D., Mayer P., Wiefels K. and Gries F. A. (1988) Assessment of small and large fiber function in long-term type 1 (insulin-dependent) diabetic patients with and without painful neuropathy. Pain 34, 1-10.