Structure-function relationship of recombinant follicle stimulating hormone (Puregon®)

Molecular Human Reproduction

Volumn 2, Issue 5, 1996, Pages 361-369

  De Leeuw, Renato ^a   Mulders, John ^a   Voortman, Gerrit ^a   Rombout, Ferdy ^a   Damm, Jan ^a   Kloosterboer, Lenus ^a  

^a NV ORGANON   (Netherlands)

Author keywords

Biological properties; Isohormones; Recombinant FSH (Org 32489); Structure

Indexed keywords

FOLLITROPIN; RECOMBINANT PROTEIN;

ANIMAL; CHEMISTRY; DOG; FEMALE; HAMSTER; HUMAN; METABOLISM; RAT; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; CRICETINAE; DOGS; FEMALE; FOLLICLE STIMULATING HORMONE; HUMANS; RATS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030132584     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/2.5.361     Document Type: Article

References (33)

1. Baenziger, J.U. and Green, E.D. (1988) Pituitary glycoprotein hormone oligosaccharides structure, synthesis and function of asparagine linked oligosaccharides on lutropin, follitropin and thyrotropin. Biochem. Biophys. Acta, 947, 287-306.
2. Blum, W.E. and Gupta, D. (1985) Heterogenicity of rat FSH in chromatofocusing studies on serum FSH hormone released in vitro and metabolic clearance rates of its various forms. J. Endocrinol., 105, 29-37.
3. Catt, J.K. and Pierce, J. (1986) Gonadotrophic hormones of the adenohypophysis. In Yen, S.C.C. and Jaffe, R.B. (eds), Reproductive Endocrinology. 2nd edn. W.B. Saunders, Philadelphia, USA, pp. 75-114.
4. Cerpa-Poljak, A., Bishop, L.A., Hort, Y.J. et al. (1993) Isoelectric charge of recombinant human follicle-stimulating hormone isoforms determines receptor affinity and in vitro bioactivity. Endocrinology, 132, 351-356.
5. Chappel, S. (1990) Biological to immunological ratios: reevaluation of a concept (Editorial). J. Clin. Endocrinol. Metab., 70, 1494-5.
6. Chappel, S.C. (1995) Heterogeneity of follicle stimulating hormone: control and physiological function. Hum. Reprod. Update 1, 479-487.
7. Chappel, S.C., Bethea, C.L. and Spies, H.G. (1984) Existence of multiple forms of follicle stimulating hormone within the anterior pituitary of Cynomolgus monkeys. Endocrinology, 115, 452-461.
8. Dahl, K.D. and Stone, M.P. (1992) FSH isoforms, radioimmunoassays, and their significance. J. Androl., 13, 11-22.
9. Damm, J.B.L., Kamerling, J.P., Van Dedem, G.W.K. and Vliegenthart, J.F.G. (1987) A general strategy for the isolation of carbohydrate chains from N,O-glycoproteins and its application to human chorionic gonadotrophin. Glycoconj. J., 4, 129-144.
10. Damm, J.B.L., Voshol, H., Hård, K. et al. (1989) Analysis of N-acetyl-4-0-acetyl neuraminic acid-containing carbohydrate chains released by peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase-F. Eur. J. Biochem., 180, 101-110.
11. Hård, K., Mekking, A., Damm, J.B.L. et al. (1990) Isolation and structure determination of the intact sialylated N-linked carbohydrate chains of recombinant human follitropin (hFSH) expressed in Chinese hamster ovary cells. Eur. J. Biochem., 193, 263-271.
12. Hsueh, A.J.W., Adashi, E.Y., Jones, P.B.C. and Welsh, T.H. (1984) Hormonal regulation of the differentiation of cultured ovarian granulosa cells. Endocr. Rev., 5, 76-127.
13. Kamerling, J.P. and Vliegenthart, J.F.G. (1989) In Lawson, A.M. (ed.), Clinical Biochemistry; Principles, Methods, Applications. Vol. 1. Mass spectrometry. Walter de Gruyter & Co., Berlin, pp. 175-263.
14. Mannaerts, B.M.J.L., Kloosterboer, H.J. and Schuurs, A.H.W.M. (1987) Applications of in vitro bioassays for gonadotrophins. In Rolland, R., Heineman, M.J., Naaktgeboren, N. et al. (eds), Neuro-Endocrinology of Reproduction. Excerpt. Med. Int. Congr. Ser. 751, Elsevier, Amsterdam, pp. 49-58.
15. Mannaerts, B., De Leeuw, R., Geelen, J. et al. (1991) Comparative in vitro and in vivo studies on the biological characteristics of recombinant human follicle-stimulating hormone. Endocrinology, 129, 2624-2630.
16. Mannaerts, B., Uilenbroek, J., Schot, P. and De Leeuw, R. (1994) Folliculogenesis in hypophysectomized rats after treatment with recombinant human follicle-stimulating hormone. Biol. Reprod., 51, 72-81.
17. Mannaerts, B.M.J.L., Rombout, F., Out, H.J. and Coelingh Bennink, H.J.T. (1996) Clinical profiling of Puregon: relation between serum FSH and efficacy. Hum Reprod., 11, in press.
18. Matikainen, T., De Leeuw, R., Mannaerts, B. and Huhtaniemi, I. (1994) Circulating bioactive and immunoreactive recombinant human follicle stimulating hormone (Org 32489) after administration to gonadotrophin-deficient subjects. Fertil. Steril., 61, 62-69.
19. Moore, S. and Stein, W.M.J. (1951) Chromatography of amino acids on polystyrene resins. J. Biol. Chem., 192, 662-681.
20. Olijve, W., De Boer, W., Mulders, J.W.M. and Van Wezenbeek, P.M.G.F. (1996) Molecular biology and biochemistry of human recombinant follicle stimulating hormone (Puregon®). Mol. Hum. Reprod., 2, 371-382.
21. Out, H.J., Mannaerts, B.M.J.L., Driessen, S.G.A.J. and Coelingh Bennink, H.J.T. (1996) Puregon in assisted reproduction: more oocytes, more pregnancies! Hum. Reprod., 11, in press.
22. Out, H.J., Mannaerts, B.M.J.L., Driessen, S.G.A.J. and Coelingh Bennink, H.J.T. (1995) A prospective randomized assessor-blind, multicentre study comparing recombinant and urinary follicle stimulating hormone (Puregon vs. Metrodin) in in-vitro fertilization. Hum Reprod., 10, 2534-2540.
23. Overes, H.W.T.M., De Leeuw, R.and Kloosterboer, H.J. (1992) Regulation of aromatase activity in FSH-primed rat granulosa cells in vitro by follicle stimulating hormone and various amounts of human chorion gonadotrophin. Hum. Reprod., 7, 191-196.
24. Porchet, H.C., LeCotonnec, J.Y., Canali, S. and Zanolo, G. (1993) Pharmacokinetics of recombinant human follicle stimulating hormone after intravenous, intramuscular, and subcutaneous administration in monkeys, and comparison with intravenous administration of urinary follicle stimulating hormone. Drug Metab. Dispos., 21, 144-150.
25. Reader, S.C.J., Robertson, W.R. and Diczfalusy, E.(1983) Microheterogeneity of luteinizing hormone in pituitary glands from women of pre- and postmenopausal age. Clin. Endocrinol., 19, 355-363.
26. Sharp, R.M. (1990) Intratesticular control of steroidogenesis. Clin. Endocrinol., 33, 787-807.
27. Steelman, S.L. and Pohley, F.M. (1953) Assay of the follicle stimulating hormone based on the augmentation with human chorionic gonadotrophin. Endocrinology, 53, 604-616.
28. Ulloa-Aguirre, A., Mejia, J.J., Dominguez, R. et al. (1986) Microheterogeneity of anterior pituitary FSH in male rat: isoelectrofocusing pattern throughout sexual maturation. J. Endocrinol., 110, 539-549.
29. Ulloa-Aquirre, A., Espinoza, R., Damian-Matsumura, P. and Chappel, S.C. (1988) Immunological and biological potencies of different molecular species of gonadotrophins. Hum. Reprod., 3, 491-501.
30. Van Wezenbeek, P., Draaier, J., Van Meel, F. and Olyve, W. (1990) Recombinant follicle stimulating hormone. I. Construction, selection and characterization of a cell line. In Crommelin D.J.A. and Schellekens, H. (eds), From Clone to Clinic, Developments in Biotherapy. Vol. 1. Kluwer, Dordrecht, pp. 245-251.
31. Wide, L. (1982) Male and female forms of human follicle stimulating hormone in serum. J. Clin. Endocrinol. Metab., 55, 682-688.
32. Wide L. (1985) Median charge and charge heterogeneity of human pituitary FSH, LH and TSH. II. Relationship to sex and age. Acta Endocrinol., 109, 190-197.
33. Zaidi, A.A., Robertson, D.M. and Diczfalusy, E. (1981) Studies on the biological and immunological properties of human follitropin: profiles of two international reference preparations and of an aqueous extract of pituitary glands after electrofocusing. Acta Endocrinol., 97, 157-165.