Inhibitory effect of KW-4679, an anti-allergic drug, on tachykinin-mediated airway response induced by electric vagal stimulation in guinea pigs

Japanese Journal of Pharmacology

Volumn 71, Issue 2, 1996, Pages 179-182

  Ikemura, Toshihide ^a   Sasaki, Yasuo ^a   Ishii, Hidee ^a   Ohmori, Kenji ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

KW 4679; Tachykinin; Vagal stimulation

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; ATROPINE; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ A; OLOPATADINE; PROPRANOLOL; SAREDUTANT; SUBSTANCE P; TACHYKININ;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; GUINEA PIG; LUNG; LUNG COMPLIANCE; MALE; NONHUMAN; PRESYNAPTIC INHIBITION; SENSORY NERVE; VAGUS NERVE STIMULATION;

EID: 0030037530     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.71.179     Document Type: Article

References (15)

1. Lundberg JM, Lundbland L, Martling CR, Saria A, Stjarne P and Anggard A: Coexistence of multiple peptides and classic transmitters in airway neurons: functional and pathophysiologic aspects. Am Rev Respir Dis 136, s16-s22 (1987)
2. Szolcsanyi J: Antidromic vasodilation and neurogenic inflammation. Agents Actions 23, 4-11 (1988)
3. Bertrand C, Geppetti P, Graf PD, Foresi A and Nadel JA: Involvement of neurogenic inflammation in antigen-induced bronchoconstriction in guinea pigs. Am J Physiol 265, L507-L511 (1993)
4. Bertrand C, Nadel JA, Yamawaki I and Geppetti P: Role of kinins in the vascular extravasation evoked by antigen and mediated by tachykinins in guinea pig trachea. J Immunol 151, 4902-4907 (1993)
5. Matsuse T, Thomson RJ, Chen XR, Salari H and Schellenberg RR: Capsaicin inhibits airway hyperresponsiveness but not lipoxygenase activity or eosinophilia after repeated aerosolized antigen in guinea pigs. Am Rev Resp Dis 144, 368-372 (1991)
6. Ohmori K, Ishii H, Sasaki Y, Ikemura T, Manabe H and Kitamura S: Effects of KW-4679, a new orally active antiallergic drug, on antigen-induced bronchial hyperresponsiveness, airway inflammation and immediate and late asthmatic responses in guinea pigs. Int Arch Allergy Immunol 110, 64-72 (1996)
7. Ikemura T, Okamura K, Sasaki Y, Ishii H and Ohmori K: KW-4679-induced inhibition of tachykininergic contraction in the guinea pig bronchi by prejunctional inhibition of peripheral sensory nerves. Br J Pharmacol 117, 967-973 (1996)
8. Aoki S, Tsukagoshi H and Kurosawa M: Changes in respiratory resistance and dynamic compliance induced by histamine in the guinea pig. Jpn J Thor Dis 29, 1239-1246 (1991) (Abstr in English)
9. Lei Y-H, Barnes PJ and Rogers D: Regulation of NANC neural bronchoconstriction in vivo in the guinea pig: involvement of nitric oxide, vasoactive intestinal peptide and soluble guanylyl cyclase. Br J Pharmacol 108, 228-235 (1993)
10. Coyle AJ, Ackerman SJ, Burch R, Proud D and Irvin CG: Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on bradykinin generation. J Clin Invest 95, 1735-1740 (1995)
11. Boni P, Ballati L and Evangelista S: Tachykinin NK1 and NK2 receptors mediate the non-cholinergic bronchospastic response to capsaicin and vagal stimulation in guinea pigs. J Auton Pharmacol 15, 49-54 (1995)
12. Shah MV and Hirshman CA: Mode of action of halothane on histamine-induced airway constriction in dogs with reactive airways. Anesthesiology 65, 170-174 (1986)
13. Sasaki Y, Ikemura T, Ishii H, Kitamura S and Ohmori K: Effect of KW-4679, a novel antiallergic drug, on platelet-activating factor (PAF)-induced bronchoconstriction, airway hyperresponsiveness and pulmonary cell accumulation in guinea pigs. Folia Pharmacol Jpn 106, 347-357 (1995) (Abstr in English)
14. Perretti F, Ballad L, Manzini S, Maggi CA and Evangelista S: Antibronchospastic activity of MEN10, 627, a novel tachykinin NK2 receptor antagonist, in guinea pig airways. Eur J Pharmacol 273, 129-135 (1995)
15. Perretti F and Manzini S: Activation of capsaicin-sensitive sensory fibers modulation PAF-induced bronchial hyperresponsiveness in anesthetized guinea pigs. Am Rev Respir Dis 148, 927-931 (1993)