The design and synthesis of 2,5-linked pyrrolinones. A potential non- peptide peptidomimetic scaffold

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 7, 1996, Pages 1021-1034

  Smith III, Amos B ^a   Knight, Steven D ^a   Sprengeler, Paul A ^a   Hirschmann, Ralph ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PYRROLINE DERIVATIVE;

ARTICLE; OXIDATION; PROTEIN ANALYSIS; PROTEIN STRUCTURE; SYNTHESIS;

EID: 0030181824     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(96)00094-6     Document Type: Article

References (66)

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66. 36. Compounds of this type in which the aldehyde is flanked by an iso-butyl group (derived from leucine) are also more stable than aldehyde 42, but are not as robust as 55. This is presumably due to the added steric bulk of the iso-propyl group of aldehyde 55, rendering it much less susceptible to nucleophilic attack.